| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGGGGGSGGGGSFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:04)
[INFO] Main: Simulation completed successfully. (00:02:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.3776 | |
| 2 | S | A | -0.1440 | |
| 3 | R | A | -1.6297 | |
| 4 | P | A | -1.0851 | |
| 5 | G | A | -0.9876 | |
| 6 | L | A | -0.5682 | |
| 7 | P | A | -0.2813 | |
| 8 | V | A | -0.1074 | |
| 9 | E | A | -0.2801 | |
| 10 | Y | A | 0.6363 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.7896 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.5413 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9732 | |
| 17 | S | A | -0.6705 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3300 | |
| 20 | R | A | -1.8995 | |
| 21 | D | A | -2.6652 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.3848 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8938 | |
| 29 | G | A | -1.0779 | |
| 30 | G | A | -1.6573 | |
| 31 | N | A | -2.4113 | |
| 32 | N | A | -2.5115 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | -1.0389 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.1168 | |
| 43 | R | A | -2.4844 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.4823 | |
| 46 | D | A | -2.9688 | |
| 47 | D | A | -2.1063 | |
| 48 | Y | A | -0.4506 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.8964 | |
| 54 | N | A | -0.2607 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2291 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.4782 | |
| 60 | W | A | -0.1817 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | 0.1380 | |
| 63 | Q | A | -1.0734 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.2542 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | -1.5628 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.4046 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.5815 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9206 | |
| 84 | S | A | 0.0340 | |
| 85 | P | A | -0.2004 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.4457 | |
| 88 | G | A | -1.3947 | |
| 89 | K | A | -1.9118 | |
| 90 | A | A | -0.8679 | |
| 91 | G | A | -0.5930 | |
| 92 | C | A | 0.0189 | |
| 93 | Q | A | -0.6611 | |
| 94 | T | A | -0.4895 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8392 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5641 | |
| 99 | T | A | -0.5021 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3552 | |
| 103 | S | A | -0.5163 | |
| 104 | E | A | -0.6743 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.5706 | |
| 108 | W | A | -0.8398 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.5758 | |
| 111 | A | A | -0.9674 | |
| 112 | N | A | -1.2648 | |
| 113 | R | A | -1.7151 | |
| 114 | A | A | -1.8704 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -2.1508 | |
| 117 | P | A | -1.3438 | |
| 118 | T | A | -0.9109 | |
| 119 | G | A | -0.5629 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | 0.0109 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2377 | |
| 139 | H | A | -0.4043 | |
| 140 | P | A | -0.9443 | |
| 141 | Q | A | -1.2288 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.2408 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.2601 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -1.0295 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.2622 | |
| 157 | Q | A | -1.3137 | |
| 158 | G | A | -0.5185 | |
| 159 | M | A | 0.4344 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | -0.0207 | |
| 162 | S | A | 0.3846 | |
| 163 | L | A | 0.8809 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0396 | |
| 166 | L | A | 0.7248 | |
| 167 | A | A | -0.2967 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.2320 | |
| 170 | D | A | -1.8793 | |
| 171 | A | A | -1.4999 | |
| 172 | G | A | 0.0000 | |
| 173 | G | A | -1.5177 | |
| 174 | Y | A | -1.3138 | |
| 175 | K | A | -1.6179 | |
| 176 | A | A | -0.7373 | |
| 177 | A | A | -0.7222 | |
| 178 | D | A | -0.5846 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6520 | |
| 183 | S | A | -0.9373 | |
| 184 | S | A | -0.8607 | |
| 185 | D | A | -1.0933 | |
| 186 | P | A | -1.1536 | |
| 187 | A | A | 0.0000 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -2.1531 | |
| 190 | R | A | -1.3531 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.2631 | |
| 195 | Q | A | -1.4613 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -0.9967 | |
| 199 | K | A | -1.3329 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2604 | |
| 202 | A | A | -0.9432 | |
| 203 | N | A | -1.4533 | |
| 204 | N | A | -1.8289 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.8163 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.9919 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -1.3129 | |
| 216 | P | A | -1.4990 | |
| 217 | N | A | -2.0383 | |
| 218 | E | A | -1.8233 | |
| 219 | L | A | -0.0193 | |
| 220 | G | A | -0.5062 | |
| 221 | G | A | -0.7257 | |
| 222 | A | A | -0.8383 | |
| 223 | N | A | -1.0684 | |
| 224 | I | A | 0.1943 | |
| 225 | P | A | -0.2610 | |
| 226 | A | A | -0.4729 | |
| 227 | E | A | -0.6152 | |
| 228 | F | A | 0.8167 | |
| 229 | L | A | 0.7403 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.8857 | |
| 232 | F | A | 0.3073 | |
| 233 | V | A | -0.0624 | |
| 234 | R | A | -0.4396 | |
| 235 | S | A | -0.7132 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.7187 | |
| 239 | K | A | -2.2024 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.6678 | |
| 242 | D | A | -2.7091 | |
| 243 | A | A | -1.8564 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4549 | |
| 246 | A | A | -1.3289 | |
| 247 | A | A | -0.9811 | |
| 248 | G | A | -1.1171 | |
| 249 | G | A | 0.0000 | |
| 250 | H | A | -1.6702 | |
| 251 | N | A | -1.2236 | |
| 252 | A | A | -0.5579 | |
| 253 | V | A | 0.3019 | |
| 254 | F | A | 0.4258 | |
| 255 | N | A | -0.0980 | |
| 256 | F | A | -0.0360 | |
| 257 | P | A | -0.4475 | |
| 258 | P | A | -0.7230 | |
| 259 | N | A | -1.2335 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | -0.8549 | |
| 262 | H | A | -0.6030 | |
| 263 | S | A | -0.5469 | |
| 264 | W | A | -0.8178 | |
| 265 | E | A | -1.7806 | |
| 266 | Y | A | -0.8428 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.5792 | |
| 270 | Q | A | 0.0000 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.8710 | |
| 273 | A | A | -0.5816 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0384 | |
| 276 | G | A | -1.0945 | |
| 277 | D | A | -0.8178 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.0240 | |
| 280 | S | A | -0.8867 | |
| 281 | S | A | -0.5069 | |
| 282 | L | A | -0.3868 | |
| 283 | G | A | -0.8776 | |
| 284 | A | A | -1.1067 | |
| 285 | G | A | -1.3797 | |
| 286 | G | A | -1.2774 | |
| 287 | G | A | -1.4685 | |
| 288 | G | A | -1.4240 | |
| 289 | G | A | -1.2168 | |
| 290 | S | A | -1.0565 | |
| 291 | G | A | -1.1831 | |
| 292 | G | A | -1.2339 | |
| 293 | G | A | -0.8827 | |
| 294 | G | A | -0.4744 | |
| 295 | S | A | 0.5457 | |
| 296 | F | A | 2.1719 | |
| 297 | A | A | 1.5299 | |
| 298 | V | A | 1.7089 | |
| 299 | T | A | -0.1297 | |
| 300 | N | A | -1.5770 | |
| 301 | D | A | -1.7721 | |
| 302 | G | A | -0.3042 | |
| 303 | V | A | 1.9840 | |
| 304 | I | A | 2.5708 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine