| Chain sequence(s) |
A: GPLPLNPEPAPRSTDDYVEPTDLLYYAETDLLTRTGHPTKDIVVNGKVVVPKVSAYQWKVFKLTLPDPNKLPLPSEDFIDPATHRLIWRLLAYKIHKFGPLGVGSYGHPNFNRFGDVDNPTEPQHEGADMTVNYSFTPVRYQGYIIGDRPPLGKYTAKAAPAPGLPPGAIPPLTTVTTYIMDGDMADIGFGAKDYKELLPEKNRVPDIILNTSTKVVDLEGMKAEPYGDRMFDYDEKRSSKDVKNYRYNGPDKVPLPADEPPSKLYVKPSPESPYAVRPNYNYFTIPDRGEITEDDLLFNKPIYLEETAGLNNGILWHNQLYVTVIDNTRAEIEEIRTRICTPEENVFDPSCYITSKRYTEEWQLSMIIQLCKIPLTPEILAEIARRDPSILVDWNLPDIPPVERPDPYAGMKFHEIDLTDKLSSDLSKSSLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2108 | |
| 2 | P | A | 0.4212 | |
| 3 | L | A | 1.3954 | |
| 4 | P | A | 0.7064 | |
| 5 | L | A | 0.8539 | |
| 6 | N | A | -1.0098 | |
| 7 | P | A | -1.4367 | |
| 8 | E | A | -2.2661 | |
| 9 | P | A | -1.5621 | |
| 10 | A | A | -0.8101 | |
| 11 | P | A | -0.7951 | |
| 12 | R | A | -1.3307 | |
| 13 | S | A | -1.3561 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.0842 | |
| 16 | D | A | -2.9167 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.0005 | |
| 20 | P | A | -1.5253 | |
| 21 | T | A | -1.1682 | |
| 22 | D | A | -1.6256 | |
| 23 | L | A | -0.4737 | |
| 24 | L | A | -0.0974 | |
| 25 | Y | A | 0.0072 | |
| 26 | Y | A | -0.3419 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8799 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3429 | |
| 31 | L | A | 0.2827 | |
| 32 | L | A | 0.0248 | |
| 33 | T | A | -0.2475 | |
| 34 | R | A | -0.5806 | |
| 35 | T | A | -0.5367 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.4204 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4151 | |
| 40 | K | A | -1.9891 | |
| 41 | D | A | -0.7981 | |
| 42 | I | A | 1.2750 | |
| 43 | V | A | 2.2456 | |
| 44 | V | A | 1.7815 | |
| 45 | N | A | -0.4998 | |
| 46 | G | A | -0.3463 | |
| 47 | K | A | -0.1227 | |
| 48 | V | A | 1.9310 | |
| 49 | V | A | 2.4979 | |
| 50 | V | A | 1.1939 | |
| 51 | P | A | -0.1066 | |
| 52 | K | A | -1.1353 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2341 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.2709 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.4655 | |
| 70 | K | A | -1.9447 | |
| 71 | L | A | -0.8184 | |
| 72 | P | A | -0.6330 | |
| 73 | L | A | -0.5272 | |
| 74 | P | A | -0.6381 | |
| 75 | S | A | -1.4787 | |
| 76 | E | A | -2.8089 | |
| 77 | D | A | -2.8398 | |
| 78 | F | A | -1.4261 | |
| 79 | I | A | -1.5542 | |
| 80 | D | A | -2.2699 | |
| 81 | P | A | -1.2408 | |
| 82 | A | A | -0.6489 | |
| 83 | T | A | -0.6557 | |
| 84 | H | A | -0.9818 | |
| 85 | R | A | -0.7161 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2865 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.2990 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | -0.7234 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.3635 | |
| 97 | K | A | 0.0000 | |
| 98 | F | A | 0.5457 | |
| 99 | G | A | -0.2584 | |
| 100 | P | A | -0.1072 | |
| 101 | L | A | 0.2217 | |
| 102 | G | A | 0.1279 | |
| 103 | V | A | 0.6618 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.1584 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9455 | |
| 108 | H | A | -1.3395 | |
| 109 | P | A | -1.4497 | |
| 110 | N | A | -2.0413 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.4616 | |
| 114 | F | A | -0.1423 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.9077 | |
| 117 | V | A | -1.2695 | |
| 118 | D | A | -2.7549 | |
| 119 | N | A | -2.7212 | |
| 120 | P | A | -1.9619 | |
| 121 | T | A | -1.7048 | |
| 122 | E | A | -2.4644 | |
| 123 | P | A | -1.1532 | |
| 124 | Q | A | -1.4323 | |
| 125 | H | A | -1.4728 | |
| 126 | E | A | -1.6554 | |
| 127 | G | A | -1.4415 | |
| 128 | A | A | -1.1820 | |
| 129 | D | A | -1.5870 | |
| 130 | M | A | -0.2581 | |
| 131 | T | A | -0.6694 | |
| 132 | V | A | -0.5433 | |
| 133 | N | A | -1.5534 | |
| 134 | Y | A | -0.8564 | |
| 135 | S | A | -0.5599 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.1283 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | -0.6676 | |
| 140 | R | A | 0.0000 | |
| 141 | Y | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | G | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.4124 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.0556 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.3535 | |
| 155 | Y | A | -0.3420 | |
| 156 | T | A | -0.1459 | |
| 157 | A | A | 0.0000 | |
| 158 | K | A | -0.9921 | |
| 159 | A | A | -0.0146 | |
| 160 | A | A | -0.1418 | |
| 161 | P | A | 0.0332 | |
| 162 | A | A | -0.1407 | |
| 163 | P | A | -0.3369 | |
| 164 | G | A | -0.3507 | |
| 165 | L | A | 0.4195 | |
| 166 | P | A | -0.0393 | |
| 167 | P | A | -0.2183 | |
| 168 | G | A | -0.2097 | |
| 169 | A | A | 0.9036 | |
| 170 | I | A | 2.1731 | |
| 171 | P | A | 0.9786 | |
| 172 | P | A | 0.7537 | |
| 173 | L | A | 1.2806 | |
| 174 | T | A | 0.4420 | |
| 175 | T | A | 0.1287 | |
| 176 | V | A | 0.2170 | |
| 177 | T | A | 0.0309 | |
| 178 | T | A | 0.1500 | |
| 179 | Y | A | 0.1309 | |
| 180 | I | A | 0.0000 | |
| 181 | M | A | -0.1399 | |
| 182 | D | A | 0.0000 | |
| 183 | G | A | -0.4705 | |
| 184 | D | A | -0.4047 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2768 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3641 | |
| 190 | F | A | -0.1314 | |
| 191 | G | A | -0.3174 | |
| 192 | A | A | -0.5196 | |
| 193 | K | A | -1.2504 | |
| 194 | D | A | -1.8239 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.4527 | |
| 197 | E | A | -3.2362 | |
| 198 | L | A | -1.5262 | |
| 199 | L | A | -1.7674 | |
| 200 | P | A | -1.8681 | |
| 201 | E | A | -1.7378 | |
| 202 | K | A | -2.5571 | |
| 203 | N | A | -1.6699 | |
| 204 | R | A | -1.2895 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.4053 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.3752 | |
| 211 | N | A | -2.1860 | |
| 212 | T | A | -1.4167 | |
| 213 | S | A | -1.2441 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.0244 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | -0.8781 | |
| 219 | L | A | -1.1323 | |
| 220 | E | A | -2.3989 | |
| 221 | G | A | -1.6321 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4757 | |
| 224 | A | A | -1.5130 | |
| 225 | E | A | -1.2351 | |
| 226 | P | A | -0.6692 | |
| 227 | Y | A | -0.3313 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.5768 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.5116 | |
| 234 | Y | A | -0.2713 | |
| 235 | D | A | -0.9775 | |
| 236 | E | A | -1.2836 | |
| 237 | K | A | -1.6243 | |
| 238 | R | A | -1.4716 | |
| 239 | S | A | -1.5156 | |
| 240 | S | A | -1.9847 | |
| 241 | K | A | -2.9722 | |
| 242 | D | A | -2.8432 | |
| 243 | V | A | -1.6590 | |
| 244 | K | A | -2.5200 | |
| 245 | N | A | -1.6775 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | Y | A | -0.0132 | |
| 249 | N | A | -0.7713 | |
| 250 | G | A | -1.0964 | |
| 251 | P | A | -1.0133 | |
| 252 | D | A | -1.0003 | |
| 253 | K | A | -1.1579 | |
| 254 | V | A | 0.9618 | |
| 255 | P | A | 0.1247 | |
| 256 | L | A | 0.0178 | |
| 257 | P | A | -0.7447 | |
| 258 | A | A | -1.1427 | |
| 259 | D | A | -2.2177 | |
| 260 | E | A | -1.9686 | |
| 261 | P | A | -1.2685 | |
| 262 | P | A | -0.5635 | |
| 263 | S | A | -0.5252 | |
| 264 | K | A | -0.9135 | |
| 265 | L | A | 0.8611 | |
| 266 | Y | A | 0.9530 | |
| 267 | V | A | 1.0303 | |
| 268 | K | A | -0.5614 | |
| 269 | P | A | -0.5394 | |
| 270 | S | A | -0.8018 | |
| 271 | P | A | -1.0501 | |
| 272 | E | A | -1.7020 | |
| 273 | S | A | -0.6612 | |
| 274 | P | A | -0.3482 | |
| 275 | Y | A | 0.6669 | |
| 276 | A | A | 0.1891 | |
| 277 | V | A | 0.8204 | |
| 278 | R | A | -0.4278 | |
| 279 | P | A | -0.4401 | |
| 280 | N | A | 0.0000 | |
| 281 | Y | A | 0.4260 | |
| 282 | N | A | 0.3410 | |
| 283 | Y | A | 1.1570 | |
| 284 | F | A | 0.0000 | |
| 285 | T | A | -0.4167 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -2.0884 | |
| 289 | R | A | -1.5516 | |
| 290 | G | A | -2.2825 | |
| 291 | E | A | -2.2672 | |
| 292 | I | A | -1.2624 | |
| 293 | T | A | -1.9288 | |
| 294 | E | A | -2.7141 | |
| 295 | D | A | -2.9094 | |
| 296 | D | A | -2.3195 | |
| 297 | L | A | -1.4724 | |
| 298 | L | A | -1.1276 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1433 | |
| 301 | K | A | -1.5978 | |
| 302 | P | A | -0.8033 | |
| 303 | I | A | -0.2064 | |
| 304 | Y | A | -0.5865 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5519 | |
| 307 | E | A | -2.8253 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.6441 | |
| 310 | G | A | -0.6191 | |
| 311 | L | A | -0.5342 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.5807 | |
| 319 | N | A | -0.6382 | |
| 320 | Q | A | -0.6425 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | I | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.1126 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -1.7172 | |
| 333 | I | A | -1.7693 | |
| 334 | E | A | -3.0200 | |
| 335 | E | A | -2.9288 | |
| 336 | I | A | -0.7762 | |
| 337 | R | A | -1.3009 | |
| 338 | T | A | -0.1622 | |
| 339 | R | A | -0.2346 | |
| 340 | I | A | 1.7972 | |
| 341 | C | A | 0.6921 | |
| 342 | T | A | -0.3089 | |
| 343 | P | A | -0.8663 | |
| 344 | E | A | -2.2844 | |
| 345 | E | A | -2.5707 | |
| 346 | N | A | -1.4722 | |
| 347 | V | A | 0.5507 | |
| 348 | F | A | 1.4687 | |
| 349 | D | A | 0.0845 | |
| 350 | P | A | 0.2564 | |
| 351 | S | A | 0.3938 | |
| 352 | C | A | 0.0000 | |
| 353 | Y | A | 1.0181 | |
| 354 | I | A | 1.7941 | |
| 355 | T | A | -0.1691 | |
| 356 | S | A | -0.8659 | |
| 357 | K | A | -2.1213 | |
| 358 | R | A | -1.7865 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.8602 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.1453 | |
| 363 | W | A | 0.0000 | |
| 364 | Q | A | -0.3341 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | M | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | Q | A | -0.3231 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -1.0478 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7034 | |
| 376 | L | A | -0.2481 | |
| 377 | T | A | -0.6026 | |
| 378 | P | A | -0.9935 | |
| 379 | E | A | -1.8131 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -0.4300 | |
| 382 | A | A | -0.7701 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | A | A | -0.4967 | |
| 386 | R | A | -1.2461 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -0.5940 | |
| 389 | P | A | -0.5837 | |
| 390 | S | A | -0.5591 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.7439 | |
| 394 | D | A | -1.2044 | |
| 395 | W | A | -0.9598 | |
| 396 | N | A | -1.4901 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | -1.3059 | |
| 399 | D | A | -1.9325 | |
| 400 | I | A | -0.6721 | |
| 401 | P | A | -0.5063 | |
| 402 | P | A | -0.4850 | |
| 403 | V | A | 0.3361 | |
| 404 | E | A | -1.6688 | |
| 405 | R | A | -1.7486 | |
| 406 | P | A | -1.4409 | |
| 407 | D | A | -1.6560 | |
| 408 | P | A | -0.8834 | |
| 409 | Y | A | -0.6078 | |
| 410 | A | A | -0.7419 | |
| 411 | G | A | -0.8173 | |
| 412 | M | A | -0.6994 | |
| 413 | K | A | -1.7590 | |
| 414 | F | A | -1.1524 | |
| 415 | H | A | -1.4428 | |
| 416 | E | A | -2.4971 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.6698 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6414 | |
| 421 | D | A | -2.3203 | |
| 422 | K | A | -1.8827 | |
| 423 | L | A | -0.6699 | |
| 424 | S | A | -0.8314 | |
| 425 | S | A | -0.5433 | |
| 426 | D | A | -1.4744 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.8610 | |
| 429 | K | A | -2.4149 | |
| 430 | S | A | 0.0000 | |
| 431 | S | A | -1.2721 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.6243 | |
| 435 | E | A | -1.8225 | |
| 436 | Y | A | -0.8396 | |
| 437 | L | A | -0.4029 | |
| 438 | N | A | -2.0625 | |
| 439 | R | A | -2.2525 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine