Project name: ZT1

Chain sequence(s)	A: ASQLTQSPSSLSASVGDRVTITCRASQDISSALVWYQQKPGKAPKLLIYDASSLESGVPSRFSGSESGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKGGGGSGGGGSGGGGSQVQLQESGGGVCQPGRSLRLSCQASGFTFSTYGMHWVRQAPGKGLEWVAVIWDDGSYKYRGDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGITMVRGVMKDYFDYWGQGTLVTVSS
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:43)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:44)

• Minimal score value: -3.1111
• Maximal score value: 1.725
• Average score: -0.6821
• Total score value: -168.4908

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	-0.4604
2	S	A	-1.4276
3	Q	A	-1.6738
4	L	A	-1.3762
5	T	A	-1.2187
6	Q	A	-1.0202
7	S	A	-0.8011
8	P	A	-0.5609
9	S	A	-0.7357
10	S	A	-0.8746
11	L	A	-0.6965
12	S	A	-1.1528
13	A	A	-1.1238
14	S	A	-0.9077
15	V	A	0.1922
16	G	A	-0.6653
17	D	A	-1.5964
18	R	A	-2.2622
19	V	A	0.0000
20	T	A	-0.6241
21	I	A	0.0000
22	T	A	-0.8786
23	C	A	0.0000
24	R	A	-2.8885
25	A	A	0.0000
26	S	A	-2.0154
27	Q	A	-2.6665
28	D	A	-2.8136
29	I	A	0.0000
30	S	A	-1.4583
31	S	A	-0.9550
32	A	A	0.0000
33	L	A	0.0000
34	V	A	0.0000
35	W	A	0.0000
36	Y	A	0.0000
37	Q	A	0.0000
38	Q	A	0.0000
39	K	A	-1.5162
40	P	A	-1.0515
41	G	A	-1.5556
42	K	A	-2.3085
43	A	A	-1.4711
44	P	A	0.0000
45	K	A	-1.3654
46	L	A	0.0000
47	L	A	0.0000
48	I	A	0.0000
49	Y	A	0.0848
50	D	A	-0.2536
51	A	A	0.0000
52	S	A	-0.5286
53	S	A	-0.0727
54	L	A	0.1593
55	E	A	-0.5032
56	S	A	-0.5035
57	G	A	-0.5637
58	V	A	-0.3827
59	P	A	-0.3610
60	S	A	-0.4306
61	R	A	-0.7333
62	F	A	0.0000
63	S	A	-0.2554
64	G	A	0.0000
65	S	A	-1.1131
66	E	A	-2.0445
67	S	A	-1.4859
68	G	A	-1.8014
69	T	A	-2.1965
70	D	A	-2.1012
71	F	A	0.0000
72	T	A	-0.9152
73	L	A	0.0000
74	T	A	-0.5772
75	I	A	0.0000
76	S	A	-1.3063
77	S	A	-1.0727
78	L	A	0.0000
79	Q	A	-0.5790
80	P	A	-1.2139
81	E	A	-1.5641
82	D	A	0.0000
83	F	A	-0.3839
84	A	A	0.0000
85	T	A	-0.7085
86	Y	A	0.0000
87	Y	A	0.0000
88	C	A	0.0000
89	Q	A	0.0000
90	Q	A	0.0000
91	F	A	0.0000
92	N	A	-0.3528
93	S	A	-0.2396
94	Y	A	0.1763
95	P	A	-0.2721
96	L	A	0.0000
97	T	A	-0.3625
98	F	A	-0.2881
99	G	A	0.0000
100	G	A	-1.0053
101	G	A	0.0000
102	T	A	0.0000
103	K	A	-1.3064
104	V	A	0.0000
105	E	A	-1.6402
106	I	A	-1.2708
107	K	A	-1.9955
108	G	A	-1.5525
109	G	A	-1.4650
110	G	A	-1.3517
111	G	A	-1.2452
112	S	A	-1.2103
113	G	A	-1.5549
114	G	A	-1.3796
115	G	A	-1.1973
116	G	A	-1.1852
117	S	A	-1.0255
118	G	A	-1.1593
119	G	A	-1.3399
120	G	A	-1.3233
121	G	A	-1.4243
122	S	A	-1.3610
123	Q	A	-1.8181
124	V	A	-0.8668
125	Q	A	-1.5213
126	L	A	0.0000
127	Q	A	-1.7718
128	E	A	0.0000
129	S	A	-0.7788
130	G	A	-0.6021
131	G	A	0.1434
132	G	A	0.8848
133	V	A	1.6233
134	C	A	0.0000
135	Q	A	-1.4586
136	P	A	-2.0790
137	G	A	-2.2104
138	R	A	-2.7266
139	S	A	-2.0622
140	L	A	-1.2861
141	R	A	-2.0558
142	L	A	0.0000
143	S	A	-0.9500
144	C	A	0.0000
145	Q	A	-1.5114
146	A	A	0.0000
147	S	A	-1.1701
148	G	A	-0.9716
149	F	A	-0.2901
150	T	A	-0.1640
151	F	A	0.0000
152	S	A	-0.9985
153	T	A	-0.4598
154	Y	A	-0.0163
155	G	A	0.0000
156	M	A	0.0000
157	H	A	0.0000
158	W	A	0.0000
159	V	A	0.0000
160	R	A	0.0000
161	Q	A	-0.6205
162	A	A	-1.0336
163	P	A	-0.9875
164	G	A	-1.4599
165	K	A	-2.2861
166	G	A	-1.4341
167	L	A	0.0000
168	E	A	-0.9815
169	W	A	0.0000
170	V	A	0.0000
171	A	A	0.0000
172	V	A	0.0000
173	I	A	0.0000
174	W	A	-0.6160
175	D	A	-1.3009
176	D	A	-2.1862
177	G	A	-1.4308
178	S	A	-0.8108
179	Y	A	-0.2022
180	K	A	-0.3320
181	Y	A	-0.2180
182	R	A	-1.4025
183	G	A	0.0000
184	D	A	-2.6016
185	S	A	-1.9610
186	V	A	0.0000
187	K	A	-2.7735
188	G	A	-1.8680
189	R	A	-1.6017
190	F	A	0.0000
191	T	A	-0.9455
192	I	A	0.0000
193	S	A	-0.4636
194	R	A	-1.3943
195	D	A	-2.1440
196	N	A	-2.2517
197	S	A	-1.7330
198	K	A	-2.5576
199	N	A	-1.9130
200	T	A	0.0000
201	L	A	0.0000
202	Y	A	-0.6882
203	L	A	0.0000
204	Q	A	-1.2040
205	M	A	0.0000
206	N	A	-1.9095
207	S	A	-1.8756
208	L	A	0.0000
209	R	A	-3.1111
210	A	A	-1.9651
211	E	A	-2.4497
212	D	A	0.0000
213	T	A	-0.4432
214	A	A	0.0000
215	V	A	0.8243
216	Y	A	0.0000
217	Y	A	0.0000
218	C	A	0.0000
219	A	A	0.0000
220	R	A	0.1676
221	D	A	0.0000
222	G	A	0.0000
223	I	A	1.2740
224	T	A	1.0677
225	M	A	1.2714
226	V	A	0.0000
227	R	A	-1.2670
228	G	A	-0.1596
229	V	A	1.3173
230	M	A	1.4659
231	K	A	0.6618
232	D	A	0.0000
233	Y	A	0.2754
234	F	A	0.0000
235	D	A	0.0029
236	Y	A	0.1795
237	W	A	-0.5461
238	G	A	0.0000
239	Q	A	-1.8302
240	G	A	-0.7136
241	T	A	0.2232
242	L	A	1.7250
243	V	A	0.0000
244	T	A	0.4214
245	V	A	0.0000
246	S	A	-0.5741
247	S	A	-0.3326