| Chain sequence(s) |
A: GPLPLNPEPPLRSTDEYVEDTDLLYVAETDLITETGHPFKDIVVNGKVVVPQVSAYQYRLFLLKLPDPNTMPLPSPDFVDRSTEILIWRLRAFKIGVFGPLGKGTYGLANFNKLGDVTNPTEYQQETTDDTVNFSFTPKLLQEYIIGDRPPLGVYTALADPEPGLPPGATPPTKKVTDIIQDGDVADIGFGAKDYKALDPEKNNVPEIIKDTVTKEIDYEGMKADPYGDRMFTHDRYEKSKDVKKLVKSGKEKKPLPDKPGPSKLYVKPPPTSPYWKLPSTNYFTIPDAGEIKEEDLLFNKPIFLEKTEGLNQGVLWHNRLYILVVDNTRAEIEEIKTRISTPAIDVFNPENYVTSKRYTREYQLSLIVQLCRIPLTPEILEELRRRDPSILENANLPEIPPVSRPDPLAGKKFHEIDLTDKFSSDLEKYELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2438 | |
| 2 | P | A | 0.4619 | |
| 3 | L | A | 1.3694 | |
| 4 | P | A | 0.3754 | |
| 5 | L | A | 0.9153 | |
| 6 | N | A | -1.0310 | |
| 7 | P | A | -1.3331 | |
| 8 | E | A | -2.2862 | |
| 9 | P | A | -1.5206 | |
| 10 | P | A | -0.8831 | |
| 11 | L | A | -0.4822 | |
| 12 | R | A | -1.3191 | |
| 13 | S | A | -1.3883 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.3016 | |
| 16 | E | A | -3.1059 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -3.1577 | |
| 20 | D | A | -3.1081 | |
| 21 | T | A | -1.9726 | |
| 22 | D | A | -1.8969 | |
| 23 | L | A | -0.6542 | |
| 24 | L | A | -0.1067 | |
| 25 | Y | A | -0.1343 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1487 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2553 | |
| 31 | L | A | 0.3319 | |
| 32 | I | A | 0.1686 | |
| 33 | T | A | -0.1128 | |
| 34 | E | A | -0.3490 | |
| 35 | T | A | -0.5594 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.2922 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -1.0428 | |
| 40 | K | A | -1.2238 | |
| 41 | D | A | -0.0913 | |
| 42 | I | A | 1.7385 | |
| 43 | V | A | 2.5123 | |
| 44 | V | A | 1.8378 | |
| 45 | N | A | -0.4946 | |
| 46 | G | A | -0.3326 | |
| 47 | K | A | -0.0035 | |
| 48 | V | A | 2.2351 | |
| 49 | V | A | 2.8433 | |
| 50 | V | A | 1.7179 | |
| 51 | P | A | 0.4066 | |
| 52 | Q | A | -0.7196 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0050 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.8600 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.7240 | |
| 70 | T | A | -0.3371 | |
| 71 | M | A | -0.0511 | |
| 72 | P | A | -0.1210 | |
| 73 | L | A | -0.1457 | |
| 74 | P | A | -0.3651 | |
| 75 | S | A | -0.7496 | |
| 76 | P | A | -1.2998 | |
| 77 | D | A | -2.3863 | |
| 78 | F | A | -1.3400 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -3.1512 | |
| 81 | R | A | -3.1680 | |
| 82 | S | A | -1.9695 | |
| 83 | T | A | -1.3492 | |
| 84 | E | A | -1.5834 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7909 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.9487 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.6278 | |
| 99 | G | A | -0.2329 | |
| 100 | P | A | -0.3360 | |
| 101 | L | A | -0.4280 | |
| 102 | G | A | -1.2072 | |
| 103 | K | A | -1.7866 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.6534 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.6312 | |
| 108 | L | A | 0.0000 | |
| 109 | A | A | -0.8391 | |
| 110 | N | A | -1.4567 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | K | A | -0.7079 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.3035 | |
| 117 | V | A | -0.6952 | |
| 118 | T | A | -1.1349 | |
| 119 | N | A | -1.9572 | |
| 120 | P | A | -1.3445 | |
| 121 | T | A | -1.3847 | |
| 122 | E | A | -2.1815 | |
| 123 | Y | A | -1.0615 | |
| 124 | Q | A | -1.5206 | |
| 125 | Q | A | -2.1603 | |
| 126 | E | A | -2.1086 | |
| 127 | T | A | -1.5151 | |
| 128 | T | A | -1.2348 | |
| 129 | D | A | -2.1708 | |
| 130 | D | A | -1.6249 | |
| 131 | T | A | -1.0296 | |
| 132 | V | A | -0.5497 | |
| 133 | N | A | -1.1729 | |
| 134 | F | A | -0.5542 | |
| 135 | S | A | -0.4215 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.2965 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.7415 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.5101 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.5540 | |
| 155 | Y | A | -0.9663 | |
| 156 | T | A | -1.0958 | |
| 157 | A | A | -0.9802 | |
| 158 | L | A | -0.5133 | |
| 159 | A | A | -1.5901 | |
| 160 | D | A | -2.4553 | |
| 161 | P | A | -1.9734 | |
| 162 | E | A | -2.5058 | |
| 163 | P | A | -1.4949 | |
| 164 | G | A | -0.8485 | |
| 165 | L | A | -0.4301 | |
| 166 | P | A | -0.5060 | |
| 167 | P | A | -0.5166 | |
| 168 | G | A | -0.8586 | |
| 169 | A | A | -0.5621 | |
| 170 | T | A | -0.4832 | |
| 171 | P | A | -0.6293 | |
| 172 | P | A | -1.0201 | |
| 173 | T | A | -1.0976 | |
| 174 | K | A | -2.1865 | |
| 175 | K | A | -2.1518 | |
| 176 | V | A | -0.9619 | |
| 177 | T | A | -0.7649 | |
| 178 | D | A | -0.7800 | |
| 179 | I | A | 0.0000 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -1.1601 | |
| 182 | D | A | 0.0000 | |
| 183 | G | A | -0.6055 | |
| 184 | D | A | -0.5684 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.5417 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4980 | |
| 190 | F | A | -0.0404 | |
| 191 | G | A | -0.4640 | |
| 192 | A | A | -0.7439 | |
| 193 | K | A | -1.2151 | |
| 194 | D | A | -1.0816 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -2.9543 | |
| 197 | A | A | -1.3041 | |
| 198 | L | A | -0.8562 | |
| 199 | D | A | -1.9405 | |
| 200 | P | A | -2.0537 | |
| 201 | E | A | -2.5431 | |
| 202 | K | A | -3.0241 | |
| 203 | N | A | -1.7321 | |
| 204 | N | A | -1.3083 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | E | A | -1.4927 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | K | A | -2.4142 | |
| 211 | D | A | -2.8073 | |
| 212 | T | A | -1.5155 | |
| 213 | V | A | -0.6860 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | E | A | -0.9163 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | -1.1698 | |
| 219 | Y | A | -1.5329 | |
| 220 | E | A | -2.5385 | |
| 221 | G | A | -1.6439 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.8717 | |
| 224 | A | A | -1.5722 | |
| 225 | D | A | -1.3368 | |
| 226 | P | A | -0.6715 | |
| 227 | Y | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.7440 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.9428 | |
| 234 | H | A | -0.9423 | |
| 235 | D | A | -1.1324 | |
| 236 | R | A | -1.1084 | |
| 237 | Y | A | -0.6485 | |
| 238 | E | A | -1.1415 | |
| 239 | K | A | -1.8019 | |
| 240 | S | A | -2.1748 | |
| 241 | K | A | -2.9487 | |
| 242 | D | A | -2.6666 | |
| 243 | V | A | -0.9451 | |
| 244 | K | A | -1.8551 | |
| 245 | K | A | -1.9057 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | K | A | -0.7265 | |
| 249 | S | A | -1.5547 | |
| 250 | G | A | -2.0269 | |
| 251 | K | A | -2.8915 | |
| 252 | E | A | -2.8381 | |
| 253 | K | A | -3.2699 | |
| 254 | K | A | -2.8977 | |
| 255 | P | A | -1.9835 | |
| 256 | L | A | -0.4447 | |
| 257 | P | A | -1.3295 | |
| 258 | D | A | -2.4396 | |
| 259 | K | A | -2.6259 | |
| 260 | P | A | -1.4737 | |
| 261 | G | A | -1.2038 | |
| 262 | P | A | -0.6097 | |
| 263 | S | A | -0.5509 | |
| 264 | K | A | -0.7479 | |
| 265 | L | A | 1.1876 | |
| 266 | Y | A | 1.1018 | |
| 267 | V | A | 1.2359 | |
| 268 | K | A | -0.0612 | |
| 269 | P | A | -0.1969 | |
| 270 | P | A | -0.2939 | |
| 271 | P | A | -0.5463 | |
| 272 | T | A | -0.1567 | |
| 273 | S | A | -0.1977 | |
| 274 | P | A | -0.1650 | |
| 275 | Y | A | 0.2048 | |
| 276 | W | A | -0.7373 | |
| 277 | K | A | -1.9884 | |
| 278 | L | A | -1.0691 | |
| 279 | P | A | -0.9278 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.0631 | |
| 282 | N | A | -0.4853 | |
| 283 | Y | A | 0.6914 | |
| 284 | F | A | -0.0675 | |
| 285 | T | A | -0.9328 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.7007 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.9513 | |
| 291 | E | A | -2.7399 | |
| 292 | I | A | -2.1307 | |
| 293 | K | A | -3.1344 | |
| 294 | E | A | -3.3976 | |
| 295 | E | A | -3.1637 | |
| 296 | D | A | -2.3124 | |
| 297 | L | A | -1.3779 | |
| 298 | L | A | -0.8812 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2511 | |
| 301 | K | A | -1.8722 | |
| 302 | P | A | -1.0528 | |
| 303 | I | A | -0.2746 | |
| 304 | F | A | -0.7061 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.6246 | |
| 307 | K | A | -2.9424 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.1949 | |
| 310 | G | A | -1.3616 | |
| 311 | L | A | -0.8727 | |
| 312 | N | A | 0.0000 | |
| 313 | Q | A | -1.6970 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -1.0366 | |
| 319 | N | A | -0.9082 | |
| 320 | R | A | -1.2961 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | L | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.6963 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.8142 | |
| 333 | I | A | -2.4640 | |
| 334 | E | A | -3.2849 | |
| 335 | E | A | -3.1936 | |
| 336 | I | A | -1.5002 | |
| 337 | K | A | -1.8494 | |
| 338 | T | A | -0.8866 | |
| 339 | R | A | -1.2139 | |
| 340 | I | A | 0.8531 | |
| 341 | S | A | -0.0608 | |
| 342 | T | A | -0.0153 | |
| 343 | P | A | -0.1136 | |
| 344 | A | A | 0.6934 | |
| 345 | I | A | 1.9075 | |
| 346 | D | A | 0.5063 | |
| 347 | V | A | 2.2523 | |
| 348 | F | A | 2.2157 | |
| 349 | N | A | 0.1137 | |
| 350 | P | A | -0.9363 | |
| 351 | E | A | -1.6244 | |
| 352 | N | A | -0.9194 | |
| 353 | Y | A | -0.2274 | |
| 354 | V | A | 0.2578 | |
| 355 | T | A | -1.0542 | |
| 356 | S | A | -1.4007 | |
| 357 | K | A | -2.5116 | |
| 358 | R | A | -2.5606 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.9698 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.0342 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.3982 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.5834 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -1.0690 | |
| 376 | L | A | -0.7784 | |
| 377 | T | A | -0.9227 | |
| 378 | P | A | -1.5164 | |
| 379 | E | A | -2.4767 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -1.6643 | |
| 382 | E | A | -2.9207 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.0608 | |
| 386 | R | A | -1.6540 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -0.8422 | |
| 389 | P | A | -1.0472 | |
| 390 | S | A | -0.7781 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | E | A | -1.3159 | |
| 394 | N | A | -1.6793 | |
| 395 | A | A | -1.6446 | |
| 396 | N | A | -2.2444 | |
| 397 | L | A | -1.7804 | |
| 398 | P | A | -1.6362 | |
| 399 | E | A | -2.0557 | |
| 400 | I | A | -0.9827 | |
| 401 | P | A | -0.6971 | |
| 402 | P | A | -0.4492 | |
| 403 | V | A | 0.9466 | |
| 404 | S | A | -0.2594 | |
| 405 | R | A | -1.3676 | |
| 406 | P | A | -1.2885 | |
| 407 | D | A | -1.7112 | |
| 408 | P | A | -1.0597 | |
| 409 | L | A | -0.8657 | |
| 410 | A | A | -0.9712 | |
| 411 | G | A | -1.2239 | |
| 412 | K | A | -1.6106 | |
| 413 | K | A | -2.3308 | |
| 414 | F | A | -1.4657 | |
| 415 | H | A | -1.5244 | |
| 416 | E | A | -2.5388 | |
| 417 | I | A | -1.9390 | |
| 418 | D | A | -2.9324 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9351 | |
| 421 | D | A | -2.5575 | |
| 422 | K | A | -2.1790 | |
| 423 | F | A | -0.9367 | |
| 424 | S | A | -1.1085 | |
| 425 | S | A | -0.7856 | |
| 426 | D | A | -1.8900 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.4632 | |
| 429 | K | A | -3.1976 | |
| 430 | Y | A | -2.3203 | |
| 431 | E | A | -2.4629 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.9753 | |
| 435 | E | A | -1.9982 | |
| 436 | Y | A | -1.1579 | |
| 437 | L | A | -0.7404 | |
| 438 | N | A | -2.1738 | |
| 439 | R | A | -2.2295 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine