Project name: 14ab73a03f40bd0

Chain sequence(s)	H: QVQLQESGGGVVQPGRSLRLSCAASGFSLTIYGVHWVRQAPGKGLEWLGVVWSDGRTDYNPSLKSRLTISKDNSKNTVYLQMNSLRAEDTAVYYCARYYLGSSFLTYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCSVSQGISNYLNWYQQKPGKAPKLLIYYTSSLHSGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQYSILPWTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:59)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:00)

• Minimal score value: -2.7569
• Maximal score value: 1.6726
• Average score: -0.5458
• Total score value: -122.815

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5076
2	V	H	-0.9727
3	Q	H	-1.6994
4	L	H	0.0000
5	Q	H	-1.8263
6	E	H	0.0000
7	S	H	-0.8120
8	G	H	-0.4063
9	G	H	0.2326
11	G	H	0.8258
12	V	H	1.5780
13	V	H	-0.2920
14	Q	H	-1.6686
15	P	H	-2.0456
16	G	H	-2.1953
17	R	H	-2.7569
18	S	H	-1.8042
19	L	H	-0.8543
20	R	H	-1.1065
21	L	H	0.0000
22	S	H	-0.6334
23	C	H	0.0000
24	A	H	-1.0447
25	A	H	0.0000
26	S	H	-1.2491
27	G	H	-1.0390
28	F	H	-0.1774
29	S	H	-0.0354
30	L	H	0.0000
35	T	H	-0.1656
36	I	H	1.3246
37	Y	H	1.1398
38	G	H	0.0000
39	V	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5825
45	A	H	-1.0288
46	P	H	-1.0264
47	G	H	-1.4525
48	K	H	-2.3391
49	G	H	-1.5594
50	L	H	0.0000
51	E	H	-0.9047
52	W	H	0.0000
53	L	H	0.0000
54	G	H	0.0000
55	V	H	0.0000
56	V	H	0.0000
57	W	H	-0.9812
58	S	H	-0.8902
59	D	H	-2.2742
63	G	H	-2.1749
64	R	H	-2.6288
65	T	H	-1.4660
66	D	H	-1.1062
67	Y	H	-0.6435
68	N	H	-0.9534
69	P	H	-1.1141
70	S	H	-0.7919
71	L	H	0.0000
72	K	H	-1.5914
74	S	H	-1.0440
75	R	H	-0.9509
76	L	H	0.0000
77	T	H	-0.6075
78	I	H	0.0000
79	S	H	-0.6883
80	K	H	-1.2161
81	D	H	-1.8016
82	N	H	-2.3325
83	S	H	-1.8859
84	K	H	-2.5061
85	N	H	-1.8841
86	T	H	-1.3873
87	V	H	0.0000
88	Y	H	-0.3069
89	L	H	0.0000
90	Q	H	-0.7005
91	M	H	0.0000
92	N	H	-1.5773
93	S	H	-1.7570
94	L	H	0.0000
95	R	H	-2.5834
96	A	H	-1.7015
97	E	H	-2.2699
98	D	H	0.0000
99	T	H	-0.3484
100	A	H	0.0000
101	V	H	0.7900
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	Y	H	1.0296
108	Y	H	1.5062
109	L	H	1.5091
110	G	H	0.2441
112	S	H	0.6165
113	S	H	0.5890
114	F	H	0.0000
115	L	H	0.0000
116	T	H	0.3090
117	Y	H	0.2153
118	W	H	-0.4371
119	G	H	0.0000
120	Q	H	-1.9787
121	G	H	-0.7749
122	T	H	0.1680
123	L	H	1.6726
124	V	H	0.0000
125	T	H	0.4327
126	V	H	0.0000
127	S	H	-0.3830
128	S	H	-0.4648
1	D	L	-1.9139
2	I	L	0.0000
3	Q	L	-1.9542
4	M	L	0.0000
5	T	L	-0.8575
6	Q	L	0.0000
7	S	L	-0.4341
8	P	L	-0.6842
9	S	L	-0.9845
10	S	L	-1.3044
11	L	L	-1.0055
12	S	L	-1.3272
13	A	L	-1.1503
14	S	L	-0.8957
15	V	L	-0.0093
16	G	L	-0.8700
17	D	L	-1.9242
18	R	L	-2.3490
19	V	L	0.0000
20	T	L	-0.6673
21	I	L	0.0000
22	T	L	-0.4968
23	C	L	0.0000
24	S	L	-1.1743
25	V	L	0.0000
26	S	L	-1.5082
27	Q	L	-1.6110
28	G	L	-1.1904
29	I	L	0.0000
36	S	L	-0.3405
37	N	L	-0.1252
38	Y	L	0.9493
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.1978
45	K	L	-1.5111
46	P	L	-1.0678
47	G	L	-1.6479
48	K	L	-2.5467
49	A	L	-1.5544
50	P	L	0.0000
51	K	L	-1.2104
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.8873
56	Y	L	1.2343
57	T	L	0.0000
65	S	L	0.1692
66	S	L	0.3678
67	L	L	0.3930
68	H	L	-0.1964
69	S	L	-0.3790
70	G	L	-0.5051
71	V	L	-0.2969
72	P	L	-0.3214
74	S	L	-0.3616
75	R	L	-0.7590
76	F	L	0.0000
77	S	L	-0.2657
78	G	L	0.0000
79	S	L	-0.5946
80	G	L	-1.0074
83	S	L	-1.0795
84	G	L	-1.1959
85	T	L	-1.4740
86	D	L	-2.0039
87	Y	L	0.0000
88	T	L	-0.5848
89	F	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.4403
93	S	L	-1.2628
94	L	L	0.0000
95	Q	L	-0.8658
96	P	L	-1.1532
97	E	L	-1.6478
98	D	L	0.0000
99	I	L	-0.6206
100	A	L	0.0000
101	T	L	0.0000
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	S	L	0.7705
109	I	L	1.4847
114	L	L	0.7193
115	P	L	-0.0264
116	W	L	0.0000
117	T	L	-0.5553
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.7161
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-2.1933
124	V	L	0.0000
125	E	L	-1.7621
126	I	L	-1.1234
127	K	L	-1.6780