Chain sequence(s) |
A: AVTVVPDPTCCGTLSFKVPKDAKKGKHLGTFDIRQAIMDYGGLHSQEWCAKGIVNPTFTVRMHAPRNAFAGLSIACTFDDYKRIDLPALGNECPPSEMFELPTKVFMLKDADVHEWQFNYGELTGHGLCNWANVATQPTLYFFVASTNQVTMAADWQCIVTMHVDMGPVIDRFELNPTMTWPIQLGDTFAIDRYYEAKEIKLDGSTSMLSISYNFGGPVKHSKKHAISYSRAVMSRNLGWSGTISGSVKSVSSLFCTASFVIFPWECEAPPTLRQVLWGPHQIMHGDGQFEIAIKTRLHSAATTEEGFGRLGILPLSGPIAPDAHVGSYEFIVHINTWRPDSQVHPPMFSSSELYNWFTLTNLKPDANTGVVNFDIPGYIHDFASKDATVTLASNPLSWLVAATGWHYGEVDLCISWSRSKQAQAQEGSVSITTNYRDWGAYWQGQARIYDLRRTEAEIPIFLGSYAGATPSGALGKQNYVRISIVNAKDIVALRVCLRPKSIKFWGRSATLF
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:42) [INFO] Main: Simulation completed successfully. (00:05:45) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | A | A | 1.2928 | |
2 | V | A | 2.6642 | |
3 | T | A | 2.1739 | |
4 | V | A | 2.8837 | |
5 | V | A | 2.4423 | |
6 | P | A | 0.0869 | |
7 | D | A | -1.3530 | |
8 | P | A | -0.6949 | |
9 | T | A | -0.9179 | |
10 | C | A | -0.6231 | |
11 | C | A | 0.0000 | |
12 | G | A | 0.0000 | |
13 | T | A | 0.0717 | |
14 | L | A | 0.3875 | |
15 | S | A | -0.3481 | |
16 | F | A | 0.0000 | |
17 | K | A | -2.3819 | |
18 | V | A | 0.0000 | |
19 | P | A | -2.2691 | |
20 | K | A | -2.2231 | |
21 | D | A | -2.6073 | |
22 | A | A | 0.0000 | |
23 | K | A | -2.9808 | |
24 | K | A | -1.8388 | |
25 | G | A | 0.0000 | |
26 | K | A | -1.6927 | |
27 | H | A | -0.9637 | |
28 | L | A | 0.0000 | |
29 | G | A | -0.4784 | |
30 | T | A | -0.1365 | |
31 | F | A | 0.0000 | |
32 | D | A | -0.7129 | |
33 | I | A | 0.0000 | |
34 | R | A | 0.0000 | |
35 | Q | A | -1.5060 | |
36 | A | A | -0.8981 | |
37 | I | A | 0.0000 | |
38 | M | A | -0.6254 | |
39 | D | A | -1.6498 | |
40 | Y | A | -0.1963 | |
41 | G | A | -0.2282 | |
42 | G | A | -0.2971 | |
43 | L | A | 0.8318 | |
44 | H | A | -0.0755 | |
45 | S | A | -0.4148 | |
46 | Q | A | -0.9556 | |
47 | E | A | -0.6512 | |
48 | W | A | 0.0000 | |
49 | C | A | -0.0052 | |
50 | A | A | -0.1397 | |
51 | K | A | 0.0880 | |
52 | G | A | 0.2957 | |
53 | I | A | 0.7058 | |
54 | V | A | 0.0000 | |
55 | N | A | -0.2731 | |
56 | P | A | 0.0000 | |
57 | T | A | -1.2800 | |
58 | F | A | 0.0000 | |
59 | T | A | -1.1647 | |
60 | V | A | 0.0000 | |
61 | R | A | -0.8393 | |
62 | M | A | 0.0000 | |
63 | H | A | -0.7447 | |
64 | A | A | 0.0000 | |
65 | P | A | -1.6209 | |
66 | R | A | -2.4567 | |
67 | N | A | -1.3513 | |
68 | A | A | 0.2832 | |
69 | F | A | 1.9190 | |
70 | A | A | 0.0000 | |
71 | G | A | 0.0000 | |
72 | L | A | 0.0000 | |
73 | S | A | 0.0000 | |
74 | I | A | 0.0000 | |
75 | A | A | 0.0000 | |
76 | C | A | 0.0000 | |
77 | T | A | 0.0000 | |
78 | F | A | 0.0000 | |
79 | D | A | 0.0000 | |
80 | D | A | 0.0000 | |
81 | Y | A | 0.0286 | |
82 | K | A | -0.3766 | |
83 | R | A | 0.0000 | |
84 | I | A | 2.2559 | |
85 | D | A | 1.6126 | |
86 | L | A | 2.3901 | |
87 | P | A | 1.2990 | |
88 | A | A | 0.7394 | |
89 | L | A | 1.7845 | |
90 | G | A | 0.4358 | |
91 | N | A | -0.8033 | |
92 | E | A | 0.0000 | |
93 | C | A | -0.6396 | |
94 | P | A | -0.6702 | |
95 | P | A | 0.0000 | |
96 | S | A | 0.0000 | |
97 | E | A | 0.0000 | |
98 | M | A | 0.0000 | |
99 | F | A | 0.0000 | |
100 | E | A | 0.0000 | |
101 | L | A | 0.0000 | |
102 | P | A | -0.3194 | |
103 | T | A | 0.0000 | |
104 | K | A | -0.0847 | |
105 | V | A | 0.0000 | |
106 | F | A | 0.0000 | |
107 | M | A | -0.5138 | |
108 | L | A | -0.9904 | |
109 | K | A | -1.8572 | |
110 | D | A | 0.0000 | |
111 | A | A | -1.3052 | |
112 | D | A | -0.9351 | |
113 | V | A | 0.3375 | |
114 | H | A | 0.0000 | |
115 | E | A | -1.0379 | |
116 | W | A | -0.8098 | |
117 | Q | A | -1.4754 | |
118 | F | A | 0.0000 | |
119 | N | A | -1.3257 | |
120 | Y | A | 0.0000 | |
121 | G | A | 0.0000 | |
122 | E | A | -2.0342 | |
123 | L | A | -0.8311 | |
124 | T | A | 0.0000 | |
125 | G | A | 0.0000 | |
126 | H | A | 0.0000 | |
127 | G | A | 0.0000 | |
128 | L | A | 0.0000 | |
129 | C | A | 0.9050 | |
130 | N | A | 0.0000 | |
131 | W | A | 1.3499 | |
132 | A | A | 0.6242 | |
133 | N | A | 0.4180 | |
134 | V | A | 1.4545 | |
135 | A | A | 0.5827 | |
136 | T | A | 0.0000 | |
137 | Q | A | -0.5371 | |
138 | P | A | 0.0000 | |
139 | T | A | -0.4215 | |
140 | L | A | 0.0000 | |
141 | Y | A | 0.0000 | |
142 | F | A | 0.0000 | |
143 | F | A | 0.0000 | |
144 | V | A | 0.0000 | |
145 | A | A | -0.8562 | |
146 | S | A | 0.0000 | |
147 | T | A | -0.9472 | |
148 | N | A | -0.3613 | |
149 | Q | A | -0.0765 | |
150 | V | A | 1.0820 | |
151 | T | A | -0.6179 | |
152 | M | A | -0.1621 | |
153 | A | A | -0.2277 | |
154 | A | A | -1.0159 | |
155 | D | A | -1.9203 | |
156 | W | A | -1.3980 | |
157 | Q | A | -1.8477 | |
158 | C | A | 0.0000 | |
159 | I | A | 0.1140 | |
160 | V | A | 0.0000 | |
161 | T | A | -0.1855 | |
162 | M | A | 0.0000 | |
163 | H | A | 0.0000 | |
164 | V | A | 0.0000 | |
165 | D | A | -1.9597 | |
166 | M | A | 0.0000 | |
167 | G | A | -0.5295 | |
168 | P | A | 0.0871 | |
169 | V | A | 1.0509 | |
170 | I | A | 0.0666 | |
171 | D | A | -1.4642 | |
172 | R | A | -1.1693 | |
173 | F | A | 0.5649 | |
174 | E | A | -0.1167 | |
175 | L | A | -0.9301 | |
176 | N | A | -1.5806 | |
177 | P | A | -1.0436 | |
178 | T | A | -0.7716 | |
179 | M | A | -0.5733 | |
180 | T | A | -0.5520 | |
181 | W | A | 0.0000 | |
182 | P | A | -0.6905 | |
183 | I | A | -0.3067 | |
184 | Q | A | -0.8776 | |
185 | L | A | -0.6779 | |
186 | G | A | -1.5679 | |
187 | D | A | -2.6358 | |
188 | T | A | -1.8000 | |
189 | F | A | 0.0000 | |
190 | A | A | -0.6339 | |
191 | I | A | 0.0000 | |
192 | D | A | -0.9221 | |
193 | R | A | 0.0000 | |
194 | Y | A | 0.0000 | |
195 | Y | A | -0.2932 | |
196 | E | A | -0.9011 | |
197 | A | A | -0.8114 | |
198 | K | A | -0.8028 | |
199 | E | A | -1.3395 | |
200 | I | A | 0.0000 | |
201 | K | A | -0.8343 | |
202 | L | A | 0.0965 | |
203 | D | A | -1.7245 | |
204 | G | A | -1.2678 | |
205 | S | A | -0.8974 | |
206 | T | A | -0.4162 | |
207 | S | A | -0.1889 | |
208 | M | A | 0.0000 | |
209 | L | A | 0.5410 | |
210 | S | A | 0.0000 | |
211 | I | A | 0.2766 | |
212 | S | A | 0.0000 | |
213 | Y | A | 0.0000 | |
214 | N | A | -1.0503 | |
215 | F | A | 0.0000 | |
216 | G | A | 0.0000 | |
217 | G | A | -0.3603 | |
218 | P | A | -0.1090 | |
219 | V | A | -0.4236 | |
220 | K | A | -1.8628 | |
221 | H | A | -1.4506 | |
222 | S | A | -1.6810 | |
223 | K | A | -1.9305 | |
224 | K | A | -1.1499 | |
225 | H | A | -0.7480 | |
226 | A | A | 0.0000 | |
227 | I | A | 0.0000 | |
228 | S | A | 0.0000 | |
229 | Y | A | 0.0000 | |
230 | S | A | 0.0000 | |
231 | R | A | 0.0000 | |
232 | A | A | 0.0000 | |
233 | V | A | 0.0000 | |
234 | M | A | 0.0000 | |
235 | S | A | 0.0000 | |
236 | R | A | 0.0808 | |
237 | N | A | 0.3019 | |
238 | L | A | 0.6393 | |
239 | G | A | 0.2604 | |
240 | W | A | 0.0000 | |
241 | S | A | 0.0000 | |
242 | G | A | -1.6195 | |
243 | T | A | -1.4735 | |
244 | I | A | 0.0000 | |
245 | S | A | -1.6311 | |
246 | G | A | 0.0000 | |
247 | S | A | 0.0000 | |
248 | V | A | 0.0000 | |
249 | K | A | -1.0116 | |
250 | S | A | -0.5171 | |
251 | V | A | 0.0000 | |
252 | S | A | 0.0000 | |
253 | S | A | 0.0000 | |
254 | L | A | 2.5548 | |
255 | F | A | 2.7086 | |
256 | C | A | 0.0000 | |
257 | T | A | 1.0152 | |
258 | A | A | 0.2321 | |
259 | S | A | 0.0000 | |
260 | F | A | 0.0000 | |
261 | V | A | 0.0000 | |
262 | I | A | 0.0000 | |
263 | F | A | 0.0000 | |
264 | P | A | -0.4774 | |
265 | W | A | -0.3011 | |
266 | E | A | -0.6812 | |
267 | C | A | -0.4613 | |
268 | E | A | -1.6011 | |
269 | A | A | -0.7970 | |
270 | P | A | 0.0000 | |
271 | P | A | -0.7703 | |
272 | T | A | -0.5480 | |
273 | L | A | 0.0009 | |
274 | R | A | -1.3789 | |
275 | Q | A | -1.0747 | |
276 | V | A | 0.0000 | |
277 | L | A | 0.2514 | |
278 | W | A | 0.5515 | |
279 | G | A | -0.0493 | |
280 | P | A | -0.4591 | |
281 | H | A | -0.6224 | |
282 | Q | A | -0.9863 | |
283 | I | A | 0.1729 | |
284 | M | A | 0.0000 | |
285 | H | A | -1.2021 | |
286 | G | A | 0.0000 | |
287 | D | A | -1.7400 | |
288 | G | A | -1.4737 | |
289 | Q | A | -1.9266 | |
290 | F | A | 0.0000 | |
291 | E | A | -2.4605 | |
292 | I | A | 0.0000 | |
293 | A | A | -1.1606 | |
294 | I | A | 0.0000 | |
295 | K | A | -1.4500 | |
296 | T | A | -1.1143 | |
297 | R | A | -1.4240 | |
298 | L | A | 0.0912 | |
299 | H | A | -1.1912 | |
300 | S | A | -0.5269 | |
301 | A | A | 0.0000 | |
302 | A | A | -0.6664 | |
303 | T | A | 0.0000 | |
304 | T | A | -1.1129 | |
305 | E | A | -2.4977 | |
306 | E | A | -2.5772 | |
307 | G | A | -1.2270 | |
308 | F | A | -0.4827 | |
309 | G | A | 0.0000 | |
310 | R | A | -0.1366 | |
311 | L | A | 0.0000 | |
312 | G | A | 0.0000 | |
313 | I | A | 0.0000 | |
314 | L | A | 0.4445 | |
315 | P | A | 0.0444 | |
316 | L | A | 0.4543 | |
317 | S | A | 0.3192 | |
318 | G | A | 0.2007 | |
319 | P | A | 0.0000 | |
320 | I | A | 1.9974 | |
321 | A | A | 1.4913 | |
322 | P | A | -0.0728 | |
323 | D | A | -1.1431 | |
324 | A | A | -0.3345 | |
325 | H | A | 0.9268 | |
326 | V | A | 1.4565 | |
327 | G | A | 0.8019 | |
328 | S | A | -0.1951 | |
329 | Y | A | 0.0000 | |
330 | E | A | 0.0000 | |
331 | F | A | 0.0000 | |
332 | I | A | 0.0000 | |
333 | V | A | 0.0000 | |
334 | H | A | -0.6434 | |
335 | I | A | 0.0000 | |
336 | N | A | -1.1170 | |
337 | T | A | -1.3527 | |
338 | W | A | 0.0000 | |
339 | R | A | -2.9680 | |
340 | P | A | -2.1880 | |
341 | D | A | -2.0074 | |
342 | S | A | -1.1002 | |
343 | Q | A | -0.8435 | |
344 | V | A | 0.7882 | |
345 | H | A | 0.3950 | |
346 | P | A | 0.4433 | |
347 | P | A | 0.4619 | |
348 | M | A | 0.9985 | |
349 | F | A | 1.8655 | |
350 | S | A | 0.5255 | |
351 | S | A | -0.0360 | |
352 | S | A | -0.2685 | |
353 | E | A | -0.6527 | |
354 | L | A | -0.2925 | |
355 | Y | A | 0.0000 | |
356 | N | A | -1.3809 | |
357 | W | A | 0.0000 | |
358 | F | A | 0.0000 | |
359 | T | A | -0.4730 | |
360 | L | A | 0.0000 | |
361 | T | A | -0.5309 | |
362 | N | A | -1.6886 | |
363 | L | A | 0.0000 | |
364 | K | A | -3.3433 | |
365 | P | A | -2.0417 | |
366 | D | A | -2.2381 | |
367 | A | A | -1.5338 | |
368 | N | A | -1.6434 | |
369 | T | A | -0.6044 | |
370 | G | A | -0.8102 | |
371 | V | A | -0.2771 | |
372 | V | A | 0.0000 | |
373 | N | A | -1.0940 | |
374 | F | A | 0.0000 | |
375 | D | A | -1.2006 | |
376 | I | A | 0.0000 | |
377 | P | A | -0.2649 | |
378 | G | A | 0.0000 | |
379 | Y | A | 0.3131 | |
380 | I | A | 0.0000 | |
381 | H | A | -0.9574 | |
382 | D | A | -1.6346 | |
383 | F | A | 0.0000 | |
384 | A | A | -0.7655 | |
385 | S | A | -1.4070 | |
386 | K | A | -2.4713 | |
387 | D | A | -3.0352 | |
388 | A | A | -1.9477 | |
389 | T | A | -1.0071 | |
390 | V | A | -0.4921 | |
391 | T | A | 0.0698 | |
392 | L | A | 0.0981 | |
393 | A | A | -0.3153 | |
394 | S | A | -0.2976 | |
395 | N | A | 0.0000 | |
396 | P | A | 0.0000 | |
397 | L | A | 0.0000 | |
398 | S | A | -0.4246 | |
399 | W | A | 0.0143 | |
400 | L | A | 0.0000 | |
401 | V | A | 0.0000 | |
402 | A | A | -0.2377 | |
403 | A | A | 0.0000 | |
404 | T | A | 0.0000 | |
405 | G | A | -0.0751 | |
406 | W | A | 0.2128 | |
407 | H | A | 0.0000 | |
408 | Y | A | 0.7094 | |
409 | G | A | 0.0000 | |
410 | E | A | -1.3756 | |
411 | V | A | 0.0000 | |
412 | D | A | 0.0000 | |
413 | L | A | 0.0000 | |
414 | C | A | -0.9673 | |
415 | I | A | 0.0000 | |
416 | S | A | -1.5358 | |
417 | W | A | 0.0000 | |
418 | S | A | 0.0017 | |
419 | R | A | 0.0000 | |
420 | S | A | -0.9928 | |
421 | K | A | -2.5104 | |
422 | Q | A | -2.3687 | |
423 | A | A | -1.8267 | |
424 | Q | A | -2.1601 | |
425 | A | A | -1.9900 | |
426 | Q | A | -2.2074 | |
427 | E | A | -1.7243 | |
428 | G | A | 0.0863 | |
429 | S | A | 0.9348 | |
430 | V | A | 0.0000 | |
431 | S | A | 0.2009 | |
432 | I | A | 0.0000 | |
433 | T | A | 0.0000 | |
434 | T | A | -0.0383 | |
435 | N | A | 0.0000 | |
436 | Y | A | 0.0971 | |
437 | R | A | -1.7014 | |
438 | D | A | -1.8728 | |
439 | W | A | 0.0782 | |
440 | G | A | -0.1183 | |
441 | A | A | 0.4413 | |
442 | Y | A | 1.2206 | |
443 | W | A | 1.0459 | |
444 | Q | A | -0.7253 | |
445 | G | A | -1.1748 | |
446 | Q | A | -1.3242 | |
447 | A | A | -0.0807 | |
448 | R | A | 0.0000 | |
449 | I | A | 1.6546 | |
450 | Y | A | 0.3180 | |
451 | D | A | -1.2906 | |
452 | L | A | -0.9405 | |
453 | R | A | -2.6308 | |
454 | R | A | -2.0433 | |
455 | T | A | -0.9000 | |
456 | E | A | 0.0000 | |
457 | A | A | -0.3473 | |
458 | E | A | 0.0000 | |
459 | I | A | 0.3794 | |
460 | P | A | 0.0000 | |
461 | I | A | 0.0000 | |
462 | F | A | 2.1304 | |
463 | L | A | 1.8774 | |
464 | G | A | 0.0000 | |
465 | S | A | 0.0000 | |
466 | Y | A | 0.1289 | |
467 | A | A | -0.2721 | |
468 | G | A | -0.4390 | |
469 | A | A | 0.0000 | |
470 | T | A | 0.3058 | |
471 | P | A | -0.0979 | |
472 | S | A | -0.8163 | |
473 | G | A | -0.0044 | |
474 | A | A | 0.0167 | |
475 | L | A | 0.3991 | |
476 | G | A | 0.0000 | |
477 | K | A | -0.5922 | |
478 | Q | A | 0.0000 | |
479 | N | A | 0.0000 | |
480 | Y | A | 0.0000 | |
481 | V | A | 0.3422 | |
482 | R | A | 0.0000 | |
483 | I | A | 1.4870 | |
484 | S | A | 0.0000 | |
485 | I | A | 0.3923 | |
486 | V | A | 0.0000 | |
487 | N | A | -1.3614 | |
488 | A | A | -0.5286 | |
489 | K | A | -0.6988 | |
490 | D | A | 0.0000 | |
491 | I | A | 1.4630 | |
492 | V | A | 0.7007 | |
493 | A | A | 0.0000 | |
494 | L | A | 0.0000 | |
495 | R | A | -1.5872 | |
496 | V | A | 0.0000 | |
497 | C | A | -0.8126 | |
498 | L | A | 0.0000 | |
499 | R | A | -1.7319 | |
500 | P | A | 0.0000 | |
501 | K | A | -2.1912 | |
502 | S | A | -1.5643 | |
503 | I | A | 0.0000 | |
504 | K | A | -1.0598 | |
505 | F | A | 0.0000 | |
506 | W | A | 0.0000 | |
507 | G | A | 0.0000 | |
508 | R | A | -0.4509 | |
509 | S | A | 0.0000 | |
510 | A | A | 0.0000 | |
511 | T | A | 0.2802 | |
512 | L | A | 0.6797 | |
513 | F | A | 1.3981 |