| Chain sequence(s) |
E: EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNKPSNTKVDKKVEP
D: IQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input PDB |
| Selected Chain(s) | E,D |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:05)
[INFO] Main: Simulation completed successfully. (00:04:08)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 2 | I | D | -0.2432 | |
| 3 | Q | D | -1.3713 | |
| 4 | M | D | 0.0000 | |
| 5 | T | D | -1.2808 | |
| 6 | Q | D | 0.0000 | |
| 7 | S | D | -0.7977 | |
| 8 | P | D | -0.4469 | |
| 9 | S | D | -0.6543 | |
| 10 | S | D | -0.4840 | |
| 11 | L | D | -0.2875 | |
| 12 | S | D | -0.7620 | |
| 13 | A | D | -1.2351 | |
| 14 | S | D | -1.2991 | |
| 15 | V | D | -0.8610 | |
| 16 | G | D | -1.3972 | |
| 17 | D | D | -2.6507 | |
| 18 | R | D | -2.7344 | |
| 19 | V | D | 0.0000 | |
| 20 | T | D | -0.5086 | |
| 21 | I | D | 0.0000 | |
| 22 | T | D | -0.7604 | |
| 23 | C | D | 0.0000 | |
| 24 | R | D | -2.7553 | |
| 25 | A | D | 0.0000 | |
| 26 | S | D | -1.7488 | |
| 27 | Q | D | -2.3274 | |
| 28 | D | D | -2.8491 | |
| 29 | V | D | 0.0000 | |
| 30 | N | D | -2.1673 | |
| 31 | T | D | -0.8069 | |
| 32 | A | D | 0.4038 | |
| 33 | V | D | 0.0000 | |
| 34 | A | D | 0.0000 | |
| 35 | W | D | 0.0000 | |
| 36 | Y | D | 0.0000 | |
| 37 | Q | D | -1.1328 | |
| 38 | Q | D | -1.7148 | |
| 39 | K | D | -2.3431 | |
| 40 | P | D | -1.9532 | |
| 41 | G | D | -1.9193 | |
| 42 | K | D | -3.0172 | |
| 43 | A | D | 0.0000 | |
| 44 | P | D | 0.0000 | |
| 45 | K | D | -1.7468 | |
| 46 | L | D | 0.0000 | |
| 47 | L | D | 0.0000 | |
| 48 | I | D | 0.0000 | |
| 49 | Y | D | 1.3739 | |
| 50 | S | D | 0.5593 | |
| 51 | A | D | 0.0000 | |
| 52 | S | D | 0.4808 | |
| 53 | F | D | 2.2455 | |
| 54 | L | D | 1.4744 | |
| 55 | Y | D | 0.8987 | |
| 56 | S | D | 0.0552 | |
| 57 | G | D | -0.4046 | |
| 58 | V | D | -0.2634 | |
| 59 | P | D | -0.3216 | |
| 60 | S | D | -0.4364 | |
| 61 | R | D | -0.8259 | |
| 62 | F | D | 0.0000 | |
| 63 | S | D | 0.3086 | |
| 64 | G | D | 0.0518 | |
| 65 | S | D | -0.9057 | |
| 66 | R | D | -2.5167 | |
| 67 | S | D | -1.9081 | |
| 68 | G | D | -2.2192 | |
| 69 | T | D | -2.5379 | |
| 70 | D | D | -2.1849 | |
| 71 | F | D | 0.0000 | |
| 72 | T | D | -0.9040 | |
| 73 | L | D | 0.0000 | |
| 74 | T | D | -0.5986 | |
| 75 | I | D | 0.0000 | |
| 76 | S | D | -1.5345 | |
| 77 | S | D | -1.6352 | |
| 78 | L | D | 0.0000 | |
| 79 | Q | D | -1.2692 | |
| 80 | P | D | -1.7385 | |
| 81 | E | D | -2.3782 | |
| 82 | D | D | -1.2681 | |
| 83 | F | D | 0.0000 | |
| 84 | A | D | 0.0000 | |
| 85 | T | D | -0.6497 | |
| 86 | Y | D | 0.0000 | |
| 87 | Y | D | 0.0000 | |
| 88 | C | D | 0.0000 | |
| 89 | Q | D | 0.0000 | |
| 90 | Q | D | 0.0000 | |
| 92 | Y | D | 0.9613 | |
| 93 | T | D | 0.6189 | |
| 94 | T | D | -0.1427 | |
| 95 | P | D | -0.5485 | |
| 96 | P | D | 0.1766 | |
| 97 | T | D | -0.1109 | |
| 98 | F | D | 0.0000 | |
| 99 | G | D | 0.0000 | |
| 100 | Q | D | -1.4706 | |
| 101 | G | D | -1.0091 | |
| 102 | T | D | 0.0000 | |
| 103 | K | D | -0.7339 | |
| 104 | V | D | 0.0000 | |
| 105 | E | D | 0.0000 | |
| 106 | I | D | 0.0000 | |
| 107 | K | D | -1.6546 | |
| 108 | R | D | -1.7154 | |
| 109 | T | D | -0.7965 | |
| 110 | V | D | -0.1815 | |
| 111 | A | D | -0.3157 | |
| 112 | A | D | 0.1391 | |
| 113 | P | D | 0.0000 | |
| 114 | S | D | -0.0660 | |
| 115 | V | D | 0.0000 | |
| 116 | F | D | 0.0000 | |
| 117 | I | D | 0.0000 | |
| 118 | F | D | 0.0000 | |
| 119 | P | D | 0.0000 | |
| 120 | P | D | 0.0000 | |
| 121 | S | D | 0.0000 | |
| 122 | D | D | -1.9278 | |
| 123 | E | D | -2.4969 | |
| 124 | Q | D | -1.7849 | |
| 125 | L | D | 0.0000 | |
| 126 | K | D | -2.4471 | |
| 127 | S | D | -1.4338 | |
| 128 | G | D | -1.0482 | |
| 129 | T | D | -0.6930 | |
| 130 | A | D | 0.0000 | |
| 131 | S | D | -0.0919 | |
| 132 | V | D | 0.0000 | |
| 133 | V | D | 0.1530 | |
| 134 | C | D | 0.0000 | |
| 135 | L | D | 0.0000 | |
| 136 | L | D | 0.0000 | |
| 137 | N | D | 0.0000 | |
| 138 | N | D | -1.1860 | |
| 139 | F | D | 0.0000 | |
| 140 | Y | D | 0.0000 | |
| 141 | P | D | -1.3162 | |
| 142 | R | D | -1.1833 | |
| 143 | E | D | -2.4166 | |
| 144 | A | D | -1.6282 | |
| 145 | K | D | -1.2294 | |
| 146 | V | D | 0.7665 | |
| 147 | Q | D | -0.4295 | |
| 148 | W | D | -0.9999 | |
| 149 | K | D | -2.4862 | |
| 150 | V | D | 0.0000 | |
| 151 | D | D | -2.6281 | |
| 152 | N | D | -2.3464 | |
| 153 | A | D | -0.9775 | |
| 154 | L | D | 0.6116 | |
| 155 | Q | D | -0.1006 | |
| 156 | S | D | -0.2545 | |
| 157 | G | D | -0.7057 | |
| 158 | N | D | -0.8588 | |
| 159 | S | D | -1.1442 | |
| 160 | Q | D | -1.2110 | |
| 161 | E | D | -1.7905 | |
| 162 | S | D | -0.3701 | |
| 163 | V | D | 0.5461 | |
| 164 | T | D | -0.3941 | |
| 165 | E | D | -1.8384 | |
| 166 | Q | D | 0.0000 | |
| 167 | D | D | -2.3176 | |
| 168 | S | D | -2.5853 | |
| 169 | K | D | -3.0645 | |
| 170 | D | D | -3.1539 | |
| 171 | S | D | 0.0000 | |
| 172 | T | D | 0.0000 | |
| 173 | Y | D | 0.0000 | |
| 174 | S | D | 0.0000 | |
| 175 | L | D | 0.0000 | |
| 176 | S | D | -0.3776 | |
| 177 | S | D | 0.0000 | |
| 178 | T | D | -0.4539 | |
| 179 | L | D | -0.0093 | |
| 180 | T | D | -0.1291 | |
| 181 | L | D | 0.1171 | |
| 182 | S | D | -0.5067 | |
| 183 | K | D | -1.0378 | |
| 184 | A | D | -1.5347 | |
| 185 | D | D | 0.0000 | |
| 186 | Y | D | -2.0580 | |
| 187 | E | D | -2.8421 | |
| 188 | K | D | -2.7242 | |
| 189 | H | D | -1.9968 | |
| 190 | K | D | -1.8052 | |
| 191 | V | D | -0.9780 | |
| 192 | Y | D | 0.0000 | |
| 193 | A | D | -1.1045 | |
| 194 | C | D | 0.0000 | |
| 195 | E | D | -1.1855 | |
| 196 | V | D | 0.0000 | |
| 197 | T | D | -0.9738 | |
| 198 | H | D | 0.0000 | |
| 199 | Q | D | -1.7670 | |
| 200 | G | D | -0.9858 | |
| 201 | L | D | -0.3241 | |
| 202 | S | D | -0.3328 | |
| 203 | S | D | -0.1924 | |
| 204 | P | D | 0.0000 | |
| 205 | V | D | 0.5219 | |
| 206 | T | D | 0.0838 | |
| 207 | K | D | 0.0000 | |
| 208 | S | D | -0.6262 | |
| 209 | F | D | 0.0000 | |
| 210 | N | D | -2.5494 | |
| 211 | R | D | -2.6912 | |
| 212 | G | D | -1.6807 | |
| 213 | E | D | -1.2944 | |
| 214 | C | D | -0.4073 | |
| 1 | E | E | -2.0190 | |
| 2 | V | E | -1.3057 | |
| 3 | Q | E | -1.0683 | |
| 4 | L | E | 0.0000 | |
| 5 | V | E | 1.1438 | |
| 6 | E | E | 0.3571 | |
| 7 | S | E | -0.2942 | |
| 8 | G | E | -1.0160 | |
| 9 | G | E | -0.3612 | |
| 10 | G | E | -0.1849 | |
| 11 | L | E | 0.0637 | |
| 12 | V | E | -0.7072 | |
| 13 | Q | E | -1.7586 | |
| 14 | P | E | -2.0554 | |
| 15 | G | E | -1.5144 | |
| 16 | G | E | -1.2646 | |
| 17 | S | E | -1.4335 | |
| 18 | L | E | 0.0000 | |
| 19 | R | E | -2.2710 | |
| 20 | L | E | 0.0000 | |
| 21 | S | E | -0.3626 | |
| 22 | C | E | 0.0000 | |
| 23 | A | E | -0.1018 | |
| 24 | A | E | -0.5021 | |
| 25 | S | E | -0.7754 | |
| 26 | G | E | -1.2701 | |
| 27 | F | E | -1.3701 | |
| 28 | N | E | -2.3361 | |
| 29 | I | E | 0.0000 | |
| 30 | K | E | -2.6373 | |
| 31 | D | E | -2.8217 | |
| 32 | T | E | 0.0000 | |
| 33 | Y | E | -0.2668 | |
| 34 | I | E | 0.0000 | |
| 36 | W | E | 0.0000 | |
| 37 | V | E | 0.0000 | |
| 38 | R | E | 0.0000 | |
| 39 | Q | E | -0.6895 | |
| 40 | A | E | -1.0273 | |
| 41 | P | E | -1.0412 | |
| 42 | G | E | -1.5213 | |
| 43 | K | E | -2.3484 | |
| 44 | G | E | -1.5544 | |
| 45 | L | E | 0.0000 | |
| 46 | E | E | -0.9918 | |
| 47 | W | E | 0.0000 | |
| 48 | V | E | 0.0000 | |
| 49 | A | E | 0.0000 | |
| 50 | R | E | -0.5323 | |
| 51 | I | E | 0.0000 | |
| 52 | Y | E | -0.5148 | |
| 53 | P | E | -1.1477 | |
| 54 | T | E | -1.1957 | |
| 55 | N | E | -1.0341 | |
| 56 | G | E | -0.4062 | |
| 57 | Y | E | 0.4691 | |
| 58 | T | E | -0.3950 | |
| 59 | R | E | -1.8483 | |
| 60 | Y | E | -1.7224 | |
| 61 | A | E | 0.0000 | |
| 62 | D | E | -2.7024 | |
| 63 | S | E | -1.5941 | |
| 64 | V | E | 0.0000 | |
| 65 | K | E | -2.8673 | |
| 66 | G | E | -1.7337 | |
| 67 | R | E | -1.4936 | |
| 68 | F | E | 0.0000 | |
| 69 | T | E | -1.0431 | |
| 70 | I | E | 0.0000 | |
| 71 | S | E | -0.1678 | |
| 72 | A | E | -0.7367 | |
| 73 | D | E | -1.3473 | |
| 74 | T | E | -1.8361 | |
| 75 | S | E | -1.5921 | |
| 76 | K | E | -2.2571 | |
| 77 | N | E | -1.8882 | |
| 78 | T | E | -0.9738 | |
| 79 | A | E | 0.0000 | |
| 80 | Y | E | -0.4646 | |
| 81 | L | E | 0.0000 | |
| 82 | Q | E | -1.4486 | |
| 83 | M | E | 0.0000 | |
| 84 | N | E | -1.3704 | |
| 85 | S | E | -1.2981 | |
| 86 | L | E | 0.0000 | |
| 87 | R | E | -2.9085 | |
| 88 | A | E | -2.0133 | |
| 89 | E | E | -2.4445 | |
| 90 | D | E | 0.0000 | |
| 91 | T | E | -0.6319 | |
| 92 | A | E | 0.0000 | |
| 93 | V | E | 0.7226 | |
| 94 | Y | E | 0.0000 | |
| 95 | Y | E | 0.0000 | |
| 96 | C | E | 0.0000 | |
| 97 | S | E | 0.0000 | |
| 98 | R | E | 0.0000 | |
| 99 | W | E | 0.1969 | |
| 100 | G | E | -0.2569 | |
| 101 | G | E | -1.0964 | |
| 102 | D | E | -2.1030 | |
| 103 | G | E | -0.9474 | |
| 104 | F | E | 0.0306 | |
| 105 | Y | E | 1.2218 | |
| 106 | A | E | 0.0000 | |
| 107 | M | E | 0.0000 | |
| 108 | D | E | 0.0000 | |
| 109 | Y | E | -0.3783 | |
| 110 | W | E | 0.0000 | |
| 111 | G | E | -0.9461 | |
| 112 | Q | E | -1.8735 | |
| 113 | G | E | -0.4661 | |
| 114 | T | E | 0.4049 | |
| 115 | L | E | 1.2174 | |
| 116 | V | E | 0.0000 | |
| 117 | T | E | -0.3063 | |
| 118 | V | E | 0.0000 | |
| 119 | S | E | -1.0771 | |
| 120 | S | E | -0.6291 | |
| 121 | A | E | -0.5642 | |
| 122 | S | E | -0.6152 | |
| 123 | T | E | -0.7154 | |
| 124 | K | E | -1.3096 | |
| 125 | G | E | -1.5463 | |
| 126 | P | E | -0.8464 | |
| 127 | S | E | -0.7007 | |
| 128 | V | E | 0.0000 | |
| 129 | F | E | 0.0000 | |
| 130 | P | E | -0.6869 | |
| 131 | L | E | 0.0000 | |
| 132 | A | E | -0.3488 | |
| 133 | P | E | -0.6292 | |
| 134 | S | E | -1.0992 | |
| 135 | S | E | -1.2852 | |
| 136 | K | E | -2.1173 | |
| 137 | S | E | -1.4477 | |
| 138 | T | E | -1.0725 | |
| 139 | S | E | -0.5725 | |
| 140 | G | E | -0.8647 | |
| 141 | G | E | -0.8679 | |
| 142 | T | E | -0.5437 | |
| 143 | A | E | -0.2897 | |
| 144 | A | E | 0.0000 | |
| 145 | L | E | 0.0000 | |
| 146 | G | E | 0.0000 | |
| 147 | C | E | 0.0000 | |
| 148 | L | E | 0.0000 | |
| 149 | V | E | 0.0000 | |
| 150 | K | E | 0.0000 | |
| 151 | D | E | -0.3252 | |
| 152 | Y | E | 0.0000 | |
| 153 | F | E | 0.0000 | |
| 154 | P | E | -0.6789 | |
| 155 | E | E | -0.7653 | |
| 156 | P | E | -0.7540 | |
| 157 | V | E | -0.6683 | |
| 158 | T | E | -0.7311 | |
| 159 | V | E | -0.2613 | |
| 160 | S | E | -0.5071 | |
| 161 | W | E | 0.0000 | |
| 162 | N | E | -1.4700 | |
| 163 | S | E | -0.9886 | |
| 164 | G | E | -0.7724 | |
| 165 | A | E | -0.5683 | |
| 166 | L | E | -0.4226 | |
| 167 | T | E | -0.2044 | |
| 168 | S | E | -0.1178 | |
| 169 | G | E | -0.1809 | |
| 170 | V | E | 0.2951 | |
| 171 | H | E | -0.1843 | |
| 172 | T | E | 0.0055 | |
| 173 | F | E | 0.0000 | |
| 174 | P | E | -0.1642 | |
| 175 | A | E | 0.1538 | |
| 176 | V | E | 0.5630 | |
| 177 | L | E | 1.2209 | |
| 178 | Q | E | 0.2390 | |
| 179 | S | E | -0.2727 | |
| 180 | S | E | -0.3931 | |
| 181 | G | E | -0.2826 | |
| 182 | L | E | -0.0139 | |
| 183 | Y | E | 0.4642 | |
| 184 | S | E | 0.0000 | |
| 185 | L | E | 0.0000 | |
| 186 | S | E | 0.0000 | |
| 187 | S | E | 0.0000 | |
| 188 | V | E | 0.0000 | |
| 189 | V | E | 0.0000 | |
| 190 | T | E | -0.0901 | |
| 191 | V | E | 0.0524 | |
| 192 | P | E | -0.3070 | |
| 193 | S | E | -0.3440 | |
| 194 | S | E | -0.2610 | |
| 195 | S | E | -0.0310 | |
| 196 | L | E | 0.3597 | |
| 197 | G | E | -0.2997 | |
| 198 | T | E | -0.3034 | |
| 199 | Q | E | -0.6742 | |
| 200 | T | E | -0.4974 | |
| 201 | Y | E | 0.0000 | |
| 202 | I | E | -1.0041 | |
| 203 | C | E | 0.0000 | |
| 204 | N | E | -1.9722 | |
| 205 | V | E | 0.0000 | |
| 206 | N | E | -2.4383 | |
| 208 | K | E | -2.8021 | |
| 209 | P | E | -1.7771 | |
| 210 | S | E | -1.9486 | |
| 211 | N | E | -2.7038 | |
| 212 | T | E | -2.2295 | |
| 213 | K | E | -2.8113 | |
| 214 | V | E | -2.0246 | |
| 215 | D | E | -2.6714 | |
| 216 | K | E | -2.3380 | |
| 217 | K | E | -1.6907 | |
| 218 | V | E | 0.0000 | |
| 219 | E | E | -0.6859 | |
| 220 | P | E | 0.0000 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine