Project name: 15220c07cac17ec

Chain sequence(s)	A: GIVEQCCTSICSLYQLENYCN; C: GIVEQCCTSICSLYQLENYCN; B: FVNQHLCGSHLVEALYLVCGERGFFYTPKA; D: FVNQHLCGSHLVEALYLVCGERGFFYTPKA
Selected Chain(s)	A,C,B,D
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:59)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:00)

• Minimal score value: -2.8335
• Maximal score value: 2.3797
• Average score: -0.4338
• Total score value: -44.2482

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	G	A	-1.3627
2	I	A	0.0000
3	V	A	0.0000
4	E	A	-2.5759
5	Q	A	-1.6029
6	C	A	0.0000
7	C	A	-0.3510
8	T	A	-0.3071
9	S	A	0.3675
10	I	A	1.8913
11	C	A	1.0984
12	S	A	1.2301
13	L	A	1.8933
14	Y	A	1.1489
15	Q	A	-0.0566
16	L	A	0.0000
17	E	A	-1.1539
18	N	A	-1.5785
19	Y	A	-0.5350
20	C	A	-1.1599
21	N	A	-1.6350
1	F	B	1.7320
2	V	B	0.4908
3	N	B	-0.6609
4	Q	B	-1.2772
5	H	B	-1.1070
6	L	B	0.3382
7	C	B	-0.2966
8	G	B	0.0000
9	S	B	-0.5256
10	H	B	-1.3128
11	L	B	0.0000
12	V	B	0.0000
13	E	B	-1.4488
14	A	B	-0.1338
15	L	B	0.0000
16	Y	B	-0.0486
17	L	B	1.4087
18	V	B	0.8669
19	C	B	0.0000
20	G	B	-1.0536
21	E	B	-2.7518
22	R	B	-2.6769
23	G	B	0.0000
24	F	B	0.0000
25	F	B	1.7323
26	Y	B	0.0000
27	T	B	-0.8646
28	P	B	-1.8447
29	K	B	-2.4284
30	A	B	-1.3758
1	G	C	-1.2312
2	I	C	0.0000
3	V	C	-1.0880
4	E	C	-2.2404
5	Q	C	-1.6530
6	C	C	0.0000
7	C	C	-0.7689
8	T	C	-0.8436
9	S	C	-0.7201
10	I	C	-0.3575
11	C	C	0.0000
12	S	C	0.4663
13	L	C	1.0182
14	Y	C	0.6370
15	Q	C	-0.5896
16	L	C	0.0000
17	E	C	-1.0752
18	N	C	-1.5575
19	Y	C	-0.8377
20	C	C	-1.2876
21	N	C	-1.6885
1	F	D	2.3797
2	V	D	1.6699
3	N	D	-0.2962
4	Q	D	-0.6669
5	H	D	-1.1924
6	L	D	0.0000
7	C	D	-0.4967
8	G	D	-0.2480
9	S	D	-0.7554
10	H	D	-1.4089
11	L	D	0.0000
12	V	D	0.0000
13	E	D	-0.8454
14	A	D	0.0000
15	L	D	0.0000
16	Y	D	-0.0468
17	L	D	1.1323
18	V	D	0.7749
19	C	D	0.0000
20	G	D	-1.2826
21	E	D	-2.8335
22	R	D	-2.5527
23	G	D	0.0000
24	F	D	0.0000
25	F	D	0.7815
26	Y	D	0.0000
27	T	D	-0.9034
28	P	D	-1.7851
29	K	D	-2.5813
30	A	D	-1.3467