Chain sequence(s) |
A: MGSSHHHHHHSSGLVPRGSHMASENLYFQGSMERDVQSSIEGPDIITPPGPRGLPGVGSLGPLLGKHLHVTLNDLAKKYGNIFQIRMGDRTVVALNGIKTITEALIKQQKNFINRADFEFFDIPADGGLFEAKSGQAWEKHRGIAAKAMRTFVIDKSDRVEHHIMEEAAKLADSFLSYNGQPFDPDIPSSLAVGSIIHRVLFGTRGSEEDEDFVATARILQLFPPVTQRILISEFLPKILRPVFFIFNQKSLQDFQDVPATVDKLVSKNIEQHRNSFDPDNIRDMTDAFLKAANDLSESDKKNFNLSENHILRGTLMQLTGAGLEPVLIQLIWALLYMIAYPDIQAKIQQELDEVVGLGQQPCLNHRGKLPFTEACINEILRHSSISPIPFLYASTTDTTINGYSVHQGTPVIINLYSLTRDERYWQNPDKFDPDRFLDENCKIRSDLLDKFYPFGIGQRRCMGEYLARLEIFIFFTTLMHKCKLEKVPREKLSLEPKPGFFMRPQKYNIIAKSRF
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:01) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:08:41) [INFO] Main: Simulation completed successfully. (00:08:45) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | -0.0509 | |
2 | G | A | -0.5641 | |
3 | S | A | -1.2207 | |
4 | S | A | -1.5691 | |
5 | H | A | -2.0409 | |
6 | H | A | -2.1032 | |
7 | H | A | -2.3078 | |
8 | H | A | -2.0466 | |
9 | H | A | -1.6685 | |
10 | H | A | -1.2306 | |
11 | S | A | -1.1830 | |
12 | S | A | -1.0214 | |
13 | G | A | 0.0000 | |
14 | L | A | 0.0000 | |
15 | V | A | -1.0695 | |
16 | P | A | -1.4736 | |
17 | R | A | -2.3917 | |
18 | G | A | -1.7416 | |
19 | S | A | -1.2318 | |
20 | H | A | -1.3591 | |
21 | M | A | -0.9597 | |
22 | A | A | -0.2417 | |
23 | S | A | 0.2840 | |
24 | E | A | 0.0956 | |
25 | N | A | 0.5811 | |
26 | L | A | 1.5617 | |
27 | Y | A | 1.1493 | |
28 | F | A | 0.0000 | |
29 | Q | A | -0.8706 | |
30 | G | A | -0.5242 | |
31 | S | A | -0.5455 | |
32 | M | A | -1.3189 | |
33 | E | A | -2.4933 | |
34 | R | A | -1.7801 | |
35 | D | A | 0.0000 | |
36 | V | A | 1.3362 | |
37 | Q | A | 0.2057 | |
38 | S | A | 0.0000 | |
39 | S | A | 0.7735 | |
40 | I | A | 1.7212 | |
41 | E | A | -0.1799 | |
42 | G | A | -0.5756 | |
43 | P | A | -0.7868 | |
44 | D | A | -1.4628 | |
45 | I | A | 0.2393 | |
46 | I | A | 0.5019 | |
47 | T | A | -0.0214 | |
48 | P | A | 0.0000 | |
49 | P | A | 0.0000 | |
50 | G | A | 0.0000 | |
51 | P | A | -1.2451 | |
52 | R | A | -1.8839 | |
53 | G | A | -0.2156 | |
54 | L | A | 1.3680 | |
55 | P | A | 0.3073 | |
56 | G | A | -0.4008 | |
57 | V | A | 0.5864 | |
58 | G | A | 0.0000 | |
59 | S | A | 0.0000 | |
60 | L | A | 0.2805 | |
61 | G | A | -0.1343 | |
62 | P | A | -0.2896 | |
63 | L | A | 0.0000 | |
64 | L | A | 0.1634 | |
65 | G | A | -0.6127 | |
66 | K | A | -1.8090 | |
67 | H | A | -0.7279 | |
68 | L | A | 0.0000 | |
69 | H | A | 0.0000 | |
70 | V | A | 0.3232 | |
71 | T | A | -0.2963 | |
72 | L | A | 0.0000 | |
73 | N | A | -1.0192 | |
74 | D | A | -1.9617 | |
75 | L | A | 0.0000 | |
76 | A | A | 0.0000 | |
77 | K | A | -2.7457 | |
78 | K | A | -2.0439 | |
79 | Y | A | 0.0000 | |
80 | G | A | 0.0000 | |
81 | N | A | 0.0000 | |
82 | I | A | 0.0000 | |
83 | F | A | 0.0000 | |
84 | Q | A | 0.0000 | |
85 | I | A | 0.0000 | |
86 | R | A | -0.8147 | |
87 | M | A | 0.0000 | |
88 | G | A | 0.0000 | |
89 | D | A | -2.6626 | |
90 | R | A | -2.2245 | |
91 | T | A | -1.3033 | |
92 | V | A | 0.0000 | |
93 | V | A | 0.0000 | |
94 | A | A | 0.0000 | |
95 | L | A | 0.0000 | |
96 | N | A | 0.0000 | |
97 | G | A | 0.0000 | |
98 | I | A | 0.0000 | |
99 | K | A | -0.9457 | |
100 | T | A | 0.0000 | |
101 | I | A | 0.0000 | |
102 | T | A | -0.4799 | |
103 | E | A | -0.9265 | |
104 | A | A | 0.0000 | |
105 | L | A | 0.0000 | |
106 | I | A | -0.3589 | |
107 | K | A | -1.7004 | |
108 | Q | A | -1.4154 | |
109 | Q | A | -1.5352 | |
110 | K | A | -2.1340 | |
111 | N | A | 0.0000 | |
112 | F | A | 0.0000 | |
113 | I | A | 0.0000 | |
114 | N | A | -1.2642 | |
115 | R | A | 0.0000 | |
116 | A | A | 0.0000 | |
117 | D | A | -2.7172 | |
118 | F | A | 0.0000 | |
119 | E | A | -2.5961 | |
120 | F | A | 0.0000 | |
121 | F | A | 0.0000 | |
122 | D | A | -2.2001 | |
123 | I | A | -0.4056 | |
124 | P | A | -0.5422 | |
125 | A | A | -0.3618 | |
126 | D | A | -0.8708 | |
127 | G | A | -0.5431 | |
128 | G | A | 0.0000 | |
129 | L | A | 0.0000 | |
130 | F | A | 0.3903 | |
131 | E | A | -0.5496 | |
132 | A | A | -0.8870 | |
133 | K | A | -1.5640 | |
134 | S | A | -1.5628 | |
135 | G | A | -1.7312 | |
136 | Q | A | -2.4698 | |
137 | A | A | -2.1362 | |
138 | W | A | 0.0000 | |
139 | E | A | -2.8730 | |
140 | K | A | -1.9207 | |
141 | H | A | 0.0000 | |
142 | R | A | -1.5691 | |
143 | G | A | -1.5060 | |
144 | I | A | -1.1214 | |
145 | A | A | 0.0000 | |
146 | A | A | -1.4648 | |
147 | K | A | -2.2723 | |
148 | A | A | 0.0000 | |
149 | M | A | 0.0000 | |
150 | R | A | -2.6306 | |
151 | T | A | -1.8668 | |
152 | F | A | -1.5023 | |
153 | V | A | 0.0000 | |
154 | I | A | -1.4368 | |
155 | D | A | -2.7614 | |
156 | K | A | -2.8065 | |
157 | S | A | -2.2635 | |
158 | D | A | -2.9823 | |
159 | R | A | -3.3630 | |
160 | V | A | 0.0000 | |
161 | E | A | 0.0000 | |
162 | H | A | -2.5427 | |
163 | H | A | -2.2594 | |
164 | I | A | 0.0000 | |
165 | M | A | -1.5007 | |
166 | E | A | -2.3527 | |
167 | E | A | 0.0000 | |
168 | A | A | 0.0000 | |
169 | A | A | -1.7145 | |
170 | K | A | -2.1825 | |
171 | L | A | 0.0000 | |
172 | A | A | 0.0000 | |
173 | D | A | -2.2075 | |
174 | S | A | -1.2574 | |
175 | F | A | 0.0000 | |
176 | L | A | -1.4814 | |
177 | S | A | -1.0906 | |
178 | Y | A | -0.9194 | |
179 | N | A | -1.6916 | |
180 | G | A | -1.5496 | |
181 | Q | A | -1.6736 | |
182 | P | A | -1.2859 | |
183 | F | A | 0.0000 | |
184 | D | A | -0.6584 | |
185 | P | A | 0.0000 | |
186 | D | A | -0.5731 | |
187 | I | A | 0.4088 | |
188 | P | A | 0.1465 | |
189 | S | A | 0.0000 | |
190 | S | A | 0.0000 | |
191 | L | A | -0.1210 | |
192 | A | A | 0.0000 | |
193 | V | A | 0.0000 | |
194 | G | A | 0.0000 | |
195 | S | A | 0.0000 | |
196 | I | A | 0.0000 | |
197 | I | A | 0.0000 | |
198 | H | A | 0.0000 | |
199 | R | A | -0.8581 | |
200 | V | A | 0.0000 | |
201 | L | A | 0.0000 | |
202 | F | A | 0.0000 | |
203 | G | A | -1.0868 | |
204 | T | A | -0.8760 | |
205 | R | A | -1.4655 | |
206 | G | A | 0.0000 | |
207 | S | A | -2.1895 | |
208 | E | A | -3.2823 | |
209 | E | A | -3.4071 | |
210 | D | A | -2.7970 | |
211 | E | A | -3.0326 | |
212 | D | A | -2.6612 | |
213 | F | A | 0.0000 | |
214 | V | A | -1.5357 | |
215 | A | A | -1.3345 | |
216 | T | A | 0.0000 | |
217 | A | A | 0.0000 | |
218 | R | A | -1.1804 | |
219 | I | A | -0.5291 | |
220 | L | A | 0.0000 | |
221 | Q | A | -0.8657 | |
222 | L | A | -0.0771 | |
223 | F | A | 0.2084 | |
224 | P | A | 0.0000 | |
225 | P | A | -0.2622 | |
226 | V | A | 0.0000 | |
227 | T | A | 0.0000 | |
228 | Q | A | -0.5267 | |
229 | R | A | -0.7700 | |
230 | I | A | 0.0000 | |
231 | L | A | -0.2097 | |
232 | I | A | 0.1900 | |
233 | S | A | 0.0000 | |
234 | E | A | 0.0000 | |
235 | F | A | 0.0000 | |
236 | L | A | 0.1654 | |
237 | P | A | -0.4074 | |
238 | K | A | -0.6895 | |
239 | I | A | 1.5501 | |
240 | L | A | 1.3872 | |
241 | R | A | 0.8494 | |
242 | P | A | 1.4277 | |
243 | V | A | 2.5800 | |
244 | F | A | 2.1704 | |
245 | F | A | 1.7622 | |
246 | I | A | 2.9227 | |
247 | F | A | 2.6866 | |
248 | N | A | 0.4177 | |
249 | Q | A | -0.9504 | |
250 | K | A | -2.0226 | |
251 | S | A | 0.0000 | |
252 | L | A | -1.1022 | |
253 | Q | A | -2.3624 | |
254 | D | A | 0.0000 | |
255 | F | A | 0.0000 | |
256 | Q | A | -1.5218 | |
257 | D | A | -1.3227 | |
258 | V | A | 0.0000 | |
259 | P | A | -0.6646 | |
260 | A | A | -1.0004 | |
261 | T | A | -1.1540 | |
262 | V | A | 0.0000 | |
263 | D | A | -1.5194 | |
264 | K | A | -2.3795 | |
265 | L | A | 0.0000 | |
266 | V | A | 0.0000 | |
267 | S | A | -2.2443 | |
268 | K | A | -3.1044 | |
269 | N | A | -2.3611 | |
270 | I | A | 0.0000 | |
271 | E | A | -3.6028 | |
272 | Q | A | -3.2060 | |
273 | H | A | 0.0000 | |
274 | R | A | -2.6122 | |
275 | N | A | -2.6325 | |
276 | S | A | -1.5882 | |
277 | F | A | -1.8156 | |
278 | D | A | -2.2290 | |
279 | P | A | -2.1524 | |
280 | D | A | -2.8158 | |
281 | N | A | -2.4681 | |
282 | I | A | -1.3752 | |
283 | R | A | -1.6550 | |
284 | D | A | 0.0000 | |
285 | M | A | 0.0000 | |
286 | T | A | 0.0000 | |
287 | D | A | 0.0000 | |
288 | A | A | -0.7514 | |
289 | F | A | 0.0000 | |
290 | L | A | 0.0000 | |
291 | K | A | -2.0009 | |
292 | A | A | -1.4348 | |
293 | A | A | 0.0000 | |
294 | N | A | -2.5286 | |
295 | D | A | -2.8506 | |
296 | L | A | -2.0642 | |
297 | S | A | -2.2835 | |
298 | E | A | -3.1301 | |
299 | S | A | -2.4995 | |
300 | D | A | -2.7981 | |
301 | K | A | -3.3875 | |
302 | K | A | -3.7101 | |
303 | N | A | -3.1127 | |
304 | F | A | -2.5055 | |
305 | N | A | -2.5331 | |
306 | L | A | 0.0000 | |
307 | S | A | -1.8579 | |
308 | E | A | -1.7585 | |
309 | N | A | -1.3023 | |
310 | H | A | -1.1458 | |
311 | I | A | 0.0000 | |
312 | L | A | 0.0000 | |
313 | R | A | -1.0648 | |
314 | G | A | 0.0000 | |
315 | T | A | 0.0000 | |
316 | L | A | 0.0000 | |
317 | M | A | -0.4055 | |
318 | Q | A | -0.1436 | |
319 | L | A | 0.0000 | |
320 | T | A | 0.0000 | |
321 | G | A | -0.1360 | |
322 | A | A | 0.0151 | |
323 | G | A | -0.1857 | |
324 | L | A | 0.0000 | |
325 | E | A | 0.0000 | |
326 | P | A | -0.0318 | |
327 | V | A | 0.0000 | |
328 | L | A | 0.0000 | |
329 | I | A | 0.0000 | |
330 | Q | A | 0.0000 | |
331 | L | A | 0.0000 | |
332 | I | A | 0.0000 | |
333 | W | A | 0.0000 | |
334 | A | A | 0.0000 | |
335 | L | A | 0.0000 | |
336 | L | A | 0.0000 | |
337 | Y | A | 0.0000 | |
338 | M | A | 0.0000 | |
339 | I | A | 0.0000 | |
340 | A | A | -0.4041 | |
341 | Y | A | -0.4568 | |
342 | P | A | -1.4742 | |
343 | D | A | -2.0118 | |
344 | I | A | -1.2056 | |
345 | Q | A | 0.0000 | |
346 | A | A | -1.6522 | |
347 | K | A | -2.2010 | |
348 | I | A | 0.0000 | |
349 | Q | A | 0.0000 | |
350 | Q | A | -2.0843 | |
351 | E | A | -1.8827 | |
352 | L | A | 0.0000 | |
353 | D | A | -1.4490 | |
354 | E | A | -1.8975 | |
355 | V | A | -1.0608 | |
356 | V | A | 0.0000 | |
357 | G | A | -0.5568 | |
358 | L | A | 0.7605 | |
359 | G | A | -0.1359 | |
360 | Q | A | -1.2171 | |
361 | Q | A | -0.9747 | |
362 | P | A | 0.0000 | |
363 | C | A | -0.5757 | |
364 | L | A | -0.8614 | |
365 | N | A | -1.6656 | |
366 | H | A | -1.5707 | |
367 | R | A | -1.6741 | |
368 | G | A | -1.9907 | |
369 | K | A | -2.4786 | |
370 | L | A | 0.0000 | |
371 | P | A | -1.2051 | |
372 | F | A | 0.0000 | |
373 | T | A | 0.0000 | |
374 | E | A | 0.0000 | |
375 | A | A | 0.0000 | |
376 | C | A | 0.0000 | |
377 | I | A | 0.0000 | |
378 | N | A | 0.0000 | |
379 | E | A | 0.0000 | |
380 | I | A | 0.0000 | |
381 | L | A | 0.0000 | |
382 | R | A | 0.0000 | |
383 | H | A | -0.7848 | |
384 | S | A | 0.0000 | |
385 | S | A | 0.0000 | |
386 | I | A | 0.0000 | |
387 | S | A | 0.1875 | |
388 | P | A | 0.0000 | |
389 | I | A | 0.2800 | |
390 | P | A | 0.2356 | |
391 | F | A | 0.3849 | |
392 | L | A | 0.0000 | |
393 | Y | A | 0.0000 | |
394 | A | A | 0.0000 | |
395 | S | A | 0.0000 | |
396 | T | A | -1.6075 | |
397 | T | A | -2.0278 | |
398 | D | A | -2.7902 | |
399 | T | A | -1.4692 | |
400 | T | A | -0.6236 | |
401 | I | A | 0.0000 | |
402 | N | A | -1.0078 | |
403 | G | A | -0.5784 | |
404 | Y | A | 0.0000 | |
405 | S | A | -0.3942 | |
406 | V | A | 0.0000 | |
407 | H | A | -2.4372 | |
408 | Q | A | -2.6027 | |
409 | G | A | -1.8344 | |
410 | T | A | -1.5505 | |
411 | P | A | 0.0000 | |
412 | V | A | 0.0000 | |
413 | I | A | 0.0000 | |
414 | I | A | 0.0000 | |
415 | N | A | 0.0000 | |
416 | L | A | 0.0000 | |
417 | Y | A | 0.0000 | |
418 | S | A | 0.0000 | |
419 | L | A | 0.0000 | |
420 | T | A | 0.0000 | |
421 | R | A | -1.6853 | |
422 | D | A | -1.6788 | |
423 | E | A | -2.7942 | |
424 | R | A | -1.7728 | |
425 | Y | A | 0.0000 | |
426 | W | A | 0.0000 | |
427 | Q | A | -2.8640 | |
428 | N | A | -3.4285 | |
429 | P | A | -3.0673 | |
430 | D | A | -3.4457 | |
431 | K | A | -3.1613 | |
432 | F | A | 0.0000 | |
433 | D | A | -1.8787 | |
434 | P | A | 0.0000 | |
435 | D | A | -1.9739 | |
436 | R | A | -1.4108 | |
437 | F | A | 0.0000 | |
438 | L | A | -1.8760 | |
439 | D | A | -2.6800 | |
440 | E | A | -2.9362 | |
441 | N | A | -2.6606 | |
442 | C | A | -1.9517 | |
443 | K | A | -2.5305 | |
444 | I | A | -1.2325 | |
445 | R | A | -1.3687 | |
446 | S | A | -0.9925 | |
447 | D | A | -1.1318 | |
448 | L | A | 0.0000 | |
449 | L | A | -0.5752 | |
450 | D | A | -1.6424 | |
451 | K | A | 0.0000 | |
452 | F | A | 0.0000 | |
453 | Y | A | -0.1511 | |
454 | P | A | 0.0459 | |
455 | F | A | 0.1030 | |
456 | G | A | -0.2112 | |
457 | I | A | 0.0000 | |
458 | G | A | -0.5278 | |
459 | Q | A | -1.2453 | |
460 | R | A | -0.6917 | |
461 | R | A | -0.7298 | |
462 | C | A | -0.0458 | |
463 | M | A | -0.2939 | |
464 | G | A | -0.3241 | |
465 | E | A | -0.4062 | |
466 | Y | A | 0.1892 | |
467 | L | A | 0.0000 | |
468 | A | A | 0.0000 | |
469 | R | A | -0.2115 | |
470 | L | A | 0.0000 | |
471 | E | A | 0.0000 | |
472 | I | A | 0.0000 | |
473 | F | A | 0.0000 | |
474 | I | A | 0.0000 | |
475 | F | A | 0.0000 | |
476 | F | A | 0.0000 | |
477 | T | A | 0.0000 | |
478 | T | A | 0.0000 | |
479 | L | A | 0.0000 | |
480 | M | A | 0.0000 | |
481 | H | A | 0.0000 | |
482 | K | A | -0.9235 | |
483 | C | A | 0.0000 | |
484 | K | A | -1.6342 | |
485 | L | A | 0.0000 | |
486 | E | A | -1.8670 | |
487 | K | A | -2.6013 | |
488 | V | A | 0.0000 | |
489 | P | A | -2.0711 | |
490 | R | A | -2.8421 | |
491 | E | A | -2.6439 | |
492 | K | A | -2.6275 | |
493 | L | A | -1.7764 | |
494 | S | A | -1.2513 | |
495 | L | A | -0.6817 | |
496 | E | A | -1.9528 | |
497 | P | A | -1.6060 | |
498 | K | A | -1.9045 | |
499 | P | A | -1.4731 | |
500 | G | A | 0.0000 | |
501 | F | A | 0.1385 | |
502 | F | A | 0.1076 | |
503 | M | A | 0.0000 | |
504 | R | A | 0.0000 | |
505 | P | A | 0.0000 | |
506 | Q | A | -1.9456 | |
507 | K | A | -2.2455 | |
508 | Y | A | 0.0000 | |
509 | N | A | -1.6589 | |
510 | I | A | 0.0000 | |
511 | I | A | -1.5259 | |
512 | A | A | 0.0000 | |
513 | K | A | -1.8938 | |
514 | S | A | -1.1590 | |
515 | R | A | -0.1928 | |
516 | F | A | 1.4752 |