| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGGGGGSGGGGSGGGGSFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:05)
[INFO] Main: Simulation completed successfully. (00:02:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.5002 | |
| 2 | S | A | -0.0773 | |
| 3 | R | A | -1.3862 | |
| 4 | P | A | -0.9486 | |
| 5 | G | A | -0.9407 | |
| 6 | L | A | -0.6192 | |
| 7 | P | A | -0.2505 | |
| 8 | V | A | -0.0018 | |
| 9 | E | A | -0.3143 | |
| 10 | Y | A | 0.5901 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8629 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.6045 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -1.0142 | |
| 17 | S | A | -0.7048 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3966 | |
| 20 | R | A | -2.0728 | |
| 21 | D | A | -2.7830 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.4708 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.9216 | |
| 29 | G | A | -1.1021 | |
| 30 | G | A | -1.7555 | |
| 31 | N | A | -2.3486 | |
| 32 | N | A | -2.2783 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -0.6320 | |
| 43 | R | A | -1.5429 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.0200 | |
| 46 | D | A | -2.7233 | |
| 47 | D | A | -1.8732 | |
| 48 | Y | A | -0.2356 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9142 | |
| 54 | N | A | 0.3213 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.0598 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.6973 | |
| 60 | W | A | -0.3983 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.1306 | |
| 63 | Q | A | -1.1281 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.2542 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.0239 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6304 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9452 | |
| 84 | S | A | 0.0890 | |
| 85 | P | A | -0.1471 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.4784 | |
| 88 | G | A | -1.4910 | |
| 89 | K | A | -1.9717 | |
| 90 | A | A | -0.8548 | |
| 91 | G | A | -0.5347 | |
| 92 | C | A | 0.0955 | |
| 93 | Q | A | -0.5309 | |
| 94 | T | A | -0.4633 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8614 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5726 | |
| 99 | T | A | -0.5106 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | S | A | -0.5262 | |
| 104 | E | A | -0.6686 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4526 | |
| 108 | W | A | -0.8465 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.3135 | |
| 111 | A | A | -0.8655 | |
| 112 | N | A | -1.2671 | |
| 113 | R | A | -1.5889 | |
| 114 | A | A | -1.6488 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.2971 | |
| 117 | P | A | -0.9861 | |
| 118 | T | A | -0.7427 | |
| 119 | G | A | -0.4770 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | 0.0978 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2312 | |
| 139 | H | A | -0.4397 | |
| 140 | P | A | -0.9779 | |
| 141 | Q | A | -1.3039 | |
| 142 | Q | A | -0.7868 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.3363 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.2139 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | 0.0000 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.3325 | |
| 157 | Q | A | -1.2803 | |
| 158 | G | A | -0.3810 | |
| 159 | M | A | 0.5976 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0926 | |
| 162 | S | A | 0.4932 | |
| 163 | L | A | 0.8818 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0685 | |
| 166 | L | A | 0.6589 | |
| 167 | A | A | -0.2825 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.4660 | |
| 170 | D | A | -1.6968 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | 0.0000 | |
| 173 | G | A | -1.8050 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.7072 | |
| 176 | A | A | -0.7541 | |
| 177 | A | A | -0.6543 | |
| 178 | D | A | -0.4645 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6224 | |
| 183 | S | A | -0.9585 | |
| 184 | S | A | -0.8987 | |
| 185 | D | A | -1.1420 | |
| 186 | P | A | -1.2849 | |
| 187 | A | A | -0.9494 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -2.6617 | |
| 190 | R | A | -1.6675 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.3897 | |
| 195 | Q | A | -2.0090 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.0766 | |
| 199 | K | A | -1.3521 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2762 | |
| 202 | A | A | -0.9393 | |
| 203 | N | A | -1.4861 | |
| 204 | N | A | -1.8556 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.9673 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.9464 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -0.8551 | |
| 216 | P | A | -1.1510 | |
| 217 | N | A | -1.4467 | |
| 218 | E | A | -1.9743 | |
| 219 | L | A | -0.3936 | |
| 220 | G | A | -0.4127 | |
| 221 | G | A | -0.4128 | |
| 222 | A | A | -0.1030 | |
| 223 | N | A | 0.8574 | |
| 224 | I | A | 2.2076 | |
| 225 | P | A | 1.7285 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | -0.0419 | |
| 228 | F | A | 1.6262 | |
| 229 | L | A | 0.9885 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.8441 | |
| 232 | F | A | 0.1612 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5282 | |
| 235 | S | A | -0.4980 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.3058 | |
| 239 | K | A | -1.5205 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.4714 | |
| 242 | D | A | -2.4839 | |
| 243 | A | A | -1.7407 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4098 | |
| 246 | A | A | -1.3418 | |
| 247 | A | A | -0.9996 | |
| 248 | G | A | -1.1366 | |
| 249 | G | A | -1.7809 | |
| 250 | H | A | -1.7190 | |
| 251 | N | A | -1.3376 | |
| 252 | A | A | -0.6771 | |
| 253 | V | A | 0.1239 | |
| 254 | F | A | 0.4583 | |
| 255 | N | A | 0.0598 | |
| 256 | F | A | 0.1709 | |
| 257 | P | A | -0.2755 | |
| 258 | P | A | -0.6010 | |
| 259 | N | A | -0.9194 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.2181 | |
| 263 | S | A | 0.0000 | |
| 264 | W | A | 0.0011 | |
| 265 | E | A | 0.1305 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.3156 | |
| 270 | Q | A | -0.4977 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9873 | |
| 273 | A | A | -0.6463 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0716 | |
| 276 | G | A | -1.0769 | |
| 277 | D | A | -0.8901 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.0972 | |
| 280 | S | A | -0.9463 | |
| 281 | S | A | -0.6179 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -0.9841 | |
| 284 | A | A | -1.0919 | |
| 285 | G | A | -1.4374 | |
| 286 | G | A | -1.2578 | |
| 287 | G | A | -1.6084 | |
| 288 | G | A | -1.4135 | |
| 289 | G | A | -1.2110 | |
| 290 | S | A | -1.0309 | |
| 291 | G | A | -1.1300 | |
| 292 | G | A | -1.1707 | |
| 293 | G | A | -1.1513 | |
| 294 | G | A | -1.1466 | |
| 295 | S | A | -0.9306 | |
| 296 | G | A | -1.1366 | |
| 297 | G | A | -1.1611 | |
| 298 | G | A | -0.9226 | |
| 299 | G | A | -0.6537 | |
| 300 | S | A | 0.2014 | |
| 301 | F | A | 1.4796 | |
| 302 | A | A | 1.2088 | |
| 303 | V | A | 1.4058 | |
| 304 | T | A | -0.2934 | |
| 305 | N | A | -1.7238 | |
| 306 | D | A | -1.9586 | |
| 307 | G | A | -0.7489 | |
| 308 | V | A | 0.8325 | |
| 309 | I | A | 2.0740 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine