| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGEGKSSGSGSESKSTFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:05)
[INFO] Main: Simulation completed successfully. (00:02:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4019 | |
| 2 | S | A | -0.2462 | |
| 3 | R | A | -1.7346 | |
| 4 | P | A | -1.1374 | |
| 5 | G | A | -1.0173 | |
| 6 | L | A | -0.6688 | |
| 7 | P | A | -0.3313 | |
| 8 | V | A | -0.1508 | |
| 9 | E | A | -0.2214 | |
| 10 | Y | A | 0.6245 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8574 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.6060 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9759 | |
| 17 | S | A | -0.6845 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3233 | |
| 20 | R | A | -1.9451 | |
| 21 | D | A | -2.6971 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.6306 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8915 | |
| 29 | G | A | -1.0630 | |
| 30 | G | A | -1.5991 | |
| 31 | N | A | -2.2265 | |
| 32 | N | A | -2.2308 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0782 | |
| 43 | R | A | -2.4715 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.3145 | |
| 46 | D | A | -2.8626 | |
| 47 | D | A | -1.8726 | |
| 48 | Y | A | -0.3198 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9276 | |
| 54 | N | A | 0.0042 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2510 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.8675 | |
| 60 | W | A | -0.4158 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.1205 | |
| 63 | Q | A | -1.0957 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.4480 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.4012 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6154 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.8803 | |
| 84 | S | A | 0.0085 | |
| 85 | P | A | -0.3405 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5309 | |
| 88 | G | A | -1.4448 | |
| 89 | K | A | -1.9157 | |
| 90 | A | A | -0.8160 | |
| 91 | G | A | -0.4878 | |
| 92 | C | A | 0.1355 | |
| 93 | Q | A | -0.4151 | |
| 94 | T | A | -0.4151 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8403 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | 0.0000 | |
| 99 | T | A | -0.4394 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.2960 | |
| 103 | S | A | -0.4800 | |
| 104 | E | A | -0.6458 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4524 | |
| 108 | W | A | -0.8557 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.3392 | |
| 111 | A | A | -0.8867 | |
| 112 | N | A | -1.3170 | |
| 113 | R | A | -1.6489 | |
| 114 | A | A | -1.6609 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.3860 | |
| 117 | P | A | -0.9627 | |
| 118 | T | A | -0.6654 | |
| 119 | G | A | -0.3443 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.0890 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2596 | |
| 139 | H | A | -0.3969 | |
| 140 | P | A | -0.8597 | |
| 141 | Q | A | -1.1929 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.1461 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.1872 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -1.0700 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.2051 | |
| 157 | Q | A | -1.3347 | |
| 158 | G | A | -0.4997 | |
| 159 | M | A | 0.5001 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | -0.0055 | |
| 162 | S | A | 0.3977 | |
| 163 | L | A | 0.8993 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0287 | |
| 166 | L | A | 0.7436 | |
| 167 | A | A | -0.3047 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.2688 | |
| 170 | D | A | -2.1007 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | -1.8073 | |
| 173 | G | A | -1.6305 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.9074 | |
| 176 | A | A | -0.8938 | |
| 177 | A | A | -0.7520 | |
| 178 | D | A | -0.6684 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6502 | |
| 183 | S | A | -0.8315 | |
| 184 | S | A | -0.7739 | |
| 185 | D | A | -0.9880 | |
| 186 | P | A | -1.0129 | |
| 187 | A | A | -0.7032 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -1.8604 | |
| 190 | R | A | -1.3566 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.2169 | |
| 195 | Q | A | -1.7388 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.0875 | |
| 199 | K | A | -1.4049 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.3012 | |
| 202 | A | A | -0.9580 | |
| 203 | N | A | -1.4940 | |
| 204 | N | A | -1.7459 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.8713 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.6870 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -0.7191 | |
| 216 | P | A | -1.0386 | |
| 217 | N | A | -1.3053 | |
| 218 | E | A | -1.7617 | |
| 219 | L | A | -0.5981 | |
| 220 | G | A | -0.8476 | |
| 221 | G | A | -0.6455 | |
| 222 | A | A | -0.4483 | |
| 223 | N | A | 0.0313 | |
| 224 | I | A | 1.8493 | |
| 225 | P | A | 1.0750 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.5166 | |
| 228 | F | A | 1.9305 | |
| 229 | L | A | 1.3389 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.6030 | |
| 232 | F | A | 0.3349 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5774 | |
| 235 | S | A | -0.7155 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.6550 | |
| 239 | K | A | -2.2041 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.7280 | |
| 242 | D | A | -2.7311 | |
| 243 | A | A | -1.9146 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4704 | |
| 246 | A | A | -1.3571 | |
| 247 | A | A | -1.0064 | |
| 248 | G | A | -1.1442 | |
| 249 | G | A | -1.7767 | |
| 250 | H | A | -1.6733 | |
| 251 | N | A | -1.2527 | |
| 252 | A | A | -0.5651 | |
| 253 | V | A | 0.2880 | |
| 254 | F | A | 0.5081 | |
| 255 | N | A | 0.0986 | |
| 256 | F | A | 0.1919 | |
| 257 | P | A | -0.2570 | |
| 258 | P | A | -0.5645 | |
| 259 | N | A | -0.8120 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.3325 | |
| 263 | S | A | -0.4593 | |
| 264 | W | A | -0.3528 | |
| 265 | E | A | -0.9544 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.4374 | |
| 270 | Q | A | -0.5890 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9705 | |
| 273 | A | A | -0.6587 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.1225 | |
| 276 | G | A | -1.0965 | |
| 277 | D | A | -0.8634 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.1657 | |
| 280 | S | A | -1.0507 | |
| 281 | S | A | -0.5461 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -1.1894 | |
| 284 | A | A | -1.4945 | |
| 285 | G | A | -2.1572 | |
| 286 | E | A | -2.9152 | |
| 287 | G | A | -2.5102 | |
| 288 | K | A | -2.7927 | |
| 289 | S | A | -1.9452 | |
| 290 | S | A | -1.5087 | |
| 291 | G | A | -1.2692 | |
| 292 | S | A | -1.0938 | |
| 293 | G | A | -1.4266 | |
| 294 | S | A | -1.7735 | |
| 295 | E | A | -2.7479 | |
| 296 | S | A | -2.1276 | |
| 297 | K | A | -2.2461 | |
| 298 | S | A | -0.8419 | |
| 299 | T | A | 0.4578 | |
| 300 | F | A | 2.1345 | |
| 301 | A | A | 1.6351 | |
| 302 | V | A | 1.7933 | |
| 303 | T | A | 0.0458 | |
| 304 | N | A | -1.8643 | |
| 305 | D | A | -2.0678 | |
| 306 | G | A | -0.3038 | |
| 307 | V | A | 2.1242 | |
| 308 | I | A | 2.7724 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine