| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGRGTVGHPLFNKLGDTENPTEYLHEGADDRVPFSFDPKQTQLFIVGCEPPTGEHWDIAPPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPDGHPLPDDPPPSPLYVKPPPSSPYAVRPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPKENVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9411 | |
| 2 | L | A | 1.9629 | |
| 3 | P | A | 0.8381 | |
| 4 | P | A | 0.3715 | |
| 5 | T | A | 0.1194 | |
| 6 | T | A | 0.1266 | |
| 7 | P | A | 0.1745 | |
| 8 | V | A | 1.2127 | |
| 9 | A | A | 0.0810 | |
| 10 | K | A | -1.0388 | |
| 11 | V | A | -0.1849 | |
| 12 | Q | A | -1.4323 | |
| 13 | S | A | -1.5601 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4028 | |
| 16 | E | A | -2.4345 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4626 | |
| 20 | P | A | 0.1303 | |
| 21 | T | A | 0.1608 | |
| 22 | S | A | -0.0945 | |
| 23 | L | A | 0.0968 | |
| 24 | F | A | -0.0337 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2804 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8950 | |
| 31 | R | A | -2.6815 | |
| 32 | L | A | -0.7987 | |
| 33 | L | A | 1.1525 | |
| 34 | T | A | 1.3537 | |
| 35 | V | A | 1.7934 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2245 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6293 | |
| 40 | K | A | -1.6749 | |
| 41 | D | A | -0.7061 | |
| 42 | I | A | 1.2654 | |
| 43 | V | A | 2.2185 | |
| 44 | V | A | 1.6775 | |
| 45 | N | A | -0.5274 | |
| 46 | G | A | -0.3631 | |
| 47 | K | A | -0.1362 | |
| 48 | V | A | 2.0200 | |
| 49 | L | A | 2.5272 | |
| 50 | V | A | 1.4313 | |
| 51 | P | A | 0.3235 | |
| 52 | K | A | -0.6935 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1300 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3836 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2258 | |
| 70 | K | A | -1.7733 | |
| 71 | F | A | -0.6161 | |
| 72 | A | A | -0.5737 | |
| 73 | L | A | -0.8676 | |
| 74 | P | A | -1.2119 | |
| 75 | Q | A | -2.5104 | |
| 76 | K | A | -3.1105 | |
| 77 | D | A | -2.9918 | |
| 78 | F | A | -1.6679 | |
| 79 | Y | A | -1.8879 | |
| 80 | D | A | -2.6934 | |
| 81 | P | A | -2.3689 | |
| 82 | E | A | -3.0582 | |
| 83 | K | A | -3.3996 | |
| 84 | E | A | -2.4646 | |
| 85 | R | A | -1.3007 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6804 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9563 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3548 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6985 | |
| 99 | G | A | -0.5374 | |
| 100 | P | A | -0.3723 | |
| 101 | L | A | 0.1066 | |
| 102 | G | A | -0.0530 | |
| 103 | R | A | -0.2999 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3548 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.0935 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.2795 | |
| 110 | L | A | 0.2414 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1147 | |
| 113 | K | A | -0.4910 | |
| 114 | L | A | -1.0781 | |
| 115 | G | A | -0.9745 | |
| 116 | D | A | -1.4549 | |
| 117 | T | A | -0.9893 | |
| 118 | E | A | -1.7939 | |
| 119 | N | A | -2.1461 | |
| 120 | P | A | -1.8207 | |
| 121 | T | A | -1.4689 | |
| 122 | E | A | -2.0076 | |
| 123 | Y | A | -0.3578 | |
| 124 | L | A | -0.6890 | |
| 125 | H | A | -1.2886 | |
| 126 | E | A | -1.8324 | |
| 127 | G | A | -1.8354 | |
| 128 | A | A | -1.4127 | |
| 129 | D | A | -2.3589 | |
| 130 | D | A | -1.9318 | |
| 131 | R | A | -1.1929 | |
| 132 | V | A | -0.0108 | |
| 133 | P | A | 0.0949 | |
| 134 | F | A | 0.0974 | |
| 135 | S | A | -0.1550 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5887 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5676 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2241 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1482 | |
| 157 | D | A | 0.4943 | |
| 158 | I | A | 1.2197 | |
| 159 | A | A | 0.9061 | |
| 160 | P | A | 0.0647 | |
| 161 | P | A | 0.4346 | |
| 162 | C | A | 0.5061 | |
| 163 | P | A | 0.0083 | |
| 164 | G | A | -0.0782 | |
| 165 | L | A | 0.5957 | |
| 166 | P | A | -0.0981 | |
| 167 | P | A | -0.3323 | |
| 168 | G | A | -0.4199 | |
| 169 | A | A | -0.0208 | |
| 170 | C | A | 0.7343 | |
| 171 | P | A | 0.7815 | |
| 172 | P | A | 1.1897 | |
| 173 | I | A | 2.3522 | |
| 174 | Q | A | 1.2416 | |
| 175 | L | A | 1.5168 | |
| 176 | V | A | 0.8590 | |
| 177 | N | A | -0.2952 | |
| 178 | S | A | 0.0239 | |
| 179 | V | A | 0.4345 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3780 | |
| 182 | D | A | 0.0777 | |
| 183 | G | A | -0.1619 | |
| 184 | D | A | -0.5451 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1185 | |
| 190 | F | A | 0.0635 | |
| 191 | G | A | -0.1045 | |
| 192 | N | A | -0.2704 | |
| 193 | M | A | -0.1180 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3910 | |
| 197 | E | A | -2.6314 | |
| 198 | L | A | -1.2223 | |
| 199 | Q | A | -2.5463 | |
| 200 | Q | A | -3.3161 | |
| 201 | D | A | -3.5824 | |
| 202 | R | A | -3.3223 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2081 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3485 | |
| 211 | S | A | -1.8730 | |
| 212 | T | A | -1.4285 | |
| 213 | R | A | -2.0963 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1711 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3431 | |
| 220 | L | A | 0.6084 | |
| 221 | K | A | -1.1040 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8113 | |
| 224 | N | A | -1.4902 | |
| 225 | E | A | -1.2321 | |
| 226 | A | A | -0.6032 | |
| 227 | Y | A | -0.3534 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6535 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0821 | |
| 234 | F | A | 0.2646 | |
| 235 | G | A | -0.8180 | |
| 236 | R | A | -2.6005 | |
| 237 | R | A | -2.8628 | |
| 238 | E | A | -2.0924 | |
| 239 | Q | A | -0.1628 | |
| 240 | V | A | 1.4472 | |
| 241 | Y | A | 1.1256 | |
| 242 | A | A | 0.1459 | |
| 243 | R | A | -1.1357 | |
| 244 | H | A | -0.9087 | |
| 245 | F | A | 0.0042 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5781 | |
| 249 | C | A | -1.0384 | |
| 250 | G | A | -0.9174 | |
| 251 | P | A | -1.0532 | |
| 252 | D | A | -1.2325 | |
| 253 | G | A | -1.2549 | |
| 254 | H | A | -1.3753 | |
| 255 | P | A | -1.1349 | |
| 256 | L | A | -0.3945 | |
| 257 | P | A | -1.0479 | |
| 258 | D | A | -2.0828 | |
| 259 | D | A | -1.7812 | |
| 260 | P | A | -1.3032 | |
| 261 | P | A | -0.7026 | |
| 262 | P | A | -0.2427 | |
| 263 | S | A | -0.1943 | |
| 264 | P | A | 0.5341 | |
| 265 | L | A | 1.4692 | |
| 266 | Y | A | 1.1929 | |
| 267 | V | A | 1.2283 | |
| 268 | K | A | -0.2801 | |
| 269 | P | A | 0.1116 | |
| 270 | P | A | -0.3528 | |
| 271 | P | A | -0.2797 | |
| 272 | S | A | -0.1429 | |
| 273 | S | A | 0.1362 | |
| 274 | P | A | 0.4284 | |
| 275 | Y | A | 1.0874 | |
| 276 | A | A | 0.7380 | |
| 277 | V | A | 1.3980 | |
| 278 | R | A | 0.1528 | |
| 279 | P | A | -0.3085 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | -0.0603 | |
| 282 | D | A | -0.4537 | |
| 283 | Y | A | 1.0545 | |
| 284 | F | A | 0.7814 | |
| 285 | G | A | 0.2022 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9260 | |
| 291 | L | A | 1.6560 | |
| 292 | V | A | 0.6907 | |
| 293 | S | A | -0.1664 | |
| 294 | S | A | -0.9628 | |
| 295 | D | A | -1.8429 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1007 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6318 | |
| 301 | R | A | -1.8207 | |
| 302 | P | A | -0.9625 | |
| 303 | F | A | -0.1920 | |
| 304 | W | A | -0.5715 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0918 | |
| 307 | R | A | -2.8348 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2577 | |
| 310 | G | A | -1.2237 | |
| 311 | N | A | -1.2748 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8547 | |
| 319 | N | A | -0.9438 | |
| 320 | E | A | -1.0382 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.2567 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | 0.0498 | |
| 333 | N | A | 0.6471 | |
| 334 | F | A | 1.7890 | |
| 335 | T | A | 0.9437 | |
| 336 | I | A | 0.4962 | |
| 337 | S | A | -1.1010 | |
| 338 | Q | A | -2.0402 | |
| 339 | Q | A | -2.0303 | |
| 340 | L | A | -0.2578 | |
| 341 | S | A | -0.5884 | |
| 342 | T | A | -1.0262 | |
| 343 | P | A | -1.7481 | |
| 344 | K | A | -2.5780 | |
| 345 | E | A | -2.6110 | |
| 346 | N | A | -1.4922 | |
| 347 | V | A | 0.6404 | |
| 348 | Y | A | 0.8457 | |
| 349 | D | A | -0.4928 | |
| 350 | P | A | -0.8540 | |
| 351 | S | A | -0.8178 | |
| 352 | N | A | -1.2142 | |
| 353 | F | A | -1.4490 | |
| 354 | K | A | -2.2108 | |
| 355 | N | A | -1.7536 | |
| 356 | Y | A | 0.0915 | |
| 357 | L | A | 0.7569 | |
| 358 | R | A | 1.0131 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3745 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0794 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0430 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6892 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2746 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3117 | |
| 376 | L | A | -1.7066 | |
| 377 | D | A | -1.9790 | |
| 378 | P | A | -1.0316 | |
| 379 | G | A | -1.0121 | |
| 380 | V | A | -0.9331 | |
| 381 | L | A | -0.5293 | |
| 382 | A | A | -0.6585 | |
| 383 | H | A | -0.8174 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4275 | |
| 386 | T | A | -0.5618 | |
| 387 | M | A | -0.3074 | |
| 388 | N | A | -0.8767 | |
| 389 | P | A | -1.2627 | |
| 390 | T | A | -1.4854 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4817 | |
| 393 | E | A | -2.8301 | |
| 394 | N | A | -2.3148 | |
| 395 | W | A | -1.4315 | |
| 396 | N | A | -1.1825 | |
| 397 | L | A | -0.2308 | |
| 398 | G | A | 0.4820 | |
| 399 | F | A | 2.4118 | |
| 400 | V | A | 1.8391 | |
| 401 | P | A | 0.0392 | |
| 402 | P | A | -1.8590 | |
| 403 | K | A | -3.2740 | |
| 404 | E | A | -3.8589 | |
| 405 | R | A | -4.0861 | |
| 406 | E | A | -3.8800 | |
| 407 | D | A | -2.9169 | |
| 408 | P | A | -1.7920 | |
| 409 | Y | A | -0.9863 | |
| 410 | K | A | -2.1283 | |
| 411 | G | A | -0.6369 | |
| 412 | L | A | 0.6721 | |
| 413 | I | A | 1.5890 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3735 | |
| 416 | E | A | -1.6543 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9332 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0356 | |
| 421 | E | A | -2.7648 | |
| 422 | R | A | -2.6007 | |
| 423 | F | A | -1.2599 | |
| 424 | S | A | -1.4525 | |
| 425 | Q | A | -1.8382 | |
| 426 | D | A | -2.8896 | |
| 427 | L | A | -1.9773 | |
| 428 | D | A | -2.7595 | |
| 429 | Q | A | -2.6089 | |
| 430 | F | A | -1.4169 | |
| 431 | A | A | -0.8906 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5675 | |
| 435 | K | A | -0.7171 | |
| 436 | F | A | 0.1425 | |
| 437 | L | A | 1.0298 | |
| 438 | Y | A | 0.8233 | |
| 439 | Q | A | -0.2751 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine