Project name: 7MXL

Chain sequence(s)	H: EVQLVESGGDLVQPGGSLRLSCAASGFTFSSYEMNWVRQAPGKGLEWVSFISDSSSNIYYADSVKGRFTISRDNAKKSLYLQMTSLRAEDTAVYYCAREAIGSTSFDNWGQGTLVTVSS; L: EIVMTQSPATLSVSPGERATLSCRASQSVSSSLAWYQQKPGQAPRRLIYSASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAIYYCHQYNNWPLTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:56)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:57)

• Minimal score value: -3.1875
• Maximal score value: 1.6675
• Average score: -0.578
• Total score value: -130.6297

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.8689
2	V	H	-0.8807
3	Q	H	-0.7704
4	L	H	0.0000
5	V	H	1.2044
6	E	H	0.4435
7	S	H	-0.3453
8	G	H	-0.8606
9	G	H	-0.5100
11	D	H	-0.8739
12	L	H	0.6312
13	V	H	-0.4298
14	Q	H	-1.3276
15	P	H	-1.5593
16	G	H	-1.3075
17	G	H	-1.0283
18	S	H	-0.8334
19	L	H	-0.8565
20	R	H	-1.5534
21	L	H	0.0000
22	S	H	-0.2663
23	C	H	0.0000
24	A	H	-0.1054
25	A	H	0.0000
26	S	H	-0.6032
27	G	H	-1.0120
28	F	H	-0.4524
29	T	H	-0.3575
30	F	H	0.0000
35	S	H	-1.1088
36	S	H	-0.3040
37	Y	H	0.0298
38	E	H	-0.4265
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6233
45	A	H	-1.0324
46	P	H	-0.8095
47	G	H	-1.4822
48	K	H	-2.2587
49	G	H	-1.3508
50	L	H	0.0000
51	E	H	-0.8876
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	F	H	0.0000
56	I	H	0.0000
57	S	H	-0.8424
58	D	H	-1.4513
59	S	H	-1.0354
62	S	H	-0.8867
63	S	H	-0.7418
64	N	H	-0.8023
65	I	H	0.4496
66	Y	H	0.2937
67	Y	H	-0.4776
68	A	H	0.0000
69	D	H	-2.6480
70	S	H	-1.7456
71	V	H	0.0000
72	K	H	-2.5391
74	G	H	-1.6468
75	R	H	-1.3043
76	F	H	0.0000
77	T	H	-0.6392
78	I	H	0.0000
79	S	H	-0.2940
80	R	H	-1.0787
81	D	H	-1.5667
82	N	H	-1.8325
83	A	H	-1.4186
84	K	H	-2.3670
85	K	H	-1.9679
86	S	H	-1.0895
87	L	H	0.0000
88	Y	H	-0.4710
89	L	H	0.0000
90	Q	H	-1.0896
91	M	H	0.0000
92	T	H	-0.8748
93	S	H	-0.9694
94	L	H	0.0000
95	R	H	-2.2039
96	A	H	-1.6980
97	E	H	-2.2305
98	D	H	0.0000
99	T	H	-0.5168
100	A	H	0.0000
101	V	H	0.7621
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	E	H	0.0000
108	A	H	0.0000
109	I	H	1.6675
110	G	H	0.4664
112	S	H	0.3038
113	T	H	0.1682
114	S	H	0.0000
115	F	H	0.0000
116	D	H	-0.6335
117	N	H	-0.9188
118	W	H	-0.6345
119	G	H	0.0000
120	Q	H	-1.0330
121	G	H	-0.0556
122	T	H	0.3056
123	L	H	1.1323
124	V	H	0.0000
125	T	H	-0.0794
126	V	H	0.0000
127	S	H	-0.7516
128	S	H	-0.6861
1	E	L	-1.8211
2	I	L	0.0000
3	V	L	0.7153
4	M	L	0.0000
5	T	L	-0.6263
6	Q	L	-0.6658
7	S	L	-0.6506
8	P	L	-0.4504
9	A	L	-0.4080
10	T	L	-0.4956
11	L	L	-0.1725
12	S	L	-0.2659
13	V	L	-0.7884
14	S	L	-1.2901
15	P	L	-1.6621
16	G	L	-2.2145
17	E	L	-3.1875
18	R	L	-2.9593
19	A	L	0.0000
20	T	L	-0.5462
21	L	L	0.0000
22	S	L	-0.9322
23	C	L	0.0000
24	R	L	-2.4283
25	A	L	0.0000
26	S	L	-1.0534
27	Q	L	-1.7452
28	S	L	-1.4644
29	V	L	0.0000
36	S	L	-0.8401
37	S	L	-0.6361
38	S	L	-0.4820
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.2618
46	P	L	-0.9715
47	G	L	-1.3504
48	Q	L	-1.9012
49	A	L	-1.3693
50	P	L	0.0000
51	R	L	-1.5486
52	R	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.0867
56	S	L	-0.2704
57	A	L	0.0000
65	S	L	-0.6083
66	T	L	-0.5398
67	R	L	-0.9760
68	A	L	-0.7463
69	T	L	-0.5564
70	G	L	-0.6353
71	I	L	0.0000
72	P	L	-0.4218
74	A	L	-0.3806
75	R	L	-0.7805
76	F	L	0.0000
77	S	L	-0.5851
78	G	L	-0.5211
79	S	L	-0.7199
80	G	L	-1.1588
83	S	L	-1.1518
84	G	L	-1.2984
85	T	L	-1.8847
86	E	L	-2.3699
87	F	L	0.0000
88	T	L	-0.8467
89	L	L	0.0000
90	T	L	-0.6271
91	I	L	0.0000
92	S	L	-1.5698
93	S	L	-2.0601
94	L	L	0.0000
95	Q	L	-1.9718
96	S	L	-1.0124
97	E	L	-1.3833
98	D	L	0.0000
99	F	L	-0.2499
100	A	L	0.0000
101	I	L	-0.2904
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	H	L	0.0000
106	Q	L	0.0000
107	Y	L	-0.3303
108	N	L	-0.9531
109	N	L	-1.2278
114	W	L	-0.3112
115	P	L	-0.7090
116	L	L	0.0000
117	T	L	-0.1235
118	F	L	0.1911
119	G	L	0.0000
120	G	L	-0.7704
121	G	L	-0.7499
122	T	L	0.0000
123	K	L	-1.1379
124	V	L	0.0000
125	E	L	-0.0343
126	I	L	0.9987
127	K	L	-0.8453