Project name: 18b5d01b4bafec9

Chain sequence(s)	A: QVQLVESGGGLVQAGGSLRLSCAASGSTFSRYALAWYRQTPGKQREWVATITSGGVTSYVDSVKGRFTVSRDNAANTVYLQMISLKPEDTAVYYCKAPEILSPWGQGTQVTVSSGGGGSGGGGSGGGGSQVQLVESGGGLVQPGGSLRLSCAASGFTRDAYAIGWFRQAPGKEREGVSCISASGSRTNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYCAATEFGTGYVCYGGLEGNEFSFWGQGTQVTVSS
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:52)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:54)

• Minimal score value: -3.7692
• Maximal score value: 1.6083
• Average score: -0.7875
• Total score value: -203.1771

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.2274
2	V	A	-0.3439
3	Q	A	-0.6037
4	L	A	0.0000
5	V	A	0.0000
6	E	A	0.0000
7	S	A	-0.6475
8	G	A	-0.9749
9	G	A	-0.7152
10	G	A	-0.4282
11	L	A	-0.0748
12	V	A	-0.5492
13	Q	A	-1.6335
14	A	A	-1.5385
15	G	A	-1.0123
16	G	A	-0.5886
17	S	A	-0.5597
18	L	A	-0.7561
19	R	A	-1.9282
20	L	A	0.0000
21	S	A	-0.5711
22	C	A	0.0000
23	A	A	-0.2161
24	A	A	-0.3516
25	S	A	-0.6484
26	G	A	-0.8589
27	S	A	-0.9320
28	T	A	-0.8420
29	F	A	0.0000
30	S	A	-1.7586
31	R	A	-2.3104
32	Y	A	-1.1829
33	A	A	-0.6633
34	L	A	0.0000
35	A	A	0.0000
36	W	A	0.0000
37	Y	A	-0.3855
38	R	A	-1.0676
39	Q	A	-1.6896
40	T	A	-1.8043
41	P	A	-1.2997
42	G	A	-1.7914
43	K	A	-3.0054
44	Q	A	-2.8034
45	R	A	-2.1932
46	E	A	-1.8807
47	W	A	-0.4583
48	V	A	0.0000
49	A	A	0.0000
50	T	A	0.2323
51	I	A	0.0000
52	T	A	-0.0866
53	S	A	-1.0509
54	G	A	-0.6027
55	G	A	0.0461
56	V	A	1.3507
57	T	A	0.5471
58	S	A	-0.1365
59	Y	A	-0.8161
60	V	A	-1.1459
61	D	A	-2.3417
62	S	A	-1.6866
63	V	A	0.0000
64	K	A	-2.5666
65	G	A	-1.5396
66	R	A	-0.9217
67	F	A	0.0000
68	T	A	-0.7216
69	V	A	0.0000
70	S	A	-0.4679
71	R	A	-1.2386
72	D	A	-1.7193
73	N	A	-2.2486
74	A	A	-0.9907
75	A	A	-0.8497
76	N	A	-1.4555
77	T	A	-0.8325
78	V	A	0.0000
79	Y	A	-0.6371
80	L	A	0.0000
81	Q	A	-1.0509
82	M	A	0.0000
83	I	A	0.0870
84	S	A	-0.3582
85	L	A	0.0000
86	K	A	-1.8252
87	P	A	-1.7655
88	E	A	-2.2189
89	D	A	0.0000
90	T	A	-0.8891
91	A	A	0.0000
92	V	A	-0.1747
93	Y	A	0.0000
94	Y	A	-0.1438
95	C	A	0.0000
96	K	A	-0.0670
97	A	A	0.0000
98	P	A	-0.6540
99	E	A	-1.5560
100	I	A	0.1751
101	L	A	1.2888
102	S	A	0.0000
103	P	A	0.1821
104	W	A	0.3677
105	G	A	0.0000
106	Q	A	-0.5988
107	G	A	0.0000
108	T	A	0.0000
109	Q	A	-0.6555
110	V	A	0.0000
111	T	A	-0.6089
112	V	A	0.0000
113	S	A	-1.1196
114	S	A	-1.3789
115	G	A	-1.3687
116	G	A	-1.2586
117	G	A	-1.1861
118	G	A	-1.1873
119	S	A	-1.0538
120	G	A	-1.1369
121	G	A	-1.1827
122	G	A	-1.1571
123	G	A	-1.1488
124	S	A	-0.9819
125	G	A	-1.1331
126	G	A	-1.1546
127	G	A	-1.2621
128	G	A	-1.2339
129	S	A	-1.2036
130	Q	A	-1.4734
131	V	A	-0.4507
132	Q	A	-0.5383
133	L	A	0.0000
134	V	A	-0.0117
135	E	A	0.0000
136	S	A	-0.5663
137	G	A	-1.0270
138	G	A	-0.5866
139	G	A	-0.3127
140	L	A	0.0644
141	V	A	-0.4617
142	Q	A	-1.4928
143	P	A	-1.6657
144	G	A	-1.3985
145	G	A	-1.0094
146	S	A	-1.1589
147	L	A	-0.9964
148	R	A	-2.0803
149	L	A	0.0000
150	S	A	-0.5620
151	C	A	0.0000
152	A	A	-0.4325
153	A	A	0.0000
154	S	A	-0.9155
155	G	A	-0.9065
156	F	A	-1.1380
157	T	A	-1.3958
158	R	A	-2.9758
159	D	A	-2.6872
160	A	A	-1.2629
161	Y	A	-0.8010
162	A	A	0.0000
163	I	A	0.0000
164	G	A	0.0000
165	W	A	0.0000
166	F	A	0.0000
167	R	A	0.0000
168	Q	A	-2.0161
169	A	A	-1.9276
170	P	A	-1.3907
171	G	A	-1.9784
172	K	A	-3.4246
173	E	A	-3.7692
174	R	A	-3.4239
175	E	A	-2.8804
176	G	A	-1.7528
177	V	A	0.0000
178	S	A	0.0000
179	C	A	0.0000
180	I	A	0.0000
181	S	A	-0.6812
182	A	A	-1.1932
183	S	A	-1.0015
184	G	A	-1.4268
185	S	A	-1.3368
186	R	A	-1.9206
187	T	A	-0.9169
188	N	A	-0.8102
189	Y	A	-1.0385
190	A	A	-1.5847
191	D	A	-2.5169
192	S	A	-1.8409
193	V	A	0.0000
194	K	A	-2.6743
195	G	A	-1.7753
196	R	A	-1.4893
197	F	A	0.0000
198	T	A	-0.8974
199	I	A	0.0000
200	S	A	-0.7096
201	R	A	-1.0282
202	D	A	-1.4865
203	N	A	-2.1754
204	A	A	-1.7055
205	K	A	-2.3472
206	N	A	-2.0529
207	T	A	0.0000
208	V	A	0.0000
209	Y	A	-0.6495
210	L	A	0.0000
211	Q	A	-1.2847
212	M	A	0.0000
213	N	A	-1.4069
214	S	A	-1.2442
215	L	A	0.0000
216	K	A	-2.4092
217	P	A	-1.9477
218	E	A	-2.3700
219	D	A	0.0000
220	T	A	-0.8616
221	A	A	0.0000
222	I	A	-0.0851
223	Y	A	0.0000
224	Y	A	-0.3089
225	C	A	0.0000
226	A	A	0.0000
227	A	A	0.0000
228	T	A	0.0000
229	E	A	-1.1838
230	F	A	0.7448
231	G	A	-0.0492
232	T	A	-0.0209
233	G	A	0.4999
234	Y	A	1.6083
235	V	A	0.0000
236	C	A	0.1379
237	Y	A	1.1464
238	G	A	0.1278
239	G	A	-0.5533
240	L	A	-1.2690
241	E	A	-2.8083
242	G	A	-2.1769
243	N	A	-2.1775
244	E	A	-1.7287
245	F	A	0.0000
246	S	A	-0.4170
247	F	A	0.4850
248	W	A	0.4139
249	G	A	-0.1969
250	Q	A	-0.9957
251	G	A	0.0000
252	T	A	0.0000
253	Q	A	-0.3680
254	V	A	0.0000
255	T	A	0.0000
256	V	A	0.0000
257	S	A	-0.9576
258	S	A	-0.6640