| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGEAAAKEAAAKEAAAKFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:17)
[INFO] Main: Simulation completed successfully. (00:03:19)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4376 | |
| 2 | S | A | -0.1948 | |
| 3 | R | A | -1.6520 | |
| 4 | P | A | -1.0993 | |
| 5 | G | A | -1.0031 | |
| 6 | L | A | -0.6479 | |
| 7 | P | A | -0.2571 | |
| 8 | V | A | -0.0213 | |
| 9 | E | A | 0.0380 | |
| 10 | Y | A | 0.7408 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8441 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.6326 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9889 | |
| 17 | S | A | -0.7072 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3567 | |
| 20 | R | A | -2.0054 | |
| 21 | D | A | -2.7548 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.6071 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.7942 | |
| 29 | G | A | -0.9298 | |
| 30 | G | A | -1.5104 | |
| 31 | N | A | -2.4584 | |
| 32 | N | A | -2.5387 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0903 | |
| 43 | R | A | -2.4763 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.2869 | |
| 46 | D | A | -2.8255 | |
| 47 | D | A | -1.7877 | |
| 48 | Y | A | -0.2331 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9606 | |
| 54 | N | A | 0.0346 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2049 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.8211 | |
| 60 | W | A | -0.4005 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.1667 | |
| 63 | Q | A | -1.0345 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | 0.0000 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | -1.0726 | |
| 75 | Q | A | -1.4386 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6656 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.8845 | |
| 84 | S | A | 0.0066 | |
| 85 | P | A | -0.3529 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5680 | |
| 88 | G | A | -1.5277 | |
| 89 | K | A | -1.9709 | |
| 90 | A | A | -0.8371 | |
| 91 | G | A | -0.5089 | |
| 92 | C | A | 0.1085 | |
| 93 | Q | A | -0.4810 | |
| 94 | T | A | -0.4500 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.9050 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.6108 | |
| 99 | T | A | -0.5300 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3430 | |
| 103 | S | A | -0.5072 | |
| 104 | E | A | -0.6675 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4924 | |
| 108 | W | A | -0.8610 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.4458 | |
| 111 | A | A | -0.9362 | |
| 112 | N | A | -1.3401 | |
| 113 | R | A | -1.7269 | |
| 114 | A | A | -1.7409 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.6914 | |
| 117 | P | A | -1.0953 | |
| 118 | T | A | -0.7543 | |
| 119 | G | A | -0.3633 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.0855 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2451 | |
| 139 | H | A | -0.3997 | |
| 140 | P | A | -0.8801 | |
| 141 | Q | A | -1.1991 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.2103 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.2224 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -1.0622 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.1865 | |
| 157 | Q | A | -1.3417 | |
| 158 | G | A | -0.5019 | |
| 159 | M | A | 0.5077 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0124 | |
| 162 | S | A | 0.4263 | |
| 163 | L | A | 0.9256 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0608 | |
| 166 | L | A | 0.6984 | |
| 167 | A | A | -0.3475 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.4407 | |
| 170 | D | A | -2.1931 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | -1.8757 | |
| 173 | G | A | -1.8275 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.9690 | |
| 176 | A | A | -0.9242 | |
| 177 | A | A | -0.7511 | |
| 178 | D | A | -0.6674 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6505 | |
| 183 | S | A | -0.8291 | |
| 184 | S | A | -0.7745 | |
| 185 | D | A | -0.9777 | |
| 186 | P | A | -0.9858 | |
| 187 | A | A | -0.6669 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -1.8089 | |
| 190 | R | A | -1.2581 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.2038 | |
| 195 | Q | A | -1.7199 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.0854 | |
| 199 | K | A | -1.4133 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.3281 | |
| 202 | A | A | -0.9666 | |
| 203 | N | A | -1.5511 | |
| 204 | N | A | -1.8915 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -1.0770 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.6674 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -0.4886 | |
| 216 | P | A | -0.9993 | |
| 217 | N | A | -1.2713 | |
| 218 | E | A | -1.7288 | |
| 219 | L | A | -0.5352 | |
| 220 | G | A | -0.8042 | |
| 221 | G | A | -0.5908 | |
| 222 | A | A | -0.3774 | |
| 223 | N | A | 0.1529 | |
| 224 | I | A | 1.9160 | |
| 225 | P | A | 1.1241 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.5542 | |
| 228 | F | A | 1.9715 | |
| 229 | L | A | 1.3581 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.5810 | |
| 232 | F | A | 0.3575 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5335 | |
| 235 | S | A | -0.6762 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.5635 | |
| 239 | K | A | -2.1506 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.6815 | |
| 242 | D | A | -2.7116 | |
| 243 | A | A | -1.9001 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4730 | |
| 246 | A | A | -1.3568 | |
| 247 | A | A | -0.9970 | |
| 248 | G | A | -1.1245 | |
| 249 | G | A | -1.8094 | |
| 250 | H | A | -1.6902 | |
| 251 | N | A | -1.3192 | |
| 252 | A | A | -0.5322 | |
| 253 | V | A | 0.4940 | |
| 254 | F | A | 0.6540 | |
| 255 | N | A | 0.1824 | |
| 256 | F | A | 0.2597 | |
| 257 | P | A | -0.2437 | |
| 258 | P | A | -0.5568 | |
| 259 | N | A | -0.8562 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.3004 | |
| 263 | S | A | -0.4222 | |
| 264 | W | A | -0.3236 | |
| 265 | E | A | -0.9065 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.4048 | |
| 270 | Q | A | -0.5578 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9089 | |
| 273 | A | A | -0.6279 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0804 | |
| 276 | G | A | -1.1032 | |
| 277 | D | A | -0.8915 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.1154 | |
| 280 | S | A | -0.9705 | |
| 281 | S | A | -0.4491 | |
| 282 | L | A | -0.4608 | |
| 283 | G | A | -0.9434 | |
| 284 | A | A | 0.0000 | |
| 285 | G | A | -1.6842 | |
| 286 | E | A | -2.5649 | |
| 287 | A | A | -2.1308 | |
| 288 | A | A | -1.8189 | |
| 289 | A | A | -1.5470 | |
| 290 | K | A | -2.9968 | |
| 291 | E | A | -2.4863 | |
| 292 | A | A | -1.6407 | |
| 293 | A | A | -1.7274 | |
| 294 | A | A | -2.0205 | |
| 295 | K | A | -2.8535 | |
| 296 | E | A | -2.9479 | |
| 297 | A | A | -1.4387 | |
| 298 | A | A | -0.6681 | |
| 299 | A | A | -0.7507 | |
| 300 | K | A | -0.9939 | |
| 301 | F | A | 0.7376 | |
| 302 | A | A | 0.2175 | |
| 303 | V | A | 0.9407 | |
| 304 | T | A | 0.0907 | |
| 305 | N | A | -0.5778 | |
| 306 | D | A | -0.8375 | |
| 307 | G | A | -0.0148 | |
| 308 | V | A | 1.7367 | |
| 309 | I | A | 2.1154 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine