Project name: 8JEL

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMYWVRQAPGKGLEWVAYITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSS; L: EIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:02)

• Minimal score value: -2.9609
• Maximal score value: 1.3444
• Average score: -0.5761
• Total score value: -130.1948

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9247
2	V	H	-0.7886
3	Q	H	-0.7271
4	L	H	0.0000
5	V	H	1.2867
6	E	H	0.0000
7	S	H	-0.1580
8	G	H	-0.7291
9	G	H	-0.0024
11	G	H	0.5453
12	L	H	1.3444
13	V	H	-0.0060
14	Q	H	-1.3179
15	P	H	-1.5807
16	G	H	-1.3988
17	G	H	-0.9870
18	S	H	-1.1561
19	L	H	-0.8226
20	R	H	-1.7720
21	L	H	0.0000
22	S	H	-0.2732
23	C	H	0.0000
24	A	H	-0.0311
25	A	H	0.0000
26	S	H	-0.8220
27	G	H	-1.1761
28	F	H	-0.6410
29	T	H	-0.5460
30	F	H	0.0000
35	S	H	-1.3635
36	D	H	-1.6418
37	Y	H	-0.7532
38	Y	H	-0.3647
39	M	H	0.0000
40	Y	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6782
45	A	H	-1.0823
46	P	H	-0.8734
47	G	H	-1.4555
48	K	H	-2.2664
49	G	H	-1.3818
50	L	H	0.0000
51	E	H	-0.9474
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	Y	H	0.0000
56	I	H	0.0000
57	T	H	-0.6991
58	K	H	-1.5993
59	G	H	-1.4796
62	G	H	-1.1207
63	G	H	-0.9035
64	S	H	-0.3825
65	T	H	0.2499
66	Y	H	0.6869
67	Y	H	-0.3541
68	P	H	-1.3577
69	D	H	-2.4161
70	S	H	-1.7152
71	V	H	0.0000
72	K	H	-2.4735
74	G	H	-1.7438
75	R	H	-1.5601
76	F	H	0.0000
77	T	H	-0.6588
78	I	H	0.0000
79	S	H	-0.5005
80	R	H	-1.2752
81	D	H	-1.8187
82	N	H	-2.1091
83	A	H	-1.4583
84	K	H	-2.4067
85	N	H	-1.9249
86	T	H	-1.0654
87	L	H	0.0000
88	Y	H	-0.4851
89	L	H	0.0000
90	Q	H	-1.0603
91	M	H	0.0000
92	N	H	-1.2968
93	S	H	-1.2341
94	L	H	0.0000
95	R	H	-2.1799
96	A	H	-1.6372
97	E	H	-2.1916
98	D	H	0.0000
99	T	H	-0.4305
100	A	H	0.0000
101	V	H	0.5610
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	Q	H	0.0000
108	T	H	0.0000
109	N	H	-0.6073
110	Y	H	0.8605
112	D	H	0.0000
113	F	H	0.8911
114	T	H	0.0000
115	M	H	0.0000
116	D	H	0.0000
117	Y	H	0.1274
118	W	H	-0.1675
119	G	H	0.0000
120	Q	H	-1.0115
121	G	H	0.0000
122	T	H	0.3698
123	L	H	0.9945
124	V	H	0.0000
125	T	H	0.2082
126	V	H	0.0000
127	S	H	-0.6883
128	S	H	-0.4739
1	E	L	-1.4893
2	I	L	0.0000
3	V	L	0.8239
4	M	L	0.0000
5	T	L	-0.3955
6	Q	L	0.0000
7	S	L	-0.5937
8	P	L	-0.4276
9	A	L	-0.3679
10	T	L	-0.4816
11	L	L	-0.2090
12	S	L	-0.3786
13	V	L	0.0000
14	S	L	-1.1074
15	P	L	-1.2389
16	G	L	-1.7892
17	E	L	-2.3530
18	R	L	-2.6188
19	A	L	0.0000
20	T	L	-0.6569
21	L	L	0.0000
22	S	L	-0.8342
23	C	L	0.0000
24	K	L	-1.9537
25	A	L	0.0000
26	S	L	-1.2522
27	Q	L	-2.4495
28	D	L	-2.9609
29	V	L	0.0000
36	G	L	-1.3072
37	T	L	-0.6249
38	S	L	0.0000
39	V	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7359
44	Q	L	0.0000
45	K	L	-1.5354
46	P	L	-1.0596
47	G	L	-1.4693
48	Q	L	-2.1189
49	A	L	-1.3888
50	P	L	0.0000
51	R	L	-1.3459
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.2046
56	W	L	0.3925
57	A	L	0.0000
65	S	L	-0.4322
66	A	L	-0.4602
67	R	L	-1.1535
68	H	L	-0.8668
69	T	L	-0.5677
70	G	L	-0.6282
71	I	L	-0.5981
72	P	L	-0.4153
74	A	L	-0.3849
75	R	L	-0.7190
76	F	L	0.0000
77	S	L	-0.5377
78	G	L	-0.4070
79	S	L	-0.6480
80	G	L	-1.1163
83	S	L	-1.3839
84	G	L	-1.9850
85	T	L	-2.4081
86	E	L	-2.8217
87	F	L	0.0000
88	T	L	-0.8062
89	L	L	0.0000
90	T	L	-0.6225
91	I	L	0.0000
92	S	L	-1.4630
93	S	L	-1.7545
94	L	L	0.0000
95	Q	L	-1.7305
96	S	L	-1.0680
97	E	L	-1.6831
98	D	L	0.0000
99	F	L	-0.3245
100	A	L	0.0000
101	V	L	-0.2165
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	S	L	-0.3341
109	S	L	-0.1921
114	Y	L	0.2310
115	P	L	-0.4113
116	L	L	0.0000
117	T	L	-0.0704
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.7071
121	G	L	-0.7371
122	T	L	0.0000
123	K	L	-0.8329
124	V	L	0.0000
125	E	L	-0.0739
126	I	L	0.8076
127	K	L	-0.9196