Project name: 7V5N

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:00)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:01)

• Minimal score value: -3.2327
• Maximal score value: 1.5986
• Average score: -0.5167
• Total score value: -118.8401

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9447
2	V	H	-0.8979
3	Q	H	-0.9904
4	L	H	0.0000
5	V	H	1.1427
6	E	H	0.0000
7	S	H	-0.2210
8	G	H	-0.5555
9	G	H	0.1040
11	G	H	0.7532
12	L	H	1.3283
13	V	H	-0.0570
14	Q	H	-1.3114
15	P	H	-1.3708
16	G	H	-1.4187
17	G	H	-1.1794
18	S	H	-1.1796
19	L	H	-0.8889
20	R	H	-1.8592
21	L	H	0.0000
22	S	H	-0.2498
23	C	H	0.0000
24	A	H	0.0889
25	A	H	0.0000
26	S	H	-0.7685
27	G	H	-1.0669
28	Y	H	-0.5636
29	T	H	-0.3961
30	F	H	0.0000
35	T	H	-0.1131
36	N	H	-0.9772
37	Y	H	-0.3326
38	G	H	0.0000
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7509
45	A	H	-1.0743
46	P	H	-0.8136
47	G	H	-1.4787
48	K	H	-2.3729
49	G	H	-1.6481
50	L	H	0.0000
51	E	H	-1.4081
52	W	H	0.0000
53	V	H	0.0000
54	G	H	0.0000
55	W	H	-0.1137
56	I	H	0.0000
57	N	H	-0.6227
58	T	H	0.0000
59	Y	H	0.6392
62	T	H	-0.1269
63	G	H	-0.7927
64	E	H	-1.8115
65	P	H	-1.0781
66	T	H	-0.4984
67	Y	H	-0.7706
68	A	H	0.0000
69	A	H	-1.6610
70	D	H	-2.7071
71	F	H	0.0000
72	K	H	-3.1554
74	R	H	-3.2327
75	R	H	-2.2202
76	F	H	0.0000
77	T	H	-1.0825
78	F	H	0.0000
79	S	H	-0.3830
80	L	H	-0.2290
81	D	H	-0.8385
82	T	H	-0.6531
83	S	H	-1.1330
84	K	H	-1.9236
85	S	H	-1.0109
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.3475
89	L	H	0.0000
90	Q	H	-1.1576
91	M	H	0.0000
92	N	H	-1.4848
93	S	H	-1.4155
94	L	H	0.0000
95	R	H	-2.2222
96	A	H	-1.6470
97	E	H	-2.1832
98	D	H	0.0000
99	T	H	-0.3645
100	A	H	0.0000
101	V	H	0.7245
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	Y	H	0.0000
108	P	H	0.0000
109	H	H	-0.2243
110	Y	H	0.8877
111	Y	H	1.2289
111A	G	H	0.2097
112B	S	H	-0.0384
112A	S	H	0.1672
112	H	H	0.4165
113	W	H	0.3667
114	Y	H	0.0000
115	F	H	0.0000
116	D	H	-0.3480
117	V	H	-0.0898
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.2993
121	G	H	-0.3393
122	T	H	0.0000
123	L	H	1.5986
124	V	H	0.0000
125	T	H	0.3229
126	V	H	0.0000
127	S	H	-0.4809
128	S	H	-0.5358
1	D	L	-1.9764
2	I	L	0.0000
3	Q	L	-1.9876
4	M	L	0.0000
5	T	L	-0.8778
6	Q	L	0.0000
7	S	L	-0.5476
8	P	L	-0.5093
9	S	L	-0.7965
10	S	L	-0.9534
11	L	L	-0.7616
12	S	L	-0.9305
13	A	L	-0.9362
14	S	L	-0.7354
15	V	L	0.3014
16	G	L	-0.6211
17	D	L	-1.7216
18	R	L	-2.2344
19	V	L	0.0000
20	T	L	-0.6264
21	I	L	0.0000
22	T	L	-0.5796
23	C	L	0.0000
24	S	L	-1.4727
25	A	L	0.0000
26	S	L	-1.9337
27	Q	L	-2.5855
28	D	L	-2.6700
29	I	L	0.0000
36	S	L	-1.0188
37	N	L	-0.3641
38	Y	L	0.5990
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7011
44	Q	L	-1.1016
45	K	L	-1.4001
46	P	L	-1.1332
47	G	L	-1.6707
48	K	L	-2.5447
49	A	L	-1.5165
50	P	L	0.0000
51	K	L	-1.1430
52	V	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.7356
56	F	L	1.0138
57	T	L	0.0000
65	S	L	0.0316
66	S	L	0.3128
67	L	L	0.4310
68	H	L	-0.1781
69	S	L	-0.3553
70	G	L	-0.4918
71	V	L	-0.2702
72	P	L	-0.3495
74	S	L	-0.4146
75	R	L	-0.8172
76	F	L	0.0000
77	S	L	-0.3169
78	G	L	0.0000
79	S	L	-0.6495
80	G	L	-1.0152
83	S	L	-1.1770
84	G	L	-1.7474
85	T	L	-2.0975
86	D	L	-2.4641
87	F	L	0.0000
88	T	L	-0.6415
89	L	L	0.0000
90	T	L	-0.6025
91	I	L	0.0000
92	S	L	-1.3398
93	S	L	-1.1757
94	L	L	0.0000
95	Q	L	-0.6702
96	P	L	-0.8194
97	E	L	-1.1426
98	D	L	0.0000
99	F	L	-0.2034
100	A	L	0.0000
101	T	L	-0.8146
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	S	L	-0.0344
109	T	L	0.2724
114	V	L	0.8324
115	P	L	0.1365
116	W	L	0.0000
117	T	L	-0.7550
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.5701
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4295
124	V	L	0.0000
125	E	L	-1.4171
126	I	L	-0.8296
127	K	L	-1.5332