| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFADIVVNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEYVHCGPDDRVAYSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFHRRCGPDGHPLPNAPPPSPLYVPPPPTSPYAVLPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPVPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9410 | |
| 2 | L | A | 1.9612 | |
| 3 | P | A | 0.8337 | |
| 4 | P | A | 0.3800 | |
| 5 | T | A | 0.1259 | |
| 6 | T | A | 0.1288 | |
| 7 | P | A | 0.1875 | |
| 8 | V | A | 1.2111 | |
| 9 | A | A | 0.0851 | |
| 10 | K | A | -1.0261 | |
| 11 | V | A | -0.1672 | |
| 12 | Q | A | -1.4132 | |
| 13 | S | A | -1.5525 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4087 | |
| 16 | E | A | -2.4352 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4606 | |
| 20 | P | A | 0.1314 | |
| 21 | T | A | 0.1611 | |
| 22 | S | A | -0.0937 | |
| 23 | L | A | 0.0937 | |
| 24 | F | A | -0.0268 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2710 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8968 | |
| 31 | R | A | -2.6906 | |
| 32 | L | A | -0.8051 | |
| 33 | L | A | 1.1522 | |
| 34 | T | A | 1.3577 | |
| 35 | V | A | 1.7988 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | 0.2273 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | 0.1937 | |
| 40 | A | A | 0.0154 | |
| 41 | D | A | 0.0940 | |
| 42 | I | A | 1.9703 | |
| 43 | V | A | 2.6232 | |
| 44 | V | A | 1.9154 | |
| 45 | N | A | -0.4348 | |
| 46 | G | A | -0.2568 | |
| 47 | K | A | 0.0023 | |
| 48 | V | A | 2.3491 | |
| 49 | V | A | 2.8134 | |
| 50 | V | A | 1.8425 | |
| 51 | P | A | 0.6983 | |
| 52 | K | A | -0.0722 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1387 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3739 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2581 | |
| 70 | K | A | -1.7753 | |
| 71 | F | A | -0.6192 | |
| 72 | A | A | -0.5841 | |
| 73 | L | A | -0.8814 | |
| 74 | P | A | -1.2212 | |
| 75 | Q | A | -2.5070 | |
| 76 | K | A | -3.1137 | |
| 77 | D | A | -2.9958 | |
| 78 | F | A | -1.6788 | |
| 79 | Y | A | -1.9007 | |
| 80 | D | A | -2.7023 | |
| 81 | P | A | -2.3137 | |
| 82 | E | A | -3.0548 | |
| 83 | K | A | -3.3998 | |
| 84 | E | A | -2.4618 | |
| 85 | R | A | -1.2941 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6589 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9755 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3710 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7030 | |
| 99 | G | A | -0.5405 | |
| 100 | P | A | -0.4123 | |
| 101 | L | A | 0.0260 | |
| 102 | G | A | -0.2253 | |
| 103 | K | A | -0.6162 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3629 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1482 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3825 | |
| 110 | L | A | 0.3103 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1023 | |
| 113 | K | A | -0.4523 | |
| 114 | L | A | -0.7343 | |
| 115 | G | A | -0.9926 | |
| 116 | D | A | -1.6742 | |
| 117 | T | A | -1.1313 | |
| 118 | E | A | -1.9027 | |
| 119 | N | A | -2.2896 | |
| 120 | P | A | -1.8705 | |
| 121 | T | A | -1.4750 | |
| 122 | E | A | -1.8666 | |
| 123 | Y | A | 0.0918 | |
| 124 | V | A | 0.0397 | |
| 125 | H | A | 0.1878 | |
| 126 | C | A | -0.3918 | |
| 127 | G | A | -1.0044 | |
| 128 | P | A | -1.3632 | |
| 129 | D | A | -2.2615 | |
| 130 | D | A | -1.7169 | |
| 131 | R | A | -1.1533 | |
| 132 | V | A | 0.1847 | |
| 133 | A | A | 0.4121 | |
| 134 | Y | A | 0.2252 | |
| 135 | S | A | -0.0671 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2172 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5681 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1875 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1718 | |
| 157 | D | A | 0.3468 | |
| 158 | L | A | 0.8135 | |
| 159 | A | A | 0.1846 | |
| 160 | E | A | -1.4492 | |
| 161 | P | A | -0.2027 | |
| 162 | C | A | 0.1944 | |
| 163 | P | A | -0.1621 | |
| 164 | G | A | -0.0642 | |
| 165 | L | A | 0.6210 | |
| 166 | P | A | -0.1054 | |
| 167 | P | A | -0.3357 | |
| 168 | G | A | -0.4255 | |
| 169 | A | A | -0.0321 | |
| 170 | C | A | 0.6518 | |
| 171 | P | A | 0.5390 | |
| 172 | P | A | 0.7751 | |
| 173 | I | A | 2.0497 | |
| 174 | Q | A | 0.8807 | |
| 175 | L | A | 1.5190 | |
| 176 | V | A | 0.8716 | |
| 177 | N | A | -0.2896 | |
| 178 | S | A | -0.0859 | |
| 179 | V | A | 0.4270 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3830 | |
| 182 | D | A | 0.0884 | |
| 183 | G | A | -0.1534 | |
| 184 | D | A | -0.5383 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1245 | |
| 190 | F | A | 0.0689 | |
| 191 | G | A | -0.1004 | |
| 192 | N | A | -0.2594 | |
| 193 | M | A | -0.1076 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3980 | |
| 197 | E | A | -2.5936 | |
| 198 | L | A | -1.2194 | |
| 199 | Q | A | -2.5627 | |
| 200 | Q | A | -3.3313 | |
| 201 | D | A | -3.5996 | |
| 202 | R | A | -3.3322 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.4536 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3720 | |
| 211 | S | A | -1.7028 | |
| 212 | T | A | -1.4363 | |
| 213 | R | A | -2.0853 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1533 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3813 | |
| 220 | L | A | 0.6154 | |
| 221 | K | A | -1.0898 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8081 | |
| 224 | N | A | -1.4839 | |
| 225 | E | A | -1.2200 | |
| 226 | A | A | -0.5930 | |
| 227 | Y | A | -0.3489 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6675 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0805 | |
| 234 | F | A | 0.2617 | |
| 235 | G | A | -0.8134 | |
| 236 | R | A | -2.5875 | |
| 237 | R | A | -2.8551 | |
| 238 | E | A | -2.1423 | |
| 239 | Q | A | -0.2152 | |
| 240 | V | A | 1.4155 | |
| 241 | Y | A | 1.1301 | |
| 242 | A | A | 0.2680 | |
| 243 | R | A | -0.8010 | |
| 244 | H | A | -0.9704 | |
| 245 | F | A | -0.0328 | |
| 246 | H | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.4488 | |
| 249 | C | A | -0.8070 | |
| 250 | G | A | -1.0016 | |
| 251 | P | A | -0.8707 | |
| 252 | D | A | -1.3027 | |
| 253 | G | A | -1.2852 | |
| 254 | H | A | -1.4230 | |
| 255 | P | A | -1.0157 | |
| 256 | L | A | -0.1366 | |
| 257 | P | A | -0.6635 | |
| 258 | N | A | -1.0840 | |
| 259 | A | A | -0.4216 | |
| 260 | P | A | -0.6722 | |
| 261 | P | A | -0.2055 | |
| 262 | P | A | -0.0778 | |
| 263 | S | A | 0.3352 | |
| 264 | P | A | 0.5613 | |
| 265 | L | A | 1.7219 | |
| 266 | Y | A | 1.6128 | |
| 267 | V | A | 1.8184 | |
| 268 | P | A | 1.0019 | |
| 269 | P | A | 0.7076 | |
| 270 | P | A | -0.1138 | |
| 271 | P | A | -0.0724 | |
| 272 | T | A | 0.0099 | |
| 273 | S | A | 0.2957 | |
| 274 | P | A | 0.7582 | |
| 275 | Y | A | 1.7187 | |
| 276 | A | A | 1.3077 | |
| 277 | V | A | 2.3026 | |
| 278 | L | A | 1.8682 | |
| 279 | P | A | 0.8460 | |
| 280 | P | A | 0.1537 | |
| 281 | Y | A | 0.0447 | |
| 282 | D | A | -0.5908 | |
| 283 | Y | A | 0.9638 | |
| 284 | F | A | 0.7418 | |
| 285 | G | A | 0.2524 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9557 | |
| 291 | L | A | 1.6065 | |
| 292 | V | A | 0.6160 | |
| 293 | S | A | -0.1568 | |
| 294 | S | A | -0.9607 | |
| 295 | D | A | -1.8415 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1042 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6588 | |
| 301 | R | A | -1.8638 | |
| 302 | P | A | -0.9547 | |
| 303 | F | A | -0.1979 | |
| 304 | W | A | -0.5708 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0864 | |
| 307 | R | A | -2.8349 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2657 | |
| 310 | G | A | -1.2242 | |
| 311 | N | A | -1.2671 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8241 | |
| 319 | N | A | -0.8479 | |
| 320 | E | A | -1.0348 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3503 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0789 | |
| 333 | N | A | 0.5538 | |
| 334 | F | A | 1.7740 | |
| 335 | T | A | 0.8804 | |
| 336 | I | A | 0.4461 | |
| 337 | S | A | -0.9783 | |
| 338 | Q | A | -1.7870 | |
| 339 | Q | A | -1.1700 | |
| 340 | L | A | 0.7112 | |
| 341 | C | A | 0.6229 | |
| 342 | T | A | 0.4751 | |
| 343 | P | A | 0.2522 | |
| 344 | V | A | 1.2027 | |
| 345 | P | A | 0.5175 | |
| 346 | N | A | 0.0171 | |
| 347 | V | A | 1.7235 | |
| 348 | Y | A | 1.5990 | |
| 349 | D | A | 0.2180 | |
| 350 | P | A | -0.4017 | |
| 351 | S | A | -0.3497 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7580 | |
| 354 | K | A | -1.8501 | |
| 355 | N | A | -1.7937 | |
| 356 | Y | A | -0.1006 | |
| 357 | L | A | 0.6407 | |
| 358 | R | A | 0.9693 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3750 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0904 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0638 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6914 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3042 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3142 | |
| 376 | L | A | -1.7080 | |
| 377 | D | A | -1.9806 | |
| 378 | P | A | -1.0331 | |
| 379 | G | A | -1.0131 | |
| 380 | V | A | -0.9332 | |
| 381 | L | A | -0.5317 | |
| 382 | A | A | -0.6570 | |
| 383 | H | A | -0.8122 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4197 | |
| 386 | T | A | -0.5543 | |
| 387 | M | A | -0.2990 | |
| 388 | N | A | -0.8668 | |
| 389 | P | A | -1.2502 | |
| 390 | T | A | -1.4370 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4226 | |
| 393 | E | A | -2.7491 | |
| 394 | N | A | -2.3347 | |
| 395 | W | A | -1.3313 | |
| 396 | N | A | -1.0157 | |
| 397 | L | A | -0.1753 | |
| 398 | G | A | 0.5478 | |
| 399 | F | A | 2.4325 | |
| 400 | V | A | 1.8585 | |
| 401 | P | A | 0.0608 | |
| 402 | P | A | -1.7912 | |
| 403 | K | A | -3.3207 | |
| 404 | E | A | -3.7829 | |
| 405 | R | A | -3.9272 | |
| 406 | E | A | -3.7983 | |
| 407 | D | A | -2.8877 | |
| 408 | P | A | -1.7716 | |
| 409 | Y | A | -0.9949 | |
| 410 | K | A | -2.1230 | |
| 411 | G | A | -0.6419 | |
| 412 | L | A | 0.6702 | |
| 413 | I | A | 1.5912 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3813 | |
| 416 | E | A | -1.6634 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9329 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0259 | |
| 421 | E | A | -2.7495 | |
| 422 | R | A | -2.5678 | |
| 423 | F | A | -1.2470 | |
| 424 | S | A | -1.4545 | |
| 425 | Q | A | -1.8511 | |
| 426 | D | A | -2.8995 | |
| 427 | L | A | -1.9819 | |
| 428 | D | A | -2.7686 | |
| 429 | Q | A | -2.6159 | |
| 430 | F | A | -1.4189 | |
| 431 | A | A | -0.8915 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5781 | |
| 435 | K | A | -0.6971 | |
| 436 | F | A | 0.1505 | |
| 437 | L | A | 1.0317 | |
| 438 | Y | A | 0.8307 | |
| 439 | Q | A | -0.2706 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine