Project name: 1bd9bb9646f45fd

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDFKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:36)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:37)

• Minimal score value: -3.2473
• Maximal score value: 1.522
• Average score: -0.5757
• Total score value: -149.1129

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.4575
245	C	P	0.1886
246	G	P	-0.2725
247	E	P	-0.4638
248	L	P	0.0000
249	V	P	0.8203
250	W	P	0.2124
251	V	P	0.0000
252	G	P	0.0000
253	E	P	-2.1219
254	P	P	-0.9300
255	L	P	0.7114
256	T	P	0.3796
257	L	P	0.7186
258	R	P	-0.4587
259	T	P	-0.6498
260	A	P	-0.6164
261	E	P	-1.3400
262	T	P	-0.0067
263	I	P	1.5220
264	T	P	0.5134
265	G	P	0.2761
266	K	P	0.1179
267	Y	P	0.4698
268	G	P	0.0000
269	V	P	-0.2747
270	W	P	0.0000
271	M	P	0.0000
272	R	P	-0.9379
273	D	P	-1.2603
274	P	P	0.0000
275	K	P	-1.7933
276	P	P	-0.9112
277	T	P	-0.1591
278	Y	P	0.8490
279	P	P	0.4096
280	Y	P	-0.3827
281	T	P	-0.8997
282	Q	P	-2.1686
283	E	P	-1.9997
284	T	P	0.0000
285	T	P	0.0000
286	W	P	0.0000
287	R	P	-0.7590
288	I	P	0.0000
289	D	P	-1.4538
290	T	P	0.0000
291	V	P	1.3133
292	G	P	0.0000
293	T	P	-0.4654
294	D	P	-1.9826
295	V	P	-1.4206
296	R	P	-1.7033
297	Q	P	-0.8879
298	V	P	0.0000
299	F	P	0.1908
300	E	P	0.0000
301	Y	P	0.0000
302	D	P	-1.0298
303	L	P	0.3131
304	I	P	0.3264
305	S	P	0.0461
306	Q	P	-0.1250
307	F	P	0.0000
308	M	P	-0.2418
309	Q	P	-1.0325
310	G	P	-0.1514
311	Y	P	0.6753
312	P	P	0.0309
313	S	P	-0.3520
314	K	P	-0.6312
315	V	P	0.6403
316	H	P	0.0000
317	I	P	0.6522
318	L	P	0.0000
319	P	P	-0.7168
320	R	P	-1.5766
321	P	P	-1.5654
322	L	P	0.0000
323	E	P	-1.1408
324	S	P	0.0000
325	T	P	0.0000
326	G	P	-0.0868
327	A	P	0.0000
328	V	P	0.0000
329	V	P	0.0000
330	Y	P	0.0000
331	S	P	-0.6194
332	G	P	-0.3508
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	0.0000
339	A	P	-1.5278
340	E	P	-2.2465
341	S	P	-1.5838
342	R	P	-1.7741
343	T	P	-1.9505
344	V	P	0.0000
345	I	P	0.0000
346	R	P	-1.6620
347	Y	P	0.0000
348	E	P	-1.3884
349	L	P	0.0000
350	N	P	-1.7257
351	T	P	-1.1596
352	E	P	-1.3950
353	T	P	-0.9456
354	V	P	-0.6427
355	K	P	-2.2427
356	A	P	-2.3650
357	E	P	-2.9998
358	K	P	-2.7804
359	E	P	-2.8765
360	I	P	0.0000
361	P	P	-1.2398
362	G	P	-1.4485
363	A	P	0.0000
364	G	P	-1.5011
365	Y	P	-1.1223
366	H	P	-1.6943
367	G	P	-1.0568
368	Q	P	-1.1650
369	F	P	-0.3948
370	P	P	0.1528
371	Y	P	0.0742
372	S	P	0.0195
373	W	P	1.0498
374	G	P	0.4497
375	G	P	0.5843
376	Y	P	0.9217
377	T	P	0.0000
378	D	P	0.0000
379	I	P	0.0000
380	D	P	-0.2545
381	L	P	-0.0580
382	A	P	-0.1724
383	V	P	0.0000
384	D	P	-1.3776
385	E	P	-2.0807
386	A	P	-1.0796
387	G	P	0.0000
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	0.0000
393	S	P	-1.4742
394	T	P	-1.9134
395	D	P	-3.1586
396	E	P	-3.2473
397	A	P	-2.4771
398	K	P	-2.9596
399	G	P	0.0000
400	A	P	-2.1692
401	I	P	0.0000
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	-1.3329
406	L	P	0.0000
407	N	P	-2.0276
408	P	P	-1.8131
409	E	P	-2.9492
410	N	P	-3.0482
411	L	P	0.0000
412	E	P	-2.8618
413	L	P	-1.9087
414	E	P	-2.7048
415	Q	P	-2.2034
416	T	P	-1.2961
417	W	P	-0.7734
418	E	P	-1.6749
419	T	P	0.0000
420	N	P	-1.2826
421	I	P	0.0000
422	R	P	-2.2824
423	K	P	0.0000
424	Q	P	-0.8648
425	S	P	-0.8549
426	V	P	0.0000
427	A	P	0.0000
428	N	P	0.0000
429	A	P	-0.0586
430	F	P	0.0000
431	I	P	0.0000
432	I	P	0.0000
433	C	P	0.0464
434	G	P	0.0000
435	T	P	0.0000
436	L	P	0.0000
437	Y	P	0.0000
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.2002
441	S	P	-0.3464
442	Y	P	-0.5285
443	T	P	-0.5218
444	S	P	-0.8775
445	A	P	-1.3834
446	D	P	-2.4361
447	A	P	0.0000
448	T	P	-0.7037
449	V	P	0.0000
450	N	P	-0.3878
451	F	P	0.5250
452	A	P	0.0000
453	Y	P	0.0000
454	D	P	-0.0247
455	T	P	0.0000
456	G	P	-0.3459
457	T	P	-0.0107
458	G	P	0.1208
459	I	P	1.2145
460	S	P	0.4542
461	K	P	0.0846
462	T	P	-0.1039
463	L	P	0.0331
464	T	P	0.0575
465	I	P	0.2273
466	P	P	-0.6182
467	F	P	0.0000
468	K	P	-1.8978
469	N	P	0.0000
470	R	P	-2.5104
471	Y	P	-0.9187
472	K	P	-1.9504
473	Y	P	-0.6419
474	S	P	0.0000
475	S	P	-0.0090
476	M	P	0.1277
477	I	P	0.0000
478	D	P	-0.6126
479	Y	P	-0.9523
480	N	P	0.0000
481	P	P	-1.9065
482	L	P	-1.7925
483	E	P	-2.9961
484	K	P	-3.1069
485	K	P	-2.9395
486	L	P	0.0000
487	F	P	-0.4168
488	A	P	0.0000
489	W	P	0.0000
490	D	P	0.0000
491	N	P	-0.1071
492	L	P	0.1581
493	N	P	0.0000
494	M	P	0.0000
495	V	P	0.0000
496	T	P	-0.2105
497	Y	P	0.0000
498	D	P	-2.5196
499	F	P	-1.5098
500	K	P	-1.2165
501	L	P	-0.1568
502	S	P	-0.2850