| Chain sequence(s) |
A: FRTVGYYVDWAIYGRNFKPQDLKADQFSILFAFVKINRDTGEIQLADPWADTDIWDESWDVPAGVTNVYGIFLQLFKLKKVRNLKTMLSIGGWTYSQDGSFAAGASTPEKRDKFARSAVQMVKDFGLDGIDLWYPVDATEAANYVDLLRLCRQYLNEANPAFELSIAAPCGADKIQKLDIPGMDRYLDFWNLMAYDFAGSWSQAAGASNIFGSTSNPASTEFSFDTALRMYSAVNPKLVVGMPLYGRGFANTDGPGKPYQGTGQGNWETGVWDYKNLPLPGSQEYQDDQLIASYSYDPAQRLMISYDTPIAELKAKYIMSRGLGGAMWWETSGDKVGAGSLVQTVIDTFPPK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:08)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:08)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:08)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:08)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:08)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:09)
[INFO] Main: Simulation completed successfully. (00:00:12)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 0.9245 | |
| 2 | R | A | 0.1532 | |
| 3 | T | A | 0.0000 | |
| 4 | V | A | 0.0000 | |
| 5 | G | A | 0.0000 | |
| 6 | Y | A | 0.0000 | |
| 7 | Y | A | 0.0000 | |
| 8 | V | A | 0.0000 | |
| 9 | D | A | 0.0000 | |
| 10 | W | A | 0.4416 | |
| 11 | A | A | 0.0000 | |
| 12 | I | A | -0.0126 | |
| 13 | Y | A | 0.3119 | |
| 14 | G | A | -0.3479 | |
| 15 | R | A | -0.7163 | |
| 16 | N | A | -1.3150 | |
| 17 | F | A | -0.9353 | |
| 18 | K | A | -1.1873 | |
| 19 | P | A | 0.0000 | |
| 20 | Q | A | -1.6883 | |
| 21 | D | A | -2.1069 | |
| 22 | L | A | 0.0000 | |
| 23 | K | A | -2.2074 | |
| 24 | A | A | -1.8066 | |
| 25 | D | A | -2.4706 | |
| 26 | Q | A | -1.6265 | |
| 27 | F | A | 0.0000 | |
| 28 | S | A | -1.0588 | |
| 30 | I | A | 0.0000 | |
| 31 | L | A | 0.0000 | |
| 32 | F | A | 0.0000 | |
| 33 | A | A | 0.0000 | |
| 34 | F | A | 0.2214 | |
| 35 | V | A | 0.0000 | |
| 36 | K | A | -0.8792 | |
| 37 | I | A | 0.0000 | |
| 38 | N | A | -1.8697 | |
| 39 | R | A | -2.5324 | |
| 40 | D | A | -2.6298 | |
| 41 | T | A | -2.1158 | |
| 42 | G | A | 0.0000 | |
| 43 | E | A | -1.9055 | |
| 44 | I | A | 0.0000 | |
| 45 | Q | A | -0.7489 | |
| 46 | L | A | -0.1556 | |
| 47 | A | A | -0.1842 | |
| 48 | D | A | -0.2909 | |
| 49 | P | A | -0.2227 | |
| 50 | W | A | 0.2823 | |
| 51 | A | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | T | A | -0.1709 | |
| 54 | D | A | -0.7563 | |
| 55 | I | A | -0.0079 | |
| 57 | W | A | -0.7518 | |
| 58 | D | A | -1.6462 | |
| 59 | E | A | -1.0437 | |
| 60 | S | A | -0.5891 | |
| 61 | W | A | 0.1029 | |
| 62 | D | A | -1.0531 | |
| 63 | V | A | 0.0441 | |
| 64 | P | A | -0.0549 | |
| 65 | A | A | 0.0339 | |
| 66 | G | A | 0.0728 | |
| 67 | V | A | 0.8281 | |
| 68 | T | A | 0.1684 | |
| 69 | N | A | -0.4964 | |
| 70 | V | A | -0.1819 | |
| 71 | Y | A | 0.0288 | |
| 72 | G | A | 0.0000 | |
| 73 | I | A | 0.0000 | |
| 74 | F | A | 0.0000 | |
| 75 | L | A | 0.4974 | |
| 76 | Q | A | 0.0000 | |
| 77 | L | A | 0.0000 | |
| 78 | F | A | 0.7068 | |
| 79 | K | A | -0.3826 | |
| 80 | L | A | -0.5974 | |
| 81 | K | A | -1.2623 | |
| 82 | K | A | -1.4961 | |
| 83 | V | A | 0.0575 | |
| 85 | R | A | -2.7759 | |
| 86 | N | A | -2.6007 | |
| 87 | L | A | 0.0000 | |
| 88 | K | A | -1.2380 | |
| 89 | T | A | 0.0000 | |
| 90 | M | A | 0.0000 | |
| 91 | L | A | 0.0000 | |
| 92 | S | A | 0.0000 | |
| 93 | I | A | 0.0000 | |
| 94 | G | A | 0.0000 | |
| 95 | G | A | 0.3988 | |
| 96 | W | A | 0.8170 | |
| 97 | T | A | -0.0476 | |
| 98 | Y | A | -0.3661 | |
| 99 | S | A | -0.3743 | |
| 100 | Q | A | -1.1853 | |
| 101 | D | A | -1.3039 | |
| 102 | G | A | -1.0272 | |
| 103 | S | A | 0.0000 | |
| 104 | F | A | 0.0000 | |
| 105 | A | A | -0.2843 | |
| 106 | A | A | -1.0702 | |
| 107 | G | A | 0.0000 | |
| 108 | A | A | 0.0000 | |
| 109 | S | A | -0.9288 | |
| 110 | T | A | -1.0466 | |
| 111 | P | A | -1.5646 | |
| 112 | E | A | -2.4676 | |
| 113 | K | A | -2.4516 | |
| 114 | R | A | 0.0000 | |
| 115 | D | A | -2.2330 | |
| 116 | K | A | -2.2869 | |
| 117 | F | A | 0.0000 | |
| 118 | A | A | 0.0000 | |
| 119 | R | A | -2.3188 | |
| 120 | S | A | -1.6530 | |
| 121 | A | A | 0.0000 | |
| 122 | V | A | 0.0000 | |
| 123 | Q | A | -2.0388 | |
| 124 | M | A | -1.5450 | |
| 125 | V | A | 0.0000 | |
| 126 | K | A | -2.5203 | |
| 127 | D | A | -2.4528 | |
| 128 | F | A | -0.8181 | |
| 129 | G | A | -0.8422 | |
| 130 | L | A | 0.0000 | |
| 131 | D | A | -0.7139 | |
| 132 | G | A | 0.0000 | |
| 133 | I | A | 0.0000 | |
| 134 | D | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 137 | W | A | 0.0000 | |
| 139 | Y | A | 0.4146 | |
| 140 | P | A | 0.0000 | |
| 141 | V | A | 0.9032 | |
| 142 | D | A | -0.6892 | |
| 143 | A | A | -0.6891 | |
| 144 | T | A | -0.3633 | |
| 145 | E | A | -0.2711 | |
| 146 | A | A | 0.0000 | |
| 147 | A | A | -0.5487 | |
| 148 | N | A | -0.4237 | |
| 149 | Y | A | 0.0000 | |
| 150 | V | A | -0.6453 | |
| 151 | D | A | -0.6788 | |
| 152 | L | A | 0.0000 | |
| 153 | L | A | 0.0000 | |
| 154 | R | A | -1.3232 | |
| 155 | L | A | 0.0000 | |
| 156 | C | A | 0.0000 | |
| 157 | R | A | -1.5004 | |
| 158 | Q | A | -1.8363 | |
| 159 | Y | A | 0.0000 | |
| 160 | L | A | 0.0000 | |
| 161 | N | A | -2.1572 | |
| 162 | E | A | -2.5441 | |
| 163 | A | A | -1.7830 | |
| 164 | N | A | -1.6384 | |
| 165 | P | A | -1.2914 | |
| 166 | A | A | -0.3802 | |
| 167 | F | A | -0.7177 | |
| 168 | E | A | -0.6314 | |
| 169 | L | A | 0.0000 | |
| 170 | S | A | 0.0000 | |
| 171 | I | A | 0.0000 | |
| 172 | A | A | 0.0745 | |
| 173 | A | A | 0.0000 | |
| 174 | P | A | 0.0000 | |
| 175 | C | A | 0.0000 | |
| 176 | G | A | -0.7217 | |
| 177 | A | A | -0.8952 | |
| 178 | D | A | -1.6056 | |
| 179 | K | A | -1.2912 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -2.1451 | |
| 182 | K | A | -1.5944 | |
| 183 | L | A | -1.1743 | |
| 184 | D | A | -1.4330 | |
| 185 | I | A | 0.0000 | |
| 186 | P | A | -1.0376 | |
| 187 | G | A | 0.0000 | |
| 188 | M | A | 0.0000 | |
| 189 | D | A | -1.6019 | |
| 190 | R | A | -2.1024 | |
| 191 | Y | A | -1.2633 | |
| 192 | L | A | 0.0000 | |
| 193 | D | A | -0.9353 | |
| 194 | F | A | 0.0000 | |
| 195 | W | A | 0.0000 | |
| 196 | N | A | 0.0000 | |
| 197 | L | A | 0.0000 | |
| 198 | M | A | 0.1487 | |
| 199 | A | A | 0.0000 | |
| 200 | Y | A | 0.0035 | |
| 201 | D | A | -0.4633 | |
| 202 | F | A | 0.0000 | |
| 203 | A | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | S | A | -0.1496 | |
| 206 | W | A | 0.7857 | |
| 207 | S | A | 0.0000 | |
| 208 | Q | A | -1.4915 | |
| 209 | A | A | -1.2924 | |
| 210 | A | A | 0.0000 | |
| 211 | G | A | -0.8132 | |
| 213 | A | A | 0.0000 | |
| 214 | S | A | 0.0000 | |
| 215 | N | A | 0.0000 | |
| 216 | I | A | 0.0000 | |
| 217 | F | A | 0.1983 | |
| 218 | G | A | -0.4497 | |
| 219 | S | A | -0.6657 | |
| 220 | T | A | -0.3864 | |
| 221 | S | A | -0.5830 | |
| 222 | N | A | -1.1153 | |
| 223 | P | A | -0.9670 | |
| 224 | A | A | -1.1947 | |
| 225 | S | A | 0.0000 | |
| 226 | T | A | -0.7305 | |
| 227 | E | A | -1.6442 | |
| 228 | F | A | -0.0614 | |
| 229 | S | A | 0.0000 | |
| 230 | F | A | 0.0000 | |
| 231 | D | A | 0.0000 | |
| 232 | T | A | -0.2929 | |
| 233 | A | A | 0.0000 | |
| 234 | L | A | -0.8169 | |
| 235 | R | A | -1.6668 | |
| 236 | M | A | -0.7324 | |
| 237 | Y | A | 0.0000 | |
| 238 | S | A | -0.9369 | |
| 239 | A | A | -0.6392 | |
| 240 | V | A | 0.0000 | |
| 241 | N | A | -1.5965 | |
| 242 | P | A | -1.3312 | |
| 244 | K | A | -1.0948 | |
| 245 | L | A | 0.0000 | |
| 246 | V | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | G | A | 0.0000 | |
| 249 | M | A | 0.0000 | |
| 250 | P | A | 0.0000 | |
| 251 | L | A | 0.0000 | |
| 252 | Y | A | 0.0000 | |
| 253 | G | A | 0.0000 | |
| 254 | R | A | -0.2866 | |
| 255 | G | A | 0.0000 | |
| 256 | F | A | 0.0000 | |
| 257 | A | A | -1.9946 | |
| 258 | N | A | -2.7918 | |
| 259 | T | A | 0.0000 | |
| 260 | D | A | -2.6682 | |
| 261 | G | A | 0.0000 | |
| 262 | P | A | -0.9054 | |
| 263 | G | A | -1.5111 | |
| 264 | K | A | -2.1903 | |
| 265 | P | A | -1.8025 | |
| 266 | Y | A | -1.9788 | |
| 267 | Q | A | -1.9466 | |
| 268 | G | A | -1.4923 | |
| 269 | T | A | -1.1035 | |
| 270 | G | A | -1.6703 | |
| 271 | Q | A | -1.6992 | |
| 272 | G | A | -1.3558 | |
| 273 | N | A | -0.9580 | |
| 274 | W | A | -0.6108 | |
| 275 | E | A | -1.8190 | |
| 276 | T | A | -1.4465 | |
| 277 | G | A | 0.0000 | |
| 278 | V | A | -0.6867 | |
| 279 | W | A | -0.6527 | |
| 280 | D | A | 0.0000 | |
| 281 | Y | A | 0.0000 | |
| 282 | K | A | -0.9681 | |
| 283 | N | A | -1.1580 | |
| 284 | L | A | 0.0000 | |
| 285 | P | A | -0.7803 | |
| 286 | L | A | -0.4908 | |
| 287 | P | A | -0.6670 | |
| 288 | G | A | -1.0084 | |
| 289 | S | A | -1.2325 | |
| 290 | Q | A | -1.5578 | |
| 291 | E | A | -1.2983 | |
| 292 | Y | A | -0.7490 | |
| 293 | Q | A | -2.0079 | |
| 294 | D | A | -2.4046 | |
| 295 | D | A | -2.8599 | |
| 296 | Q | A | -2.2408 | |
| 297 | L | A | -1.2028 | |
| 298 | I | A | 0.0000 | |
| 299 | A | A | -0.8833 | |
| 300 | S | A | 0.0000 | |
| 301 | Y | A | -0.3984 | |
| 302 | S | A | 0.0000 | |
| 303 | Y | A | -1.0099 | |
| 304 | D | A | 0.0000 | |
| 305 | P | A | -1.5866 | |
| 306 | A | A | -1.1098 | |
| 307 | Q | A | -1.9915 | |
| 308 | R | A | -2.4229 | |
| 309 | L | A | 0.0000 | |
| 310 | M | A | 0.0000 | |
| 311 | I | A | 0.0000 | |
| 312 | S | A | 0.0000 | |
| 313 | Y | A | 0.0000 | |
| 314 | D | A | 0.0000 | |
| 315 | T | A | 0.0000 | |
| 316 | P | A | -0.4291 | |
| 318 | I | A | 0.0000 | |
| 319 | A | A | 0.0000 | |
| 320 | E | A | -1.3362 | |
| 321 | L | A | -0.9036 | |
| 322 | K | A | 0.0000 | |
| 323 | A | A | 0.0000 | |
| 324 | K | A | -1.3290 | |
| 325 | Y | A | 0.0000 | |
| 326 | I | A | 0.0000 | |
| 327 | M | A | -0.5222 | |
| 328 | S | A | -1.1104 | |
| 329 | R | A | -1.7152 | |
| 330 | G | A | -1.2487 | |
| 331 | L | A | 0.0000 | |
| 332 | G | A | -0.3090 | |
| 333 | G | A | 0.0000 | |
| 334 | A | A | 0.0000 | |
| 335 | M | A | 0.0000 | |
| 336 | W | A | 0.0000 | |
| 337 | W | A | 0.2477 | |
| 338 | E | A | 0.0000 | |
| 339 | T | A | 0.0000 | |
| 340 | S | A | 0.0000 | |
| 341 | G | A | 0.0000 | |
| 342 | D | A | -0.4070 | |
| 343 | K | A | -0.2053 | |
| 344 | V | A | 0.9537 | |
| 345 | G | A | 0.1975 | |
| 346 | A | A | 0.0198 | |
| 347 | G | A | -0.1445 | |
| 348 | S | A | 0.0000 | |
| 349 | L | A | 0.0000 | |
| 350 | V | A | 0.0000 | |
| 351 | Q | A | -0.9653 | |
| 352 | T | A | -0.9804 | |
| 353 | V | A | 0.0000 | |
| 354 | I | A | -0.6702 | |
| 355 | D | A | -1.9396 | |
| 356 | T | A | -1.2662 | |
| 357 | F | A | 0.0000 | |
| 358 | P | A | -0.8270 | |
| 359 | P | A | -1.2990 | |
| 360 | K | A | -1.6869 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine