Project name: AAB-PP3130

Chain sequence(s)	H: QVQLVESGGGVVQPGESLKISCAASGFTFSSYGMHWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNELRAEDTAVYYCARSTYYYDYSGYDYYFLGWGPGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQHIRSSLAWYQQKPGKAPKLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLQPEDFATYYCQHTYITPYTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:00)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:02)

• Minimal score value: -3.2804
• Maximal score value: 2.1461
• Average score: -0.5545
• Total score value: -128.6374

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
0	Q	H	-1.0765
1	V	H	-0.1405
2	Q	H	-0.6106
3	L	H	0.0000
4	V	H	1.3864
5	E	H	0.0000
6	S	H	-0.1095
7	G	H	-0.7656
8	G	H	0.1480
9	G	H	0.9286
10	V	H	1.5513
11	V	H	0.0000
12	Q	H	-1.9619
13	P	H	-2.4193
14	G	H	-2.7575
15	E	H	-2.7366
16	S	H	-2.0285
17	L	H	-1.1934
18	K	H	-1.9278
19	I	H	0.0000
20	S	H	-0.3054
21	C	H	0.0000
22	A	H	0.0168
23	A	H	0.0000
24	S	H	-0.4398
25	G	H	-0.6659
26	F	H	-0.1678
27	T	H	-0.1268
28	F	H	0.0000
29	S	H	-0.8420
30	S	H	-0.1261
31	Y	H	0.2643
32	G	H	0.0506
33	M	H	0.0000
34	H	H	0.0000
35	W	H	0.0000
36	V	H	0.0000
37	R	H	0.0000
38	Q	H	-0.7177
39	A	H	-1.0403
40	P	H	-0.9825
41	G	H	-1.5079
42	K	H	-2.3816
43	G	H	-1.6176
44	L	H	0.0000
45	E	H	-1.2066
46	W	H	0.0000
47	V	H	0.0000
48	S	H	0.0000
49	A	H	0.0000
50	I	H	0.0000
51	S	H	-0.3416
52	G	H	-0.3996
53	S	H	-0.7269
54	G	H	-0.8296
55	G	H	-0.7423
56	S	H	-0.3100
57	T	H	0.2033
58	Y	H	0.5070
59	Y	H	-0.4013
60	A	H	0.0000
61	D	H	-2.3544
62	S	H	-1.7176
63	V	H	0.0000
64	K	H	-2.4445
65	G	H	-1.8758
66	R	H	-1.6565
67	F	H	0.0000
68	T	H	-0.6701
69	I	H	0.0000
70	S	H	-0.4642
71	R	H	-1.0922
72	D	H	-1.6513
73	N	H	-1.8084
74	S	H	-1.6329
75	K	H	-2.4353
76	N	H	-1.8568
77	T	H	-1.0017
78	L	H	0.0000
79	Y	H	-0.4583
80	L	H	0.0000
81	Q	H	-1.1068
82	M	H	0.0000
83	N	H	-2.4852
84	E	H	-3.2804
85	L	H	0.0000
86	R	H	-3.1186
87	A	H	-1.9000
88	E	H	-2.3233
89	D	H	0.0000
90	T	H	-0.4267
91	A	H	0.0000
92	V	H	0.9008
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	0.0000
98	S	H	0.0000
99	T	H	1.1330
100	Y	H	1.6581
101	Y	H	1.5196
102	Y	H	1.2614
103	D	H	-0.1358
104	Y	H	0.8084
105	S	H	0.0262
106	G	H	0.5284
107	Y	H	1.7834
108	D	H	1.1099
109	Y	H	1.4115
110	Y	H	0.7646
111	F	H	0.0000
112	L	H	0.9304
113	G	H	0.2760
114	W	H	-0.0153
115	G	H	0.0000
116	P	H	-0.3613
117	G	H	0.2020
118	T	H	0.7584
119	L	H	1.7382
120	V	H	0.0000
121	T	H	0.3721
122	V	H	0.0000
123	S	H	-0.6492
124	S	H	-0.5895
125	D	L	-2.0101
126	I	L	0.0000
127	Q	L	-2.1967
128	M	L	0.0000
129	T	L	-1.2843
130	Q	L	0.0000
131	S	L	-0.7321
132	P	L	-0.5975
133	S	L	-0.9627
134	S	L	-1.1359
135	L	L	-0.6545
136	S	L	-0.7065
137	A	L	0.0000
138	S	L	-0.1513
139	V	L	0.7167
140	G	L	-0.7096
141	D	L	-1.6686
142	R	L	-2.3431
143	V	L	0.0000
144	T	L	-0.6341
145	I	L	0.0000
146	T	L	-0.9482
147	C	L	0.0000
148	R	L	-3.0429
149	A	L	0.0000
150	S	L	-2.2609
151	Q	L	-2.8610
152	H	L	-2.5614
153	I	L	0.0000
154	R	L	-2.6131
155	S	L	-1.4837
156	S	L	-0.4709
157	L	L	0.0000
158	A	L	0.0000
159	W	L	0.0000
160	Y	L	0.0000
161	Q	L	-1.0255
162	Q	L	0.0000
163	K	L	-2.1695
164	P	L	-1.4614
165	G	L	-1.6520
166	K	L	-2.5451
167	A	L	-1.5799
168	P	L	0.0000
169	K	L	-1.8374
170	L	L	0.0000
171	L	L	0.0000
172	I	L	0.0000
173	Y	L	0.0195
174	G	L	-0.8043
175	A	L	0.0000
176	S	L	-0.7774
177	S	L	-0.8110
178	R	L	-1.6518
179	A	L	0.0000
180	T	L	-0.4901
181	G	L	-0.9179
182	I	L	0.0000
183	P	L	-1.3858
184	D	L	-2.3065
185	R	L	-1.6194
186	F	L	0.0000
187	S	L	-1.0275
188	G	L	-0.5836
189	S	L	-0.8399
190	G	L	-1.4506
191	S	L	-1.8406
192	G	L	-2.4387
193	T	L	-2.6678
194	D	L	-3.1633
195	F	L	0.0000
196	T	L	-0.9100
197	L	L	0.0000
198	T	L	-0.6126
199	I	L	0.0000
200	S	L	-1.6847
201	S	L	-1.2917
202	L	L	0.0000
203	Q	L	-0.7762
204	P	L	-0.6484
205	E	L	-1.8859
206	D	L	0.0000
207	F	L	-0.5701
208	A	L	0.0000
209	T	L	-1.2480
210	Y	L	0.0000
211	Y	L	0.0000
212	C	L	0.0000
213	Q	L	0.0000
214	H	L	0.0000
215	T	L	1.1579
216	Y	L	1.5299
217	I	L	2.1461
218	T	L	0.8334
219	P	L	-0.0080
220	Y	L	0.0000
221	T	L	-0.4517
222	F	L	-0.4790
223	G	L	0.0000
224	Q	L	-1.5976
225	G	L	0.0000
226	T	L	0.0000
227	K	L	-2.1531
228	V	L	0.0000
229	E	L	-0.9172
230	I	L	0.9357
231	K	L	-0.7859