Project name: 35r0

Chain sequence(s)	A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGFAVTNDGVI
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:46)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:47)

• Minimal score value: -3.0245
• Maximal score value: 2.6805
• Average score: -0.4411
• Total score value: -129.6942

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	F	A	1.0443
2	S	A	-0.3714
3	R	A	-1.7732
4	P	A	-1.1415
5	G	A	-1.0373
6	L	A	-0.6487
7	P	A	-0.4879
8	V	A	-0.1595
9	E	A	-0.0540
10	Y	A	0.6437
11	L	A	0.0000
12	Q	A	-1.7992
13	V	A	0.0000
14	P	A	-1.6023
15	S	A	0.0000
16	P	A	-0.9936
17	S	A	-0.7029
18	M	A	0.0000
19	G	A	-1.3492
20	R	A	-1.9986
21	D	A	-2.7245
22	I	A	0.0000
23	K	A	-1.5038
24	V	A	0.0000
25	Q	A	0.0000
26	F	A	0.0000
27	Q	A	0.0000
28	S	A	-0.9140
29	G	A	-1.0563
30	G	A	-1.6719
31	N	A	-2.3167
32	N	A	-2.4085
33	S	A	0.0000
34	P	A	0.0000
35	A	A	0.0000
36	V	A	0.0000
37	Y	A	0.0000
38	L	A	0.0000
39	L	A	0.0000
40	D	A	0.0000
41	G	A	0.0000
42	L	A	-1.1087
43	R	A	-2.5371
44	A	A	0.0000
45	Q	A	-2.5649
46	D	A	-3.0245
47	D	A	-2.0995
48	Y	A	-0.4926
49	N	A	0.0000
50	G	A	0.0000
51	W	A	0.0000
52	D	A	0.0000
53	I	A	0.8043
54	N	A	-0.3214
55	T	A	0.0000
56	P	A	-0.2840
57	A	A	0.0000
58	F	A	0.0000
59	E	A	-0.6428
60	W	A	-0.2590
61	Y	A	0.0000
62	Y	A	-0.0759
63	Q	A	-1.1043
64	S	A	0.0000
65	G	A	-0.7910
66	L	A	0.0000
67	S	A	0.0000
68	I	A	0.0000
69	V	A	0.0000
70	M	A	0.0000
71	P	A	0.0000
72	V	A	0.0000
73	G	A	0.0000
74	G	A	0.0000
75	Q	A	-1.4740
76	S	A	0.0000
77	S	A	0.0000
78	F	A	0.0000
79	Y	A	0.0000
80	S	A	0.0000
81	D	A	-0.6066
82	W	A	0.0000
83	Y	A	0.8881
84	S	A	0.0498
85	P	A	-0.1192
86	A	A	0.0000
87	C	A	-0.5479
88	G	A	-1.4611
89	K	A	-1.9595
90	A	A	-0.8619
91	G	A	-0.6004
92	C	A	0.0894
93	Q	A	-0.4316
94	T	A	-0.3988
95	Y	A	0.0000
96	K	A	-0.8383
97	W	A	0.0000
98	E	A	-0.5897
99	T	A	-0.5163
100	F	A	0.0000
101	L	A	0.0000
102	T	A	-0.3519
103	S	A	-0.5249
104	E	A	-0.6937
105	L	A	0.0000
106	P	A	0.0000
107	Q	A	-1.5245
108	W	A	-0.8581
109	L	A	0.0000
110	S	A	-1.4636
111	A	A	-0.9375
112	N	A	-1.3325
113	R	A	-1.7433
114	A	A	-1.7832
115	V	A	0.0000
116	K	A	-1.8135
117	P	A	-1.1645
118	T	A	-0.7836
119	G	A	-0.3979
120	S	A	0.0000
121	A	A	0.0000
122	A	A	0.0000
123	I	A	0.0000
124	G	A	0.0000
125	L	A	0.0000
126	S	A	-0.1166
127	M	A	0.0000
128	A	A	0.0000
129	G	A	0.0000
130	S	A	0.0000
131	S	A	0.0000
132	A	A	0.0000
133	M	A	0.0000
134	I	A	0.0000
135	L	A	0.0000
136	A	A	0.0000
137	A	A	0.0000
138	Y	A	-0.2243
139	H	A	-0.4186
140	P	A	-0.8223
141	Q	A	-1.1855
142	Q	A	0.0000
143	F	A	0.0000
144	I	A	-0.0059
145	Y	A	0.0000
146	A	A	0.0000
147	G	A	0.0000
148	S	A	0.0000
149	L	A	0.0000
150	S	A	0.0000
151	A	A	0.0000
152	L	A	0.0131
153	L	A	0.0000
154	D	A	-1.2658
155	P	A	0.0000
156	S	A	-1.5785
157	Q	A	-1.6680
158	G	A	-0.5953
159	M	A	0.4637
160	G	A	0.0000
161	P	A	-0.0567
162	S	A	0.3573
163	L	A	0.8740
164	I	A	0.0000
165	G	A	-0.0724
166	L	A	0.7225
167	A	A	-0.3112
168	M	A	0.0000
169	G	A	-1.3020
170	D	A	-2.1248
171	A	A	0.0000
172	G	A	-1.8300
173	G	A	-1.6615
174	Y	A	0.0000
175	K	A	-1.9034
176	A	A	0.0000
177	A	A	-0.7648
178	D	A	-0.6796
179	M	A	0.0000
180	W	A	0.0000
181	G	A	0.0000
182	P	A	-0.6575
183	S	A	-1.0287
184	S	A	-0.9086
185	D	A	-1.1679
186	P	A	-1.2812
187	A	A	0.0000
188	W	A	0.0000
189	E	A	-2.7031
190	R	A	-1.6984
191	N	A	0.0000
192	D	A	0.0000
193	P	A	0.0000
194	T	A	-1.4078
195	Q	A	-2.0874
196	Q	A	0.0000
197	I	A	0.0000
198	P	A	-1.0343
199	K	A	-1.2777
200	L	A	0.0000
201	V	A	-1.1799
202	A	A	-0.8557
203	N	A	-1.3128
204	N	A	-1.5576
205	T	A	0.0000
206	R	A	-0.6602
207	L	A	0.0000
208	W	A	0.0000
209	V	A	0.0000
210	Y	A	0.0000
211	C	A	0.0000
212	G	A	0.0000
213	N	A	-0.7650
214	G	A	-0.3684
215	T	A	-0.7286
216	P	A	-1.0451
217	N	A	-1.3670
218	E	A	-1.9050
219	L	A	-0.6510
220	G	A	-0.8572
221	G	A	-0.5989
222	A	A	-0.3672
223	N	A	0.1964
224	I	A	1.9366
225	P	A	1.0586
226	A	A	0.0000
227	E	A	0.5740
228	F	A	1.8928
229	L	A	1.0926
230	E	A	0.0000
231	N	A	-0.6787
232	F	A	0.2822
233	V	A	0.0000
234	R	A	-0.6304
235	S	A	-0.6527
236	S	A	0.0000
237	N	A	0.0000
238	L	A	-0.6017
239	K	A	-2.1418
240	F	A	0.0000
241	Q	A	-1.6783
242	D	A	-2.7064
243	A	A	-1.8926
244	Y	A	0.0000
245	N	A	-2.4645
246	A	A	-1.2370
247	A	A	-1.0044
248	G	A	-1.1486
249	G	A	-1.7306
250	H	A	-1.6678
251	N	A	-1.2113
252	A	A	-0.5682
253	V	A	0.2267
254	F	A	0.4898
255	N	A	0.0751
256	F	A	0.1561
257	P	A	-0.3161
258	P	A	-0.6328
259	N	A	-0.9519
260	G	A	0.0000
261	T	A	0.0000
262	H	A	-0.3217
263	S	A	-0.4971
264	W	A	-0.4288
265	E	A	-1.1171
266	Y	A	0.0000
267	W	A	0.0000
268	G	A	0.0000
269	A	A	-0.4027
270	Q	A	-0.5549
271	L	A	0.0000
272	N	A	-0.8886
273	A	A	-0.6093
274	M	A	0.0000
275	K	A	-1.0272
276	G	A	-1.1120
277	D	A	-0.8394
278	L	A	0.0000
279	Q	A	-0.7667
280	S	A	-0.6340
281	S	A	-0.4718
282	L	A	-0.2989
283	G	A	-0.3724
284	A	A	0.0000
285	G	A	0.3003
286	F	A	2.1336
287	A	A	1.5380
288	V	A	1.6611
289	T	A	-0.2436
290	N	A	-1.5823
291	D	A	-1.7591
292	G	A	-0.3665
293	V	A	2.1292
294	I	A	2.6805