Project name: 1ce1ca635644b41

Chain sequence(s)	H: EVQLQESGGGVVQPGGSLRLSCAASGFTFSNYGMHWIRQAPGKGLEWVSYISSGSSTIYYADSVKGRFTISRDNSKNTLYLQMNSLRSEDTAVYYCARRGLLLDYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTISCRASKSVSTSSYSYMHWYQQKPEKAPKLLIKYASYLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQHSREFPWTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:08)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:10)

• Minimal score value: -3.3804
• Maximal score value: 1.6331
• Average score: -0.5923
• Total score value: -134.4607

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0251
2	V	H	-0.9519
3	Q	H	-1.5306
4	L	H	-0.9939
5	Q	H	-1.6621
6	E	H	0.0000
7	S	H	-0.6565
8	G	H	-0.6464
9	G	H	0.2094
11	G	H	0.9250
12	V	H	1.6331
13	V	H	0.0535
14	Q	H	-1.3320
15	P	H	-1.6814
16	G	H	-1.4939
17	G	H	-1.1645
18	S	H	-1.1511
19	L	H	-0.7839
20	R	H	-1.7306
21	L	H	0.0000
22	S	H	-0.7179
23	C	H	0.0000
24	A	H	-0.9702
25	A	H	0.0000
26	S	H	-1.2672
27	G	H	-1.2001
28	F	H	-0.6371
29	T	H	-0.5216
30	F	H	0.0000
35	S	H	-1.3260
36	N	H	-1.3925
37	Y	H	-0.4165
38	G	H	-0.2763
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	I	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6249
45	A	H	-1.0507
46	P	H	-0.8094
47	G	H	-1.4564
48	K	H	-2.1762
49	G	H	-1.2759
50	L	H	0.0000
51	E	H	-0.8724
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	Y	H	0.0000
56	I	H	0.0000
57	S	H	-0.2592
58	S	H	-0.8074
59	G	H	-0.9929
62	S	H	-0.4850
63	S	H	-0.2751
64	T	H	0.2515
65	I	H	1.0080
66	Y	H	0.7258
67	Y	H	-0.3983
68	A	H	0.0000
69	D	H	-2.4241
70	S	H	-1.7534
71	V	H	0.0000
72	K	H	-2.4792
74	G	H	-1.6979
75	R	H	-1.4341
76	F	H	0.0000
77	T	H	-0.6381
78	I	H	0.0000
79	S	H	-0.2583
80	R	H	-1.0062
81	D	H	-1.5690
82	N	H	-1.9689
83	S	H	-1.6254
84	K	H	-2.4140
85	N	H	-1.8228
86	T	H	-1.2741
87	L	H	0.0000
88	Y	H	-0.4339
89	L	H	0.0000
90	Q	H	-1.1082
91	M	H	0.0000
92	N	H	-1.3119
93	S	H	-1.2382
94	L	H	0.0000
95	R	H	-2.3670
96	S	H	-1.9439
97	E	H	-2.3351
98	D	H	0.0000
99	T	H	-0.4215
100	A	H	0.0000
101	V	H	0.7332
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	R	H	-0.1799
108	G	H	0.0445
109	L	H	0.6026
114	L	H	0.0000
115	L	H	0.0000
116	D	H	-0.1898
117	Y	H	0.0913
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-2.0264
121	G	H	-0.9507
122	T	H	0.1446
123	L	H	1.5096
124	V	H	0.0000
125	T	H	0.3580
126	V	H	0.0000
127	S	H	-0.5307
128	S	H	-0.5507
1	D	L	-2.1710
2	I	L	0.0000
3	Q	L	-2.1548
4	M	L	0.0000
5	T	L	-1.1955
6	Q	L	0.0000
7	S	L	-0.6278
8	P	L	-0.5923
9	S	L	-0.7817
10	S	L	-1.2749
11	L	L	-1.0063
12	S	L	-1.3482
13	A	L	0.0000
14	S	L	-0.9831
15	V	L	0.0821
16	G	L	-0.7818
17	D	L	-1.9361
18	R	L	-2.4476
19	V	L	0.0000
20	T	L	-0.6477
21	I	L	0.0000
22	S	L	-0.8384
23	C	L	0.0000
24	R	L	-2.6761
25	A	L	0.0000
26	S	L	-1.7774
27	K	L	-1.7596
28	S	L	-1.0274
29	V	L	0.0000
30	S	L	-0.1522
31	T	L	-0.0002
34	S	L	-0.1211
35	S	L	0.1197
36	Y	L	0.7711
37	S	L	0.2160
38	Y	L	0.2283
39	M	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.6658
45	K	L	-2.2551
46	P	L	-1.9349
47	E	L	-3.1185
48	K	L	-3.3804
49	A	L	-1.9858
50	P	L	0.0000
51	K	L	-1.4739
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	0.4795
56	Y	L	0.7279
57	A	L	0.0000
65	S	L	0.4840
66	Y	L	1.3818
67	L	L	0.8642
68	Q	L	-0.0573
69	S	L	-0.2850
70	G	L	-0.5792
71	V	L	0.0000
72	P	L	-0.4076
74	S	L	-0.4768
75	R	L	-0.8093
76	F	L	0.0000
77	S	L	-0.0909
78	G	L	-0.0120
79	S	L	-0.4551
80	G	L	-1.0237
83	S	L	-0.8004
84	G	L	-0.8405
85	T	L	-1.5012
86	D	L	-1.9537
87	F	L	0.0000
88	T	L	-0.7399
89	L	L	0.0000
90	T	L	-0.6464
91	I	L	0.0000
92	S	L	-1.4992
93	S	L	-1.3379
94	L	L	0.0000
95	Q	L	-0.9743
96	P	L	-1.0376
97	E	L	-1.5048
98	D	L	0.0000
99	V	L	-1.0694
100	A	L	0.0000
101	T	L	-1.1917
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	H	L	0.0000
107	S	L	-0.1423
108	R	L	-0.6936
109	E	L	-0.7121
114	F	L	0.1152
115	P	L	-0.5036
116	W	L	0.0000
117	T	L	-0.7915
118	F	L	0.0000
119	G	L	0.0000
120	A	L	-0.7326
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-2.2165
124	L	L	0.0000
125	E	L	-2.1548
126	L	L	-1.1890
127	K	L	-1.7086