| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKDGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTEPLHDTEDVRVSFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFVRSGPVGHPLPSSPPPSPLYVPPPPSSPYATLPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEENVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9464 | |
| 2 | L | A | 1.9727 | |
| 3 | P | A | 0.6530 | |
| 4 | P | A | 0.3601 | |
| 5 | T | A | 0.1076 | |
| 6 | T | A | 0.1229 | |
| 7 | P | A | 0.1748 | |
| 8 | V | A | 1.2070 | |
| 9 | A | A | 0.0242 | |
| 10 | K | A | -1.1502 | |
| 11 | V | A | -0.4138 | |
| 12 | Q | A | -1.5333 | |
| 13 | S | A | -1.6053 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4041 | |
| 16 | E | A | -2.4319 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4640 | |
| 20 | P | A | 0.1098 | |
| 21 | T | A | 0.1165 | |
| 22 | S | A | -0.1698 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1060 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1609 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7613 | |
| 31 | R | A | -2.6153 | |
| 32 | L | A | -0.7523 | |
| 33 | L | A | 1.2155 | |
| 34 | T | A | 1.4421 | |
| 35 | V | A | 1.9635 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2258 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6240 | |
| 40 | K | A | -1.6237 | |
| 41 | D | A | -0.8827 | |
| 42 | I | A | 0.8335 | |
| 43 | V | A | 0.9060 | |
| 44 | K | A | -1.4203 | |
| 45 | D | A | -2.4376 | |
| 46 | G | A | -1.4809 | |
| 47 | K | A | -1.0943 | |
| 48 | V | A | 1.4288 | |
| 49 | V | A | 1.9969 | |
| 50 | V | A | 1.3041 | |
| 51 | P | A | 0.5034 | |
| 52 | K | A | -0.6121 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0977 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4330 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2944 | |
| 70 | K | A | -1.8113 | |
| 71 | F | A | -0.6697 | |
| 72 | A | A | -0.5735 | |
| 73 | L | A | -0.8554 | |
| 74 | P | A | -1.2562 | |
| 75 | Q | A | -2.4734 | |
| 76 | K | A | -3.0889 | |
| 77 | D | A | -2.9791 | |
| 78 | F | A | -1.6251 | |
| 79 | Y | A | -1.9039 | |
| 80 | D | A | -2.7436 | |
| 81 | P | A | -2.3385 | |
| 82 | E | A | -3.0654 | |
| 83 | K | A | -3.4350 | |
| 84 | E | A | -2.4962 | |
| 85 | R | A | -1.3086 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6527 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9424 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3523 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7369 | |
| 99 | G | A | -0.5409 | |
| 100 | P | A | -0.4189 | |
| 101 | L | A | 0.0119 | |
| 102 | G | A | -0.2965 | |
| 103 | K | A | -0.7785 | |
| 104 | G | A | -0.5587 | |
| 105 | T | A | -0.4860 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1029 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3183 | |
| 110 | L | A | 0.3689 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9764 | |
| 113 | K | A | -0.4681 | |
| 114 | L | A | -0.8649 | |
| 115 | G | A | -1.0706 | |
| 116 | D | A | -1.3241 | |
| 117 | T | A | -1.0151 | |
| 118 | E | A | -1.9378 | |
| 119 | N | A | -2.2556 | |
| 120 | P | A | -1.9122 | |
| 121 | T | A | -1.6109 | |
| 122 | E | A | -2.2900 | |
| 123 | P | A | -1.0563 | |
| 124 | L | A | -0.9162 | |
| 125 | H | A | -1.6250 | |
| 126 | D | A | -2.4210 | |
| 127 | T | A | -2.1243 | |
| 128 | E | A | -3.1401 | |
| 129 | D | A | -2.8135 | |
| 130 | V | A | -1.5768 | |
| 131 | R | A | -0.9730 | |
| 132 | V | A | 0.3064 | |
| 133 | S | A | 0.2014 | |
| 134 | F | A | 0.1908 | |
| 135 | S | A | -0.1187 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7137 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5573 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2692 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0998 | |
| 157 | D | A | 0.3509 | |
| 158 | I | A | 0.8572 | |
| 159 | A | A | 0.1154 | |
| 160 | E | A | -1.4749 | |
| 161 | P | A | -0.2375 | |
| 162 | C | A | 0.1823 | |
| 163 | P | A | -0.1565 | |
| 164 | G | A | -0.0500 | |
| 165 | L | A | 0.6333 | |
| 166 | P | A | -0.0887 | |
| 167 | P | A | -0.3301 | |
| 168 | G | A | -0.4085 | |
| 169 | A | A | -0.0040 | |
| 170 | C | A | 0.7651 | |
| 171 | P | A | 0.5550 | |
| 172 | P | A | 0.7900 | |
| 173 | I | A | 2.0355 | |
| 174 | Q | A | 0.8270 | |
| 175 | L | A | 1.4167 | |
| 176 | V | A | 0.8133 | |
| 177 | N | A | -0.3428 | |
| 178 | S | A | -0.0062 | |
| 179 | V | A | 0.3741 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3736 | |
| 182 | D | A | 0.0905 | |
| 183 | G | A | -0.1535 | |
| 184 | D | A | -0.5696 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1445 | |
| 190 | F | A | 0.0519 | |
| 191 | G | A | -0.1062 | |
| 192 | N | A | -0.2900 | |
| 193 | M | A | -0.1632 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4157 | |
| 197 | E | A | -2.6274 | |
| 198 | L | A | -1.2147 | |
| 199 | Q | A | -2.5302 | |
| 200 | Q | A | -3.3350 | |
| 201 | D | A | -3.5972 | |
| 202 | R | A | -3.3315 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1590 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.4008 | |
| 211 | S | A | -1.9228 | |
| 212 | T | A | -1.4990 | |
| 213 | R | A | -2.1929 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1732 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2491 | |
| 220 | L | A | 0.4324 | |
| 221 | K | A | -1.4374 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -1.0082 | |
| 224 | N | A | -1.7364 | |
| 225 | E | A | -1.3545 | |
| 226 | A | A | -0.6737 | |
| 227 | Y | A | -0.4586 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7278 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1411 | |
| 234 | F | A | -0.0069 | |
| 235 | G | A | -0.9091 | |
| 236 | R | A | -2.6383 | |
| 237 | R | A | -2.8534 | |
| 238 | E | A | -2.0624 | |
| 239 | Q | A | -0.1057 | |
| 240 | V | A | 1.5372 | |
| 241 | Y | A | 1.2200 | |
| 242 | A | A | 0.1128 | |
| 243 | R | A | -1.3569 | |
| 244 | H | A | -1.1026 | |
| 245 | F | A | -0.0385 | |
| 246 | F | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5409 | |
| 249 | S | A | -1.2180 | |
| 250 | G | A | -1.1116 | |
| 251 | P | A | -0.7393 | |
| 252 | V | A | -0.5096 | |
| 253 | G | A | -0.8945 | |
| 254 | H | A | -1.1253 | |
| 255 | P | A | -0.4668 | |
| 256 | L | A | 0.4588 | |
| 257 | P | A | -0.0479 | |
| 258 | S | A | -0.0074 | |
| 259 | S | A | -0.0538 | |
| 260 | P | A | -0.4006 | |
| 261 | P | A | -0.0556 | |
| 262 | P | A | 0.0936 | |
| 263 | S | A | 0.0000 | |
| 264 | P | A | 0.6877 | |
| 265 | L | A | 1.8729 | |
| 266 | Y | A | 1.7427 | |
| 267 | V | A | 1.9006 | |
| 268 | P | A | 0.9510 | |
| 269 | P | A | 0.4599 | |
| 270 | P | A | -0.1493 | |
| 271 | P | A | -0.3705 | |
| 272 | S | A | -0.3046 | |
| 273 | S | A | -0.0158 | |
| 274 | P | A | -0.0070 | |
| 275 | Y | A | 1.0154 | |
| 276 | A | A | 0.4538 | |
| 277 | T | A | 0.4865 | |
| 278 | L | A | 0.9256 | |
| 279 | P | A | 0.0422 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.3291 | |
| 282 | D | A | -0.3267 | |
| 283 | Y | A | 1.1131 | |
| 284 | F | A | 0.7998 | |
| 285 | G | A | 0.1774 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9163 | |
| 291 | L | A | 1.6104 | |
| 292 | V | A | 0.6090 | |
| 293 | S | A | -0.1584 | |
| 294 | S | A | -0.9657 | |
| 295 | D | A | -1.8432 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1114 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6160 | |
| 301 | R | A | -1.8249 | |
| 302 | P | A | -0.9321 | |
| 303 | F | A | -0.2109 | |
| 304 | W | A | -0.5116 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0833 | |
| 307 | R | A | -2.9263 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7858 | |
| 310 | G | A | -1.4292 | |
| 311 | N | A | -1.4013 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7942 | |
| 319 | N | A | -0.8526 | |
| 320 | E | A | -1.0291 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3698 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1974 | |
| 333 | N | A | 0.3936 | |
| 334 | F | A | 1.4572 | |
| 335 | T | A | 0.7413 | |
| 336 | I | A | 0.4231 | |
| 337 | S | A | -0.9401 | |
| 338 | Q | A | -1.6939 | |
| 339 | Q | A | -1.2872 | |
| 340 | L | A | 0.6816 | |
| 341 | C | A | 0.3205 | |
| 342 | T | A | -0.5022 | |
| 343 | P | A | -0.9600 | |
| 344 | E | A | -2.3360 | |
| 345 | E | A | -2.6121 | |
| 346 | N | A | -1.5459 | |
| 347 | V | A | 0.4050 | |
| 348 | Y | A | 0.8798 | |
| 349 | D | A | -0.0998 | |
| 350 | P | A | -0.3486 | |
| 351 | S | A | -0.2909 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7489 | |
| 354 | K | A | -1.7371 | |
| 355 | N | A | -1.7321 | |
| 356 | Y | A | -0.0977 | |
| 357 | L | A | 0.5596 | |
| 358 | R | A | 0.8933 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4503 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0033 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9045 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6681 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3027 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3145 | |
| 376 | L | A | -1.7423 | |
| 377 | D | A | -2.0206 | |
| 378 | P | A | -1.0567 | |
| 379 | G | A | -1.0158 | |
| 380 | V | A | -0.9283 | |
| 381 | L | A | -0.5372 | |
| 382 | A | A | -0.6565 | |
| 383 | H | A | -0.8457 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3942 | |
| 386 | T | A | -0.5746 | |
| 387 | M | A | -0.3327 | |
| 388 | N | A | -0.8732 | |
| 389 | P | A | -1.2432 | |
| 390 | T | A | -1.4524 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4532 | |
| 393 | E | A | -2.7966 | |
| 394 | N | A | -2.4002 | |
| 395 | W | A | -1.4168 | |
| 396 | N | A | -1.3299 | |
| 397 | L | A | -0.2008 | |
| 398 | G | A | 0.5381 | |
| 399 | F | A | 2.4064 | |
| 400 | V | A | 1.8333 | |
| 401 | P | A | 0.0521 | |
| 402 | P | A | -1.8298 | |
| 403 | K | A | -3.4289 | |
| 404 | E | A | -3.7428 | |
| 405 | R | A | -3.8666 | |
| 406 | E | A | -3.7230 | |
| 407 | D | A | -2.8340 | |
| 408 | P | A | -1.7135 | |
| 409 | Y | A | -0.9666 | |
| 410 | K | A | -2.0700 | |
| 411 | G | A | -0.6220 | |
| 412 | L | A | 0.7488 | |
| 413 | I | A | 1.5933 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3552 | |
| 416 | E | A | -1.5890 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8224 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8869 | |
| 421 | E | A | -2.4956 | |
| 422 | R | A | -2.0009 | |
| 423 | F | A | -1.0228 | |
| 424 | S | A | -1.3241 | |
| 425 | Q | A | -1.7907 | |
| 426 | D | A | -2.8887 | |
| 427 | L | A | -1.9827 | |
| 428 | D | A | -2.7609 | |
| 429 | Q | A | -2.6011 | |
| 430 | F | A | -1.4281 | |
| 431 | A | A | -0.8895 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5599 | |
| 435 | K | A | -0.7091 | |
| 436 | F | A | 0.1669 | |
| 437 | L | A | 1.0435 | |
| 438 | Y | A | 0.8364 | |
| 439 | Q | A | -0.2599 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine