Project name: 1dbff1673f4c222

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:54)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:55)

• Minimal score value: -3.4497
• Maximal score value: 1.5146
• Average score: -0.6301
• Total score value: -163.2081

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.3210
245	C	P	0.4414
246	G	P	0.2118
247	E	P	0.1824
248	L	P	0.0000
249	V	P	1.2987
250	W	P	0.6320
251	V	P	-0.6322
252	G	P	-1.5916
253	E	P	-2.0905
254	P	P	-0.8382
255	L	P	0.8433
256	T	P	0.5385
257	L	P	0.8602
258	R	P	-0.0260
259	T	P	-0.5170
260	A	P	-0.7589
261	E	P	-1.6700
262	T	P	-0.9129
263	I	P	-0.4623
264	T	P	0.0000
265	G	P	-1.1270
266	K	P	-1.6152
267	Y	P	-0.5788
268	G	P	-0.3836
269	V	P	0.0000
270	W	P	0.0280
271	M	P	0.0000
272	R	P	-0.8082
273	D	P	0.0000
274	P	P	0.0000
275	K	P	-1.4593
276	P	P	-0.7702
277	T	P	0.0499
278	Y	P	1.0443
279	P	P	0.5996
280	Y	P	0.2973
281	T	P	-0.7868
282	Q	P	-1.6312
283	E	P	-2.0533
284	T	P	0.0000
285	T	P	0.0000
286	W	P	0.0000
287	R	P	0.0000
288	I	P	0.0000
289	D	P	-0.5771
290	T	P	-0.1390
291	V	P	0.6638
292	G	P	-0.3183
293	T	P	-0.6905
294	D	P	-1.3126
295	V	P	0.6746
296	R	P	0.1075
297	Q	P	0.7988
298	V	P	0.0000
299	F	P	-0.1203
300	E	P	-0.9278
301	Y	P	0.0000
302	D	P	-1.7609
303	L	P	0.4274
304	I	P	0.5803
305	S	P	0.2262
306	Q	P	-0.1960
307	F	P	0.0000
308	M	P	0.0648
309	Q	P	-0.8643
310	G	P	-0.0882
311	Y	P	0.3369
312	P	P	-0.1812
313	S	P	-0.8750
314	K	P	-1.6490
315	V	P	-0.1350
316	H	P	-0.0443
317	I	P	1.5146
318	L	P	0.0000
319	P	P	-0.1997
320	R	P	-0.4342
321	P	P	-1.0158
322	L	P	0.0000
323	E	P	-1.2009
324	S	P	-0.8928
325	T	P	-0.5577
326	G	P	-0.3062
327	A	P	0.0000
328	V	P	0.0000
329	V	P	0.0000
330	Y	P	-0.5538
331	S	P	-0.5384
332	G	P	-0.3254
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	0.0000
339	A	P	-1.5872
340	E	P	-1.9841
341	S	P	-1.4130
342	R	P	-1.5542
343	T	P	-1.8502
344	V	P	0.0000
345	I	P	0.0000
346	R	P	-1.5925
347	Y	P	0.0000
348	E	P	-1.6324
349	L	P	0.0000
350	N	P	-1.9658
351	T	P	-1.8280
352	E	P	-2.3703
353	T	P	-1.5990
354	V	P	-1.3404
355	K	P	-2.6130
356	A	P	-2.3391
357	E	P	-2.6256
358	K	P	-2.8933
359	E	P	-2.6550
360	I	P	0.0000
361	P	P	-1.0723
362	G	P	-1.1084
363	A	P	0.0000
364	G	P	-1.0249
365	Y	P	0.1295
366	H	P	-0.5448
367	G	P	-0.3589
368	Q	P	-1.1537
369	F	P	-1.0128
370	P	P	-0.1295
371	Y	P	0.0000
372	S	P	-0.2914
373	W	P	0.0107
374	G	P	-0.1638
375	G	P	0.0000
376	Y	P	0.7451
377	T	P	0.0000
378	D	P	-0.3087
379	I	P	0.0000
380	D	P	-0.5327
381	L	P	0.0000
382	A	P	-0.2773
383	V	P	-0.4097
384	D	P	-0.9050
385	E	P	-1.4556
386	A	P	-0.8196
387	G	P	0.0000
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	0.0000
393	S	P	0.0000
394	T	P	-2.4094
395	D	P	-3.3419
396	E	P	-3.2480
397	A	P	-2.5893
398	K	P	-3.3899
399	G	P	0.0000
400	A	P	0.0000
401	I	P	0.0000
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	-1.8750
406	L	P	0.0000
407	N	P	-2.3805
408	P	P	-1.6531
409	E	P	-3.2614
410	N	P	-3.4067
411	L	P	0.0000
412	E	P	-3.4497
413	L	P	-2.2409
414	E	P	-2.9775
415	Q	P	-2.4363
416	T	P	-1.4878
417	W	P	-0.9324
418	E	P	-1.8000
419	T	P	-1.3661
420	N	P	-1.9435
421	I	P	-1.4269
422	R	P	-2.2035
423	K	P	0.0000
424	Q	P	-1.2195
425	S	P	-0.9611
426	V	P	0.0000
427	A	P	0.0000
428	N	P	0.0000
429	A	P	-0.1542
430	F	P	0.0000
431	I	P	0.0000
432	I	P	0.0000
433	C	P	0.3061
434	G	P	-0.0572
435	T	P	0.0000
436	L	P	0.0000
437	Y	P	0.0000
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.4291
441	S	P	-0.6337
442	Y	P	-0.4172
443	T	P	-0.7169
444	S	P	-1.3085
445	A	P	-1.9165
446	D	P	-2.8228
447	A	P	0.0000
448	T	P	-1.3274
449	V	P	0.0000
450	N	P	-1.0538
451	F	P	-0.4999
452	A	P	0.0000
453	Y	P	0.0000
454	D	P	0.0000
455	T	P	-0.1959
456	G	P	-0.2662
457	T	P	-0.0057
458	G	P	0.1059
459	I	P	1.2859
460	S	P	0.2017
461	K	P	-0.7289
462	T	P	-0.6858
463	L	P	-0.3974
464	T	P	-0.3676
465	I	P	0.0000
466	P	P	-0.7143
467	F	P	0.0000
468	K	P	-3.1457
469	N	P	0.0000
470	R	P	-2.3798
471	Y	P	-1.2043
472	K	P	-1.7500
473	Y	P	-0.3426
474	S	P	0.0000
475	S	P	-0.1859
476	M	P	0.0000
477	I	P	-0.1867
478	D	P	-0.8392
479	Y	P	-0.9307
480	N	P	-1.4796
481	P	P	-1.5577
482	L	P	-1.7242
483	E	P	-2.6863
484	K	P	-2.8132
485	K	P	-2.5011
486	L	P	0.0000
487	F	P	0.0000
488	A	P	0.0000
489	W	P	0.0000
490	D	P	0.0000
491	N	P	-1.0207
492	L	P	-0.5288
493	N	P	-0.6506
494	M	P	0.0000
495	V	P	0.0000
496	T	P	0.0000
497	Y	P	0.0000
498	D	P	-2.2784
499	I	P	0.0000
500	K	P	-1.2743
501	L	P	0.0201
502	S	P	0.0946