Project name: 1de4af531eb33d6

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVAEIRLKSDNYATHYAESVKGRFTISRDDSKNSLYLQMNSLRAEDTAVYYCTGYYADAMDYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKLLIKYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWEIPYTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:51)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:52)

• Minimal score value: -2.7692
• Maximal score value: 1.6609
• Average score: -0.5884
• Total score value: -135.335

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1068
2	V	H	-1.2414
3	Q	H	-1.3186
4	L	H	0.0000
5	V	H	0.7335
6	E	H	0.0000
7	S	H	-0.2172
8	G	H	-0.5914
9	G	H	0.2340
11	G	H	0.7960
12	L	H	1.3781
13	V	H	-0.0835
14	Q	H	-1.3932
15	P	H	-1.6520
16	G	H	-1.4713
17	G	H	-1.0262
18	S	H	-1.1010
19	L	H	-0.5411
20	R	H	-1.4045
21	L	H	0.0000
22	S	H	-0.2754
23	C	H	0.0000
24	A	H	-0.2064
25	A	H	0.0000
26	S	H	-0.8904
27	G	H	-1.2130
28	F	H	-0.5029
29	T	H	-0.2322
30	F	H	0.0000
35	S	H	-0.7124
36	S	H	-0.2065
37	Y	H	0.0000
38	W	H	0.1750
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6015
45	A	H	-0.9971
46	P	H	-0.8175
47	G	H	-1.4488
48	K	H	-2.2682
49	G	H	-1.4444
50	L	H	0.0000
51	E	H	-1.0011
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	E	H	0.0000
56	I	H	0.0000
57	R	H	-0.7996
58	L	H	-1.1414
59	K	H	-2.2554
60	S	H	-1.5809
61	D	H	-1.6566
62	N	H	-1.9335
63	Y	H	-1.0115
64	A	H	-0.7167
65	T	H	-0.2858
66	H	H	-0.6015
67	Y	H	-1.0493
68	A	H	0.0000
69	E	H	-2.5485
70	S	H	-1.7472
71	V	H	0.0000
72	K	H	-2.6562
74	G	H	-1.7223
75	R	H	-1.4544
76	F	H	0.0000
77	T	H	-0.8201
78	I	H	0.0000
79	S	H	-0.2813
80	R	H	-0.9120
81	D	H	-1.3257
82	D	H	-1.6467
83	S	H	-1.4785
84	K	H	-2.2681
85	N	H	-1.6276
86	S	H	-0.9710
87	L	H	0.0000
88	Y	H	-0.3899
89	L	H	0.0000
90	Q	H	-0.9734
91	M	H	0.0000
92	N	H	-1.2767
93	S	H	-1.2692
94	L	H	0.0000
95	R	H	-2.2846
96	A	H	-1.7062
97	E	H	-2.2331
98	D	H	0.0000
99	T	H	-0.3567
100	A	H	0.0000
101	V	H	0.8310
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	G	H	0.0000
107	Y	H	0.0000
108	Y	H	0.8792
109	A	H	0.3146
113	D	H	0.0457
114	A	H	0.0000
115	M	H	0.0000
116	D	H	0.0622
117	Y	H	0.3171
118	W	H	-0.2430
119	G	H	0.0000
120	Q	H	-1.4537
121	G	H	-0.2844
122	T	H	0.5483
123	L	H	1.6609
124	V	H	0.0000
125	T	H	0.3536
126	V	H	0.0000
127	S	H	-0.7291
128	S	H	-0.5680
1	D	L	-2.1729
2	I	L	0.0000
3	Q	L	-2.2459
4	M	L	0.0000
5	T	L	-1.4156
6	Q	L	-1.1642
7	S	L	-0.7195
8	P	L	-0.5015
9	S	L	-0.6379
10	S	L	-0.7403
11	L	L	-0.6134
12	S	L	-1.0429
13	A	L	0.0000
14	S	L	-0.9118
15	V	L	-0.0062
16	G	L	-0.7600
17	D	L	-1.8074
18	R	L	-2.3562
19	V	L	0.0000
20	T	L	-0.6101
21	I	L	0.0000
22	T	L	-0.8527
23	C	L	0.0000
24	R	L	-2.7692
25	A	L	0.0000
26	S	L	-1.9010
27	Q	L	-1.8707
28	S	L	-0.9951
29	V	L	0.0000
30	S	L	-0.1072
31	T	L	0.0587
34	S	L	-0.1533
35	S	L	0.1356
36	Y	L	0.8000
37	S	L	0.2573
38	Y	L	0.4667
39	M	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7476
44	Q	L	-1.1225
45	K	L	-1.4809
46	P	L	-1.1256
47	G	L	-1.6868
48	K	L	-2.5800
49	A	L	-1.5323
50	P	L	0.0000
51	K	L	-1.1438
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	-0.5632
56	Y	L	-0.1678
57	A	L	0.0000
65	S	L	-0.8357
66	N	L	-1.3021
67	L	L	-0.5592
68	E	L	-0.7679
69	S	L	-0.6201
70	G	L	-0.6070
71	V	L	0.0000
72	P	L	-0.4348
74	S	L	-0.4767
75	R	L	-0.8055
76	F	L	0.0000
77	S	L	-0.6128
78	G	L	-0.5770
79	S	L	-0.8046
80	G	L	-1.0320
83	S	L	-0.8441
84	G	L	-0.9364
85	T	L	-1.6241
86	D	L	-2.0919
87	F	L	0.0000
88	T	L	-0.7390
89	L	L	0.0000
90	T	L	-0.6297
91	I	L	0.0000
92	S	L	-1.3854
93	S	L	-1.2174
94	L	L	0.0000
95	Q	L	-0.9743
96	P	L	-1.0887
97	E	L	-1.6946
98	D	L	0.0000
99	F	L	-0.4660
100	A	L	0.0000
101	T	L	-0.5899
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	H	L	0.0000
107	S	L	0.1831
108	W	L	0.0537
109	E	L	-0.2387
114	I	L	0.0631
115	P	L	-0.5784
116	Y	L	0.0000
117	T	L	-0.7199
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.1925
121	G	L	-0.8529
122	T	L	0.0000
123	K	L	-0.8694
124	V	L	0.0000
125	E	L	-1.2604
126	I	L	-0.9077
127	K	L	-1.6143