| Chain sequence(s) |
A: KSNTATSATQRLANFLVHSSNNFGAIPLPTPNVGSNTYASASLSAQAVLTQPPSASGTPGQRVTISCSGSSSNIGSNSVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGRVLFGGGTKLTVLGSRGGGGSGGGGSGGGGSLEMAQVQLVQSGAEVKKPGASVKVSCKTSGYTFTGYYIHWVRQAPGQGLEWMGHISPHSGGTDYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGVYGMDRWGQGTLVTVSSAGGGGGGSGGGFYQRYASLRHYLNLVTRQRYGKGFGGGGGSHHHHH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:24)
[INFO] Main: Simulation completed successfully. (00:04:26)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | K | A | -2.0989 | |
| 2 | S | A | -1.6651 | |
| 3 | N | A | -1.8151 | |
| 4 | T | A | -0.9317 | |
| 5 | A | A | -0.4384 | |
| 6 | T | A | -0.8552 | |
| 7 | S | A | -1.0583 | |
| 8 | A | A | -0.6648 | |
| 9 | T | A | -0.9009 | |
| 10 | Q | A | -1.9203 | |
| 11 | R | A | -1.7435 | |
| 12 | L | A | 0.6463 | |
| 13 | A | A | 0.4886 | |
| 14 | N | A | 0.1375 | |
| 15 | F | A | 2.4856 | |
| 16 | L | A | 2.9356 | |
| 17 | V | A | 2.1350 | |
| 18 | H | A | 0.0706 | |
| 19 | S | A | -0.4030 | |
| 20 | S | A | -1.2189 | |
| 21 | N | A | -1.7554 | |
| 22 | N | A | -1.1438 | |
| 23 | F | A | 0.7998 | |
| 24 | G | A | 0.5120 | |
| 25 | A | A | 1.2322 | |
| 26 | I | A | 2.1059 | |
| 27 | P | A | 1.4096 | |
| 28 | L | A | 1.6762 | |
| 29 | P | A | 0.3894 | |
| 30 | T | A | -0.0659 | |
| 31 | P | A | -0.3898 | |
| 32 | N | A | -0.7353 | |
| 33 | V | A | 0.6590 | |
| 34 | G | A | -0.4184 | |
| 35 | S | A | -0.6359 | |
| 36 | N | A | -0.9658 | |
| 37 | T | A | -0.1685 | |
| 38 | Y | A | 0.8868 | |
| 39 | A | A | 0.3858 | |
| 40 | S | A | 0.3794 | |
| 41 | A | A | 0.4203 | |
| 42 | S | A | 0.4649 | |
| 43 | L | A | 1.1525 | |
| 44 | S | A | 0.1944 | |
| 45 | A | A | 0.0325 | |
| 46 | Q | A | -0.4912 | |
| 47 | A | A | 0.0212 | |
| 48 | V | A | 1.3781 | |
| 49 | L | A | 0.0000 | |
| 50 | T | A | 0.1337 | |
| 51 | Q | A | 0.0000 | |
| 52 | P | A | -0.4546 | |
| 53 | P | A | -0.5329 | |
| 54 | S | A | -0.4235 | |
| 55 | A | A | -0.3869 | |
| 56 | S | A | -0.3626 | |
| 57 | G | A | 0.0000 | |
| 58 | T | A | -0.6829 | |
| 59 | P | A | -1.3506 | |
| 60 | G | A | -1.6999 | |
| 61 | Q | A | -2.3199 | |
| 62 | R | A | -2.5912 | |
| 63 | V | A | 0.0000 | |
| 64 | T | A | -0.5796 | |
| 65 | I | A | 0.0000 | |
| 66 | S | A | -0.3609 | |
| 67 | C | A | 0.0000 | |
| 68 | S | A | -0.2180 | |
| 69 | G | A | 0.0343 | |
| 70 | S | A | -0.2034 | |
| 71 | S | A | -0.8428 | |
| 72 | S | A | -0.9848 | |
| 73 | N | A | 0.0000 | |
| 74 | I | A | 0.0000 | |
| 75 | G | A | -0.8267 | |
| 76 | S | A | -0.8473 | |
| 77 | N | A | -0.7164 | |
| 78 | S | A | -0.2602 | |
| 79 | V | A | 0.0000 | |
| 80 | N | A | 0.0000 | |
| 81 | W | A | 0.0000 | |
| 82 | Y | A | 0.0000 | |
| 83 | Q | A | 0.0000 | |
| 84 | Q | A | 0.0000 | |
| 85 | L | A | -0.2654 | |
| 86 | P | A | -0.6627 | |
| 87 | G | A | 0.0000 | |
| 88 | T | A | -0.4893 | |
| 89 | A | A | -0.4870 | |
| 90 | P | A | 0.0000 | |
| 91 | K | A | -1.5360 | |
| 92 | L | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | I | A | 0.0000 | |
| 95 | Y | A | -0.3571 | |
| 96 | S | A | -0.5903 | |
| 97 | N | A | -1.4365 | |
| 98 | N | A | -2.1085 | |
| 99 | Q | A | -1.7899 | |
| 100 | R | A | -1.8250 | |
| 101 | P | A | -0.9471 | |
| 102 | S | A | -0.6925 | |
| 103 | G | A | -0.8619 | |
| 104 | V | A | -1.0861 | |
| 105 | P | A | -1.3339 | |
| 106 | D | A | -2.2031 | |
| 107 | R | A | -1.6186 | |
| 108 | F | A | 0.0000 | |
| 109 | S | A | -1.3340 | |
| 110 | G | A | -1.1987 | |
| 111 | S | A | -1.1983 | |
| 112 | K | A | -1.2761 | |
| 113 | S | A | -0.8689 | |
| 114 | G | A | -0.9130 | |
| 115 | T | A | -0.7667 | |
| 116 | S | A | -0.7191 | |
| 117 | A | A | 0.0000 | |
| 118 | S | A | -0.6244 | |
| 119 | L | A | 0.0000 | |
| 120 | A | A | -0.6302 | |
| 121 | I | A | 0.0000 | |
| 122 | S | A | -1.7960 | |
| 123 | G | A | -1.6051 | |
| 124 | L | A | 0.0000 | |
| 125 | Q | A | -1.6883 | |
| 126 | S | A | -1.8623 | |
| 127 | E | A | -2.2636 | |
| 128 | D | A | 0.0000 | |
| 129 | E | A | -1.2075 | |
| 130 | A | A | 0.0000 | |
| 131 | D | A | 0.0000 | |
| 132 | Y | A | 0.0000 | |
| 133 | Y | A | 0.0000 | |
| 134 | C | A | 0.0000 | |
| 135 | A | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | W | A | -0.3885 | |
| 138 | D | A | 0.0000 | |
| 139 | D | A | -2.4385 | |
| 140 | S | A | -1.5737 | |
| 141 | L | A | -1.4716 | |
| 142 | N | A | -2.1188 | |
| 143 | G | A | -1.6464 | |
| 144 | R | A | -1.2024 | |
| 145 | V | A | 0.0000 | |
| 146 | L | A | 0.5270 | |
| 147 | F | A | 0.3876 | |
| 148 | G | A | 0.0000 | |
| 149 | G | A | -0.5276 | |
| 150 | G | A | 0.0000 | |
| 151 | T | A | 0.0000 | |
| 152 | K | A | -0.4965 | |
| 153 | L | A | 0.0000 | |
| 154 | T | A | -0.3503 | |
| 155 | V | A | 0.0000 | |
| 156 | L | A | 0.3336 | |
| 157 | G | A | -0.6552 | |
| 158 | S | A | -1.5534 | |
| 159 | R | A | -2.2984 | |
| 160 | G | A | -1.9003 | |
| 161 | G | A | -1.6513 | |
| 162 | G | A | -1.4015 | |
| 163 | G | A | -1.2246 | |
| 164 | S | A | -1.0541 | |
| 165 | G | A | -1.1862 | |
| 166 | G | A | -1.2255 | |
| 167 | G | A | -1.1967 | |
| 168 | G | A | -1.2001 | |
| 169 | S | A | -1.0392 | |
| 170 | G | A | -1.1767 | |
| 171 | G | A | -1.1772 | |
| 172 | G | A | -0.9550 | |
| 173 | G | A | -0.9011 | |
| 174 | S | A | -0.2242 | |
| 175 | L | A | 0.6975 | |
| 176 | E | A | -0.9148 | |
| 177 | M | A | 0.2246 | |
| 178 | A | A | -0.4855 | |
| 179 | Q | A | -1.3517 | |
| 180 | V | A | -0.7881 | |
| 181 | Q | A | -0.8397 | |
| 182 | L | A | 0.0000 | |
| 183 | V | A | 0.8329 | |
| 184 | Q | A | 0.0000 | |
| 185 | S | A | -0.4279 | |
| 186 | G | A | -0.5278 | |
| 187 | A | A | -0.1972 | |
| 188 | E | A | -0.3764 | |
| 189 | V | A | 0.6832 | |
| 190 | K | A | -1.0838 | |
| 191 | K | A | -2.4515 | |
| 192 | P | A | -2.5800 | |
| 193 | G | A | -2.2682 | |
| 194 | A | A | -1.7331 | |
| 195 | S | A | -1.7360 | |
| 196 | V | A | 0.0000 | |
| 197 | K | A | -1.8657 | |
| 198 | V | A | 0.0000 | |
| 199 | S | A | -0.5472 | |
| 200 | C | A | 0.0000 | |
| 201 | K | A | -0.3370 | |
| 202 | T | A | 0.0000 | |
| 203 | S | A | -0.3421 | |
| 204 | G | A | -0.4829 | |
| 205 | Y | A | -0.2110 | |
| 206 | T | A | -0.2048 | |
| 207 | F | A | 0.0000 | |
| 208 | T | A | -0.5533 | |
| 209 | G | A | -0.2341 | |
| 210 | Y | A | 0.7358 | |
| 211 | Y | A | 0.8777 | |
| 212 | I | A | 0.0000 | |
| 213 | H | A | 0.0000 | |
| 214 | W | A | 0.0000 | |
| 215 | V | A | 0.0000 | |
| 216 | R | A | 0.0000 | |
| 217 | Q | A | 0.0000 | |
| 218 | A | A | -0.8825 | |
| 219 | P | A | -1.2427 | |
| 220 | G | A | -1.5268 | |
| 221 | Q | A | -1.6596 | |
| 222 | G | A | -0.9536 | |
| 223 | L | A | 0.0000 | |
| 224 | E | A | -0.5905 | |
| 225 | W | A | 0.0000 | |
| 226 | M | A | 0.0000 | |
| 227 | G | A | 0.0000 | |
| 228 | H | A | -0.3456 | |
| 229 | I | A | 0.0000 | |
| 230 | S | A | -0.5655 | |
| 231 | P | A | 0.0000 | |
| 232 | H | A | -1.2405 | |
| 233 | S | A | -0.9480 | |
| 234 | G | A | -0.8766 | |
| 235 | G | A | -0.7856 | |
| 236 | T | A | -0.6804 | |
| 237 | D | A | -1.6137 | |
| 238 | Y | A | -1.4333 | |
| 239 | A | A | -1.7490 | |
| 240 | Q | A | -2.5709 | |
| 241 | K | A | -2.6849 | |
| 242 | F | A | 0.0000 | |
| 243 | Q | A | -2.4932 | |
| 244 | G | A | -1.7276 | |
| 245 | R | A | -1.6090 | |
| 246 | V | A | 0.0000 | |
| 247 | T | A | -0.8957 | |
| 248 | M | A | 0.0000 | |
| 249 | T | A | -0.7345 | |
| 250 | R | A | -1.2613 | |
| 251 | D | A | -0.9101 | |
| 252 | T | A | -0.4885 | |
| 253 | S | A | 0.0976 | |
| 254 | I | A | 0.7877 | |
| 255 | S | A | -0.0522 | |
| 256 | T | A | 0.0000 | |
| 257 | A | A | 0.0000 | |
| 258 | Y | A | -0.8260 | |
| 259 | M | A | 0.0000 | |
| 260 | E | A | -1.4249 | |
| 261 | L | A | 0.0000 | |
| 262 | S | A | -1.8208 | |
| 263 | R | A | -2.8144 | |
| 264 | L | A | 0.0000 | |
| 265 | R | A | -3.4739 | |
| 266 | S | A | -2.3805 | |
| 267 | D | A | -2.5314 | |
| 268 | D | A | 0.0000 | |
| 269 | T | A | -0.9436 | |
| 270 | A | A | 0.0000 | |
| 271 | V | A | 0.0000 | |
| 272 | Y | A | 0.0000 | |
| 273 | Y | A | 0.0000 | |
| 274 | C | A | 0.0000 | |
| 275 | A | A | 0.0000 | |
| 276 | R | A | 0.0000 | |
| 277 | G | A | 0.0000 | |
| 278 | V | A | 1.4629 | |
| 279 | Y | A | 1.7385 | |
| 280 | G | A | 0.6302 | |
| 281 | M | A | 0.0000 | |
| 282 | D | A | -0.9379 | |
| 283 | R | A | -1.5081 | |
| 284 | W | A | 0.0000 | |
| 285 | G | A | 0.0000 | |
| 286 | Q | A | -0.4338 | |
| 287 | G | A | 0.0000 | |
| 288 | T | A | 0.0000 | |
| 289 | L | A | 0.0000 | |
| 290 | V | A | 0.0000 | |
| 291 | T | A | -0.3911 | |
| 292 | V | A | 0.0000 | |
| 293 | S | A | -1.1523 | |
| 294 | S | A | -1.3274 | |
| 295 | A | A | -0.8326 | |
| 296 | G | A | -1.1146 | |
| 297 | G | A | -0.9749 | |
| 298 | G | A | -1.2277 | |
| 299 | G | A | -1.2062 | |
| 300 | G | A | -1.1867 | |
| 301 | G | A | -1.1330 | |
| 302 | S | A | -0.9205 | |
| 303 | G | A | -0.8521 | |
| 304 | G | A | -0.5566 | |
| 305 | G | A | -0.0006 | |
| 306 | F | A | 1.5285 | |
| 307 | Y | A | 1.0771 | |
| 308 | Q | A | -0.8146 | |
| 309 | R | A | -1.3715 | |
| 310 | Y | A | -0.3487 | |
| 311 | A | A | -0.5799 | |
| 312 | S | A | -0.8817 | |
| 313 | L | A | -0.6901 | |
| 314 | R | A | -1.6934 | |
| 315 | H | A | -1.6584 | |
| 316 | Y | A | 0.0000 | |
| 317 | L | A | 0.0000 | |
| 318 | N | A | -1.4591 | |
| 319 | L | A | -1.5039 | |
| 320 | V | A | 0.0000 | |
| 321 | T | A | -1.5267 | |
| 322 | R | A | -2.6982 | |
| 323 | Q | A | -2.6937 | |
| 324 | R | A | -2.0337 | |
| 325 | Y | A | -1.3183 | |
| 326 | G | A | -1.8390 | |
| 327 | K | A | -2.0955 | |
| 328 | G | A | -0.5799 | |
| 329 | F | A | 0.8342 | |
| 330 | G | A | -0.4220 | |
| 331 | G | A | -0.5604 | |
| 332 | G | A | -0.9597 | |
| 333 | G | A | -1.2882 | |
| 334 | G | A | -1.3707 | |
| 335 | S | A | -1.4906 | |
| 336 | H | A | -2.1415 | |
| 337 | H | A | -2.4361 | |
| 338 | H | A | -2.4919 | |
| 339 | H | A | -2.3406 | |
| 340 | H | A | -1.8358 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine