| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIIKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPQHEGADVRVSFSFDPKQTQLFIVGCEPPTGEHWDIAPPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPDGHPLPSAPPPSPLYVPPPPDSPYAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQISTPENNVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9504 | |
| 2 | L | A | 1.9794 | |
| 3 | P | A | 0.7104 | |
| 4 | P | A | 0.1249 | |
| 5 | T | A | 0.2138 | |
| 6 | T | A | 0.1535 | |
| 7 | P | A | 0.2441 | |
| 8 | V | A | 1.2497 | |
| 9 | A | A | 0.0477 | |
| 10 | K | A | -1.1208 | |
| 11 | V | A | -0.3393 | |
| 12 | Q | A | -1.4814 | |
| 13 | S | A | -1.6247 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.5908 | |
| 16 | E | A | -2.5486 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4354 | |
| 20 | P | A | 0.0776 | |
| 21 | T | A | 0.1006 | |
| 22 | S | A | -0.1803 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1305 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2524 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7494 | |
| 31 | R | A | -2.6825 | |
| 32 | L | A | -0.8196 | |
| 33 | L | A | 1.1022 | |
| 34 | T | A | 1.4115 | |
| 35 | V | A | 1.9262 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1982 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5592 | |
| 40 | K | A | -1.4274 | |
| 41 | D | A | -0.6180 | |
| 42 | I | A | 0.8632 | |
| 43 | I | A | 1.1517 | |
| 44 | K | A | -1.1685 | |
| 45 | N | A | -1.9350 | |
| 46 | G | A | -1.2629 | |
| 47 | K | A | -0.9919 | |
| 48 | V | A | 1.4134 | |
| 49 | V | A | 1.7745 | |
| 50 | V | A | 1.3579 | |
| 51 | P | A | 0.4780 | |
| 52 | K | A | -0.4967 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1455 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.6160 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3321 | |
| 70 | K | A | -1.8702 | |
| 71 | F | A | -0.9220 | |
| 72 | A | A | -0.5884 | |
| 73 | L | A | -0.9286 | |
| 74 | P | A | -1.2536 | |
| 75 | Q | A | -2.4799 | |
| 76 | K | A | -3.1001 | |
| 77 | D | A | -2.9951 | |
| 78 | F | A | -1.6706 | |
| 79 | Y | A | -1.9335 | |
| 80 | D | A | -2.7485 | |
| 81 | P | A | -2.3390 | |
| 82 | E | A | -3.0427 | |
| 83 | K | A | -3.3917 | |
| 84 | E | A | -2.4528 | |
| 85 | R | A | -1.2817 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6209 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -1.0224 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3930 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7737 | |
| 99 | G | A | -0.6194 | |
| 100 | P | A | -0.4276 | |
| 101 | L | A | -0.0003 | |
| 102 | G | A | -0.3890 | |
| 103 | K | A | -0.6280 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4031 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1210 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3212 | |
| 110 | L | A | 0.3197 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9652 | |
| 113 | K | A | -0.1558 | |
| 114 | L | A | -0.9424 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.1318 | |
| 117 | T | A | -0.8245 | |
| 118 | E | A | -1.8384 | |
| 119 | N | A | -1.8534 | |
| 120 | P | A | -1.3824 | |
| 121 | T | A | -0.8981 | |
| 122 | A | A | -1.0260 | |
| 123 | P | A | -1.2454 | |
| 124 | Q | A | -1.7375 | |
| 125 | H | A | -2.5190 | |
| 126 | E | A | -2.8866 | |
| 127 | G | A | -2.2172 | |
| 128 | A | A | -1.5134 | |
| 129 | D | A | -2.2153 | |
| 130 | V | A | -1.6298 | |
| 131 | R | A | -0.7896 | |
| 132 | V | A | 0.4214 | |
| 133 | S | A | 0.2307 | |
| 134 | F | A | 0.1930 | |
| 135 | S | A | -0.1612 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6825 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.2154 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5123 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2249 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1192 | |
| 157 | D | A | 0.5588 | |
| 158 | I | A | 1.2088 | |
| 159 | A | A | 0.8628 | |
| 160 | P | A | 0.0720 | |
| 161 | P | A | 0.4347 | |
| 162 | C | A | 0.4952 | |
| 163 | P | A | -0.0335 | |
| 164 | G | A | -0.1244 | |
| 165 | L | A | 0.5008 | |
| 166 | P | A | -0.1568 | |
| 167 | P | A | -0.3579 | |
| 168 | G | A | -0.4282 | |
| 169 | A | A | -0.0214 | |
| 170 | C | A | 0.7293 | |
| 171 | P | A | 0.8331 | |
| 172 | P | A | 1.0571 | |
| 173 | I | A | 2.0688 | |
| 174 | Q | A | 1.0843 | |
| 175 | L | A | 1.3842 | |
| 176 | V | A | 0.8293 | |
| 177 | N | A | -0.3006 | |
| 178 | S | A | -0.0261 | |
| 179 | V | A | 0.3104 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3750 | |
| 182 | D | A | 0.2729 | |
| 183 | G | A | -0.1833 | |
| 184 | D | A | -0.5492 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4221 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1134 | |
| 190 | F | A | 0.0541 | |
| 191 | G | A | -0.0896 | |
| 192 | N | A | -0.2841 | |
| 193 | M | A | -0.1136 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.2831 | |
| 197 | E | A | -2.4785 | |
| 198 | L | A | -1.1589 | |
| 199 | Q | A | -2.4778 | |
| 200 | Q | A | -3.2645 | |
| 201 | D | A | -3.5492 | |
| 202 | R | A | -3.3051 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2118 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3577 | |
| 211 | S | A | -1.8383 | |
| 212 | T | A | -1.4107 | |
| 213 | R | A | -1.9622 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2060 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2991 | |
| 220 | L | A | 0.5530 | |
| 221 | K | A | -1.2059 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8962 | |
| 224 | N | A | -1.6210 | |
| 225 | E | A | -1.2295 | |
| 226 | A | A | -0.7697 | |
| 227 | Y | A | -0.3766 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6204 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.0897 | |
| 234 | F | A | 0.1313 | |
| 235 | G | A | -0.7323 | |
| 236 | R | A | -2.2201 | |
| 237 | R | A | -2.5027 | |
| 238 | E | A | -1.5390 | |
| 239 | Q | A | 0.1413 | |
| 240 | V | A | 1.5171 | |
| 241 | Y | A | 0.9524 | |
| 242 | A | A | 0.0736 | |
| 243 | R | A | -1.1910 | |
| 244 | H | A | -0.7862 | |
| 245 | F | A | 0.2278 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | -0.0058 | |
| 248 | R | A | -0.6477 | |
| 249 | A | A | -1.1396 | |
| 250 | G | A | -0.9015 | |
| 251 | P | A | -1.1223 | |
| 252 | D | A | -1.3850 | |
| 253 | G | A | -1.2793 | |
| 254 | H | A | -1.3927 | |
| 255 | P | A | -0.8716 | |
| 256 | L | A | 0.3101 | |
| 257 | P | A | -0.0568 | |
| 258 | S | A | 0.1259 | |
| 259 | A | A | 0.3757 | |
| 260 | P | A | -0.3073 | |
| 261 | P | A | -0.0659 | |
| 262 | P | A | 0.0205 | |
| 263 | S | A | 0.4767 | |
| 264 | P | A | 0.6643 | |
| 265 | L | A | 1.8509 | |
| 266 | Y | A | 1.6777 | |
| 267 | V | A | 1.8898 | |
| 268 | P | A | 1.1498 | |
| 269 | P | A | 0.4529 | |
| 270 | P | A | -0.6314 | |
| 271 | P | A | -0.9004 | |
| 272 | D | A | -1.8663 | |
| 273 | S | A | -0.4646 | |
| 274 | P | A | 0.2998 | |
| 275 | Y | A | 1.5395 | |
| 276 | A | A | 1.0087 | |
| 277 | V | A | 2.3738 | |
| 278 | L | A | 1.7267 | |
| 279 | P | A | 0.4372 | |
| 280 | S | A | -0.2865 | |
| 281 | T | A | -0.3039 | |
| 282 | D | A | -0.7379 | |
| 283 | Y | A | 0.9897 | |
| 284 | F | A | 0.7897 | |
| 285 | G | A | 0.3669 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.6727 | |
| 291 | L | A | 1.6271 | |
| 292 | V | A | 0.5610 | |
| 293 | S | A | -0.1997 | |
| 294 | S | A | -0.8342 | |
| 295 | D | A | -1.8777 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0767 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.7027 | |
| 301 | R | A | -2.0101 | |
| 302 | P | A | -1.0147 | |
| 303 | F | A | -0.1763 | |
| 304 | W | A | -0.3611 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.1787 | |
| 307 | R | A | -2.9008 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7177 | |
| 310 | G | A | -1.3512 | |
| 311 | N | A | -1.3644 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7042 | |
| 319 | N | A | -0.7678 | |
| 320 | E | A | 0.0000 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3826 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1890 | |
| 333 | N | A | 0.3480 | |
| 334 | F | A | 1.3739 | |
| 335 | T | A | 0.6395 | |
| 336 | I | A | 0.4256 | |
| 337 | S | A | -0.9319 | |
| 338 | Q | A | -1.6792 | |
| 339 | Q | A | -1.2277 | |
| 340 | I | A | 0.7200 | |
| 341 | S | A | -0.1362 | |
| 342 | T | A | -0.7404 | |
| 343 | P | A | -1.0739 | |
| 344 | E | A | -2.3682 | |
| 345 | N | A | -2.0534 | |
| 346 | N | A | -1.3849 | |
| 347 | V | A | 0.7124 | |
| 348 | Y | A | 0.9925 | |
| 349 | D | A | -0.2993 | |
| 350 | P | A | -0.6475 | |
| 351 | S | A | -0.4503 | |
| 352 | N | A | -0.5501 | |
| 353 | F | A | -0.8917 | |
| 354 | K | A | -1.9171 | |
| 355 | N | A | -1.7622 | |
| 356 | Y | A | -0.0469 | |
| 357 | L | A | 0.6021 | |
| 358 | R | A | 0.8158 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.1490 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.2339 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0202 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6735 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2801 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3264 | |
| 376 | L | A | -1.7283 | |
| 377 | D | A | -2.0071 | |
| 378 | P | A | -1.0772 | |
| 379 | G | A | -1.0820 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -0.5930 | |
| 382 | A | A | -0.6908 | |
| 383 | H | A | -0.8767 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3807 | |
| 386 | T | A | -0.5664 | |
| 387 | M | A | -0.3202 | |
| 388 | N | A | -0.8686 | |
| 389 | P | A | -1.2271 | |
| 390 | T | A | -1.4701 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4475 | |
| 393 | E | A | -2.8060 | |
| 394 | N | A | -2.2960 | |
| 395 | W | A | -1.4640 | |
| 396 | N | A | -1.3052 | |
| 397 | L | A | -0.2413 | |
| 398 | G | A | 0.5543 | |
| 399 | F | A | 2.3760 | |
| 400 | V | A | 1.7591 | |
| 401 | P | A | 0.0483 | |
| 402 | P | A | -1.8928 | |
| 403 | K | A | -3.3379 | |
| 404 | E | A | -3.7847 | |
| 405 | R | A | -3.9579 | |
| 406 | E | A | -3.7757 | |
| 407 | D | A | -2.8416 | |
| 408 | P | A | -1.7494 | |
| 409 | Y | A | -0.9989 | |
| 410 | K | A | -2.1087 | |
| 411 | G | A | -0.6403 | |
| 412 | L | A | 0.6493 | |
| 413 | I | A | 1.6315 | |
| 414 | F | A | 0.6845 | |
| 415 | W | A | -0.3144 | |
| 416 | E | A | -1.6783 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9531 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0943 | |
| 421 | E | A | -2.7867 | |
| 422 | R | A | -2.2951 | |
| 423 | F | A | -1.2553 | |
| 424 | S | A | -1.5072 | |
| 425 | Q | A | -1.8508 | |
| 426 | D | A | -3.0412 | |
| 427 | L | A | 0.0000 | |
| 428 | D | A | -2.9300 | |
| 429 | Q | A | -2.6842 | |
| 430 | F | A | -1.5403 | |
| 431 | A | A | -0.9030 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6587 | |
| 435 | K | A | -0.8001 | |
| 436 | F | A | 0.1245 | |
| 437 | L | A | 0.9549 | |
| 438 | Y | A | 0.8066 | |
| 439 | Q | A | -0.3078 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine