| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTYGHPLFNKLGDTENPTSYQHEGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGPEGHPLPADPPPSPLYTPPPPTSPYAVLPSHDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPVPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9476 | |
| 2 | L | A | 1.9677 | |
| 3 | P | A | 0.6541 | |
| 4 | P | A | 0.3640 | |
| 5 | T | A | 0.1194 | |
| 6 | T | A | 0.1304 | |
| 7 | P | A | 0.1925 | |
| 8 | V | A | 1.2214 | |
| 9 | A | A | 0.0351 | |
| 10 | K | A | -1.1631 | |
| 11 | V | A | -0.4187 | |
| 12 | Q | A | -1.5391 | |
| 13 | S | A | -1.6179 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4611 | |
| 16 | E | A | -2.4603 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4514 | |
| 20 | P | A | 0.1034 | |
| 21 | T | A | 0.1169 | |
| 22 | S | A | -0.1689 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0868 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1746 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7821 | |
| 31 | R | A | -2.6275 | |
| 32 | L | A | -0.7505 | |
| 33 | L | A | 1.2165 | |
| 34 | T | A | 1.4401 | |
| 35 | V | A | 1.9604 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2370 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6394 | |
| 40 | K | A | -1.6307 | |
| 41 | D | A | -0.8956 | |
| 42 | I | A | 0.8348 | |
| 43 | V | A | 1.0256 | |
| 44 | K | A | -1.1903 | |
| 45 | N | A | -1.9295 | |
| 46 | G | A | -1.2344 | |
| 47 | K | A | -0.9389 | |
| 48 | V | A | 1.5074 | |
| 49 | V | A | 2.0673 | |
| 50 | V | A | 1.3077 | |
| 51 | P | A | 0.4996 | |
| 52 | K | A | -0.6164 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1318 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4665 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2668 | |
| 70 | K | A | -1.8099 | |
| 71 | F | A | -0.6643 | |
| 72 | A | A | -0.5730 | |
| 73 | L | A | -0.8592 | |
| 74 | P | A | -1.2573 | |
| 75 | Q | A | -2.4761 | |
| 76 | K | A | -3.0957 | |
| 77 | D | A | -2.9901 | |
| 78 | F | A | -1.6359 | |
| 79 | Y | A | -1.9205 | |
| 80 | D | A | -2.7679 | |
| 81 | P | A | -2.4179 | |
| 82 | E | A | -3.0785 | |
| 83 | K | A | -3.4472 | |
| 84 | E | A | -2.5134 | |
| 85 | R | A | -1.3241 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6125 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9683 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3696 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6632 | |
| 99 | G | A | -0.5226 | |
| 100 | P | A | -0.3691 | |
| 101 | L | A | 0.1162 | |
| 102 | G | A | -0.1735 | |
| 103 | K | A | -0.6166 | |
| 104 | G | A | -0.4978 | |
| 105 | T | A | -0.4485 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | 0.1378 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4081 | |
| 110 | L | A | 0.2850 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0566 | |
| 113 | K | A | -0.5389 | |
| 114 | L | A | -1.2335 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4171 | |
| 117 | T | A | -0.9759 | |
| 118 | E | A | -1.9906 | |
| 119 | N | A | -2.1051 | |
| 120 | P | A | -1.5289 | |
| 121 | T | A | -0.8807 | |
| 122 | S | A | -0.7261 | |
| 123 | Y | A | 0.0500 | |
| 124 | Q | A | -1.3650 | |
| 125 | H | A | -1.4991 | |
| 126 | E | A | -2.2273 | |
| 127 | G | A | -2.0623 | |
| 128 | A | A | -1.4662 | |
| 129 | D | A | -2.3921 | |
| 130 | D | A | -1.9671 | |
| 131 | R | A | -1.1166 | |
| 132 | V | A | 0.2153 | |
| 133 | A | A | 0.4309 | |
| 134 | F | A | 0.2716 | |
| 135 | S | A | -0.0822 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6857 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5564 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2479 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0927 | |
| 157 | D | A | 0.2765 | |
| 158 | I | A | 0.8541 | |
| 159 | A | A | 0.1187 | |
| 160 | E | A | -1.4807 | |
| 161 | P | A | -0.2663 | |
| 162 | C | A | 0.1574 | |
| 163 | P | A | -0.1876 | |
| 164 | G | A | -0.1002 | |
| 165 | L | A | 0.5418 | |
| 166 | P | A | -0.1332 | |
| 167 | P | A | -0.3514 | |
| 168 | G | A | -0.4228 | |
| 169 | A | A | -0.0255 | |
| 170 | C | A | 0.7461 | |
| 171 | P | A | 0.5349 | |
| 172 | P | A | 0.6822 | |
| 173 | I | A | 2.0284 | |
| 174 | Q | A | 0.8281 | |
| 175 | L | A | 1.4308 | |
| 176 | V | A | 0.8152 | |
| 177 | N | A | -0.3411 | |
| 178 | S | A | 0.0161 | |
| 179 | V | A | 0.4155 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3727 | |
| 182 | D | A | 0.0780 | |
| 183 | G | A | -0.1551 | |
| 184 | D | A | -0.5755 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1497 | |
| 190 | F | A | 0.0464 | |
| 191 | G | A | -0.1114 | |
| 192 | N | A | -0.3011 | |
| 193 | M | A | -0.1765 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4146 | |
| 197 | E | A | -2.6108 | |
| 198 | L | A | -1.2112 | |
| 199 | Q | A | -2.5267 | |
| 200 | Q | A | -3.3395 | |
| 201 | D | A | -3.5997 | |
| 202 | R | A | -3.3382 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1588 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.4069 | |
| 211 | S | A | -1.9365 | |
| 212 | T | A | -1.5140 | |
| 213 | R | A | -2.2279 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1784 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2884 | |
| 220 | L | A | 0.4912 | |
| 221 | K | A | -1.3287 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9729 | |
| 224 | N | A | -1.7013 | |
| 225 | E | A | -1.3234 | |
| 226 | A | A | -0.6732 | |
| 227 | Y | A | -0.4532 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7109 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1367 | |
| 234 | F | A | 0.0346 | |
| 235 | G | A | -0.8975 | |
| 236 | R | A | -2.6345 | |
| 237 | R | A | -2.8467 | |
| 238 | E | A | -2.0801 | |
| 239 | Q | A | -0.0774 | |
| 240 | V | A | 1.6001 | |
| 241 | Y | A | 1.2463 | |
| 242 | A | A | 0.1483 | |
| 243 | R | A | -1.2782 | |
| 244 | H | A | -1.0901 | |
| 245 | F | A | -0.0602 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6353 | |
| 249 | C | A | -1.1451 | |
| 250 | G | A | -0.9866 | |
| 251 | P | A | -1.0086 | |
| 252 | E | A | -1.3236 | |
| 253 | G | A | -1.2453 | |
| 254 | H | A | -1.4303 | |
| 255 | P | A | -0.7142 | |
| 256 | L | A | 0.2893 | |
| 257 | P | A | -0.1475 | |
| 258 | A | A | -0.3041 | |
| 259 | D | A | -0.9750 | |
| 260 | P | A | -0.9732 | |
| 261 | P | A | -0.6742 | |
| 262 | P | A | -0.5114 | |
| 263 | S | A | -0.1448 | |
| 264 | P | A | 0.2657 | |
| 265 | L | A | 1.4449 | |
| 266 | Y | A | 0.8143 | |
| 267 | T | A | -0.0004 | |
| 268 | P | A | -0.0164 | |
| 269 | P | A | 0.2668 | |
| 270 | P | A | -0.3190 | |
| 271 | P | A | -0.0790 | |
| 272 | T | A | -0.1759 | |
| 273 | S | A | 0.2842 | |
| 274 | P | A | 0.5301 | |
| 275 | Y | A | 1.5648 | |
| 276 | A | A | 1.3737 | |
| 277 | V | A | 2.2039 | |
| 278 | L | A | 1.7203 | |
| 279 | P | A | 0.1939 | |
| 280 | S | A | 0.0000 | |
| 281 | H | A | -0.4014 | |
| 282 | D | A | -0.7642 | |
| 283 | Y | A | 0.8795 | |
| 284 | F | A | 0.6966 | |
| 285 | G | A | 0.1737 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9517 | |
| 291 | L | A | 1.6375 | |
| 292 | V | A | 0.6518 | |
| 293 | S | A | -0.1429 | |
| 294 | S | A | -0.9556 | |
| 295 | D | A | -1.8454 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1228 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6558 | |
| 301 | R | A | -1.9031 | |
| 302 | P | A | -0.9670 | |
| 303 | F | A | -0.1588 | |
| 304 | W | A | -0.5006 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0728 | |
| 307 | R | A | -2.9233 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7785 | |
| 310 | G | A | -1.4152 | |
| 311 | N | A | -1.3972 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9068 | |
| 319 | N | A | -0.9943 | |
| 320 | E | A | -1.0493 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3020 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1351 | |
| 333 | N | A | 0.4157 | |
| 334 | F | A | 1.4200 | |
| 335 | T | A | 0.7160 | |
| 336 | I | A | 0.3871 | |
| 337 | S | A | -0.8182 | |
| 338 | Q | A | -1.3844 | |
| 339 | Q | A | -0.3993 | |
| 340 | L | A | 1.1230 | |
| 341 | C | A | 0.9369 | |
| 342 | T | A | 0.7096 | |
| 343 | P | A | 0.5190 | |
| 344 | V | A | 1.7440 | |
| 345 | P | A | 0.7674 | |
| 346 | N | A | 0.1284 | |
| 347 | V | A | 1.7806 | |
| 348 | Y | A | 1.6729 | |
| 349 | D | A | 0.2745 | |
| 350 | P | A | -0.2954 | |
| 351 | S | A | -0.2396 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.3130 | |
| 354 | K | A | -1.6161 | |
| 355 | N | A | -1.6756 | |
| 356 | Y | A | -0.1115 | |
| 357 | L | A | 0.5545 | |
| 358 | R | A | 0.8884 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4398 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0034 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9180 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6828 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2821 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3229 | |
| 376 | L | A | -1.7514 | |
| 377 | D | A | -2.0293 | |
| 378 | P | A | -1.0628 | |
| 379 | G | A | -1.0198 | |
| 380 | V | A | -0.9293 | |
| 381 | L | A | -0.5424 | |
| 382 | A | A | -0.6625 | |
| 383 | H | A | -0.8487 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4023 | |
| 386 | T | A | -0.5786 | |
| 387 | M | A | -0.3340 | |
| 388 | N | A | -0.8692 | |
| 389 | P | A | -1.2717 | |
| 390 | T | A | -1.5198 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5116 | |
| 393 | E | A | -2.8932 | |
| 394 | N | A | -2.6487 | |
| 395 | W | A | -1.4798 | |
| 396 | N | A | -1.2971 | |
| 397 | L | A | -0.1750 | |
| 398 | G | A | 0.5498 | |
| 399 | F | A | 2.4363 | |
| 400 | V | A | 1.8606 | |
| 401 | P | A | 0.0566 | |
| 402 | P | A | -1.8425 | |
| 403 | K | A | -3.4963 | |
| 404 | E | A | -3.8423 | |
| 405 | R | A | -4.1058 | |
| 406 | E | A | -3.8352 | |
| 407 | D | A | -2.8711 | |
| 408 | P | A | -1.7630 | |
| 409 | Y | A | -0.9913 | |
| 410 | K | A | -2.0953 | |
| 411 | G | A | -0.6429 | |
| 412 | L | A | 0.6597 | |
| 413 | I | A | 1.5789 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3987 | |
| 416 | E | A | -1.6713 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8437 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8861 | |
| 421 | E | A | -2.4862 | |
| 422 | R | A | -2.0479 | |
| 423 | F | A | -1.0082 | |
| 424 | S | A | -1.3064 | |
| 425 | Q | A | -1.8202 | |
| 426 | D | A | -2.8807 | |
| 427 | L | A | -1.9892 | |
| 428 | D | A | -2.7846 | |
| 429 | Q | A | -2.6161 | |
| 430 | F | A | -1.4623 | |
| 431 | A | A | -0.9446 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6170 | |
| 435 | K | A | -0.7544 | |
| 436 | F | A | 0.1433 | |
| 437 | L | A | 1.0226 | |
| 438 | Y | A | 0.8147 | |
| 439 | Q | A | -0.2757 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine