| Chain sequence(s) |
A: GLPLLNPEPPLKSTDEYVTPTDLYYVAQTDTLTETGNPFADIVVNGKVLVPKVSAWDWRLFKLTLPDPNKLPLPSEDFIDPKTEILIWRLLAYKIGVGGALGRGTVGLPNFNALGDVSNPTSYVHEGPDVTKNLSFTPITKQMYIIGDLPPIGVYTAPAAPAPGLPPGARPPTTKVTTIIQDGDKADIGFGAKNYKELLPSKNEVPEDILDTSTKVVDLDGMKAEPTGRRMFDYDYSSSSSASKLLRRSGPVLNPLPDEPPPSPLYVRPPPSSPYWKLPSYRFFTIPDGGAITSSNLLFNKPRYFTKTSGLNNGILWHNQLYILVLDNTRAAIETITTQTSTPAVNVFDPANYVTSKRYTRTYQISLIVQLCKIPLTPETLALISRIDPSILVDANLPDIPPVVRPDPYAGKKFKEIDLTNKLSTNLSKYDLGREFLNK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.4292 | |
| 2 | L | A | 1.8763 | |
| 3 | P | A | 1.2937 | |
| 4 | L | A | 1.8917 | |
| 5 | L | A | 1.5934 | |
| 6 | N | A | -0.8188 | |
| 7 | P | A | -1.2073 | |
| 8 | E | A | -2.0976 | |
| 9 | P | A | -1.5219 | |
| 10 | P | A | -0.9103 | |
| 11 | L | A | -0.5207 | |
| 12 | K | A | -1.4050 | |
| 13 | S | A | -1.3431 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.6537 | |
| 16 | E | A | -2.7124 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.8684 | |
| 20 | P | A | -0.9033 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.5702 | |
| 23 | L | A | -0.3843 | |
| 24 | Y | A | 0.1499 | |
| 25 | Y | A | 0.3340 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | Q | A | -0.9658 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.9945 | |
| 31 | T | A | -1.1256 | |
| 32 | L | A | -0.5694 | |
| 33 | T | A | -0.5215 | |
| 34 | E | A | -0.5712 | |
| 35 | T | A | -0.4942 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.7423 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.3902 | |
| 40 | A | A | -0.2310 | |
| 41 | D | A | 0.0652 | |
| 42 | I | A | 1.9095 | |
| 43 | V | A | 2.5810 | |
| 44 | V | A | 1.6972 | |
| 45 | N | A | -0.5331 | |
| 46 | G | A | -0.3284 | |
| 47 | K | A | -0.0830 | |
| 48 | V | A | 2.2329 | |
| 49 | L | A | 2.5525 | |
| 50 | V | A | 1.4443 | |
| 51 | P | A | 0.2494 | |
| 52 | K | A | -0.5876 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2547 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4700 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.8607 | |
| 70 | K | A | -2.0662 | |
| 71 | L | A | -0.9031 | |
| 72 | P | A | -0.6538 | |
| 73 | L | A | -0.5991 | |
| 74 | P | A | -0.6196 | |
| 75 | S | A | -1.4931 | |
| 76 | E | A | -2.7902 | |
| 77 | D | A | -2.8180 | |
| 78 | F | A | -1.4193 | |
| 79 | I | A | 0.0000 | |
| 80 | D | A | -2.6486 | |
| 81 | P | A | -2.1222 | |
| 82 | K | A | -2.6069 | |
| 83 | T | A | -1.5958 | |
| 84 | E | A | -1.5450 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2052 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.1015 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | -1.0970 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -0.7826 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.4852 | |
| 99 | G | A | -0.3975 | |
| 100 | A | A | 0.0304 | |
| 101 | L | A | 0.4574 | |
| 102 | G | A | 0.0413 | |
| 103 | R | A | -0.3608 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.1665 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.6906 | |
| 108 | L | A | 0.0000 | |
| 109 | P | A | -1.8200 | |
| 110 | N | A | -2.4854 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.5147 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.6101 | |
| 116 | D | A | -1.0914 | |
| 117 | V | A | -0.1793 | |
| 118 | S | A | -1.0155 | |
| 119 | N | A | -1.7180 | |
| 120 | P | A | -0.9959 | |
| 121 | T | A | -0.5990 | |
| 122 | S | A | -0.2376 | |
| 123 | Y | A | 0.5956 | |
| 124 | V | A | 0.2651 | |
| 125 | H | A | -0.8218 | |
| 126 | E | A | -1.8932 | |
| 127 | G | A | -1.4162 | |
| 128 | P | A | -1.4086 | |
| 129 | D | A | -2.3760 | |
| 130 | V | A | -1.6293 | |
| 131 | T | A | -2.0911 | |
| 132 | K | A | -2.8868 | |
| 133 | N | A | -2.4654 | |
| 134 | L | A | -1.3117 | |
| 135 | S | A | -0.7507 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4476 | |
| 138 | P | A | 0.0000 | |
| 139 | I | A | 0.0000 | |
| 140 | T | A | 0.0000 | |
| 141 | K | A | -0.1931 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.4324 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.0956 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.4563 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.2945 | |
| 155 | Y | A | -0.2766 | |
| 156 | T | A | -0.7313 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -1.2421 | |
| 159 | A | A | -0.5255 | |
| 160 | A | A | -0.1522 | |
| 161 | P | A | -0.4867 | |
| 162 | A | A | -0.1288 | |
| 163 | P | A | -0.3115 | |
| 164 | G | A | -0.2950 | |
| 165 | L | A | -0.0351 | |
| 166 | P | A | -0.4709 | |
| 167 | P | A | -0.7019 | |
| 168 | G | A | -0.6781 | |
| 169 | A | A | -0.7767 | |
| 170 | R | A | -1.7557 | |
| 171 | P | A | -1.2482 | |
| 172 | P | A | -0.7403 | |
| 173 | T | A | -0.8659 | |
| 174 | T | A | -0.9081 | |
| 175 | K | A | -1.5245 | |
| 176 | V | A | -0.4298 | |
| 177 | T | A | 0.0268 | |
| 178 | T | A | 0.1691 | |
| 179 | I | A | 0.0391 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -1.1551 | |
| 182 | D | A | -1.4476 | |
| 183 | G | A | -0.8927 | |
| 184 | D | A | -0.7235 | |
| 185 | K | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2197 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3388 | |
| 190 | F | A | -0.1192 | |
| 191 | G | A | -0.2616 | |
| 192 | A | A | -0.3884 | |
| 193 | K | A | -1.3255 | |
| 194 | N | A | -1.6131 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.2821 | |
| 197 | E | A | -3.0288 | |
| 198 | L | A | -1.8271 | |
| 199 | L | A | -1.5765 | |
| 200 | P | A | -1.6143 | |
| 201 | S | A | -1.3450 | |
| 202 | K | A | -2.2851 | |
| 203 | N | A | -1.6218 | |
| 204 | E | A | -1.0727 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | E | A | -1.2246 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.2841 | |
| 211 | D | A | -2.2260 | |
| 212 | T | A | -1.4578 | |
| 213 | S | A | -1.1206 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.7267 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | -0.7027 | |
| 219 | L | A | -1.1789 | |
| 220 | D | A | -2.5428 | |
| 221 | G | A | -1.7161 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.6296 | |
| 224 | A | A | -1.6009 | |
| 225 | E | A | -1.3517 | |
| 226 | P | A | -0.6997 | |
| 227 | T | A | -0.3866 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.4889 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.6525 | |
| 234 | Y | A | 0.1223 | |
| 235 | D | A | 0.1266 | |
| 236 | Y | A | 0.9351 | |
| 237 | S | A | 0.0476 | |
| 238 | S | A | -0.1719 | |
| 239 | S | A | -0.5128 | |
| 240 | S | A | -0.6802 | |
| 241 | S | A | -0.7217 | |
| 242 | A | A | -0.5251 | |
| 243 | S | A | -0.8200 | |
| 244 | K | A | -1.2744 | |
| 245 | L | A | 0.3100 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | S | A | -0.5989 | |
| 250 | G | A | -0.2743 | |
| 251 | P | A | -0.1240 | |
| 252 | V | A | 0.7726 | |
| 253 | L | A | 0.7724 | |
| 254 | N | A | -0.4659 | |
| 255 | P | A | -0.3866 | |
| 256 | L | A | -0.2269 | |
| 257 | P | A | -1.7260 | |
| 258 | D | A | -2.9898 | |
| 259 | E | A | -2.9298 | |
| 260 | P | A | -1.6060 | |
| 261 | P | A | -1.0711 | |
| 262 | P | A | -0.1706 | |
| 263 | S | A | 0.1890 | |
| 264 | P | A | 0.7417 | |
| 265 | L | A | 1.8754 | |
| 266 | Y | A | 1.7359 | |
| 267 | V | A | 1.8657 | |
| 268 | R | A | 0.2365 | |
| 269 | P | A | 0.0819 | |
| 270 | P | A | -0.1739 | |
| 271 | P | A | -0.6138 | |
| 272 | S | A | -0.2867 | |
| 273 | S | A | -0.2410 | |
| 274 | P | A | 0.0042 | |
| 275 | Y | A | 0.5976 | |
| 276 | W | A | -0.4682 | |
| 277 | K | A | -1.5585 | |
| 278 | L | A | -0.3562 | |
| 279 | P | A | -0.1188 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 1.1305 | |
| 282 | R | A | 0.9216 | |
| 283 | F | A | 2.1425 | |
| 284 | F | A | 1.1462 | |
| 285 | T | A | 0.3299 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.9401 | |
| 289 | G | A | 0.0000 | |
| 290 | G | A | -0.4617 | |
| 291 | A | A | -0.0543 | |
| 292 | I | A | 0.0477 | |
| 293 | T | A | -0.2720 | |
| 294 | S | A | -0.4866 | |
| 295 | S | A | -0.8586 | |
| 296 | N | A | -1.3204 | |
| 297 | L | A | -0.7205 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3820 | |
| 301 | K | A | -1.6158 | |
| 302 | P | A | -1.2183 | |
| 303 | R | A | -0.7400 | |
| 304 | Y | A | -0.3192 | |
| 305 | F | A | -0.3641 | |
| 306 | T | A | -0.7021 | |
| 307 | K | A | -1.8278 | |
| 308 | T | A | 0.0000 | |
| 309 | S | A | -0.9019 | |
| 310 | G | A | -0.7609 | |
| 311 | L | A | -0.5727 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7433 | |
| 319 | N | A | -0.7878 | |
| 320 | Q | A | -0.6358 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | L | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.0886 | |
| 331 | A | A | 0.0000 | |
| 332 | A | A | -0.4817 | |
| 333 | I | A | -0.8064 | |
| 334 | E | A | -1.7449 | |
| 335 | T | A | -0.7006 | |
| 336 | I | A | 0.6564 | |
| 337 | T | A | 0.5455 | |
| 338 | T | A | 0.3745 | |
| 339 | Q | A | -0.3237 | |
| 340 | T | A | -0.0319 | |
| 341 | S | A | -0.3552 | |
| 342 | T | A | -0.2954 | |
| 343 | P | A | -0.3607 | |
| 344 | A | A | 0.1832 | |
| 345 | V | A | 0.7228 | |
| 346 | N | A | 0.2517 | |
| 347 | V | A | 2.0324 | |
| 348 | F | A | 2.1300 | |
| 349 | D | A | 0.2102 | |
| 350 | P | A | 0.1428 | |
| 351 | A | A | 0.0503 | |
| 352 | N | A | 0.3000 | |
| 353 | Y | A | 0.7399 | |
| 354 | V | A | 1.7108 | |
| 355 | T | A | 0.8385 | |
| 356 | S | A | -0.0004 | |
| 357 | K | A | -1.1375 | |
| 358 | R | A | -1.1252 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.6359 | |
| 361 | R | A | 0.0000 | |
| 362 | T | A | -0.3954 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -1.0867 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6005 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8129 | |
| 376 | L | A | -0.7538 | |
| 377 | T | A | -0.6402 | |
| 378 | P | A | -0.9627 | |
| 379 | E | A | -1.7597 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.3038 | |
| 382 | A | A | -0.6446 | |
| 383 | L | A | -0.7120 | |
| 384 | I | A | 0.0000 | |
| 385 | S | A | -0.6065 | |
| 386 | R | A | -0.8532 | |
| 387 | I | A | -0.3800 | |
| 388 | D | A | -0.4849 | |
| 389 | P | A | -0.5775 | |
| 390 | S | A | 0.0000 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -0.3421 | |
| 393 | V | A | -0.1108 | |
| 394 | D | A | -1.3580 | |
| 395 | A | A | -1.3435 | |
| 396 | N | A | -1.7039 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | -1.6439 | |
| 399 | D | A | -1.9391 | |
| 400 | I | A | -0.2760 | |
| 401 | P | A | 0.0953 | |
| 402 | P | A | 0.3130 | |
| 403 | V | A | 2.0289 | |
| 404 | V | A | 1.8137 | |
| 405 | R | A | -0.0472 | |
| 406 | P | A | -0.6540 | |
| 407 | D | A | -1.5721 | |
| 408 | P | A | -1.1243 | |
| 409 | Y | A | -0.9815 | |
| 410 | A | A | -1.1596 | |
| 411 | G | A | -1.3752 | |
| 412 | K | A | -1.9236 | |
| 413 | K | A | -2.6127 | |
| 414 | F | A | -1.8584 | |
| 415 | K | A | -2.0394 | |
| 416 | E | A | -2.7378 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.6416 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.3987 | |
| 421 | N | A | -1.7879 | |
| 422 | K | A | -1.5611 | |
| 423 | L | A | -0.4553 | |
| 424 | S | A | -0.5485 | |
| 425 | T | A | -0.3043 | |
| 426 | N | A | -1.0793 | |
| 427 | L | A | -0.8145 | |
| 428 | S | A | -1.5795 | |
| 429 | K | A | -2.2538 | |
| 430 | Y | A | -1.5890 | |
| 431 | D | A | -1.8551 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.1515 | |
| 435 | E | A | -1.6261 | |
| 436 | F | A | -0.6800 | |
| 437 | L | A | -0.0879 | |
| 438 | N | A | -1.7838 | |
| 439 | K | A | -1.9898 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine