| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPVHEGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRSGPDGHPLPSGPPPSPLYTPPPPSSPWAVRPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9448 | |
| 2 | L | A | 1.9642 | |
| 3 | P | A | 0.8380 | |
| 4 | P | A | 0.3845 | |
| 5 | T | A | 0.1279 | |
| 6 | T | A | 0.1308 | |
| 7 | P | A | 0.2011 | |
| 8 | V | A | 1.2131 | |
| 9 | A | A | 0.0927 | |
| 10 | K | A | -1.0256 | |
| 11 | V | A | -0.1668 | |
| 12 | Q | A | -1.4052 | |
| 13 | S | A | -1.5601 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4428 | |
| 16 | E | A | -2.4513 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4552 | |
| 20 | P | A | 0.1268 | |
| 21 | T | A | 0.1634 | |
| 22 | S | A | -0.0918 | |
| 23 | L | A | 0.1012 | |
| 24 | F | A | -0.0188 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2956 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9047 | |
| 31 | R | A | -2.6835 | |
| 32 | L | A | -0.7995 | |
| 33 | L | A | 1.1608 | |
| 34 | T | A | 1.3705 | |
| 35 | V | A | 1.8363 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2154 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6179 | |
| 40 | K | A | -1.6222 | |
| 41 | D | A | -0.8880 | |
| 42 | I | A | 0.8442 | |
| 43 | V | A | 1.0310 | |
| 44 | K | A | -1.1713 | |
| 45 | N | A | -1.9247 | |
| 46 | G | A | -1.2243 | |
| 47 | K | A | -0.9683 | |
| 48 | V | A | 1.4578 | |
| 49 | V | A | 2.0318 | |
| 50 | V | A | 1.2508 | |
| 51 | P | A | 0.4476 | |
| 52 | K | A | -0.6292 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1448 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3914 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2654 | |
| 70 | K | A | -1.7806 | |
| 71 | F | A | -0.6234 | |
| 72 | A | A | -0.5716 | |
| 73 | L | A | -0.8683 | |
| 74 | P | A | -1.2090 | |
| 75 | Q | A | -2.5109 | |
| 76 | K | A | -3.1131 | |
| 77 | D | A | -2.9951 | |
| 78 | F | A | -1.6773 | |
| 79 | Y | A | -1.9014 | |
| 80 | D | A | -2.7022 | |
| 81 | P | A | -2.3764 | |
| 82 | E | A | -3.0605 | |
| 83 | K | A | -3.3991 | |
| 84 | E | A | -2.4668 | |
| 85 | R | A | -1.3040 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6593 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9708 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3719 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6996 | |
| 99 | G | A | -0.5350 | |
| 100 | P | A | -0.4149 | |
| 101 | L | A | 0.0203 | |
| 102 | G | A | -0.2646 | |
| 103 | K | A | -0.7212 | |
| 104 | G | A | -0.5029 | |
| 105 | T | A | -0.4809 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1311 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4145 | |
| 110 | L | A | 0.3667 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1538 | |
| 113 | K | A | -0.5653 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.3124 | |
| 117 | T | A | -0.8381 | |
| 118 | E | A | -1.8306 | |
| 119 | N | A | -1.9931 | |
| 120 | P | A | -1.3053 | |
| 121 | T | A | -0.6344 | |
| 122 | A | A | -0.2817 | |
| 123 | P | A | 0.0548 | |
| 124 | V | A | -0.2030 | |
| 125 | H | A | -1.2436 | |
| 126 | E | A | -2.1532 | |
| 127 | G | A | -2.0402 | |
| 128 | A | A | -1.5218 | |
| 129 | D | A | -2.4395 | |
| 130 | D | A | -2.0488 | |
| 131 | R | A | -1.1231 | |
| 132 | V | A | 0.2371 | |
| 133 | A | A | 0.4436 | |
| 134 | F | A | 0.2722 | |
| 135 | S | A | -0.0923 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5788 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5631 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1882 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1838 | |
| 157 | D | A | 0.3597 | |
| 158 | L | A | 0.8216 | |
| 159 | A | A | 0.1988 | |
| 160 | E | A | -1.4465 | |
| 161 | P | A | -0.2037 | |
| 162 | C | A | 0.1879 | |
| 163 | P | A | -0.1670 | |
| 164 | G | A | -0.0718 | |
| 165 | L | A | 0.6044 | |
| 166 | P | A | -0.1114 | |
| 167 | P | A | -0.3386 | |
| 168 | G | A | -0.4228 | |
| 169 | A | A | -0.0267 | |
| 170 | C | A | 0.6662 | |
| 171 | P | A | 0.5456 | |
| 172 | P | A | 0.7951 | |
| 173 | I | A | 2.0862 | |
| 174 | Q | A | 0.8998 | |
| 175 | L | A | 1.5250 | |
| 176 | V | A | 0.8665 | |
| 177 | N | A | -0.2973 | |
| 178 | S | A | 0.0268 | |
| 179 | V | A | 0.4254 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3748 | |
| 182 | D | A | 0.0709 | |
| 183 | G | A | -0.1613 | |
| 184 | D | A | -0.5435 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4578 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0714 | |
| 190 | F | A | 0.0179 | |
| 191 | G | A | -0.1577 | |
| 192 | N | A | -0.3005 | |
| 193 | M | A | -0.1119 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3860 | |
| 197 | E | A | -2.5937 | |
| 198 | L | A | -1.2088 | |
| 199 | Q | A | -2.5546 | |
| 200 | Q | A | -3.3187 | |
| 201 | D | A | -3.5834 | |
| 202 | R | A | -3.3263 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1824 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3525 | |
| 211 | S | A | -1.8695 | |
| 212 | T | A | -1.3995 | |
| 213 | R | A | -2.0411 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1975 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3880 | |
| 220 | L | A | 0.6243 | |
| 221 | K | A | -1.0781 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8042 | |
| 224 | N | A | -1.4811 | |
| 225 | E | A | -1.2225 | |
| 226 | A | A | -0.5997 | |
| 227 | Y | A | -0.3652 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6702 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0835 | |
| 234 | F | A | 0.2734 | |
| 235 | G | A | -0.7926 | |
| 236 | R | A | -2.5575 | |
| 237 | R | A | -2.7736 | |
| 238 | E | A | -2.0648 | |
| 239 | Q | A | -0.1042 | |
| 240 | V | A | 1.4806 | |
| 241 | Y | A | 1.2600 | |
| 242 | A | A | 0.1948 | |
| 243 | R | A | -1.1561 | |
| 244 | H | A | -1.0192 | |
| 245 | F | A | -0.0081 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.7702 | |
| 249 | S | A | -1.3889 | |
| 250 | G | A | -1.1146 | |
| 251 | P | A | -1.0621 | |
| 252 | D | A | -1.3609 | |
| 253 | G | A | -1.2557 | |
| 254 | H | A | -1.3886 | |
| 255 | P | A | -0.9870 | |
| 256 | L | A | -0.0197 | |
| 257 | P | A | -0.1289 | |
| 258 | S | A | -0.4142 | |
| 259 | G | A | -0.6195 | |
| 260 | P | A | -0.6481 | |
| 261 | P | A | -0.5094 | |
| 262 | P | A | -0.3584 | |
| 263 | S | A | 0.0452 | |
| 264 | P | A | 0.3886 | |
| 265 | L | A | 1.5001 | |
| 266 | Y | A | 0.8179 | |
| 267 | T | A | 0.0528 | |
| 268 | P | A | -0.2323 | |
| 269 | P | A | -0.1152 | |
| 270 | P | A | -0.4482 | |
| 271 | P | A | -0.2060 | |
| 272 | S | A | -0.2015 | |
| 273 | S | A | 0.0899 | |
| 274 | P | A | 0.1902 | |
| 275 | W | A | 0.7414 | |
| 276 | A | A | 0.6277 | |
| 277 | V | A | 1.1002 | |
| 278 | R | A | -0.0502 | |
| 279 | P | A | -0.3616 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | -0.0656 | |
| 282 | D | A | -0.3758 | |
| 283 | Y | A | 1.0745 | |
| 284 | F | A | 0.8112 | |
| 285 | G | A | 0.2261 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9223 | |
| 291 | L | A | 1.6092 | |
| 292 | V | A | 0.6192 | |
| 293 | S | A | -0.1600 | |
| 294 | S | A | -0.9625 | |
| 295 | D | A | -1.8423 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0857 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6612 | |
| 301 | R | A | -1.8635 | |
| 302 | P | A | -0.9889 | |
| 303 | F | A | -0.1947 | |
| 304 | W | A | -0.5622 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0844 | |
| 307 | R | A | -2.8369 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2674 | |
| 310 | G | A | -1.2284 | |
| 311 | N | A | -1.2765 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8438 | |
| 319 | N | A | -0.9401 | |
| 320 | E | A | -1.0377 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3619 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1025 | |
| 333 | N | A | 0.5577 | |
| 334 | F | A | 1.7511 | |
| 335 | T | A | 0.8674 | |
| 336 | I | A | 0.4507 | |
| 337 | S | A | -0.8309 | |
| 338 | Q | A | -1.4912 | |
| 339 | Q | A | -0.8766 | |
| 340 | L | A | 0.7936 | |
| 341 | C | A | 0.4239 | |
| 342 | T | A | 0.1487 | |
| 343 | P | A | -0.2775 | |
| 344 | A | A | 0.1180 | |
| 345 | P | A | 0.1556 | |
| 346 | N | A | -0.2819 | |
| 347 | V | A | 1.5486 | |
| 348 | Y | A | 1.4582 | |
| 349 | D | A | 0.0855 | |
| 350 | P | A | -0.3183 | |
| 351 | S | A | -0.2579 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5439 | |
| 354 | K | A | -1.6435 | |
| 355 | N | A | -1.6920 | |
| 356 | Y | A | -0.0857 | |
| 357 | L | A | 0.6402 | |
| 358 | R | A | 0.9761 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3973 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0803 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0614 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6923 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3017 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3064 | |
| 376 | L | A | -1.7021 | |
| 377 | D | A | -1.9685 | |
| 378 | P | A | -1.0280 | |
| 379 | G | A | -1.0085 | |
| 380 | V | A | -0.9257 | |
| 381 | L | A | -0.5241 | |
| 382 | A | A | -0.6523 | |
| 383 | H | A | -0.8052 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4129 | |
| 386 | T | A | -0.5531 | |
| 387 | M | A | -0.3021 | |
| 388 | N | A | -0.8684 | |
| 389 | P | A | -1.2538 | |
| 390 | T | A | -1.4803 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4866 | |
| 393 | E | A | -2.8310 | |
| 394 | N | A | -2.3061 | |
| 395 | W | A | -1.4520 | |
| 396 | N | A | -1.2264 | |
| 397 | L | A | -0.2339 | |
| 398 | G | A | 0.4650 | |
| 399 | F | A | 2.3964 | |
| 400 | V | A | 1.8024 | |
| 401 | P | A | 0.0298 | |
| 402 | P | A | -1.8882 | |
| 403 | K | A | -3.2607 | |
| 404 | E | A | -3.8357 | |
| 405 | R | A | -4.0396 | |
| 406 | E | A | -3.8553 | |
| 407 | D | A | -2.9028 | |
| 408 | P | A | -1.7825 | |
| 409 | Y | A | -0.9908 | |
| 410 | K | A | -2.1217 | |
| 411 | G | A | -0.6430 | |
| 412 | L | A | 0.6640 | |
| 413 | I | A | 1.5782 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3989 | |
| 416 | E | A | -1.7007 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9577 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0615 | |
| 421 | E | A | -2.8044 | |
| 422 | R | A | -2.6756 | |
| 423 | F | A | -1.3019 | |
| 424 | S | A | -1.4791 | |
| 425 | Q | A | -1.8617 | |
| 426 | D | A | -2.9710 | |
| 427 | L | A | -2.1639 | |
| 428 | D | A | -3.0298 | |
| 429 | Q | A | -2.7558 | |
| 430 | F | A | -1.6081 | |
| 431 | A | A | -1.1307 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2525 | |
| 435 | K | A | -1.0806 | |
| 436 | F | A | -0.1004 | |
| 437 | L | A | 0.7922 | |
| 438 | Y | A | 0.6320 | |
| 439 | Q | A | -0.3826 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine