Project name: 21d9da134ae4bc0

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCAASGFTFSRYAMSWVRQAPGKGLEWVSTISSGGSYTNYADSVKGRFTISRDNVKNTLYLQMNSLRAEDTAVYYCARATARATEFAYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQGNTLPLTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:52)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:54)

• Minimal score value: -2.581
• Maximal score value: 1.6461
• Average score: -0.5536
• Total score value: -125.1224

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0660
2	V	H	-1.0601
3	Q	H	-1.0599
4	L	H	0.0000
5	L	H	0.7119
6	E	H	0.0000
7	S	H	-0.2325
8	G	H	-0.4436
9	G	H	0.2457
11	G	H	0.7264
12	L	H	1.3896
13	V	H	-0.0121
14	Q	H	-1.2947
15	P	H	-1.5221
16	G	H	-1.3625
17	G	H	-0.9743
18	S	H	-1.1090
19	L	H	-0.7145
20	R	H	-1.5786
21	L	H	0.0000
22	S	H	-0.3120
23	C	H	0.0000
24	A	H	-0.2196
25	A	H	0.0000
26	S	H	-1.0068
27	G	H	-1.2183
28	F	H	-0.6752
29	T	H	-0.6603
30	F	H	0.0000
35	S	H	-1.2284
36	R	H	-1.8547
37	Y	H	-0.6347
38	A	H	-0.4211
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6028
45	A	H	-1.0011
46	P	H	-0.7996
47	G	H	-1.4591
48	K	H	-2.2740
49	G	H	-1.4117
50	L	H	0.0000
51	E	H	-0.9746
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	T	H	-0.0376
56	I	H	0.0000
57	S	H	-0.2182
58	S	H	-0.7802
59	G	H	-0.8329
62	G	H	-0.2603
63	S	H	0.1977
64	Y	H	0.8581
65	T	H	0.1111
66	N	H	-0.8313
67	Y	H	-1.2074
68	A	H	-1.6269
69	D	H	-2.5622
70	S	H	-1.7732
71	V	H	0.0000
72	K	H	-2.5810
74	G	H	-1.6790
75	R	H	-1.4982
76	F	H	0.0000
77	T	H	-0.8800
78	I	H	0.0000
79	S	H	-0.2702
80	R	H	-0.7458
81	D	H	-0.9193
82	N	H	-0.9264
83	V	H	0.4119
84	K	H	-1.4289
85	N	H	-1.1945
86	T	H	-0.6865
87	L	H	0.0000
88	Y	H	-0.4631
89	L	H	0.0000
90	Q	H	-1.0214
91	M	H	0.0000
92	N	H	-1.2611
93	S	H	-1.2032
94	L	H	0.0000
95	R	H	-2.1122
96	A	H	-1.6147
97	E	H	-2.1927
98	D	H	0.0000
99	T	H	-0.3066
100	A	H	0.0000
101	V	H	0.9300
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	A	H	-0.0751
108	T	H	-0.2666
109	A	H	-0.9887
110	R	H	-1.8177
112	A	H	-0.8096
113	T	H	-0.3424
114	E	H	0.0000
115	F	H	0.0000
116	A	H	0.0696
117	Y	H	0.3143
118	W	H	-0.2163
119	G	H	0.0000
120	Q	H	-1.2047
121	G	H	-0.1859
122	T	H	0.6064
123	L	H	1.6461
124	V	H	0.0000
125	T	H	0.4022
126	V	H	0.0000
127	S	H	-0.6989
128	S	H	-0.5549
1	D	L	-2.0796
2	I	L	0.0000
3	Q	L	-2.0697
4	M	L	0.0000
5	T	L	-1.0521
6	Q	L	-0.8793
7	S	L	-0.5416
8	P	L	-0.5288
9	S	L	-0.7003
10	S	L	-0.8833
11	L	L	-0.5287
12	S	L	-0.7246
13	A	L	0.0000
14	S	L	-0.1575
15	V	L	0.7105
16	G	L	-0.3969
17	D	L	-1.3704
18	R	L	-2.0489
19	V	L	0.0000
20	T	L	-0.5694
21	I	L	0.0000
22	T	L	-0.6669
23	C	L	0.0000
24	Q	L	-2.0106
25	A	L	0.0000
26	S	L	-1.9160
27	Q	L	-2.3211
28	D	L	-2.2031
29	I	L	0.0000
36	S	L	-0.8276
37	N	L	-0.6155
38	Y	L	0.0095
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.9154
44	Q	L	0.0000
45	K	L	-1.5082
46	P	L	-1.1049
47	G	L	-1.5997
48	K	L	-2.5005
49	A	L	-1.5307
50	P	L	0.0000
51	K	L	-1.5214
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1285
56	Y	L	0.0759
57	T	L	0.0000
65	S	L	-0.6956
66	R	L	-1.2612
67	L	L	-0.3361
68	H	L	-0.6142
69	S	L	-0.5537
70	G	L	-0.5119
71	V	L	-0.3493
72	P	L	-0.3354
74	S	L	-0.3776
75	R	L	-0.7245
76	F	L	0.0000
77	S	L	-0.5063
78	G	L	-0.4281
79	S	L	-0.7827
80	G	L	-0.9828
83	S	L	-1.1345
84	G	L	-1.4550
85	T	L	-1.8650
86	D	L	-2.1210
87	Y	L	0.0000
88	T	L	-0.6357
89	L	L	0.0000
90	T	L	-0.5841
91	I	L	0.0000
92	S	L	-1.1542
93	S	L	-0.9477
94	L	L	0.0000
95	Q	L	-0.4996
96	P	L	-0.5775
97	E	L	-1.8579
98	D	L	0.0000
99	F	L	-0.4553
100	A	L	0.0000
101	T	L	-0.8335
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	G	L	0.0000
108	N	L	-0.6020
109	T	L	-0.2499
114	L	L	0.0949
115	P	L	-0.6898
116	L	L	0.0000
117	T	L	-0.6531
118	F	L	-0.3229
119	G	L	0.0000
120	G	L	-1.1503
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.2129
124	V	L	0.0000
125	E	L	-0.9226
126	I	L	0.7059
127	K	L	-0.8523