Project name: 2250019a53bcac9

Chain sequence(s)	A: GREEEILERARELRERAEEAIRFLDENADEPWAAGPLGQMLRDIAEAIIRIAEAVELLLEPPTEERVERALELIAEAWALALAAILELLLVKKVEVKRKQNGDDSPPTQEEIEAAREEAEKMREEFEKLLEEVKKEGPLTEVEHVLKLLEKFLKYLDKIIELAEELASIDPDNELAKNILEAAKKLKELFEKLIEELKKSPEWLLVLAETVLEAAETLYDLIVKPALEAYKA
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:02)

• Minimal score value: -4.4801
• Maximal score value: 0.0
• Average score: -1.4806
• Total score value: -343.49

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	G	A	-2.5813
2	R	A	-3.1091
3	E	A	-4.0250
4	E	A	-4.2678
5	E	A	-4.3774
6	I	A	0.0000
7	L	A	-3.2806
8	E	A	-4.3100
9	R	A	-3.7588
10	A	A	0.0000
11	R	A	-4.2632
12	E	A	-4.3148
13	L	A	0.0000
14	R	A	-3.8624
15	E	A	-4.1541
16	R	A	-3.5636
17	A	A	0.0000
18	E	A	-3.0809
19	E	A	-3.5842
20	A	A	0.0000
21	I	A	-2.5275
22	R	A	-3.5065
23	F	A	-2.4891
24	L	A	0.0000
25	D	A	-3.4842
26	E	A	-3.4051
27	N	A	-2.7009
28	A	A	-2.4478
29	D	A	-2.7461
30	E	A	-2.0764
31	P	A	-1.0040
32	W	A	-0.4456
33	A	A	-1.1518
34	A	A	-0.9350
35	G	A	-0.3295
36	P	A	-0.5837
37	L	A	-0.1642
38	G	A	0.0000
39	Q	A	-0.8187
40	M	A	0.0000
41	L	A	0.0000
42	R	A	-1.1443
43	D	A	-0.6796
44	I	A	0.0000
45	A	A	0.0000
46	E	A	-0.9785
47	A	A	0.0000
48	I	A	0.0000
49	I	A	-1.6142
50	R	A	-1.4458
51	I	A	0.0000
52	A	A	0.0000
53	E	A	-1.5113
54	A	A	0.0000
55	V	A	0.0000
56	E	A	-1.3003
57	L	A	-0.6303
58	L	A	0.0000
59	L	A	-0.8937
60	E	A	-1.4613
61	P	A	-0.9711
62	P	A	-1.4254
63	T	A	-2.1176
64	E	A	-3.1297
65	E	A	-3.3285
66	R	A	-2.8229
67	V	A	0.0000
68	E	A	0.0000
69	R	A	-1.7138
70	A	A	0.0000
71	L	A	0.0000
72	E	A	-0.9291
73	L	A	-0.2154
74	I	A	0.0000
75	A	A	0.0000
76	E	A	-1.0662
77	A	A	0.0000
78	W	A	0.0000
79	A	A	0.0000
80	L	A	0.0000
81	A	A	0.0000
82	L	A	0.0000
83	A	A	0.0000
84	A	A	0.0000
85	I	A	0.0000
86	L	A	0.0000
87	E	A	0.0000
88	L	A	0.0000
89	L	A	0.0000
90	L	A	-0.2189
91	V	A	0.0000
92	K	A	-0.4178
93	K	A	-0.6433
94	V	A	-0.6361
95	E	A	-1.6173
96	V	A	-1.5917
97	K	A	-2.2901
98	R	A	-2.8783
99	K	A	-3.3060
100	Q	A	-3.1084
101	N	A	-3.1708
102	G	A	-3.1104
103	D	A	-3.6962
104	D	A	-3.4741
105	S	A	-1.9406
106	P	A	-1.3788
107	P	A	0.0000
108	T	A	-1.5185
109	Q	A	-2.4487
110	E	A	-2.9868
111	E	A	-2.0281
112	I	A	-1.9770
113	E	A	-2.8343
114	A	A	-2.3628
115	A	A	0.0000
116	R	A	-3.0793
117	E	A	-3.6595
118	E	A	-2.9914
119	A	A	0.0000
120	E	A	-3.3558
121	K	A	-3.7854
122	M	A	0.0000
123	R	A	-2.8197
124	E	A	-3.2250
125	E	A	-2.8259
126	F	A	0.0000
127	E	A	-3.0428
128	K	A	-3.6462
129	L	A	-2.5856
130	L	A	0.0000
131	E	A	-4.3769
132	E	A	-4.4801
133	V	A	0.0000
134	K	A	-4.0537
135	K	A	-4.1970
136	E	A	-3.7443
137	G	A	-2.5938
138	P	A	-2.0563
139	L	A	0.0000
140	T	A	-1.4016
141	E	A	-1.3629
142	V	A	-1.3003
143	E	A	-2.2294
144	H	A	0.0000
145	V	A	0.0000
146	L	A	-1.6745
147	K	A	-1.3883
148	L	A	0.0000
149	L	A	0.0000
150	E	A	-2.2014
151	K	A	-1.7623
152	F	A	0.0000
153	L	A	-2.1114
154	K	A	-2.4606
155	Y	A	0.0000
156	L	A	0.0000
157	D	A	-2.1229
158	K	A	-1.9843
159	I	A	0.0000
160	I	A	-2.1152
161	E	A	-2.5794
162	L	A	-1.5800
163	A	A	0.0000
164	E	A	-2.4308
165	E	A	-1.7354
166	L	A	0.0000
167	A	A	-1.6554
168	S	A	-0.9903
169	I	A	-0.8608
170	D	A	-1.8454
171	P	A	-1.9076
172	D	A	-2.6788
173	N	A	-2.2540
174	E	A	-2.7244
175	L	A	-1.4374
176	A	A	0.0000
177	K	A	-2.4654
178	N	A	-1.7988
179	I	A	0.0000
180	L	A	-1.9938
181	E	A	-2.3362
182	A	A	0.0000
183	A	A	0.0000
184	K	A	-2.5722
185	K	A	-2.4753
186	L	A	0.0000
187	K	A	-2.8556
188	E	A	-3.3465
189	L	A	0.0000
190	F	A	0.0000
191	E	A	-3.3593
192	K	A	-3.4873
193	L	A	0.0000
194	I	A	-2.6084
195	E	A	-3.4829
196	E	A	-2.8899
197	L	A	0.0000
198	K	A	-3.2543
199	K	A	-3.2207
200	S	A	-2.2181
201	P	A	-1.7070
202	E	A	-1.8225
203	W	A	-1.1638
204	L	A	-0.1315
205	L	A	-0.6699
206	V	A	-0.2751
207	L	A	0.0000
208	A	A	0.0000
209	E	A	-1.0115
210	T	A	-0.6379
211	V	A	0.0000
212	L	A	0.0000
213	E	A	-1.1000
214	A	A	0.0000
215	A	A	0.0000
216	E	A	-1.2475
217	T	A	-1.0032
218	L	A	0.0000
219	Y	A	0.0000
220	D	A	-1.5408
221	L	A	-0.8335
222	I	A	0.0000
223	V	A	0.0000
224	K	A	-1.5294
225	P	A	-1.3044
226	A	A	-0.9936
227	L	A	0.0000
228	E	A	-1.8119
229	A	A	-1.0906
230	Y	A	-0.8024
231	K	A	-1.8703
232	A	A	-0.9017