| Chain sequence(s) |
A: ANPNYFTYFRYGNNLGLTPIENYADQFRIEAGGKLNSVKPVVPTTATDAKDGLSSSLKWEVELKHNPNNTKATINESTGQITITGLKQGQCGMMVMVTATAGEGKTAVSVKQPVFFHFSMISDSNVQLEYTPFVFQVNPARGGESIAPSSLGAGIDKSSTFRLDYRRDFFYYNIAGPDSHISGALAQKVDNFLSEMWNSYDATAGTSRKPMSYFENTTNLSKALGYIDQTDFKVHINPNLWRNKDGYANGAMIGQITYDVTGKDPQAATSGARVSSPIFIWFDTKFLEHHHHH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:18)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:18)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:18)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:18)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:18)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:22)
[INFO] Main: Simulation completed successfully. (00:05:25)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 422 | A | A | -0.0938 | |
| 423 | N | A | -0.5467 | |
| 424 | P | A | -1.0044 | |
| 425 | N | A | -1.0364 | |
| 426 | Y | A | 0.1454 | |
| 427 | F | A | 0.0000 | |
| 428 | T | A | 0.0598 | |
| 429 | Y | A | -0.0423 | |
| 430 | F | A | 0.0000 | |
| 431 | R | A | -0.3170 | |
| 432 | Y | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | N | A | -0.7299 | |
| 435 | N | A | -0.8108 | |
| 436 | L | A | -0.3424 | |
| 437 | G | A | -0.5211 | |
| 438 | L | A | -0.3676 | |
| 439 | T | A | -0.4834 | |
| 440 | P | A | -0.7868 | |
| 441 | I | A | -0.9186 | |
| 442 | E | A | -1.9119 | |
| 443 | N | A | -1.3219 | |
| 444 | Y | A | 0.0000 | |
| 445 | A | A | 0.0000 | |
| 446 | D | A | 0.0000 | |
| 447 | Q | A | 0.0000 | |
| 448 | F | A | 0.0000 | |
| 449 | R | A | 0.0000 | |
| 450 | I | A | 0.0000 | |
| 451 | E | A | -2.0896 | |
| 452 | A | A | -0.9935 | |
| 453 | G | A | -1.0836 | |
| 454 | G | A | -1.9962 | |
| 455 | K | A | -2.6166 | |
| 456 | L | A | -2.0680 | |
| 457 | N | A | -1.9844 | |
| 458 | S | A | -1.6106 | |
| 459 | V | A | -1.1469 | |
| 460 | K | A | -0.7419 | |
| 461 | P | A | 0.0000 | |
| 462 | V | A | 0.8953 | |
| 463 | P | A | 0.0000 | |
| 464 | T | A | 0.2899 | |
| 465 | A | A | -0.0926 | |
| 466 | T | A | -0.6079 | |
| 467 | D | A | -0.9798 | |
| 468 | A | A | -1.4331 | |
| 469 | K | A | -2.6412 | |
| 470 | D | A | -2.8311 | |
| 471 | G | A | -1.5251 | |
| 472 | L | A | -0.5494 | |
| 473 | S | A | -0.8914 | |
| 474 | S | A | -1.2509 | |
| 475 | L | A | 0.0000 | |
| 476 | K | A | -2.4340 | |
| 477 | W | A | 0.0000 | |
| 478 | E | A | -2.3183 | |
| 479 | V | A | -1.5370 | |
| 480 | E | A | -2.0029 | |
| 481 | L | A | -1.2635 | |
| 482 | K | A | -1.0457 | |
| 483 | H | A | 0.0000 | |
| 484 | N | A | -1.6323 | |
| 485 | P | A | -1.6799 | |
| 486 | N | A | -2.2288 | |
| 487 | N | A | -2.6024 | |
| 488 | T | A | 0.0000 | |
| 489 | K | A | -2.5205 | |
| 490 | A | A | -1.1175 | |
| 491 | T | A | -1.1364 | |
| 492 | I | A | -1.2306 | |
| 493 | N | A | -2.0458 | |
| 494 | E | A | -2.9970 | |
| 495 | S | A | -1.8800 | |
| 496 | T | A | -0.9297 | |
| 497 | G | A | 0.0000 | |
| 498 | Q | A | -0.7520 | |
| 499 | I | A | 0.0000 | |
| 500 | T | A | -0.7741 | |
| 501 | I | A | 0.0000 | |
| 502 | T | A | -1.5635 | |
| 503 | G | A | -1.8281 | |
| 504 | L | A | 0.0000 | |
| 505 | K | A | -2.4198 | |
| 506 | Q | A | -1.8840 | |
| 507 | G | A | 0.0000 | |
| 508 | Q | A | -1.0991 | |
| 509 | C | A | 0.0000 | |
| 510 | G | A | 0.0000 | |
| 511 | M | A | 0.0000 | |
| 512 | V | A | 0.0000 | |
| 513 | M | A | -0.9916 | |
| 514 | V | A | 0.0000 | |
| 515 | T | A | 0.0000 | |
| 516 | A | A | 0.0000 | |
| 517 | T | A | -1.0854 | |
| 518 | A | A | 0.0000 | |
| 519 | G | A | -1.9335 | |
| 520 | E | A | -2.7661 | |
| 521 | G | A | -2.2461 | |
| 522 | K | A | -2.3859 | |
| 523 | T | A | -1.5871 | |
| 524 | A | A | -1.4926 | |
| 525 | V | A | -0.4110 | |
| 526 | S | A | -0.6163 | |
| 527 | V | A | -0.5017 | |
| 528 | K | A | -1.6595 | |
| 529 | Q | A | -0.7578 | |
| 530 | P | A | 0.0000 | |
| 531 | V | A | 0.0000 | |
| 532 | F | A | 0.0000 | |
| 533 | F | A | 0.0000 | |
| 534 | H | A | 0.0000 | |
| 535 | F | A | 0.0000 | |
| 536 | S | A | 0.0000 | |
| 537 | M | A | -0.2336 | |
| 538 | I | A | 0.8140 | |
| 539 | S | A | -0.4347 | |
| 540 | D | A | -1.6339 | |
| 541 | S | A | -1.2196 | |
| 542 | N | A | -1.2813 | |
| 543 | V | A | 0.0000 | |
| 544 | Q | A | -0.1458 | |
| 545 | L | A | 0.0000 | |
| 546 | E | A | -0.0985 | |
| 547 | Y | A | 0.0000 | |
| 548 | T | A | 0.1480 | |
| 549 | P | A | 0.1720 | |
| 550 | F | A | 0.0000 | |
| 551 | V | A | 0.0000 | |
| 552 | F | A | -0.0727 | |
| 553 | Q | A | -0.6406 | |
| 554 | V | A | 0.0000 | |
| 555 | N | A | -1.1453 | |
| 556 | P | A | 0.0000 | |
| 557 | A | A | -1.5201 | |
| 558 | R | A | -2.0581 | |
| 559 | G | A | 0.0000 | |
| 560 | G | A | -1.7452 | |
| 561 | E | A | -2.0097 | |
| 562 | S | A | 0.0000 | |
| 563 | I | A | 0.3662 | |
| 564 | A | A | -0.3061 | |
| 565 | P | A | -0.2340 | |
| 566 | S | A | -0.4745 | |
| 567 | L | A | -0.6550 | |
| 568 | G | A | -0.6606 | |
| 569 | A | A | -0.6630 | |
| 570 | G | A | -1.1893 | |
| 571 | I | A | -1.5234 | |
| 572 | D | A | -2.4971 | |
| 573 | K | A | -2.6822 | |
| 574 | S | A | -1.6705 | |
| 575 | T | A | -1.4885 | |
| 576 | F | A | 0.0000 | |
| 577 | R | A | -1.5156 | |
| 578 | L | A | 0.0000 | |
| 579 | D | A | 0.0000 | |
| 580 | Y | A | 0.0000 | |
| 581 | R | A | -1.3512 | |
| 582 | R | A | -1.7366 | |
| 583 | D | A | -2.1020 | |
| 584 | F | A | 0.0000 | |
| 585 | F | A | 0.0000 | |
| 586 | Y | A | 0.0000 | |
| 587 | Y | A | 0.0000 | |
| 588 | N | A | -0.2427 | |
| 589 | I | A | -0.2682 | |
| 590 | A | A | -0.4344 | |
| 591 | G | A | -0.6493 | |
| 592 | P | A | -1.0947 | |
| 593 | D | A | -1.7052 | |
| 594 | S | A | -0.8741 | |
| 595 | H | A | 0.0000 | |
| 596 | I | A | 0.4982 | |
| 597 | S | A | 0.0151 | |
| 598 | G | A | 0.0542 | |
| 599 | A | A | -0.1910 | |
| 600 | L | A | -0.9580 | |
| 601 | A | A | -1.1801 | |
| 602 | Q | A | -1.9677 | |
| 603 | K | A | -2.1560 | |
| 604 | V | A | -0.7827 | |
| 605 | D | A | -1.7472 | |
| 606 | N | A | 0.0000 | |
| 607 | F | A | 0.0000 | |
| 608 | L | A | 0.0000 | |
| 609 | S | A | -1.3927 | |
| 610 | E | A | -1.6665 | |
| 611 | M | A | 0.0000 | |
| 612 | W | A | 0.0000 | |
| 613 | N | A | -2.0179 | |
| 614 | S | A | -1.2029 | |
| 615 | Y | A | -1.2042 | |
| 616 | D | A | -1.5082 | |
| 617 | A | A | -1.1078 | |
| 618 | T | A | -0.8186 | |
| 619 | A | A | 0.0000 | |
| 620 | G | A | -1.3865 | |
| 621 | T | A | -1.1485 | |
| 622 | S | A | -0.8310 | |
| 623 | R | A | 0.0000 | |
| 624 | K | A | -0.9671 | |
| 625 | P | A | 0.0000 | |
| 626 | M | A | 0.0000 | |
| 627 | S | A | 0.0000 | |
| 628 | Y | A | -0.0422 | |
| 629 | F | A | -0.4320 | |
| 630 | E | A | -0.6928 | |
| 631 | N | A | 0.0000 | |
| 632 | T | A | -0.3057 | |
| 633 | T | A | -0.4399 | |
| 634 | N | A | -0.8967 | |
| 635 | L | A | -0.5716 | |
| 636 | S | A | -1.0550 | |
| 637 | K | A | -1.7661 | |
| 638 | A | A | 0.0000 | |
| 639 | L | A | 0.0000 | |
| 640 | G | A | 0.0000 | |
| 641 | Y | A | -0.4094 | |
| 642 | I | A | 0.0000 | |
| 643 | D | A | -0.8262 | |
| 644 | Q | A | -0.9219 | |
| 645 | T | A | -1.1803 | |
| 646 | D | A | -1.5676 | |
| 647 | F | A | 0.0000 | |
| 648 | K | A | -0.9815 | |
| 649 | V | A | 0.0000 | |
| 650 | H | A | -0.9190 | |
| 651 | I | A | 0.0000 | |
| 652 | N | A | -1.4274 | |
| 653 | P | A | -1.8813 | |
| 654 | N | A | -1.8501 | |
| 655 | L | A | -1.0652 | |
| 656 | W | A | 0.0000 | |
| 657 | R | A | -1.8347 | |
| 658 | N | A | -2.1261 | |
| 659 | K | A | -2.6515 | |
| 660 | D | A | -2.6783 | |
| 661 | G | A | -1.5652 | |
| 662 | Y | A | -0.9166 | |
| 663 | A | A | 0.0000 | |
| 664 | N | A | -0.3789 | |
| 665 | G | A | 0.0000 | |
| 666 | A | A | 0.0000 | |
| 667 | M | A | 0.0000 | |
| 668 | I | A | 0.0000 | |
| 669 | G | A | 0.0000 | |
| 670 | Q | A | -1.1225 | |
| 671 | I | A | 0.0000 | |
| 672 | T | A | 0.0000 | |
| 673 | Y | A | 0.0000 | |
| 674 | D | A | -1.2697 | |
| 675 | V | A | -1.1597 | |
| 676 | T | A | -0.9563 | |
| 677 | G | A | -1.6467 | |
| 678 | K | A | -2.3381 | |
| 679 | D | A | -1.9628 | |
| 680 | P | A | 0.0000 | |
| 681 | Q | A | -1.2834 | |
| 682 | A | A | -0.7545 | |
| 683 | A | A | -0.7965 | |
| 684 | T | A | -0.6119 | |
| 685 | S | A | -0.6807 | |
| 686 | G | A | -0.7651 | |
| 687 | A | A | 0.0000 | |
| 688 | R | A | -1.0239 | |
| 689 | V | A | 0.0000 | |
| 690 | S | A | 0.0000 | |
| 691 | P | A | 0.0000 | |
| 692 | I | A | 0.0000 | |
| 693 | F | A | 0.0000 | |
| 694 | I | A | 0.0000 | |
| 695 | W | A | 0.0918 | |
| 696 | F | A | 0.0000 | |
| 697 | D | A | 0.0000 | |
| 698 | T | A | -0.8297 | |
| 699 | K | A | -1.2989 | |
| 700 | F | A | -0.6725 | |
| 701 | L | A | -0.2331 | |
| 702 | E | A | -2.0381 | |
| 703 | H | A | -2.2666 | |
| 704 | H | A | -2.7715 | |
| 705 | H | A | -2.6934 | |
| 706 | H | A | -2.3702 | |
| 707 | H | A | -2.2075 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine