| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTEYQHDGADVRVAFSFDPKQTQLFIVGCEPPTGEHWDIAPPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFHVRAGPEGHPLPAAPPPSPLFVPPPPGSPYAVPPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9418 | |
| 2 | L | A | 1.9641 | |
| 3 | P | A | 0.6597 | |
| 4 | P | A | 0.3706 | |
| 5 | T | A | 0.1207 | |
| 6 | T | A | 0.1309 | |
| 7 | P | A | 0.1647 | |
| 8 | V | A | 1.2402 | |
| 9 | A | A | 0.0892 | |
| 10 | K | A | -1.0147 | |
| 11 | V | A | -0.1455 | |
| 12 | Q | A | -1.3942 | |
| 13 | S | A | -1.5445 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4140 | |
| 16 | E | A | -2.4348 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4606 | |
| 20 | P | A | 0.1287 | |
| 21 | T | A | 0.1589 | |
| 22 | S | A | -0.0967 | |
| 23 | L | A | 0.0934 | |
| 24 | F | A | -0.0290 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2813 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8944 | |
| 31 | R | A | -2.6827 | |
| 32 | L | A | -0.8031 | |
| 33 | L | A | 1.1576 | |
| 34 | T | A | 1.3686 | |
| 35 | V | A | 1.8324 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2283 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6158 | |
| 40 | K | A | -1.6343 | |
| 41 | D | A | -0.9343 | |
| 42 | I | A | 0.8206 | |
| 43 | V | A | 1.0144 | |
| 44 | K | A | -1.1814 | |
| 45 | N | A | -1.9292 | |
| 46 | G | A | -1.2315 | |
| 47 | K | A | -0.9812 | |
| 48 | V | A | 1.4294 | |
| 49 | V | A | 2.0177 | |
| 50 | V | A | 1.2349 | |
| 51 | P | A | 0.4265 | |
| 52 | K | A | -0.6457 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1465 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3972 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2724 | |
| 70 | K | A | -1.7915 | |
| 71 | F | A | -0.6387 | |
| 72 | A | A | -0.5731 | |
| 73 | L | A | -0.8650 | |
| 74 | P | A | -1.2746 | |
| 75 | Q | A | -2.5038 | |
| 76 | K | A | -3.1066 | |
| 77 | D | A | -2.9922 | |
| 78 | F | A | -1.6701 | |
| 79 | Y | A | -1.8867 | |
| 80 | D | A | -2.6917 | |
| 81 | P | A | -2.3125 | |
| 82 | E | A | -3.0526 | |
| 83 | K | A | -3.3996 | |
| 84 | E | A | -2.4652 | |
| 85 | R | A | -1.2936 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6532 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9700 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3604 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6982 | |
| 99 | G | A | -0.5390 | |
| 100 | P | A | -0.4062 | |
| 101 | L | A | 0.0419 | |
| 102 | G | A | -0.2011 | |
| 103 | K | A | -0.5859 | |
| 104 | G | A | -0.4343 | |
| 105 | T | A | -0.4360 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1547 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4573 | |
| 110 | L | A | 0.4817 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9277 | |
| 113 | K | A | -0.2578 | |
| 114 | L | A | -1.1128 | |
| 115 | G | A | -1.1699 | |
| 116 | D | A | -1.4422 | |
| 117 | T | A | -1.0311 | |
| 118 | E | A | -1.7223 | |
| 119 | N | A | -2.1785 | |
| 120 | P | A | -1.8875 | |
| 121 | T | A | -1.5329 | |
| 122 | E | A | -2.1462 | |
| 123 | Y | A | -0.7207 | |
| 124 | Q | A | -1.2659 | |
| 125 | H | A | -1.7918 | |
| 126 | D | A | -2.7319 | |
| 127 | G | A | -2.0316 | |
| 128 | A | A | -1.3909 | |
| 129 | D | A | -2.0761 | |
| 130 | V | A | -1.2928 | |
| 131 | R | A | -0.6969 | |
| 132 | V | A | 0.4889 | |
| 133 | A | A | 0.4781 | |
| 134 | F | A | 0.3050 | |
| 135 | S | A | -0.0617 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4368 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5580 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2157 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1602 | |
| 157 | D | A | 0.5035 | |
| 158 | I | A | 1.2272 | |
| 159 | A | A | 0.9105 | |
| 160 | P | A | 0.0666 | |
| 161 | P | A | 0.4348 | |
| 162 | C | A | 0.5062 | |
| 163 | P | A | 0.0070 | |
| 164 | G | A | -0.0838 | |
| 165 | L | A | 0.5861 | |
| 166 | P | A | -0.1029 | |
| 167 | P | A | -0.3343 | |
| 168 | G | A | -0.4191 | |
| 169 | A | A | -0.0179 | |
| 170 | C | A | 0.7390 | |
| 171 | P | A | 0.7825 | |
| 172 | P | A | 1.1310 | |
| 173 | I | A | 2.3513 | |
| 174 | Q | A | 1.2376 | |
| 175 | L | A | 1.5072 | |
| 176 | V | A | 0.8505 | |
| 177 | N | A | -0.3085 | |
| 178 | S | A | 0.0115 | |
| 179 | V | A | 0.4274 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3791 | |
| 182 | D | A | 0.0794 | |
| 183 | G | A | -0.1574 | |
| 184 | D | A | -0.5399 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1106 | |
| 190 | F | A | 0.0581 | |
| 191 | G | A | -0.1058 | |
| 192 | N | A | -0.2660 | |
| 193 | M | A | -0.1163 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3891 | |
| 197 | E | A | -2.6109 | |
| 198 | L | A | -1.2198 | |
| 199 | Q | A | -2.5474 | |
| 200 | Q | A | -3.3205 | |
| 201 | D | A | -3.5860 | |
| 202 | R | A | -3.3249 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2120 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3536 | |
| 211 | S | A | -1.8809 | |
| 212 | T | A | -1.4371 | |
| 213 | R | A | -2.0928 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1584 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3518 | |
| 220 | L | A | 0.6205 | |
| 221 | K | A | -1.0789 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8040 | |
| 224 | N | A | -1.4817 | |
| 225 | E | A | -1.2248 | |
| 226 | A | A | -0.5986 | |
| 227 | Y | A | -0.3650 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6532 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0795 | |
| 234 | F | A | 0.2637 | |
| 235 | G | A | -0.8043 | |
| 236 | R | A | -2.5762 | |
| 237 | R | A | -2.8114 | |
| 238 | E | A | -2.1042 | |
| 239 | Q | A | -0.1786 | |
| 240 | V | A | 1.4253 | |
| 241 | Y | A | 1.1566 | |
| 242 | A | A | 0.3036 | |
| 243 | R | A | -0.7501 | |
| 244 | H | A | -0.8877 | |
| 245 | F | A | 0.1021 | |
| 246 | H | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.8678 | |
| 249 | A | A | -1.3946 | |
| 250 | G | A | -1.1956 | |
| 251 | P | A | -1.1935 | |
| 252 | E | A | -1.3698 | |
| 253 | G | A | -1.2855 | |
| 254 | H | A | -1.4737 | |
| 255 | P | A | -0.9928 | |
| 256 | L | A | 0.4294 | |
| 257 | P | A | 0.0791 | |
| 258 | A | A | -0.0507 | |
| 259 | A | A | 0.4345 | |
| 260 | P | A | -0.2063 | |
| 261 | P | A | -0.1166 | |
| 262 | P | A | 0.0973 | |
| 263 | S | A | 0.6592 | |
| 264 | P | A | 0.7591 | |
| 265 | L | A | 2.0451 | |
| 266 | F | A | 1.9992 | |
| 267 | V | A | 2.0746 | |
| 268 | P | A | 1.2122 | |
| 269 | P | A | 0.6420 | |
| 270 | P | A | -0.1928 | |
| 271 | P | A | -0.5122 | |
| 272 | G | A | -0.3617 | |
| 273 | S | A | 0.1343 | |
| 274 | P | A | 0.4273 | |
| 275 | Y | A | 1.3820 | |
| 276 | A | A | 1.1068 | |
| 277 | V | A | 1.8933 | |
| 278 | P | A | 0.9818 | |
| 279 | P | A | -0.2628 | |
| 280 | P | A | -0.8018 | |
| 281 | T | A | -0.5135 | |
| 282 | D | A | -1.1579 | |
| 283 | Y | A | 0.7213 | |
| 284 | F | A | 0.6241 | |
| 285 | G | A | 0.2851 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9529 | |
| 291 | L | A | 1.6270 | |
| 292 | V | A | 0.6483 | |
| 293 | S | A | -0.1553 | |
| 294 | S | A | -0.9614 | |
| 295 | D | A | -1.8414 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0954 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6486 | |
| 301 | R | A | -1.8661 | |
| 302 | P | A | -0.9809 | |
| 303 | F | A | -0.1981 | |
| 304 | W | A | -0.5682 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0824 | |
| 307 | R | A | -2.8303 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2502 | |
| 310 | G | A | -1.2199 | |
| 311 | N | A | -1.2648 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7849 | |
| 319 | N | A | -0.8418 | |
| 320 | E | A | -1.0300 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3350 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0801 | |
| 333 | N | A | 0.5383 | |
| 334 | F | A | 1.7074 | |
| 335 | T | A | 0.8453 | |
| 336 | I | A | 0.4351 | |
| 337 | S | A | -0.8084 | |
| 338 | Q | A | -1.4277 | |
| 339 | Q | A | -1.0842 | |
| 340 | L | A | 0.5770 | |
| 341 | C | A | -0.0747 | |
| 342 | T | A | -0.4647 | |
| 343 | P | A | -1.1905 | |
| 344 | E | A | -1.7413 | |
| 345 | P | A | -0.7340 | |
| 346 | N | A | -0.7527 | |
| 347 | V | A | 1.2961 | |
| 348 | Y | A | 1.2317 | |
| 349 | D | A | 0.0274 | |
| 350 | P | A | -0.3386 | |
| 351 | S | A | -0.2660 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5271 | |
| 354 | K | A | -1.6162 | |
| 355 | N | A | -1.6810 | |
| 356 | Y | A | -0.0963 | |
| 357 | L | A | 0.6254 | |
| 358 | R | A | 0.9555 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3805 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0827 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0423 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6866 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3051 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3126 | |
| 376 | L | A | -1.7077 | |
| 377 | D | A | -1.9810 | |
| 378 | P | A | -1.0327 | |
| 379 | G | A | -1.0092 | |
| 380 | V | A | -0.9260 | |
| 381 | L | A | -0.5249 | |
| 382 | A | A | -0.6500 | |
| 383 | H | A | -0.8030 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4001 | |
| 386 | T | A | -0.5433 | |
| 387 | M | A | -0.2928 | |
| 388 | N | A | -0.8601 | |
| 389 | P | A | -1.2314 | |
| 390 | T | A | -1.4163 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4174 | |
| 393 | E | A | -2.7450 | |
| 394 | N | A | -2.4900 | |
| 395 | W | A | -1.3519 | |
| 396 | N | A | -1.1087 | |
| 397 | L | A | -0.1886 | |
| 398 | G | A | 0.5365 | |
| 399 | F | A | 2.4100 | |
| 400 | V | A | 1.8106 | |
| 401 | P | A | 0.0417 | |
| 402 | P | A | -1.8229 | |
| 403 | K | A | -3.3023 | |
| 404 | E | A | -3.8138 | |
| 405 | R | A | -3.8272 | |
| 406 | E | A | -3.7492 | |
| 407 | D | A | -2.8554 | |
| 408 | P | A | -1.7530 | |
| 409 | Y | A | -0.9847 | |
| 410 | K | A | -2.1137 | |
| 411 | G | A | -0.6382 | |
| 412 | L | A | 0.6729 | |
| 413 | I | A | 1.5863 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3948 | |
| 416 | E | A | -1.6935 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9461 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0466 | |
| 421 | E | A | -2.7705 | |
| 422 | R | A | -2.6115 | |
| 423 | F | A | -1.2676 | |
| 424 | S | A | -1.4578 | |
| 425 | Q | A | -1.8675 | |
| 426 | D | A | -2.8952 | |
| 427 | L | A | -1.9864 | |
| 428 | D | A | -2.7869 | |
| 429 | Q | A | -2.6220 | |
| 430 | F | A | -1.4222 | |
| 431 | A | A | -0.8907 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5550 | |
| 435 | K | A | -0.6923 | |
| 436 | F | A | 0.1550 | |
| 437 | L | A | 1.0348 | |
| 438 | Y | A | 0.8324 | |
| 439 | Q | A | -0.2704 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine