Project name: 524

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCAASGYTNRLKCMGWFRQAPGKERELASISTGTGNTYYADSVKGRFTISRDNSKNTLYLQMNSLKAEDTAVYYCAADVRPDGTTCHYNSRGQGTLVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:46)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:46)

• Minimal score value: -3.443
• Maximal score value: 1.6571
• Average score: -0.9059
• Total score value: -109.6185

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9578
2	V	H	-1.5555
3	Q	H	-1.5770
4	L	H	0.0000
5	L	H	0.6516
6	E	H	0.1037
7	S	H	-0.3877
8	G	H	-0.9425
9	G	H	0.0419
11	G	H	0.9721
12	L	H	1.5509
13	V	H	0.0701
14	Q	H	-1.3156
15	P	H	-1.7832
16	G	H	-1.4661
17	G	H	-0.9112
18	S	H	-1.0812
19	L	H	-0.8731
20	R	H	-2.0854
21	L	H	0.0000
22	S	H	-0.5063
23	C	H	0.0000
24	A	H	-0.3897
25	A	H	0.0000
26	S	H	-1.0755
27	G	H	-1.1091
28	Y	H	-0.6912
29	T	H	-1.3468
30	N	H	-2.0534
35	R	H	-2.3234
36	L	H	-1.3506
37	K	H	-1.3167
38	C	H	-0.5375
39	M	H	-0.2549
40	G	H	0.0000
41	W	H	0.0000
42	F	H	-0.2704
43	R	H	0.0000
44	Q	H	-1.2532
45	A	H	-1.2470
46	P	H	-1.1927
47	G	H	-1.7559
48	K	H	-2.9986
49	E	H	-3.1176
50	R	H	-1.8910
51	E	H	-1.1980
52	L	H	0.1028
54	A	H	0.0000
55	S	H	0.0000
56	I	H	0.0000
57	S	H	-0.6787
58	T	H	-1.1425
59	G	H	-1.1224
62	T	H	-0.7646
63	G	H	-1.0823
64	N	H	-1.2605
65	T	H	-0.1729
66	Y	H	0.4155
67	Y	H	-0.4039
68	A	H	-1.0006
69	D	H	-2.3535
70	S	H	-1.7952
71	V	H	0.0000
72	K	H	-2.4895
74	G	H	-1.7831
75	R	H	-1.8133
76	F	H	0.0000
77	T	H	-0.7792
78	I	H	0.0000
79	S	H	-0.8030
80	R	H	-1.6438
81	D	H	-2.1833
82	N	H	-2.7199
83	S	H	-2.1280
84	K	H	-2.9332
85	N	H	-2.6809
86	T	H	-1.5127
87	L	H	0.0000
88	Y	H	-0.6636
89	L	H	0.0000
90	Q	H	-1.3178
91	M	H	0.0000
92	N	H	-1.4475
93	S	H	-1.3566
94	L	H	0.0000
95	K	H	-2.5608
96	A	H	-1.8446
97	E	H	-2.3338
98	D	H	0.0000
99	T	H	-0.3789
100	A	H	0.0000
101	V	H	0.8374
102	Y	H	0.0000
103	Y	H	-0.1279
104	C	H	0.0000
105	A	H	0.0000
106	A	H	0.0000
107	D	H	0.0000
108	V	H	0.0000
109	R	H	-3.4430
110	P	H	-2.5457
111	D	H	-2.7865
111A	G	H	-1.6391
112A	T	H	-1.3913
112	T	H	-1.1081
113	C	H	-1.1983
114	H	H	-1.8827
115	Y	H	-1.4743
116	N	H	-2.0210
117	S	H	-1.7540
118	R	H	-1.7653
119	G	H	0.0000
120	Q	H	-1.1633
121	G	H	-0.1637
122	T	H	0.5531
123	L	H	1.6571
124	V	H	0.0000
125	T	H	0.3865
126	V	H	0.0000
127	S	H	-0.6586
128	S	H	-0.8720