| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTEYQIPGADDRVNFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRSGPEGHPLPADPPPSPLYTPPPPDSPYAVRPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9414 | |
| 2 | L | A | 1.9633 | |
| 3 | P | A | 0.6594 | |
| 4 | P | A | 0.3766 | |
| 5 | T | A | 0.1251 | |
| 6 | T | A | 0.1330 | |
| 7 | P | A | 0.1800 | |
| 8 | V | A | 1.2394 | |
| 9 | A | A | 0.0877 | |
| 10 | K | A | -1.0177 | |
| 11 | V | A | -0.1589 | |
| 12 | Q | A | -1.3953 | |
| 13 | S | A | -1.5486 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4224 | |
| 16 | E | A | -2.4378 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4592 | |
| 20 | P | A | 0.1285 | |
| 21 | T | A | 0.1603 | |
| 22 | S | A | -0.0965 | |
| 23 | L | A | 0.0921 | |
| 24 | F | A | -0.0323 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2828 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8968 | |
| 31 | R | A | -2.6843 | |
| 32 | L | A | -0.8014 | |
| 33 | L | A | 1.1609 | |
| 34 | T | A | 1.3722 | |
| 35 | V | A | 1.8343 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2570 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6403 | |
| 40 | K | A | -1.6962 | |
| 41 | D | A | -0.7559 | |
| 42 | I | A | 1.2495 | |
| 43 | V | A | 2.2066 | |
| 44 | V | A | 1.6512 | |
| 45 | N | A | -0.5412 | |
| 46 | G | A | -0.3665 | |
| 47 | K | A | -0.1427 | |
| 48 | V | A | 1.9983 | |
| 49 | L | A | 2.5132 | |
| 50 | V | A | 1.4258 | |
| 51 | P | A | 0.3138 | |
| 52 | K | A | -0.7022 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1627 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3932 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2705 | |
| 70 | K | A | -1.7884 | |
| 71 | F | A | -0.6359 | |
| 72 | A | A | -0.5701 | |
| 73 | L | A | -0.8565 | |
| 74 | P | A | -1.2034 | |
| 75 | Q | A | -2.5043 | |
| 76 | K | A | -3.1075 | |
| 77 | D | A | -2.9896 | |
| 78 | F | A | -1.6662 | |
| 79 | Y | A | -1.8868 | |
| 80 | D | A | -2.6868 | |
| 81 | P | A | -2.3041 | |
| 82 | E | A | -3.0481 | |
| 83 | K | A | -3.3915 | |
| 84 | E | A | -2.4577 | |
| 85 | R | A | -1.2914 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6603 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9667 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3631 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6909 | |
| 99 | G | A | -0.5223 | |
| 100 | P | A | -0.3711 | |
| 101 | L | A | 0.1110 | |
| 102 | G | A | -0.1620 | |
| 103 | K | A | -0.5678 | |
| 104 | G | A | -0.4325 | |
| 105 | T | A | -0.4466 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | -0.1038 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1594 | |
| 110 | L | A | -0.0973 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.3059 | |
| 113 | K | A | -0.6274 | |
| 114 | L | A | -0.5222 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.2543 | |
| 117 | T | A | -0.9003 | |
| 118 | E | A | -1.6550 | |
| 119 | N | A | -2.1121 | |
| 120 | P | A | -1.8193 | |
| 121 | T | A | -1.4856 | |
| 122 | E | A | -1.6946 | |
| 123 | Y | A | 0.1616 | |
| 124 | Q | A | 0.3979 | |
| 125 | I | A | 1.8253 | |
| 126 | P | A | 0.2425 | |
| 127 | G | A | -0.7876 | |
| 128 | A | A | -1.2625 | |
| 129 | D | A | -2.2326 | |
| 130 | D | A | -1.4362 | |
| 131 | R | A | -1.4020 | |
| 132 | V | A | -0.4394 | |
| 133 | N | A | -0.8963 | |
| 134 | F | A | -0.3805 | |
| 135 | S | A | -0.3669 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6865 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5572 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1851 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1321 | |
| 157 | D | A | 0.3119 | |
| 158 | I | A | 0.8328 | |
| 159 | A | A | 0.1165 | |
| 160 | E | A | -1.4787 | |
| 161 | P | A | -0.2240 | |
| 162 | C | A | 0.1876 | |
| 163 | P | A | -0.1732 | |
| 164 | G | A | -0.0790 | |
| 165 | L | A | 0.5893 | |
| 166 | P | A | -0.1131 | |
| 167 | P | A | -0.3385 | |
| 168 | G | A | -0.4225 | |
| 169 | A | A | -0.0247 | |
| 170 | C | A | 0.7439 | |
| 171 | P | A | 0.5530 | |
| 172 | P | A | 0.8415 | |
| 173 | I | A | 2.0474 | |
| 174 | Q | A | 0.8557 | |
| 175 | L | A | 1.4607 | |
| 176 | V | A | 0.8441 | |
| 177 | N | A | -0.3024 | |
| 178 | S | A | 0.0228 | |
| 179 | V | A | 0.4266 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3852 | |
| 182 | D | A | 0.0810 | |
| 183 | G | A | -0.1549 | |
| 184 | D | A | -0.5190 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1442 | |
| 190 | F | A | 0.0596 | |
| 191 | G | A | -0.1052 | |
| 192 | N | A | -0.2444 | |
| 193 | M | A | -0.0999 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3633 | |
| 197 | E | A | -2.5855 | |
| 198 | L | A | -1.1954 | |
| 199 | Q | A | -2.5378 | |
| 200 | Q | A | -3.3149 | |
| 201 | D | A | -3.5843 | |
| 202 | R | A | -3.3306 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2102 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3420 | |
| 211 | S | A | -1.8631 | |
| 212 | T | A | -1.3928 | |
| 213 | R | A | -1.9964 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1441 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3812 | |
| 220 | L | A | 0.6175 | |
| 221 | K | A | -1.0903 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8064 | |
| 224 | N | A | -1.4878 | |
| 225 | E | A | -1.2297 | |
| 226 | A | A | -0.6023 | |
| 227 | Y | A | -0.3677 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6717 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0764 | |
| 234 | F | A | 0.2565 | |
| 235 | G | A | -0.8078 | |
| 236 | R | A | -2.5831 | |
| 237 | R | A | -2.8216 | |
| 238 | E | A | -2.1097 | |
| 239 | Q | A | -0.1128 | |
| 240 | V | A | 1.5270 | |
| 241 | Y | A | 1.2942 | |
| 242 | A | A | 0.2330 | |
| 243 | R | A | -1.0939 | |
| 244 | H | A | -0.9148 | |
| 245 | F | A | 0.1202 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7887 | |
| 249 | S | A | -0.8981 | |
| 250 | G | A | -1.1098 | |
| 251 | P | A | -1.0225 | |
| 252 | E | A | -1.3958 | |
| 253 | G | A | -1.2971 | |
| 254 | H | A | -1.4656 | |
| 255 | P | A | -1.1316 | |
| 256 | L | A | -0.0013 | |
| 257 | P | A | -0.1270 | |
| 258 | A | A | -0.2029 | |
| 259 | D | A | -0.7850 | |
| 260 | P | A | -0.8849 | |
| 261 | P | A | -0.6183 | |
| 262 | P | A | -0.4808 | |
| 263 | S | A | -0.1669 | |
| 264 | P | A | 0.2734 | |
| 265 | L | A | 1.4278 | |
| 266 | Y | A | 0.7735 | |
| 267 | T | A | -0.0052 | |
| 268 | P | A | -0.0897 | |
| 269 | P | A | -0.2528 | |
| 270 | P | A | -0.8358 | |
| 271 | P | A | -0.9372 | |
| 272 | D | A | -1.7168 | |
| 273 | S | A | -0.5578 | |
| 274 | P | A | 0.3559 | |
| 275 | Y | A | 1.1490 | |
| 276 | A | A | 0.3357 | |
| 277 | V | A | 1.5085 | |
| 278 | R | A | 0.2079 | |
| 279 | P | A | 0.2082 | |
| 280 | P | A | 0.0000 | |
| 281 | T | A | -0.6906 | |
| 282 | D | A | -1.1583 | |
| 283 | Y | A | 0.7459 | |
| 284 | F | A | 0.6564 | |
| 285 | G | A | 0.2519 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9395 | |
| 291 | L | A | 1.6288 | |
| 292 | V | A | 0.6614 | |
| 293 | S | A | -0.1499 | |
| 294 | S | A | -0.9510 | |
| 295 | D | A | -1.8423 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0961 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6427 | |
| 301 | R | A | -1.8425 | |
| 302 | P | A | -0.9482 | |
| 303 | F | A | -0.1918 | |
| 304 | W | A | -0.5615 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0839 | |
| 307 | R | A | -2.8314 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2484 | |
| 310 | G | A | -1.2179 | |
| 311 | N | A | -1.2657 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7989 | |
| 319 | N | A | -0.9286 | |
| 320 | E | A | -1.0378 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3078 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0568 | |
| 333 | N | A | 0.5565 | |
| 334 | F | A | 1.7385 | |
| 335 | T | A | 0.8597 | |
| 336 | I | A | 0.4300 | |
| 337 | S | A | -0.8449 | |
| 338 | Q | A | -1.5175 | |
| 339 | Q | A | -0.9651 | |
| 340 | L | A | 0.7801 | |
| 341 | C | A | 0.4128 | |
| 342 | T | A | 0.1427 | |
| 343 | P | A | -0.2806 | |
| 344 | A | A | 0.1171 | |
| 345 | P | A | 0.1580 | |
| 346 | N | A | -0.2807 | |
| 347 | V | A | 1.5574 | |
| 348 | Y | A | 1.4680 | |
| 349 | D | A | 0.0335 | |
| 350 | P | A | -0.3102 | |
| 351 | S | A | -0.2496 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5566 | |
| 354 | K | A | -1.6509 | |
| 355 | N | A | -1.7046 | |
| 356 | Y | A | -0.0967 | |
| 357 | L | A | 0.6350 | |
| 358 | R | A | 0.9633 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3904 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0795 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0553 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6908 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3009 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3061 | |
| 376 | L | A | -1.6976 | |
| 377 | D | A | -1.9692 | |
| 378 | P | A | -1.0283 | |
| 379 | G | A | -1.0087 | |
| 380 | V | A | -0.9279 | |
| 381 | L | A | -0.5262 | |
| 382 | A | A | -0.6537 | |
| 383 | H | A | -0.8058 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4185 | |
| 386 | T | A | -0.5551 | |
| 387 | M | A | -0.3001 | |
| 388 | N | A | -0.8638 | |
| 389 | P | A | -1.2398 | |
| 390 | T | A | -1.4172 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4048 | |
| 393 | E | A | -2.7343 | |
| 394 | N | A | -2.3113 | |
| 395 | W | A | -1.3211 | |
| 396 | N | A | -1.0538 | |
| 397 | L | A | -0.1812 | |
| 398 | G | A | 0.5417 | |
| 399 | F | A | 2.4212 | |
| 400 | V | A | 1.8455 | |
| 401 | P | A | 0.0451 | |
| 402 | P | A | -1.7794 | |
| 403 | K | A | -3.3078 | |
| 404 | E | A | -3.7638 | |
| 405 | R | A | -3.8779 | |
| 406 | E | A | -3.7722 | |
| 407 | D | A | -2.8577 | |
| 408 | P | A | -1.7555 | |
| 409 | Y | A | -0.9834 | |
| 410 | K | A | -2.1073 | |
| 411 | G | A | -0.6343 | |
| 412 | L | A | 0.6798 | |
| 413 | I | A | 1.5836 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4174 | |
| 416 | E | A | -1.7409 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9593 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0471 | |
| 421 | E | A | -2.7694 | |
| 422 | R | A | -2.6079 | |
| 423 | F | A | -1.2698 | |
| 424 | S | A | -1.4641 | |
| 425 | Q | A | -1.8513 | |
| 426 | D | A | -2.8949 | |
| 427 | L | A | -1.9817 | |
| 428 | D | A | -2.7615 | |
| 429 | Q | A | -2.6103 | |
| 430 | F | A | -1.4200 | |
| 431 | A | A | -0.8987 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5870 | |
| 435 | K | A | -0.7172 | |
| 436 | F | A | 0.1381 | |
| 437 | L | A | 1.0255 | |
| 438 | Y | A | 0.8241 | |
| 439 | Q | A | -0.2784 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine