Project name: 292e6601cd6ebfc

Chain sequence(s)	H: EVQLVESGGGVVQPGGSLRLSCAASGFTFNSYGMHWVRQAPGKGLEWVAFIRYDGGNKYYADSVKGRFTISRDNSKNTLYLQMKSLRAEDTAVYYCANLKDSRYSGSYYDYWGQGTLVTVS; L: VIWMTQSPSSLSASVGDRVTITCQASQDIRFYLNWYQQKPGKAPKLLISDASNMETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPFTFGPGTKVDFK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:35)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:37)

• Minimal score value: -2.5521
• Maximal score value: 1.6555
• Average score: -0.5251
• Total score value: -119.7226

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0232
2	V	H	-1.0660
3	Q	H	-1.1555
4	L	H	0.0000
5	V	H	0.6741
6	E	H	0.0000
7	S	H	-0.2164
8	G	H	-0.6601
9	G	H	0.2022
11	G	H	0.9589
12	V	H	1.6555
13	V	H	0.1302
14	Q	H	-1.2739
15	P	H	-1.7620
16	G	H	-1.6919
17	G	H	-1.2751
18	S	H	-1.6009
19	L	H	-0.8853
20	R	H	-1.8648
21	L	H	0.0000
22	S	H	-0.3335
23	C	H	0.0000
24	A	H	-0.2025
25	A	H	0.0000
26	S	H	-0.8203
27	G	H	-1.1436
28	F	H	-0.5205
29	T	H	-0.2565
30	F	H	0.0000
35	N	H	-1.2122
36	S	H	-0.2243
37	Y	H	0.5211
38	G	H	0.0000
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6585
45	A	H	-1.0505
46	P	H	-0.8282
47	G	H	-1.4751
48	K	H	-2.2117
49	G	H	-1.3458
50	L	H	0.0000
51	E	H	-0.8921
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	F	H	0.0000
56	I	H	0.0000
57	R	H	0.0000
58	Y	H	0.0544
59	D	H	-1.2604
62	G	H	-1.1425
63	G	H	-1.1346
64	N	H	-1.0196
65	K	H	-0.9932
66	Y	H	-0.2943
67	Y	H	-0.7831
68	A	H	0.0000
69	D	H	-2.1910
70	S	H	-1.7574
71	V	H	0.0000
72	K	H	-2.4068
74	G	H	-1.8099
75	R	H	-1.9510
76	F	H	0.0000
77	T	H	-1.0271
78	I	H	0.0000
79	S	H	-0.5682
80	R	H	-1.0202
81	D	H	-1.6731
82	N	H	-1.9021
83	S	H	-1.6651
84	K	H	-2.3967
85	N	H	-1.7804
86	T	H	-1.0068
87	L	H	0.0000
88	Y	H	-0.4351
89	L	H	0.0000
90	Q	H	-1.3661
91	M	H	0.0000
92	K	H	-2.4448
93	S	H	-1.7792
94	L	H	0.0000
95	R	H	-2.4968
96	A	H	-1.7276
97	E	H	-2.2632
98	D	H	0.0000
99	T	H	-0.3527
100	A	H	0.0000
101	V	H	0.6260
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	N	H	0.0000
107	L	H	0.0000
108	K	H	-0.3874
109	D	H	0.0000
110	S	H	-0.3636
111	R	H	-0.3929
111A	Y	H	0.8713
112A	S	H	0.0000
112	G	H	0.1124
113	S	H	0.1396
114	Y	H	-0.0611
115	Y	H	0.0000
116	D	H	-0.1122
117	Y	H	0.2532
118	W	H	-0.1399
119	G	H	0.0000
120	Q	H	-1.1785
121	G	H	-0.2955
122	T	H	0.5169
123	L	H	1.5481
124	V	H	0.0000
125	T	H	0.3422
126	V	H	0.0000
127	S	H	-0.7699
1	V	L	1.6117
2	I	L	0.0000
3	W	L	1.1931
4	M	L	0.0000
5	T	L	-0.4125
6	Q	L	0.0000
7	S	L	-0.4670
8	P	L	-0.5399
9	S	L	-0.7755
10	S	L	-0.9337
11	L	L	-0.5546
12	S	L	-0.6108
13	A	L	0.0000
14	S	L	-0.1710
15	V	L	0.7145
16	G	L	-0.3917
17	D	L	-1.2032
18	R	L	-2.1083
19	V	L	0.0000
20	T	L	-0.6200
21	I	L	0.0000
22	T	L	-0.6470
23	C	L	0.0000
24	Q	L	-1.7000
25	A	L	0.0000
26	S	L	-0.6999
27	Q	L	-2.0031
28	D	L	-2.5152
29	I	L	0.0000
36	R	L	-1.7968
37	F	L	0.4274
38	Y	L	-0.1071
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.8110
44	Q	L	0.0000
45	K	L	-1.7796
46	P	L	-1.2669
47	G	L	-1.6996
48	K	L	-2.5521
49	A	L	-1.4925
50	P	L	0.0000
51	K	L	-1.1374
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	S	L	0.0000
56	D	L	-0.5443
57	A	L	0.0000
65	S	L	-0.7590
66	N	L	-1.4040
67	M	L	-0.6438
68	E	L	-0.6376
69	T	L	-0.4592
70	G	L	-0.4845
71	V	L	-0.3192
72	P	L	-0.3657
74	S	L	-0.4461
75	R	L	-0.7962
76	F	L	0.0000
77	S	L	-0.5618
78	G	L	-0.6380
79	S	L	-0.6076
80	G	L	-0.8334
83	S	L	-1.0878
84	G	L	-1.7703
85	T	L	-1.9715
86	D	L	-2.1480
87	F	L	0.0000
88	T	L	-0.6488
89	F	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.3467
93	S	L	-1.0630
94	L	L	0.0000
95	Q	L	-0.5075
96	P	L	-0.6498
97	E	L	-1.6962
98	D	L	0.0000
99	I	L	-0.4585
100	A	L	0.0000
101	T	L	-0.9360
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	D	L	-1.0901
109	N	L	-0.5477
114	L	L	0.2835
115	P	L	0.0967
116	F	L	0.0000
117	T	L	0.3007
118	F	L	0.0000
119	G	L	0.0000
120	P	L	-0.7619
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.7147
124	V	L	0.0000
125	D	L	-0.4478
126	F	L	0.4085
127	K	L	-1.0213