| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKLGDTENPTAPLHPGPDDRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRSGPDGHPLPDAPPPSKLYVRPPPTSPYAVLPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEDNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9482 | |
| 2 | L | A | 1.9729 | |
| 3 | P | A | 0.6517 | |
| 4 | P | A | 0.3498 | |
| 5 | T | A | 0.1063 | |
| 6 | T | A | 0.1247 | |
| 7 | P | A | 0.1578 | |
| 8 | V | A | 1.2157 | |
| 9 | A | A | 0.0152 | |
| 10 | K | A | -1.1658 | |
| 11 | V | A | -0.4169 | |
| 12 | Q | A | -1.5590 | |
| 13 | S | A | -1.6353 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4948 | |
| 16 | E | A | -2.4795 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4415 | |
| 20 | P | A | 0.0963 | |
| 21 | T | A | 0.1176 | |
| 22 | S | A | -0.1674 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0918 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2826 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8763 | |
| 31 | R | A | -2.6377 | |
| 32 | L | A | -0.7622 | |
| 33 | L | A | 1.1741 | |
| 34 | T | A | 1.5386 | |
| 35 | V | A | 1.7857 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2918 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6890 | |
| 40 | E | A | -1.8202 | |
| 41 | D | A | -0.8182 | |
| 42 | I | A | 1.2127 | |
| 43 | V | A | 2.1596 | |
| 44 | V | A | 1.6605 | |
| 45 | N | A | -0.5227 | |
| 46 | G | A | -0.3656 | |
| 47 | K | A | -0.1318 | |
| 48 | V | A | 2.0092 | |
| 49 | L | A | 2.5295 | |
| 50 | V | A | 1.4206 | |
| 51 | P | A | 0.2932 | |
| 52 | K | A | -0.7534 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1289 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4782 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2705 | |
| 70 | K | A | -1.8126 | |
| 71 | F | A | -0.6659 | |
| 72 | A | A | -0.5746 | |
| 73 | L | A | -0.8634 | |
| 74 | P | A | -1.2619 | |
| 75 | Q | A | -2.4819 | |
| 76 | K | A | -3.0982 | |
| 77 | D | A | -2.9916 | |
| 78 | F | A | -1.6450 | |
| 79 | Y | A | -1.9237 | |
| 80 | D | A | -2.7645 | |
| 81 | P | A | -2.4132 | |
| 82 | E | A | -3.0769 | |
| 83 | K | A | -3.4444 | |
| 84 | E | A | -2.5102 | |
| 85 | R | A | -1.3256 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6323 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9691 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3132 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7262 | |
| 99 | G | A | -0.5396 | |
| 100 | P | A | -0.4179 | |
| 101 | L | A | 0.0146 | |
| 102 | G | A | -0.2924 | |
| 103 | K | A | -0.8230 | |
| 104 | G | A | -0.6115 | |
| 105 | S | A | -0.6345 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1034 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4127 | |
| 110 | L | A | 0.3030 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1245 | |
| 113 | K | A | -0.4491 | |
| 114 | L | A | -0.8901 | |
| 115 | G | A | -0.8858 | |
| 116 | D | A | -1.3340 | |
| 117 | T | A | -1.2084 | |
| 118 | E | A | -2.6552 | |
| 119 | N | A | -2.3751 | |
| 120 | P | A | -1.5466 | |
| 121 | T | A | -0.7713 | |
| 122 | A | A | -0.4286 | |
| 123 | P | A | 0.2404 | |
| 124 | L | A | 0.0097 | |
| 125 | H | A | -0.5580 | |
| 126 | P | A | -1.2561 | |
| 127 | G | A | -1.4778 | |
| 128 | P | A | -1.5004 | |
| 129 | D | A | -2.3272 | |
| 130 | D | A | -1.7838 | |
| 131 | R | A | -1.1481 | |
| 132 | V | A | 0.2701 | |
| 133 | A | A | 0.4513 | |
| 134 | F | A | 0.2853 | |
| 135 | S | A | -0.1116 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7953 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5623 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2283 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1035 | |
| 157 | D | A | 0.2880 | |
| 158 | I | A | 0.8412 | |
| 159 | A | A | 0.1113 | |
| 160 | E | A | -1.4837 | |
| 161 | P | A | -0.2797 | |
| 162 | C | A | 0.1460 | |
| 163 | P | A | -0.1980 | |
| 164 | G | A | -0.1166 | |
| 165 | L | A | 0.5154 | |
| 166 | P | A | -0.1450 | |
| 167 | P | A | -0.3564 | |
| 168 | G | A | -0.4248 | |
| 169 | A | A | -0.0304 | |
| 170 | C | A | 0.7464 | |
| 171 | P | A | 0.5261 | |
| 172 | P | A | 0.6820 | |
| 173 | I | A | 2.0289 | |
| 174 | Q | A | 0.8338 | |
| 175 | L | A | 1.4266 | |
| 176 | V | A | 0.8202 | |
| 177 | N | A | -0.3244 | |
| 178 | S | A | 0.0278 | |
| 179 | V | A | 0.4293 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3688 | |
| 182 | D | A | 0.0742 | |
| 183 | G | A | -0.1603 | |
| 184 | D | A | -0.5702 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4781 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0979 | |
| 190 | F | A | 0.0127 | |
| 191 | G | A | -0.1594 | |
| 192 | N | A | -0.3325 | |
| 193 | M | A | -0.1665 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3952 | |
| 197 | E | A | -2.6163 | |
| 198 | L | A | -1.2084 | |
| 199 | Q | A | -2.5279 | |
| 200 | Q | A | -3.3322 | |
| 201 | D | A | -3.6012 | |
| 202 | R | A | -3.3457 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1545 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3694 | |
| 211 | S | A | -1.9101 | |
| 212 | T | A | -1.4539 | |
| 213 | R | A | -2.1406 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2122 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3143 | |
| 220 | L | A | 0.5256 | |
| 221 | K | A | -1.2467 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9431 | |
| 224 | N | A | -1.5517 | |
| 225 | E | A | -1.3027 | |
| 226 | A | A | -0.6710 | |
| 227 | Y | A | -0.4505 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7034 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1369 | |
| 234 | F | A | 0.0328 | |
| 235 | G | A | -0.9354 | |
| 236 | R | A | -2.7126 | |
| 237 | R | A | -3.0061 | |
| 238 | E | A | -2.1591 | |
| 239 | Q | A | -0.1247 | |
| 240 | V | A | 1.5952 | |
| 241 | Y | A | 1.2749 | |
| 242 | A | A | 0.1926 | |
| 243 | R | A | -1.2966 | |
| 244 | H | A | -1.1667 | |
| 245 | F | A | -0.2119 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7463 | |
| 249 | S | A | -1.1900 | |
| 250 | G | A | -1.0615 | |
| 251 | P | A | -1.0167 | |
| 252 | D | A | -1.3598 | |
| 253 | G | A | -1.2695 | |
| 254 | H | A | -1.4377 | |
| 255 | P | A | -1.1165 | |
| 256 | L | A | -0.0817 | |
| 257 | P | A | -1.0102 | |
| 258 | D | A | -1.7863 | |
| 259 | A | A | 0.0000 | |
| 260 | P | A | -1.0657 | |
| 261 | P | A | -0.9288 | |
| 262 | P | A | -0.5931 | |
| 263 | S | A | -0.7848 | |
| 264 | K | A | -0.7963 | |
| 265 | L | A | 0.7829 | |
| 266 | Y | A | 0.6801 | |
| 267 | V | A | 0.6489 | |
| 268 | R | A | -0.8007 | |
| 269 | P | A | -0.0537 | |
| 270 | P | A | -0.4892 | |
| 271 | P | A | -0.2683 | |
| 272 | T | A | -0.1459 | |
| 273 | S | A | 0.1821 | |
| 274 | P | A | 0.6252 | |
| 275 | Y | A | 1.5392 | |
| 276 | A | A | 1.1326 | |
| 277 | V | A | 2.1300 | |
| 278 | L | A | 1.5820 | |
| 279 | P | A | 0.4953 | |
| 280 | P | A | 0.0000 | |
| 281 | T | A | -0.3978 | |
| 282 | D | A | -0.9853 | |
| 283 | Y | A | 0.8251 | |
| 284 | F | A | 0.6985 | |
| 285 | G | A | 0.1382 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9409 | |
| 291 | L | A | 1.6145 | |
| 292 | V | A | 0.6038 | |
| 293 | S | A | -0.1580 | |
| 294 | S | A | -0.9679 | |
| 295 | D | A | -1.8442 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1627 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6671 | |
| 301 | R | A | -1.9285 | |
| 302 | P | A | -0.9928 | |
| 303 | F | A | -0.1946 | |
| 304 | W | A | -0.5201 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0795 | |
| 307 | R | A | -2.9277 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6518 | |
| 310 | G | A | -1.4127 | |
| 311 | N | A | -1.4033 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9345 | |
| 319 | N | A | -1.0043 | |
| 320 | E | A | -1.0543 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3807 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1659 | |
| 333 | N | A | 0.4888 | |
| 334 | F | A | 1.7293 | |
| 335 | T | A | 0.8748 | |
| 336 | I | A | 0.4713 | |
| 337 | S | A | -0.9288 | |
| 338 | Q | A | -1.7007 | |
| 339 | Q | A | -1.2433 | |
| 340 | L | A | 0.6867 | |
| 341 | C | A | 0.2606 | |
| 342 | T | A | -0.6443 | |
| 343 | P | A | -1.0156 | |
| 344 | E | A | -2.4923 | |
| 345 | D | A | -2.5853 | |
| 346 | N | A | -1.5660 | |
| 347 | V | A | 0.5148 | |
| 348 | Y | A | 0.9305 | |
| 349 | D | A | -0.1676 | |
| 350 | P | A | -0.3862 | |
| 351 | S | A | -0.3290 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7607 | |
| 354 | K | A | -1.7638 | |
| 355 | N | A | -1.7440 | |
| 356 | Y | A | -0.0610 | |
| 357 | L | A | 0.6483 | |
| 358 | R | A | 0.9418 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3637 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0239 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9013 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6611 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2816 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3305 | |
| 376 | L | A | -1.7578 | |
| 377 | D | A | -2.0311 | |
| 378 | P | A | -1.0609 | |
| 379 | G | A | -1.0212 | |
| 380 | V | A | -0.9292 | |
| 381 | L | A | -0.5426 | |
| 382 | A | A | -0.6616 | |
| 383 | H | A | -0.8518 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4087 | |
| 386 | T | A | -0.5796 | |
| 387 | M | A | -0.3357 | |
| 388 | N | A | -0.8736 | |
| 389 | P | A | -1.2807 | |
| 390 | T | A | -1.5778 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5706 | |
| 393 | E | A | -2.9868 | |
| 394 | N | A | -2.7734 | |
| 395 | W | A | -1.5839 | |
| 396 | N | A | -1.4586 | |
| 397 | L | A | -0.2462 | |
| 398 | G | A | 0.4941 | |
| 399 | F | A | 2.4032 | |
| 400 | V | A | 1.8283 | |
| 401 | P | A | 0.0464 | |
| 402 | P | A | -1.9668 | |
| 403 | K | A | -3.5920 | |
| 404 | E | A | -3.9777 | |
| 405 | R | A | -4.3838 | |
| 406 | E | A | -3.9773 | |
| 407 | D | A | -2.9454 | |
| 408 | P | A | -1.8070 | |
| 409 | Y | A | -0.9828 | |
| 410 | K | A | -2.1030 | |
| 411 | G | A | -0.6329 | |
| 412 | L | A | 0.6635 | |
| 413 | I | A | 1.5780 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3982 | |
| 416 | E | A | -1.6717 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9421 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0794 | |
| 421 | E | A | -2.8111 | |
| 422 | R | A | -2.6987 | |
| 423 | F | A | -1.3252 | |
| 424 | S | A | -1.4763 | |
| 425 | Q | A | -1.9123 | |
| 426 | D | A | -2.8997 | |
| 427 | L | A | -2.0134 | |
| 428 | D | A | -2.8215 | |
| 429 | Q | A | -2.6313 | |
| 430 | F | A | -1.4575 | |
| 431 | A | A | -0.9255 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6524 | |
| 435 | K | A | -0.7768 | |
| 436 | F | A | 0.1195 | |
| 437 | L | A | 1.0030 | |
| 438 | Y | A | 0.8029 | |
| 439 | Q | A | -0.2818 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine