Project name: 16.28G3

Chain sequence(s)	H: EVQLQQSGPELVKPGASVKISCKASGYTFTDYYMNWVKQSHGKSLEWIGDIYPNSGGTTYNQRFKGKATLTVDKSSSTTYMELRSLTSEDSAVYYCAKTGDWTVGNFDVWGTGTTVTVSS; L: QIVLTQSPAIMSASPGEKVTISCSASSSISYMYWYQQKPGSSPKPWIYRTSNLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCQQYHSYPRTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:45)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:46)

• Minimal score value: -3.1143
• Maximal score value: 1.4218
• Average score: -0.5479
• Total score value: -123.8238

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0317
2	V	H	-1.2482
3	Q	H	-1.9926
4	L	H	0.0000
5	Q	H	-1.9645
6	Q	H	0.0000
7	S	H	-0.9874
8	G	H	-0.7806
9	P	H	-0.4111
11	E	H	-0.3946
12	L	H	0.8154
13	V	H	-0.2615
14	K	H	-1.7221
15	P	H	-1.4428
16	G	H	-1.2458
17	A	H	-1.0206
18	S	H	-1.1688
19	V	H	0.0000
20	K	H	-1.4203
21	I	H	0.0000
22	S	H	-0.7154
23	C	H	0.0000
24	K	H	-1.7785
25	A	H	0.0000
26	S	H	-1.3141
27	G	H	-1.1238
28	Y	H	-0.5566
29	T	H	-0.3507
30	F	H	0.0000
35	T	H	-1.1305
36	D	H	-1.0124
37	Y	H	0.0879
38	Y	H	0.5134
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	-0.6736
44	Q	H	-1.0765
45	S	H	-1.6027
46	H	H	-1.9428
47	G	H	-1.8251
48	K	H	-2.4640
49	S	H	-1.4526
50	L	H	0.0000
51	E	H	-1.1013
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	D	H	0.0000
56	I	H	0.0000
57	Y	H	-0.0438
58	P	H	0.0000
59	N	H	-1.6362
62	S	H	-0.9735
63	G	H	-0.8281
64	G	H	-0.4646
65	T	H	-0.0637
66	T	H	-0.1545
67	Y	H	-0.8566
68	N	H	0.0000
69	Q	H	-2.6504
70	R	H	-3.0215
71	F	H	0.0000
72	K	H	-2.7888
74	G	H	-1.9158
75	K	H	-1.7482
76	A	H	0.0000
77	T	H	-0.7311
78	L	H	0.0000
79	T	H	-0.1006
80	V	H	-0.6203
81	D	H	-1.5192
82	K	H	-2.1801
83	S	H	-1.1680
84	S	H	-1.0130
85	S	H	-1.1746
86	T	H	0.0000
87	T	H	0.0000
88	Y	H	-0.1905
89	M	H	0.0000
90	E	H	-0.9760
91	L	H	0.0000
92	R	H	-1.2901
93	S	H	-1.1027
94	L	H	0.0000
95	T	H	-1.3141
96	S	H	-1.4596
97	E	H	-2.0623
98	D	H	0.0000
99	S	H	-0.7745
100	A	H	0.0000
101	V	H	-0.1633
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	T	H	-0.0058
108	G	H	-0.2168
109	D	H	-0.4146
110	W	H	0.6750
111	T	H	0.2949
112	V	H	0.0000
113	G	H	-0.2572
114	N	H	-0.3183
115	F	H	0.0000
116	D	H	-0.5516
117	V	H	-0.2759
118	W	H	0.0000
119	G	H	0.0000
120	T	H	-0.6044
121	G	H	-0.4146
122	T	H	0.0000
123	T	H	-0.2178
124	V	H	0.0000
125	T	H	-0.1889
126	V	H	0.0000
127	S	H	-0.6161
128	S	H	-0.7495
1	Q	L	-0.8835
2	I	L	0.0000
3	V	L	0.8591
4	L	L	0.0000
5	T	L	-0.0224
6	Q	L	0.0000
7	S	L	-0.1087
8	P	L	0.2623
9	A	L	0.5923
10	I	L	1.4218
11	M	L	0.3996
12	S	L	-0.7335
13	A	L	0.0000
14	S	L	-1.8309
15	P	L	-1.9396
16	G	L	-2.0717
17	E	L	-3.1143
18	K	L	-2.8519
19	V	L	0.0000
20	T	L	-0.6880
21	I	L	0.0000
22	S	L	-0.3436
23	C	L	0.0000
24	S	L	-0.2466
25	A	L	0.0000
26	S	L	-0.0828
27	S	L	-0.3171
28	S	L	-0.5704
29	I	L	0.0000
37	S	L	-0.3865
38	Y	L	0.0279
39	M	L	0.0000
40	Y	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-0.9378
45	K	L	-1.3335
46	P	L	-0.8816
47	G	L	-0.8385
48	S	L	-0.8331
49	S	L	-0.6181
50	P	L	0.0000
51	K	L	-1.1889
52	P	L	0.0000
53	W	L	-0.2765
54	I	L	0.0000
55	Y	L	-0.3755
56	R	L	-0.9478
57	T	L	0.0000
65	S	L	-0.7953
66	N	L	-1.1334
67	L	L	-0.2272
68	A	L	0.0000
69	S	L	-0.4264
70	G	L	-0.4040
71	V	L	-0.1266
72	P	L	-0.0857
74	A	L	-0.0637
75	R	L	-0.6470
76	F	L	0.0000
77	S	L	-0.3917
78	G	L	0.0000
79	S	L	-0.6204
80	G	L	-0.5310
83	S	L	-0.4795
84	G	L	-0.4927
85	T	L	-0.4933
86	S	L	-0.6152
87	Y	L	0.0000
88	S	L	-0.3681
89	L	L	0.0000
90	T	L	-0.5743
91	I	L	0.0000
92	S	L	-1.4746
93	S	L	-1.9458
94	M	L	0.0000
95	E	L	-2.2391
96	A	L	-1.6807
97	E	L	-2.2655
98	D	L	0.0000
99	A	L	-1.5007
100	A	L	0.0000
101	T	L	-0.6128
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	-0.0693
108	H	L	-0.6229
109	S	L	-0.3122
114	Y	L	0.2257
115	P	L	-0.5469
116	R	L	-0.1867
117	T	L	0.0000
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.7706
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.5945
124	L	L	0.0000
125	E	L	-1.4301
126	I	L	-1.0253
127	K	L	-1.7927