| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLADTENPTAPVHETADVRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPEGHPLPDAPPPSRLYTPPPASSPYAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9510 | |
| 2 | L | A | 1.9739 | |
| 3 | P | A | 0.6548 | |
| 4 | P | A | 0.3570 | |
| 5 | T | A | 0.1146 | |
| 6 | T | A | 0.1352 | |
| 7 | P | A | 0.1867 | |
| 8 | V | A | 1.2183 | |
| 9 | A | A | 0.0289 | |
| 10 | K | A | -1.1589 | |
| 11 | V | A | -0.4116 | |
| 12 | Q | A | -1.5275 | |
| 13 | S | A | -1.6035 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4240 | |
| 16 | E | A | -2.4407 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4613 | |
| 20 | P | A | 0.1074 | |
| 21 | T | A | 0.1182 | |
| 22 | S | A | -0.1702 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1010 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1556 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7154 | |
| 31 | R | A | -2.5944 | |
| 32 | L | A | -0.7408 | |
| 33 | L | A | 1.2283 | |
| 34 | T | A | 1.4530 | |
| 35 | V | A | 1.9830 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2705 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6382 | |
| 40 | K | A | -1.8846 | |
| 41 | D | A | -0.7856 | |
| 42 | I | A | 1.2311 | |
| 43 | V | A | 2.1904 | |
| 44 | V | A | 1.6381 | |
| 45 | N | A | -0.5303 | |
| 46 | G | A | -0.3655 | |
| 47 | K | A | -0.1327 | |
| 48 | V | A | 2.1897 | |
| 49 | L | A | 2.5328 | |
| 50 | V | A | 1.4647 | |
| 51 | P | A | 0.3472 | |
| 52 | K | A | -0.6879 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1124 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3770 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3028 | |
| 70 | K | A | -1.8194 | |
| 71 | F | A | -0.6767 | |
| 72 | A | A | -0.5926 | |
| 73 | L | A | -0.9496 | |
| 74 | P | A | -1.2681 | |
| 75 | Q | A | -2.4768 | |
| 76 | K | A | -3.0944 | |
| 77 | D | A | -2.9863 | |
| 78 | F | A | -1.6341 | |
| 79 | Y | A | -1.9168 | |
| 80 | D | A | -2.7654 | |
| 81 | P | A | -2.3551 | |
| 82 | E | A | -3.0775 | |
| 83 | K | A | -3.4471 | |
| 84 | E | A | -2.5096 | |
| 85 | R | A | -1.3210 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6434 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9718 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3615 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7345 | |
| 99 | G | A | -0.5382 | |
| 100 | P | A | -0.4333 | |
| 101 | L | A | -0.0204 | |
| 102 | G | A | -0.3590 | |
| 103 | K | A | -0.9085 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5016 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1468 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3993 | |
| 110 | L | A | 0.3339 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9574 | |
| 113 | K | A | -0.2372 | |
| 114 | L | A | -0.7481 | |
| 115 | A | A | -0.6361 | |
| 116 | D | A | -1.2554 | |
| 117 | T | A | -1.2093 | |
| 118 | E | A | -2.6203 | |
| 119 | N | A | -2.3591 | |
| 120 | P | A | -1.4945 | |
| 121 | T | A | -0.6703 | |
| 122 | A | A | -0.1413 | |
| 123 | P | A | 0.2634 | |
| 124 | V | A | -0.1653 | |
| 125 | H | A | -1.0362 | |
| 126 | E | A | -2.0498 | |
| 127 | T | A | -1.4199 | |
| 128 | A | A | -1.1877 | |
| 129 | D | A | -1.9589 | |
| 130 | V | A | -1.2576 | |
| 131 | R | A | -0.7359 | |
| 132 | V | A | 0.3821 | |
| 133 | A | A | 0.4230 | |
| 134 | F | A | 0.2747 | |
| 135 | S | A | -0.0669 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7244 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5491 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2189 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1146 | |
| 157 | D | A | 0.2965 | |
| 158 | I | A | 0.8496 | |
| 159 | A | A | 0.1225 | |
| 160 | E | A | -1.4796 | |
| 161 | P | A | -0.2538 | |
| 162 | C | A | 0.1683 | |
| 163 | P | A | -0.1829 | |
| 164 | G | A | -0.0889 | |
| 165 | L | A | 0.5714 | |
| 166 | P | A | -0.1226 | |
| 167 | P | A | -0.3448 | |
| 168 | G | A | -0.4180 | |
| 169 | A | A | -0.0166 | |
| 170 | C | A | 0.7575 | |
| 171 | P | A | 0.5487 | |
| 172 | P | A | 0.6850 | |
| 173 | I | A | 2.0373 | |
| 174 | Q | A | 0.8488 | |
| 175 | L | A | 1.4543 | |
| 176 | V | A | 0.8284 | |
| 177 | N | A | -0.3070 | |
| 178 | S | A | 0.0391 | |
| 179 | V | A | 0.4552 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3771 | |
| 182 | D | A | 0.0740 | |
| 183 | G | A | -0.1640 | |
| 184 | D | A | -0.5586 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1505 | |
| 190 | F | A | 0.0628 | |
| 191 | G | A | -0.0971 | |
| 192 | N | A | -0.2748 | |
| 193 | M | A | -0.1456 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3912 | |
| 197 | E | A | -2.6067 | |
| 198 | L | A | -1.2112 | |
| 199 | Q | A | -2.5298 | |
| 200 | Q | A | -3.3370 | |
| 201 | D | A | -3.5937 | |
| 202 | R | A | -3.3395 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1983 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3839 | |
| 211 | S | A | -1.9005 | |
| 212 | T | A | -1.4653 | |
| 213 | R | A | -2.1415 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1754 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3321 | |
| 220 | L | A | 0.5630 | |
| 221 | K | A | -1.1784 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9283 | |
| 224 | N | A | -1.6552 | |
| 225 | E | A | -1.2961 | |
| 226 | A | A | -0.6779 | |
| 227 | Y | A | -0.4604 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7012 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1377 | |
| 234 | F | A | 0.0310 | |
| 235 | G | A | -0.9386 | |
| 236 | R | A | -2.7154 | |
| 237 | R | A | -3.0181 | |
| 238 | E | A | -2.2070 | |
| 239 | Q | A | -0.1688 | |
| 240 | V | A | 1.5172 | |
| 241 | Y | A | 1.2291 | |
| 242 | A | A | 0.1586 | |
| 243 | R | A | -1.3181 | |
| 244 | H | A | -1.1870 | |
| 245 | F | A | -0.2213 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6004 | |
| 249 | A | A | -1.2956 | |
| 250 | G | A | -1.0140 | |
| 251 | P | A | -1.1121 | |
| 252 | E | A | -1.3559 | |
| 253 | G | A | -1.2809 | |
| 254 | H | A | -1.4733 | |
| 255 | P | A | -1.1917 | |
| 256 | L | A | -0.2180 | |
| 257 | P | A | -1.0887 | |
| 258 | D | A | -1.7570 | |
| 259 | A | A | -1.2030 | |
| 260 | P | A | -1.1666 | |
| 261 | P | A | -1.0391 | |
| 262 | P | A | -0.7410 | |
| 263 | S | A | -1.0013 | |
| 264 | R | A | -1.1899 | |
| 265 | L | A | 0.5636 | |
| 266 | Y | A | 0.2297 | |
| 267 | T | A | -0.1613 | |
| 268 | P | A | 0.0241 | |
| 269 | P | A | 0.2799 | |
| 270 | P | A | -0.2247 | |
| 271 | A | A | 0.1784 | |
| 272 | S | A | -0.1613 | |
| 273 | S | A | 0.3273 | |
| 274 | P | A | 0.6286 | |
| 275 | Y | A | 1.7172 | |
| 276 | A | A | 1.4218 | |
| 277 | V | A | 2.2685 | |
| 278 | L | A | 1.6474 | |
| 279 | P | A | 0.4077 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.3073 | |
| 282 | D | A | -0.9068 | |
| 283 | Y | A | 0.8821 | |
| 284 | F | A | 0.6880 | |
| 285 | G | A | 0.1123 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.7978 | |
| 291 | L | A | 1.5876 | |
| 292 | V | A | 0.5746 | |
| 293 | S | A | -0.1675 | |
| 294 | S | A | -0.9713 | |
| 295 | D | A | -1.8449 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1443 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6326 | |
| 301 | R | A | -1.8920 | |
| 302 | P | A | -0.9730 | |
| 303 | F | A | -0.1956 | |
| 304 | W | A | -0.5223 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0803 | |
| 307 | R | A | -2.9233 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7816 | |
| 310 | G | A | -1.4188 | |
| 311 | N | A | -1.3909 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9284 | |
| 319 | N | A | -0.8815 | |
| 320 | E | A | -1.0409 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4022 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2416 | |
| 333 | N | A | 0.3583 | |
| 334 | F | A | 1.4267 | |
| 335 | T | A | 0.6007 | |
| 336 | I | A | 0.3771 | |
| 337 | S | A | -0.8416 | |
| 338 | Q | A | -1.4438 | |
| 339 | Q | A | -1.0875 | |
| 340 | L | A | 0.5877 | |
| 341 | C | A | -0.0361 | |
| 342 | T | A | -0.4460 | |
| 343 | P | A | -1.1823 | |
| 344 | E | A | -1.7383 | |
| 345 | P | A | -0.7552 | |
| 346 | N | A | -0.7524 | |
| 347 | V | A | 1.2943 | |
| 348 | Y | A | 1.2417 | |
| 349 | D | A | 0.0579 | |
| 350 | P | A | -0.3266 | |
| 351 | S | A | -0.2559 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5070 | |
| 354 | K | A | -1.6253 | |
| 355 | N | A | -1.6860 | |
| 356 | Y | A | -0.1163 | |
| 357 | L | A | 0.5585 | |
| 358 | R | A | 0.8912 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4635 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0098 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9045 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6664 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3052 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3293 | |
| 376 | L | A | -1.7646 | |
| 377 | D | A | -2.0475 | |
| 378 | P | A | -1.0694 | |
| 379 | G | A | -1.0246 | |
| 380 | V | A | -0.9364 | |
| 381 | L | A | -0.5499 | |
| 382 | A | A | -0.6653 | |
| 383 | H | A | -0.8517 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4028 | |
| 386 | T | A | -0.5770 | |
| 387 | M | A | -0.3331 | |
| 388 | N | A | -0.8661 | |
| 389 | P | A | -1.2957 | |
| 390 | T | A | -1.5522 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5620 | |
| 393 | E | A | -2.9572 | |
| 394 | N | A | -2.7167 | |
| 395 | W | A | -1.5398 | |
| 396 | N | A | -1.3076 | |
| 397 | L | A | -0.2183 | |
| 398 | G | A | 0.5543 | |
| 399 | F | A | 2.4432 | |
| 400 | V | A | 1.8687 | |
| 401 | P | A | 0.0814 | |
| 402 | P | A | -1.8379 | |
| 403 | K | A | -3.4977 | |
| 404 | E | A | -3.8148 | |
| 405 | R | A | -4.0685 | |
| 406 | E | A | -3.8127 | |
| 407 | D | A | -2.8692 | |
| 408 | P | A | -1.7624 | |
| 409 | Y | A | -0.9838 | |
| 410 | K | A | -2.0961 | |
| 411 | G | A | -0.6331 | |
| 412 | L | A | 0.6718 | |
| 413 | I | A | 1.5882 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3805 | |
| 416 | E | A | -1.6326 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8359 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8955 | |
| 421 | E | A | -2.5044 | |
| 422 | R | A | -2.0747 | |
| 423 | F | A | -1.0218 | |
| 424 | S | A | -1.3101 | |
| 425 | Q | A | -1.7878 | |
| 426 | D | A | -2.8691 | |
| 427 | L | A | -1.9695 | |
| 428 | D | A | -2.7507 | |
| 429 | Q | A | -2.5930 | |
| 430 | F | A | -1.4255 | |
| 431 | A | A | -0.8833 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5377 | |
| 435 | K | A | -0.7028 | |
| 436 | F | A | 0.1681 | |
| 437 | L | A | 1.0455 | |
| 438 | Y | A | 0.8373 | |
| 439 | Q | A | -0.2585 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine