| Chain sequence(s) |
A: GLPPLNPEPALLPTSEYVTPTDLLYIAETDLITETGHPTKDIVVNGKVLVPRVSAYQYRVFLLKLPDPNKMPLPSEDFLDPATEILIWQLRAFKIHRFGPLGKGTYGHPNFNALGDVDNPTAYQHETSDVTQNLSFTPKLLQEYIIGCLPPLGKYTAPAPPTPGLPPGAVPPTTTVTTYIQDGDMADIGFGSKDFAALEPSKDDVPDIILNTSTKRFDIEGMKADPEGLRMFTYGRYEKSYDVKKLRRAGPDLIPVPDSLPPSPLYIRPPPSSPYWVRPSTNLFTIPDAGEITEDDLLFNKPIFLEKTEGLNHGVLWHNKLYITILDNTRAEIETIKTRICTPEENVYDPECYVTSKRYTEEYRLELIVQLCRIPLTPEVRARLARLDPRILVDAELPDVPAVERPDPYAGLKFIEIDLTDKFSRDLSKYELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.1613 | |
| 2 | L | A | 1.3963 | |
| 3 | P | A | 0.4674 | |
| 4 | P | A | 0.2877 | |
| 5 | L | A | 0.5867 | |
| 6 | N | A | -1.3054 | |
| 7 | P | A | -1.3987 | |
| 8 | E | A | -1.9826 | |
| 9 | P | A | -1.0308 | |
| 10 | A | A | 0.0804 | |
| 11 | L | A | 1.0212 | |
| 12 | L | A | 0.4793 | |
| 13 | P | A | -0.1748 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.1127 | |
| 16 | E | A | -1.8143 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.7622 | |
| 20 | P | A | -0.8595 | |
| 21 | T | A | -1.1101 | |
| 22 | D | A | -1.7983 | |
| 23 | L | A | 0.0000 | |
| 24 | L | A | -0.8249 | |
| 25 | Y | A | -0.8467 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.0184 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.5265 | |
| 31 | L | A | -0.0949 | |
| 32 | I | A | -0.0940 | |
| 33 | T | A | -0.3562 | |
| 34 | E | A | -0.5804 | |
| 35 | T | A | -0.6312 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.6268 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5970 | |
| 40 | K | A | -1.9324 | |
| 41 | D | A | -0.5480 | |
| 42 | I | A | 1.4938 | |
| 43 | V | A | 2.3696 | |
| 44 | V | A | 1.6506 | |
| 45 | N | A | -0.5804 | |
| 46 | G | A | -0.3920 | |
| 47 | K | A | -0.0769 | |
| 48 | V | A | 2.1304 | |
| 49 | L | A | 2.7227 | |
| 50 | V | A | 1.4983 | |
| 51 | P | A | 0.1315 | |
| 52 | R | A | -1.1337 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -1.9309 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4476 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.7468 | |
| 70 | K | A | -1.9326 | |
| 71 | M | A | -0.8602 | |
| 72 | P | A | -0.5763 | |
| 73 | L | A | -0.4869 | |
| 74 | P | A | -0.6026 | |
| 75 | S | A | -1.4292 | |
| 76 | E | A | -2.7739 | |
| 77 | D | A | -2.8243 | |
| 78 | F | A | -1.4910 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -2.1162 | |
| 81 | P | A | -1.2439 | |
| 82 | A | A | -0.6311 | |
| 83 | T | A | -0.6391 | |
| 84 | E | A | -0.8688 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7313 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.6040 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.1468 | |
| 99 | G | A | -0.4818 | |
| 100 | P | A | -0.6458 | |
| 101 | L | A | -0.4443 | |
| 102 | G | A | -0.8910 | |
| 103 | K | A | -1.3957 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5323 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9756 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.9801 | |
| 110 | N | A | -2.8891 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.6154 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -1.1879 | |
| 116 | D | A | -2.1135 | |
| 117 | V | A | -1.6390 | |
| 118 | D | A | -2.9618 | |
| 119 | N | A | -2.6452 | |
| 120 | P | A | -1.4595 | |
| 121 | T | A | -0.7549 | |
| 122 | A | A | -0.2240 | |
| 123 | Y | A | 0.4770 | |
| 124 | Q | A | -0.6662 | |
| 125 | H | A | -0.7509 | |
| 126 | E | A | -1.6656 | |
| 127 | T | A | -1.1594 | |
| 128 | S | A | -1.3511 | |
| 129 | D | A | -2.2583 | |
| 130 | V | A | -1.3599 | |
| 131 | T | A | -1.9340 | |
| 132 | Q | A | -2.5441 | |
| 133 | N | A | -2.3814 | |
| 134 | L | A | -1.2348 | |
| 135 | S | A | -0.6940 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.0386 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | L | A | 0.0820 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1650 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -1.0111 | |
| 155 | Y | A | -0.8822 | |
| 156 | T | A | -0.4176 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.1703 | |
| 159 | A | A | -0.3067 | |
| 160 | P | A | -0.4970 | |
| 161 | P | A | -0.4665 | |
| 162 | T | A | -0.2865 | |
| 163 | P | A | -0.3677 | |
| 164 | G | A | -0.2647 | |
| 165 | L | A | 0.5717 | |
| 166 | P | A | 0.0418 | |
| 167 | P | A | -0.2084 | |
| 168 | G | A | 0.1850 | |
| 169 | A | A | 0.8964 | |
| 170 | V | A | 1.8800 | |
| 171 | P | A | 0.6379 | |
| 172 | P | A | 0.2059 | |
| 173 | T | A | -0.0746 | |
| 174 | T | A | -0.1532 | |
| 175 | T | A | -0.0795 | |
| 176 | V | A | 0.1142 | |
| 177 | T | A | -0.1483 | |
| 178 | T | A | 0.1542 | |
| 179 | Y | A | 0.1374 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.7671 | |
| 182 | D | A | 0.0000 | |
| 183 | G | A | -0.5891 | |
| 184 | D | A | -0.8228 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.8950 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3381 | |
| 190 | F | A | -0.1173 | |
| 191 | G | A | -0.6599 | |
| 192 | S | A | -1.1644 | |
| 193 | K | A | -1.2501 | |
| 194 | D | A | -0.8124 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.0311 | |
| 197 | A | A | -0.3675 | |
| 198 | L | A | -0.3054 | |
| 199 | E | A | -1.1532 | |
| 200 | P | A | -1.1227 | |
| 201 | S | A | -1.3273 | |
| 202 | K | A | -2.6049 | |
| 203 | D | A | -2.0589 | |
| 204 | D | A | -1.2350 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8418 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.2916 | |
| 211 | N | A | -1.6542 | |
| 212 | T | A | -0.9105 | |
| 213 | S | A | -0.7559 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -2.1973 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | -1.4637 | |
| 219 | I | A | 0.0000 | |
| 220 | E | A | -2.3978 | |
| 221 | G | A | -1.6228 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.3972 | |
| 224 | A | A | -1.5806 | |
| 225 | D | A | -1.6248 | |
| 226 | P | A | -0.8440 | |
| 227 | E | A | -0.6226 | |
| 228 | G | A | 0.0000 | |
| 229 | L | A | 0.0000 | |
| 230 | R | A | -0.5645 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6932 | |
| 234 | Y | A | -0.2597 | |
| 235 | G | A | -0.5480 | |
| 236 | R | A | -1.4050 | |
| 237 | Y | A | -1.1189 | |
| 238 | E | A | -1.4434 | |
| 239 | K | A | -1.3130 | |
| 240 | S | A | -0.6473 | |
| 241 | Y | A | 0.2680 | |
| 242 | D | A | -0.5344 | |
| 243 | V | A | 0.1624 | |
| 244 | K | A | -1.6843 | |
| 245 | K | A | -2.0521 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.6828 | |
| 248 | R | A | -0.5871 | |
| 249 | A | A | -0.9991 | |
| 250 | G | A | -0.8294 | |
| 251 | P | A | -0.2582 | |
| 252 | D | A | 0.4265 | |
| 253 | L | A | 2.2543 | |
| 254 | I | A | 2.5046 | |
| 255 | P | A | 0.7827 | |
| 256 | V | A | 0.7612 | |
| 257 | P | A | -0.1966 | |
| 258 | D | A | -1.6509 | |
| 259 | S | A | -0.4331 | |
| 260 | L | A | 0.7214 | |
| 261 | P | A | 0.3295 | |
| 262 | P | A | 0.4088 | |
| 263 | S | A | 0.8772 | |
| 264 | P | A | 1.1155 | |
| 265 | L | A | 1.9258 | |
| 266 | Y | A | 1.8003 | |
| 267 | I | A | 1.9083 | |
| 268 | R | A | 0.2846 | |
| 269 | P | A | 0.2902 | |
| 270 | P | A | -0.2680 | |
| 271 | P | A | -0.1433 | |
| 272 | S | A | -0.2852 | |
| 273 | S | A | 0.1859 | |
| 274 | P | A | 0.4588 | |
| 275 | Y | A | 1.2028 | |
| 276 | W | A | 1.0039 | |
| 277 | V | A | 1.5010 | |
| 278 | R | A | 0.2628 | |
| 279 | P | A | 0.0000 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.3236 | |
| 282 | N | A | -0.1565 | |
| 283 | L | A | 0.8240 | |
| 284 | F | A | 0.0090 | |
| 285 | T | A | -0.5279 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.4290 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -0.8862 | |
| 291 | E | A | -1.8314 | |
| 292 | I | A | -1.6567 | |
| 293 | T | A | -2.0808 | |
| 294 | E | A | -2.9612 | |
| 295 | D | A | -3.2354 | |
| 296 | D | A | -2.5756 | |
| 297 | L | A | 0.0000 | |
| 298 | L | A | -1.0137 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2008 | |
| 301 | K | A | -1.5887 | |
| 302 | P | A | -0.6693 | |
| 303 | I | A | -0.0924 | |
| 304 | F | A | -0.1950 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.6209 | |
| 307 | K | A | -3.0167 | |
| 308 | T | A | -2.1470 | |
| 309 | E | A | -2.5145 | |
| 310 | G | A | -1.5984 | |
| 311 | L | A | -0.5624 | |
| 312 | N | A | 0.0000 | |
| 313 | H | A | -1.3793 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8956 | |
| 319 | N | A | -0.9025 | |
| 320 | K | A | -0.9151 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.2949 | |
| 333 | I | A | -1.7275 | |
| 334 | E | A | -1.7642 | |
| 335 | T | A | -1.1972 | |
| 336 | I | A | -0.3171 | |
| 337 | K | A | -1.0873 | |
| 338 | T | A | -0.4112 | |
| 339 | R | A | -0.9896 | |
| 340 | I | A | 1.2808 | |
| 341 | C | A | 0.5147 | |
| 342 | T | A | -0.5419 | |
| 343 | P | A | -1.2581 | |
| 344 | E | A | -2.3994 | |
| 345 | E | A | -2.6820 | |
| 346 | N | A | -1.6599 | |
| 347 | V | A | 0.0947 | |
| 348 | Y | A | 0.5923 | |
| 349 | D | A | -0.7680 | |
| 350 | P | A | -0.9414 | |
| 351 | E | A | -1.3930 | |
| 352 | C | A | 0.0000 | |
| 353 | Y | A | 0.0827 | |
| 354 | V | A | 0.9858 | |
| 355 | T | A | -0.2945 | |
| 356 | S | A | -0.9021 | |
| 357 | K | A | -2.1570 | |
| 358 | R | A | -2.0790 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.9257 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.3686 | |
| 363 | Y | A | 0.0000 | |
| 364 | R | A | -0.7516 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4969 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.7177 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7858 | |
| 376 | L | A | -0.6162 | |
| 377 | T | A | -0.9004 | |
| 378 | P | A | -1.3202 | |
| 379 | E | A | -2.1065 | |
| 380 | V | A | 0.0000 | |
| 381 | R | A | -1.4168 | |
| 382 | A | A | -1.3512 | |
| 383 | R | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -1.0498 | |
| 386 | R | A | -1.8455 | |
| 387 | L | A | -0.8147 | |
| 388 | D | A | -0.7861 | |
| 389 | P | A | -1.0578 | |
| 390 | R | A | -1.4154 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.4578 | |
| 394 | D | A | -2.1281 | |
| 395 | A | A | -1.7725 | |
| 396 | E | A | -2.6302 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | -1.5091 | |
| 399 | D | A | -2.0700 | |
| 400 | V | A | -1.0108 | |
| 401 | P | A | -0.4983 | |
| 402 | A | A | -0.5156 | |
| 403 | V | A | 0.4377 | |
| 404 | E | A | -1.6399 | |
| 405 | R | A | -2.0136 | |
| 406 | P | A | -1.5141 | |
| 407 | D | A | -1.5621 | |
| 408 | P | A | -0.8604 | |
| 409 | Y | A | 0.0000 | |
| 410 | A | A | -0.7123 | |
| 411 | G | A | -0.8502 | |
| 412 | L | A | -0.7283 | |
| 413 | K | A | -1.8515 | |
| 414 | F | A | -1.0703 | |
| 415 | I | A | -1.0220 | |
| 416 | E | A | -2.2947 | |
| 417 | I | A | -1.8326 | |
| 418 | D | A | -2.8293 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8255 | |
| 421 | D | A | -2.4710 | |
| 422 | K | A | -2.2052 | |
| 423 | F | A | -1.2030 | |
| 424 | S | A | -1.6444 | |
| 425 | R | A | -2.2653 | |
| 426 | D | A | -2.1321 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.8468 | |
| 429 | K | A | -2.6247 | |
| 430 | Y | A | -1.6957 | |
| 431 | E | A | -1.8048 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7222 | |
| 435 | L | A | -0.4602 | |
| 436 | Y | A | -0.1990 | |
| 437 | L | A | 0.0701 | |
| 438 | N | A | -1.4470 | |
| 439 | R | A | -1.8875 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine