| Chain sequence(s) |
A: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFR
C: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFR B: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFR E: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFR D: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFR F: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFR input PDB |
| Selected Chain(s) | A,C,B,E,D,F |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:12:01)
[INFO] Main: Simulation completed successfully. (00:12:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 306 | V | A | 2.2580 | |
| 307 | Q | A | 0.9268 | |
| 308 | I | A | 0.0000 | |
| 309 | V | A | 0.2352 | |
| 310 | Y | A | 0.0000 | |
| 311 | K | A | -0.8087 | |
| 312 | P | A | 0.0000 | |
| 313 | V | A | 0.3996 | |
| 314 | D | A | 0.0000 | |
| 315 | L | A | 0.6844 | |
| 316 | S | A | 0.0000 | |
| 317 | K | A | -1.1637 | |
| 318 | V | A | 0.0000 | |
| 319 | T | A | -1.7012 | |
| 320 | S | A | 0.0000 | |
| 321 | K | A | -2.4060 | |
| 322 | C | A | 0.0000 | |
| 323 | G | A | -1.2022 | |
| 324 | S | A | -0.5655 | |
| 325 | L | A | 0.0000 | |
| 326 | G | A | -0.9458 | |
| 327 | N | A | -1.3959 | |
| 328 | I | A | 0.0000 | |
| 329 | H | A | -1.1269 | |
| 330 | H | A | 0.0000 | |
| 331 | K | A | 0.0000 | |
| 332 | P | A | 0.0000 | |
| 333 | G | A | 0.0000 | |
| 334 | G | A | 0.0000 | |
| 335 | G | A | 0.0000 | |
| 336 | Q | A | 0.0000 | |
| 337 | M | A | 0.0000 | |
| 338 | E | A | -2.4854 | |
| 339 | V | A | 0.0000 | |
| 340 | K | A | -2.9413 | |
| 341 | S | A | 0.0000 | |
| 342 | E | A | -4.2667 | |
| 343 | K | A | -4.3194 | |
| 344 | L | A | 0.0000 | |
| 345 | D | A | -3.0580 | |
| 346 | F | A | 0.0000 | |
| 347 | K | A | -3.9142 | |
| 348 | D | A | -3.8273 | |
| 349 | R | A | -4.4077 | |
| 350 | V | A | 0.0000 | |
| 351 | Q | A | -2.9623 | |
| 352 | S | A | 0.0000 | |
| 353 | K | A | -1.8353 | |
| 354 | I | A | 0.0000 | |
| 355 | G | A | 0.0000 | |
| 356 | S | A | 0.0000 | |
| 357 | L | A | 0.0000 | |
| 358 | D | A | 0.0000 | |
| 359 | N | A | -0.4434 | |
| 360 | I | A | 0.0643 | |
| 361 | T | A | 0.0000 | |
| 362 | H | A | -0.2176 | |
| 363 | V | A | 0.0000 | |
| 364 | P | A | 0.0000 | |
| 365 | G | A | 0.0000 | |
| 366 | G | A | 0.0000 | |
| 367 | G | A | -1.3219 | |
| 368 | N | A | 0.0000 | |
| 369 | K | A | -1.6459 | |
| 370 | K | A | 0.0000 | |
| 371 | I | A | -0.0843 | |
| 372 | E | A | 0.0000 | |
| 373 | T | A | -1.0521 | |
| 374 | H | A | 0.0000 | |
| 375 | K | A | -1.8282 | |
| 376 | L | A | 0.0000 | |
| 377 | T | A | -0.8262 | |
| 378 | F | A | 0.0000 | |
| 379 | R | A | -2.6022 | |
| 306 | V | B | 1.7316 | |
| 307 | Q | B | 0.5213 | |
| 308 | I | B | 1.2169 | |
| 309 | V | B | 1.2560 | |
| 310 | Y | B | 0.5818 | |
| 311 | K | B | -0.9153 | |
| 312 | P | B | 0.1224 | |
| 313 | V | B | 1.7038 | |
| 314 | D | B | 0.9911 | |
| 315 | L | B | 1.5838 | |
| 316 | S | B | 0.0083 | |
| 317 | K | B | -1.4941 | |
| 318 | V | B | -0.7962 | |
| 319 | T | B | -1.1760 | |
| 320 | S | B | -1.2553 | |
| 321 | K | B | -2.2900 | |
| 322 | C | B | -1.0539 | |
| 323 | G | B | -1.0401 | |
| 324 | S | B | -0.6257 | |
| 325 | L | B | -0.2394 | |
| 326 | G | B | -1.0139 | |
| 327 | N | B | -1.5191 | |
| 328 | I | B | -0.6020 | |
| 329 | H | B | -1.1528 | |
| 330 | H | B | -0.7722 | |
| 331 | K | B | -1.1306 | |
| 332 | P | B | -0.9106 | |
| 333 | G | B | -1.0438 | |
| 334 | G | B | -0.9259 | |
| 335 | G | B | -0.9847 | |
| 336 | Q | B | -1.7783 | |
| 337 | M | B | -1.3060 | |
| 338 | E | B | -2.7314 | |
| 339 | V | B | -1.6912 | |
| 340 | K | B | -3.0264 | |
| 341 | S | B | -2.5923 | |
| 342 | E | B | -4.3241 | |
| 343 | K | B | -3.8052 | |
| 344 | L | B | -2.5571 | |
| 345 | D | B | -3.3367 | |
| 346 | F | B | -2.5757 | |
| 347 | K | B | -3.6868 | |
| 348 | D | B | -3.8105 | |
| 349 | R | B | -3.6789 | |
| 350 | V | B | -2.2952 | |
| 351 | Q | B | -2.5834 | |
| 352 | S | B | -1.7550 | |
| 353 | K | B | -2.2695 | |
| 354 | I | B | -0.7656 | |
| 355 | G | B | -1.0149 | |
| 356 | S | B | -0.5154 | |
| 357 | L | B | -0.2980 | |
| 358 | D | B | -0.7562 | |
| 359 | N | B | -0.2527 | |
| 360 | I | B | 0.7878 | |
| 361 | T | B | 0.0000 | |
| 362 | H | B | -0.7984 | |
| 363 | V | B | 0.0000 | |
| 364 | P | B | -0.3641 | |
| 365 | G | B | 0.0000 | |
| 366 | G | B | -1.3016 | |
| 367 | G | B | -1.0032 | |
| 368 | N | B | -1.1750 | |
| 369 | K | B | -1.7322 | |
| 370 | K | B | -0.5158 | |
| 371 | I | B | 1.2983 | |
| 372 | E | B | -0.1015 | |
| 373 | T | B | -0.6604 | |
| 374 | H | B | -1.3455 | |
| 375 | K | B | -2.1093 | |
| 376 | L | B | -0.6426 | |
| 377 | T | B | -1.1223 | |
| 378 | F | B | -0.9534 | |
| 379 | R | B | -2.3497 | |
| 306 | V | C | 1.9149 | |
| 307 | Q | C | 0.6316 | |
| 308 | I | C | 1.0947 | |
| 309 | V | C | 0.2033 | |
| 310 | Y | C | -0.0604 | |
| 311 | K | C | -1.5925 | |
| 312 | P | C | -1.2163 | |
| 313 | V | C | 0.0015 | |
| 314 | D | C | -0.4603 | |
| 315 | L | C | 0.7004 | |
| 316 | S | C | -0.3833 | |
| 317 | K | C | -1.3966 | |
| 318 | V | C | -1.5355 | |
| 319 | T | C | -1.3306 | |
| 320 | S | C | -1.4775 | |
| 321 | K | C | -2.3999 | |
| 322 | C | C | -1.3305 | |
| 323 | G | C | -1.1941 | |
| 324 | S | C | -0.6129 | |
| 325 | L | C | -0.2527 | |
| 326 | G | C | -0.8143 | |
| 327 | N | C | -1.7072 | |
| 328 | I | C | -0.9598 | |
| 329 | H | C | -1.4137 | |
| 330 | H | C | -1.3191 | |
| 331 | K | C | -2.2936 | |
| 332 | P | C | -1.6086 | |
| 333 | G | C | -1.0175 | |
| 334 | G | C | -0.9299 | |
| 335 | G | C | -0.6986 | |
| 336 | Q | C | -0.7299 | |
| 337 | M | C | -0.4013 | |
| 338 | E | C | -1.5371 | |
| 339 | V | C | -0.8887 | |
| 340 | K | C | -2.4510 | |
| 341 | S | C | -2.1941 | |
| 342 | E | C | -3.5823 | |
| 343 | K | C | -3.1973 | |
| 344 | L | C | -1.8131 | |
| 345 | D | C | -2.6181 | |
| 346 | F | C | -2.1960 | |
| 347 | K | C | -3.4111 | |
| 348 | D | C | -3.9482 | |
| 349 | R | C | -3.8830 | |
| 350 | V | C | -2.8379 | |
| 351 | Q | C | -2.5392 | |
| 352 | S | C | -1.8296 | |
| 353 | K | C | -2.1776 | |
| 354 | I | C | -0.4116 | |
| 355 | G | C | -0.5992 | |
| 356 | S | C | -0.3604 | |
| 357 | L | C | -0.1015 | |
| 358 | D | C | -1.4598 | |
| 359 | N | C | -1.6804 | |
| 360 | I | C | -0.0576 | |
| 361 | T | C | -0.2757 | |
| 362 | H | C | -0.4442 | |
| 363 | V | C | 0.2649 | |
| 364 | P | C | -0.3412 | |
| 365 | G | C | -0.8096 | |
| 366 | G | C | -1.0769 | |
| 367 | G | C | -1.2710 | |
| 368 | N | C | -1.9982 | |
| 369 | K | C | -2.4511 | |
| 370 | K | C | -1.7457 | |
| 371 | I | C | -0.5381 | |
| 372 | E | C | -1.8157 | |
| 373 | T | C | -1.3518 | |
| 374 | H | C | -1.5217 | |
| 375 | K | C | -1.2620 | |
| 376 | L | C | 0.5608 | |
| 377 | T | C | 0.0794 | |
| 378 | F | C | 0.5183 | |
| 379 | R | C | -1.6899 | |
| 306 | V | D | 1.8565 | |
| 307 | Q | D | 0.5170 | |
| 308 | I | D | 1.0596 | |
| 309 | V | D | 0.1980 | |
| 310 | Y | D | -0.0013 | |
| 311 | K | D | -1.5302 | |
| 312 | P | D | -1.2215 | |
| 313 | V | D | -0.1500 | |
| 314 | D | D | -0.8385 | |
| 315 | L | D | 0.3917 | |
| 316 | S | D | -0.7152 | |
| 317 | K | D | -1.9090 | |
| 318 | V | D | -1.6808 | |
| 319 | T | D | -1.4195 | |
| 320 | S | D | -1.5366 | |
| 321 | K | D | -2.4517 | |
| 322 | C | D | -1.3513 | |
| 323 | G | D | -1.2009 | |
| 324 | S | D | -0.6121 | |
| 325 | L | D | -0.2220 | |
| 326 | G | D | -0.7558 | |
| 327 | N | D | -1.5870 | |
| 328 | I | D | -0.7383 | |
| 329 | H | D | -0.9777 | |
| 330 | H | D | -0.7544 | |
| 331 | K | D | -1.1410 | |
| 332 | P | D | -0.9573 | |
| 333 | G | D | 0.0000 | |
| 334 | G | D | -0.6179 | |
| 335 | G | D | -0.4841 | |
| 336 | Q | D | -1.0015 | |
| 337 | M | D | -0.4682 | |
| 338 | E | D | -1.8265 | |
| 339 | V | D | -0.9383 | |
| 340 | K | D | -2.3296 | |
| 341 | S | D | -2.2576 | |
| 342 | E | D | -3.9283 | |
| 343 | K | D | -3.8316 | |
| 344 | L | D | -2.2312 | |
| 345 | D | D | -3.1235 | |
| 346 | F | D | -2.3592 | |
| 347 | K | D | -3.4522 | |
| 348 | D | D | -3.9369 | |
| 349 | R | D | -3.9215 | |
| 350 | V | D | -2.8647 | |
| 351 | Q | D | -2.5272 | |
| 352 | S | D | -1.6357 | |
| 353 | K | D | -1.7184 | |
| 354 | I | D | -0.1184 | |
| 355 | G | D | -0.4965 | |
| 356 | S | D | -0.2024 | |
| 357 | L | D | 0.0120 | |
| 358 | D | D | -1.4132 | |
| 359 | N | D | -1.5053 | |
| 360 | I | D | -0.0442 | |
| 361 | T | D | -0.1395 | |
| 362 | H | D | -0.3668 | |
| 363 | V | D | 0.3229 | |
| 364 | P | D | -0.2751 | |
| 365 | G | D | -0.7705 | |
| 366 | G | D | -1.0372 | |
| 367 | G | D | -1.1645 | |
| 368 | N | D | -1.9408 | |
| 369 | K | D | -2.4285 | |
| 370 | K | D | -1.6991 | |
| 371 | I | D | -0.3038 | |
| 372 | E | D | -1.7444 | |
| 373 | T | D | -1.3336 | |
| 374 | H | D | -1.5682 | |
| 375 | K | D | -1.3538 | |
| 376 | L | D | 0.6147 | |
| 377 | T | D | 0.1788 | |
| 378 | F | D | 0.7658 | |
| 379 | R | D | -1.5720 | |
| 306 | V | E | 2.3097 | |
| 307 | Q | E | 1.0235 | |
| 308 | I | E | 0.0000 | |
| 309 | V | E | 0.2168 | |
| 310 | Y | E | 0.0000 | |
| 311 | K | E | -1.0230 | |
| 312 | P | E | 0.0000 | |
| 313 | V | E | 0.4750 | |
| 314 | D | E | 0.0000 | |
| 315 | L | E | 0.9388 | |
| 316 | S | E | 0.0000 | |
| 317 | K | E | -1.1614 | |
| 318 | V | E | 0.0000 | |
| 319 | T | E | 0.0000 | |
| 320 | S | E | 0.0000 | |
| 321 | K | E | -2.3878 | |
| 322 | C | E | 0.0000 | |
| 323 | G | E | -1.2143 | |
| 324 | S | E | -0.6020 | |
| 325 | L | E | 0.0000 | |
| 326 | G | E | -1.0883 | |
| 327 | N | E | -1.6811 | |
| 328 | I | E | 0.0000 | |
| 329 | H | E | -1.4689 | |
| 330 | H | E | 0.0000 | |
| 331 | K | E | -1.5434 | |
| 332 | P | E | 0.0000 | |
| 333 | G | E | 0.0000 | |
| 334 | G | E | 0.0000 | |
| 335 | G | E | 0.0000 | |
| 336 | Q | E | 0.0000 | |
| 337 | M | E | 0.0000 | |
| 338 | E | E | -2.0191 | |
| 339 | V | E | 0.0000 | |
| 340 | K | E | -2.7974 | |
| 341 | S | E | 0.0000 | |
| 342 | E | E | -3.8281 | |
| 343 | K | E | -3.9100 | |
| 344 | L | E | 0.0000 | |
| 345 | D | E | -3.0589 | |
| 346 | F | E | 0.0000 | |
| 347 | K | E | -4.0385 | |
| 348 | D | E | -3.8166 | |
| 349 | R | E | -4.0556 | |
| 350 | V | E | 0.0000 | |
| 351 | Q | E | -2.7169 | |
| 352 | S | E | 0.0000 | |
| 353 | K | E | -2.0705 | |
| 354 | I | E | 0.0000 | |
| 355 | G | E | 0.0000 | |
| 356 | S | E | 0.0000 | |
| 357 | L | E | 0.0000 | |
| 358 | D | E | 0.0000 | |
| 359 | N | E | -0.5868 | |
| 360 | I | E | 0.0467 | |
| 361 | T | E | 0.0000 | |
| 362 | H | E | -0.2490 | |
| 363 | V | E | 0.0000 | |
| 364 | P | E | 0.0000 | |
| 365 | G | E | 0.0000 | |
| 366 | G | E | 0.0000 | |
| 367 | G | E | -1.4299 | |
| 368 | N | E | 0.0000 | |
| 369 | K | E | -1.8915 | |
| 370 | K | E | 0.0000 | |
| 371 | I | E | -0.0635 | |
| 372 | E | E | 0.0000 | |
| 373 | T | E | -0.9931 | |
| 374 | H | E | 0.0000 | |
| 375 | K | E | -1.7206 | |
| 376 | L | E | 0.0000 | |
| 377 | T | E | -0.8554 | |
| 378 | F | E | 0.0000 | |
| 379 | R | E | -2.6577 | |
| 306 | V | F | 1.7457 | |
| 307 | Q | F | 0.5424 | |
| 308 | I | F | 1.2300 | |
| 309 | V | F | 1.2250 | |
| 310 | Y | F | 0.5155 | |
| 311 | K | F | -0.9944 | |
| 312 | P | F | 0.0739 | |
| 313 | V | F | 1.7026 | |
| 314 | D | F | 1.0128 | |
| 315 | L | F | 1.5846 | |
| 316 | S | F | -0.0140 | |
| 317 | K | F | -1.4972 | |
| 318 | V | F | -0.8226 | |
| 319 | T | F | -1.1974 | |
| 320 | S | F | -1.2358 | |
| 321 | K | F | -2.2658 | |
| 322 | C | F | -1.0291 | |
| 323 | G | F | -1.0369 | |
| 324 | S | F | -0.6267 | |
| 325 | L | F | -0.2811 | |
| 326 | G | F | -1.1030 | |
| 327 | N | F | -1.6185 | |
| 328 | I | F | -0.6657 | |
| 329 | H | F | -1.2263 | |
| 330 | H | F | -0.8097 | |
| 331 | K | F | -1.3406 | |
| 332 | P | F | -0.8859 | |
| 333 | G | F | -0.9357 | |
| 334 | G | F | 0.0000 | |
| 335 | G | F | -0.7212 | |
| 336 | Q | F | -1.1835 | |
| 337 | M | F | -1.0072 | |
| 338 | E | F | -2.4232 | |
| 339 | V | F | -1.5724 | |
| 340 | K | F | -2.8920 | |
| 341 | S | F | -2.4251 | |
| 342 | E | F | -4.0186 | |
| 343 | K | F | -3.6510 | |
| 344 | L | F | -2.5361 | |
| 345 | D | F | -3.3802 | |
| 346 | F | F | -2.5796 | |
| 347 | K | F | -3.6908 | |
| 348 | D | F | -3.8884 | |
| 349 | R | F | -3.5795 | |
| 350 | V | F | -2.1679 | |
| 351 | Q | F | -2.4486 | |
| 352 | S | F | -1.6997 | |
| 353 | K | F | -2.3291 | |
| 354 | I | F | -0.8048 | |
| 355 | G | F | -0.9791 | |
| 356 | S | F | -0.5186 | |
| 357 | L | F | -0.1489 | |
| 358 | D | F | -0.6579 | |
| 359 | N | F | -0.2340 | |
| 360 | I | F | 0.7813 | |
| 361 | T | F | 0.0000 | |
| 362 | H | F | -0.8418 | |
| 363 | V | F | 0.0000 | |
| 364 | P | F | -0.4086 | |
| 365 | G | F | 0.0000 | |
| 366 | G | F | -1.3416 | |
| 367 | G | F | -1.0914 | |
| 368 | N | F | -1.2229 | |
| 369 | K | F | -1.7072 | |
| 370 | K | F | 0.0000 | |
| 371 | I | F | 1.4541 | |
| 372 | E | F | 0.1876 | |
| 373 | T | F | -0.5479 | |
| 374 | H | F | -1.2953 | |
| 375 | K | F | -2.0688 | |
| 376 | L | F | -0.6189 | |
| 377 | T | F | -1.0719 | |
| 378 | F | F | -0.9619 | |
| 379 | R | F | -2.3414 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine