Project name: 2ba40e3c8a874e1

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWMNWMKQAPGQGLEWIGGIYLNGDSTDYNEKFKGKVTMTVDTSTSTVYMELSSLRSEDTAVYYCTRRGDYFGDFWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCKASQNVGKYVAWYQQKPGKAPKSLIYSASNRYDGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQYISYPLTFGAGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:47)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:49)

• Minimal score value: -3.4483
• Maximal score value: 1.5118
• Average score: -0.6353
• Total score value: -142.2973

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5052
2	V	H	-0.8322
3	Q	H	-1.0733
4	L	H	0.0000
5	V	H	0.7979
6	Q	H	0.0000
7	S	H	-0.3699
8	G	H	-0.3860
9	A	H	0.3010
11	E	H	0.2274
12	V	H	1.0752
13	K	H	-0.8940
14	K	H	-2.1712
15	P	H	-2.0673
16	G	H	-1.6198
17	A	H	-1.1023
18	S	H	-1.5405
19	V	H	0.0000
20	K	H	-2.2983
21	V	H	0.0000
22	S	H	-0.5267
23	C	H	0.0000
24	K	H	-0.4350
25	A	H	0.0000
26	S	H	-0.7299
27	G	H	-1.0429
28	Y	H	-0.5478
29	T	H	-0.3747
30	F	H	0.0000
35	T	H	-1.1656
36	N	H	-1.6099
37	Y	H	-0.7142
38	W	H	-0.5463
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	M	H	0.0000
43	K	H	-0.5128
44	Q	H	-0.6832
45	A	H	-1.0155
46	P	H	-1.0336
47	G	H	-1.2419
48	Q	H	-1.7301
49	G	H	-1.1173
50	L	H	0.0000
51	E	H	-1.3536
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	G	H	0.0000
56	I	H	0.0000
57	Y	H	-0.7690
58	L	H	0.0000
59	N	H	-2.1268
62	G	H	-1.9382
63	D	H	-2.2045
64	S	H	-1.2503
65	T	H	-0.6544
66	D	H	-0.8404
67	Y	H	-1.1850
68	N	H	-2.1404
69	E	H	-3.4483
70	K	H	-3.2367
71	F	H	0.0000
72	K	H	-3.0828
74	G	H	-2.0219
75	K	H	-1.8471
76	V	H	0.0000
77	T	H	-1.1117
78	M	H	0.0000
79	T	H	-0.5442
80	V	H	-0.1218
81	D	H	-0.2751
82	T	H	-0.5715
83	S	H	-0.3235
84	T	H	-0.3925
85	S	H	-0.4173
86	T	H	0.0000
87	V	H	0.0000
88	Y	H	-0.6130
89	M	H	0.0000
90	E	H	-2.0721
91	L	H	0.0000
92	S	H	-1.2961
93	S	H	-1.3721
94	L	H	0.0000
95	R	H	-3.0951
96	S	H	-2.3605
97	E	H	-2.5559
98	D	H	0.0000
99	T	H	-0.7402
100	A	H	0.0000
101	V	H	0.2723
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	-0.2540
106	R	H	-0.4246
107	R	H	-0.4055
108	G	H	0.0000
109	D	H	-0.8408
113	Y	H	1.1271
114	F	H	0.6447
115	G	H	-0.0973
116	D	H	-0.4303
117	F	H	-0.2041
118	W	H	-0.2882
119	G	H	0.0000
120	Q	H	-1.2164
121	G	H	-0.5096
122	T	H	0.0000
123	L	H	0.8970
124	V	H	0.0000
125	T	H	-0.0800
126	V	H	0.0000
127	S	H	-0.9424
128	S	H	-0.9049
1	D	L	-2.2665
2	I	L	-1.6904
3	Q	L	-2.0275
4	M	L	0.0000
5	T	L	-1.0266
6	Q	L	0.0000
7	S	L	-0.4882
8	P	L	-0.4829
9	S	L	-0.6780
10	S	L	-0.9015
11	L	L	-0.3372
12	S	L	-0.4834
13	A	L	0.0000
14	S	L	0.0415
15	V	L	0.8579
16	G	L	-0.3743
17	D	L	-1.3378
18	R	L	-2.0802
19	V	L	0.0000
20	T	L	-0.5549
21	I	L	0.0000
22	T	L	-0.6786
23	C	L	0.0000
24	K	L	-2.3508
25	A	L	0.0000
26	S	L	-1.9902
27	Q	L	-2.5931
28	N	L	-2.1594
29	V	L	0.0000
36	G	L	-0.9681
37	K	L	-0.7559
38	Y	L	0.8755
39	V	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.7610
46	P	L	-1.3148
47	G	L	-1.6244
48	K	L	-2.5540
49	A	L	-1.5969
50	P	L	0.0000
51	K	L	-1.5205
52	S	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1604
56	S	L	0.0000
57	A	L	0.0000
65	S	L	-0.8715
66	N	L	-1.3534
67	R	L	-1.4737
68	Y	L	-1.2968
69	D	L	-2.1310
70	G	L	-1.3276
71	V	L	-0.9671
72	P	L	-0.6357
74	S	L	-0.5425
75	R	L	-0.6941
76	F	L	0.0000
77	S	L	-0.6572
78	G	L	-0.6153
79	S	L	-0.7684
80	G	L	-1.0529
83	S	L	-1.2944
84	G	L	-1.6593
85	T	L	-2.0332
86	D	L	-2.1565
87	F	L	0.0000
88	T	L	-0.6345
89	L	L	0.0000
90	T	L	-0.5436
91	I	L	0.0000
92	S	L	-1.1229
93	S	L	-0.9956
94	L	L	0.0000
95	Q	L	-0.9216
96	P	L	-0.6330
97	E	L	-1.8669
98	D	L	0.0000
99	F	L	-0.3341
100	A	L	0.0000
101	T	L	-0.8634
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	1.2841
108	I	L	1.5118
109	S	L	0.6570
114	Y	L	0.1523
115	P	L	-0.7806
116	L	L	0.0000
117	T	L	-0.5042
118	F	L	0.0000
119	G	L	0.0000
120	A	L	-0.6659
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.6480
124	L	L	0.0000
125	E	L	-0.4728
126	I	L	1.1105
127	K	L	-0.7286