Project name: 7.34B1

Chain sequence(s)	H: EVMLVESGGGFVKPGGSLKLSCAASGFTFSSYSMSWVRQTPEKRLEWVATISGGGGITYYSDSVKGRFTISRDNAKNTLYLQMSSLRSEDTALYYCARLLLLYYAMDYWGQGTSVTVSS; L: DIQMSQSPSSLSASLGDTITITCHASQNINVWLSWYQQTPGNFPKLLIYKASNLHTGVPSRFSGSGSGTGFALTVSSLQPEDIATYYCQQGQSYPWTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:18)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:19)

• Minimal score value: -3.2225
• Maximal score value: 2.3292
• Average score: -0.4694
• Total score value: -106.0805

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.6253
2	V	H	-0.3044
3	M	H	0.5148
4	L	H	0.0000
5	V	H	0.8732
6	E	H	0.0000
7	S	H	-0.4968
8	G	H	-0.7739
9	G	H	-0.2607
11	G	H	0.6111
12	F	H	1.5198
13	V	H	-0.0279
14	K	H	-1.7851
15	P	H	-1.9950
16	G	H	-1.4913
17	G	H	-1.1921
18	S	H	-0.9616
19	L	H	-0.4780
20	K	H	-1.4199
21	L	H	0.0000
22	S	H	-0.3331
23	C	H	0.0000
24	A	H	-0.0220
25	A	H	0.0000
26	S	H	-0.4213
27	G	H	-0.7313
28	F	H	-0.2661
29	T	H	-0.2648
30	F	H	0.0000
35	S	H	-0.8360
36	S	H	-0.1706
37	Y	H	0.3049
38	S	H	0.0000
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	0.0000
45	T	H	-2.0182
46	P	H	-1.9832
47	E	H	-3.0964
48	K	H	-3.0712
49	R	H	-3.2225
50	L	H	0.0000
51	E	H	-1.0482
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	T	H	0.0000
56	I	H	0.0000
57	S	H	0.4270
58	G	H	-0.1258
59	G	H	-0.5394
62	G	H	-0.2019
63	G	H	0.2514
64	I	H	1.7368
65	T	H	1.0531
66	Y	H	0.6154
67	Y	H	-0.5601
68	S	H	-1.3849
69	D	H	-2.5181
70	S	H	-1.6705
71	V	H	0.0000
72	K	H	-2.2637
74	G	H	-1.5407
75	R	H	-1.4676
76	F	H	0.0000
77	T	H	-0.7198
78	I	H	0.0000
79	S	H	-0.2242
80	R	H	-0.9951
81	D	H	-1.4299
82	N	H	-1.6880
83	A	H	-1.3457
84	K	H	-2.3331
85	N	H	-1.8567
86	T	H	-1.0480
87	L	H	0.0000
88	Y	H	-0.4158
89	L	H	0.0000
90	Q	H	-1.2330
91	M	H	0.0000
92	S	H	-0.9958
93	S	H	-1.1161
94	L	H	0.0000
95	R	H	-2.3323
96	S	H	-1.9943
97	E	H	-2.3513
98	D	H	0.0000
99	T	H	-0.6490
100	A	H	0.0000
101	L	H	-0.1190
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	L	H	0.0000
108	L	H	1.5511
109	L	H	2.1087
110	L	H	2.3292
112	Y	H	1.6999
113	Y	H	1.2602
114	A	H	0.0000
115	M	H	0.0000
116	D	H	0.0000
117	Y	H	0.5973
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-0.7920
121	G	H	-0.3764
122	T	H	0.0000
123	S	H	-0.1060
124	V	H	0.0000
125	T	H	-0.0074
126	V	H	0.0000
127	S	H	-0.7041
128	S	H	-0.6538
1	D	L	-2.3626
2	I	L	0.0000
3	Q	L	-2.0023
4	M	L	0.0000
5	S	L	-1.1419
6	Q	L	-0.9058
7	S	L	-0.6543
8	P	L	-0.7124
9	S	L	-0.9552
10	S	L	-1.2749
11	L	L	-0.9806
12	S	L	-1.2787
13	A	L	0.0000
14	S	L	-0.6887
15	L	L	0.2867
16	G	L	-0.3961
17	D	L	-0.7066
18	T	L	-0.4193
19	I	L	0.0000
20	T	L	-0.1278
21	I	L	0.0000
22	T	L	-0.5625
23	C	L	0.0000
24	H	L	-1.7440
25	A	L	0.0000
26	S	L	-1.7956
27	Q	L	-2.2770
28	N	L	-2.0129
29	I	L	0.0000
36	N	L	-1.2133
37	V	L	0.0740
38	W	L	0.1567
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-0.4323
45	T	L	-0.7110
46	P	L	-0.4681
47	G	L	-0.8352
48	N	L	-0.7927
49	F	L	-0.0854
50	P	L	0.0000
51	K	L	-0.3273
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1898
56	K	L	-0.0386
57	A	L	0.0000
65	S	L	-0.3646
66	N	L	-0.4658
67	L	L	0.0266
68	H	L	-0.1242
69	T	L	-0.2361
70	G	L	-0.4022
71	V	L	-0.1553
72	P	L	-0.3148
74	S	L	-0.3906
75	R	L	-0.5991
76	F	L	0.0000
77	S	L	-0.3756
78	G	L	-0.3997
79	S	L	-0.5342
80	G	L	-0.7331
83	S	L	-0.8381
84	G	L	-1.2581
85	T	L	-1.4092
86	G	L	-1.2329
87	F	L	0.0000
88	A	L	-0.4819
89	L	L	0.0000
90	T	L	-0.2501
91	V	L	0.0000
92	S	L	-0.5400
93	S	L	-0.5843
94	L	L	0.0000
95	Q	L	-0.8816
96	P	L	-1.0467
97	E	L	-1.8213
98	D	L	0.0000
99	I	L	-0.8458
100	A	L	0.0000
101	T	L	-1.1279
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	G	L	0.0000
108	Q	L	-0.4289
109	S	L	-0.3464
114	Y	L	-0.2182
115	P	L	-0.6367
116	W	L	0.0000
117	T	L	-0.7269
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.8283
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-2.1127
124	L	L	0.0000
125	E	L	-1.8463
126	I	L	-1.0830
127	K	L	-1.6681