Project name: 2d74dfe44446cd0

Chain sequence(s)	H: QVQLVQSGSELKKPGASVKVSCKASGYTFTDNNMDWVRQAPGQGLEWMGDINTRSGGSIYNEEFQDRVIMTVDKSTDTAYMELSSLRSEDTATYHCARRKSYGYYLDEWGEGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCKASRNIERQLAWYQQKPGQAPELLIYQASRKESGVPDRFSGSRYGTDFTLTISSLQPEDIATYYCQQYSDPPLTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:12)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:13)

• Minimal score value: -3.4896
• Maximal score value: 1.0365
• Average score: -0.7795
• Total score value: -176.1567

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4097
2	V	H	-1.0583
3	Q	H	-1.3260
4	L	H	0.0000
5	V	H	0.0675
6	Q	H	-0.4712
7	S	H	-0.7275
8	G	H	-0.7640
9	S	H	-0.2500
11	E	H	-0.2546
12	L	H	0.6784
13	K	H	-0.9869
14	K	H	-2.1572
15	P	H	-2.1272
16	G	H	-1.5147
17	A	H	-1.1924
18	S	H	-1.2570
19	V	H	0.0000
20	K	H	-1.7915
21	V	H	0.0000
22	S	H	-0.5008
23	C	H	0.0000
24	K	H	-0.8282
25	A	H	0.0000
26	S	H	-0.8424
27	G	H	-0.8982
28	Y	H	-0.7068
29	T	H	-0.7467
30	F	H	0.0000
35	T	H	-2.0879
36	D	H	-2.4699
37	N	H	-1.5836
38	N	H	-1.3674
39	M	H	0.0000
40	D	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7456
45	A	H	-1.0861
46	P	H	-1.0439
47	G	H	-1.2200
48	Q	H	-1.7502
49	G	H	-1.1260
50	L	H	0.0000
51	E	H	-0.6999
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	D	H	0.0000
56	I	H	0.0000
57	N	H	-1.5608
58	T	H	0.0000
59	R	H	-2.8363
62	S	H	-1.4914
63	G	H	-1.4277
64	G	H	-0.9536
65	S	H	0.0797
66	I	H	0.1257
67	Y	H	-0.7018
68	N	H	0.0000
69	E	H	-3.4896
70	E	H	-3.3409
71	F	H	0.0000
72	Q	H	-2.7966
74	D	H	-2.8217
75	R	H	0.0000
76	V	H	0.0000
77	I	H	0.5918
78	M	H	0.0000
79	T	H	-0.1257
80	V	H	-0.9803
81	D	H	-1.3692
82	K	H	-2.0837
83	S	H	-1.1519
84	T	H	-1.1533
85	D	H	-1.6156
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.1572
89	M	H	0.0000
90	E	H	-0.7213
91	L	H	0.0000
92	S	H	-0.8877
93	S	H	-1.2068
94	L	H	0.0000
95	R	H	-2.5813
96	S	H	-2.1344
97	E	H	-2.4036
98	D	H	0.0000
99	T	H	-0.8151
100	A	H	0.0000
101	T	H	-0.2606
102	Y	H	0.0000
103	H	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.7636
107	R	H	-0.7514
108	K	H	-0.5923
109	S	H	-0.1265
110	Y	H	1.0365
112	G	H	0.3715
113	Y	H	0.1635
114	Y	H	0.0000
115	L	H	0.0000
116	D	H	-0.9507
117	E	H	-1.3477
118	W	H	0.0000
119	G	H	0.0000
120	E	H	-2.1236
121	G	H	-1.0848
122	T	H	0.0000
123	L	H	0.1530
124	V	H	0.0000
125	T	H	-0.3274
126	V	H	0.0000
127	S	H	-0.9934
128	S	H	-0.8704
1	D	L	-2.6349
2	I	L	0.0000
3	Q	L	-2.2224
4	M	L	0.0000
5	T	L	-1.2135
6	Q	L	-0.9872
7	S	L	-0.7339
8	P	L	-0.5120
9	S	L	-0.6693
10	S	L	-0.7957
11	L	L	-0.6435
12	S	L	-1.0113
13	A	L	-1.0672
14	S	L	-0.8567
15	V	L	0.1631
16	G	L	-0.8137
17	D	L	-1.8296
18	R	L	-2.3305
19	V	L	0.0000
20	T	L	-0.6549
21	I	L	0.0000
22	T	L	-0.6909
23	C	L	0.0000
24	K	L	-2.2785
25	A	L	0.0000
26	S	L	-2.1485
27	R	L	-2.9623
28	N	L	-3.0191
29	I	L	0.0000
36	E	L	-2.9262
37	R	L	-2.4702
38	Q	L	-1.7840
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.0225
45	K	L	-1.3639
46	P	L	-0.9374
47	G	L	-1.5370
48	Q	L	-2.2572
49	A	L	-1.7461
50	P	L	0.0000
51	E	L	-1.5598
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-1.0813
56	Q	L	-1.6992
57	A	L	0.0000
65	S	L	-1.5719
66	R	L	-2.3133
67	K	L	-1.9424
68	E	L	-1.2487
69	S	L	-0.8671
70	G	L	-0.8533
71	V	L	-0.8718
72	P	L	-1.2032
74	D	L	-2.1093
75	R	L	-1.5090
76	F	L	0.0000
77	S	L	-1.1179
78	G	L	-0.8679
79	S	L	-0.7554
80	R	L	-0.8218
83	Y	L	0.2369
84	G	L	-1.0813
85	T	L	-1.7885
86	D	L	-1.1294
87	F	L	0.0000
88	T	L	-0.4172
89	L	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.6436
93	S	L	-1.3687
94	L	L	0.0000
95	Q	L	-0.6390
96	P	L	-0.9733
97	E	L	-1.6989
98	D	L	0.0000
99	I	L	-0.1876
100	A	L	0.0000
101	T	L	-0.5998
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	S	L	-1.4155
109	D	L	-1.3080
114	P	L	-1.0719
115	P	L	-1.2411
116	L	L	0.0000
117	T	L	-0.7940
118	F	L	-0.2845
119	G	L	0.0000
120	G	L	-1.0519
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.1192
124	V	L	0.0000
125	E	L	-1.1563
126	I	L	-0.7598
127	K	L	-1.5897