Project name: 15.37E11

Chain sequence(s)	H: EVQLQQSGPELVKPGASVKISCKASGYTFTDYYMNWVKQSHGKSLEWIGDIYPKNGGTNYNQKFKGKATLTVDKSSSTAYMELRSLTSEDSVVYYCAKTGDWTVGYFDVWGTGTTVTVSS; L: QIVLTQSPAIMSASPGEKVTITCSASSSVIYTNWFQQKPGTSPKVWIYRTSNLASGVPARFSGSGSGTSYSLTISRMEAEDAATYYCQQRSSHPPTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:02)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:03)

• Minimal score value: -3.314
• Maximal score value: 1.8434
• Average score: -0.6094
• Total score value: -137.715

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9628
2	V	H	-1.2120
3	Q	H	-1.9802
4	L	H	0.0000
5	Q	H	-2.0355
6	Q	H	0.0000
7	S	H	-1.0793
8	G	H	-0.7405
9	P	H	-0.3234
11	E	H	-0.3026
12	L	H	0.8994
13	V	H	-0.2090
14	K	H	-1.7107
15	P	H	-1.4464
16	G	H	-1.2544
17	A	H	-1.0225
18	S	H	-1.2616
19	V	H	0.0000
20	K	H	-1.9461
21	I	H	0.0000
22	S	H	-0.9648
23	C	H	0.0000
24	K	H	-2.0430
25	A	H	0.0000
26	S	H	-1.3269
27	G	H	-1.0608
28	Y	H	-0.4998
29	T	H	-0.2842
30	F	H	0.0000
35	T	H	-1.4716
36	D	H	-1.0547
37	Y	H	0.0307
38	Y	H	0.2710
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	0.0000
45	S	H	-1.5441
46	H	H	-1.9139
47	G	H	-1.8032
48	K	H	-2.3271
49	S	H	-1.2616
50	L	H	0.0000
51	E	H	-1.0878
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	D	H	-0.4229
56	I	H	0.0000
57	Y	H	-0.9084
58	P	H	0.0000
59	K	H	-2.7158
62	N	H	-2.3767
63	G	H	-1.5537
64	G	H	-1.2042
65	T	H	-0.8015
66	N	H	-1.5048
67	Y	H	-1.6075
68	N	H	-2.1893
69	Q	H	-2.9946
70	K	H	-2.9478
71	F	H	0.0000
72	K	H	-2.9679
74	G	H	-1.9266
75	K	H	-1.7448
76	A	H	0.0000
77	T	H	-0.9245
78	L	H	0.0000
79	T	H	-0.3852
80	V	H	-0.8949
81	D	H	-1.2590
82	K	H	-2.0818
83	S	H	-1.0172
84	S	H	-0.9643
85	S	H	-1.1226
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.4677
89	M	H	0.0000
90	E	H	-1.1930
91	L	H	0.0000
92	R	H	-1.3356
93	S	H	-1.1045
94	L	H	0.0000
95	T	H	-1.2678
96	S	H	-1.4541
97	E	H	-2.0823
98	D	H	0.0000
99	S	H	-0.6849
100	V	H	0.0000
101	V	H	-0.0200
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	T	H	0.0000
108	G	H	-0.1308
109	D	H	-0.0497
110	W	H	0.9350
111	T	H	0.4513
112	V	H	0.1543
113	G	H	-0.0616
114	Y	H	-0.1133
115	F	H	0.0000
116	D	H	-1.0501
117	V	H	-0.6461
118	W	H	0.0000
119	G	H	0.0000
120	T	H	-0.6070
121	G	H	-0.3607
122	T	H	0.0000
123	T	H	-0.1212
124	V	H	0.0000
125	T	H	-0.1547
126	V	H	0.0000
127	S	H	-0.6192
128	S	H	-0.7522
1	Q	L	-1.2002
2	I	L	0.0000
3	V	L	1.2248
4	L	L	0.0000
5	T	L	0.2246
6	Q	L	0.0000
7	S	L	-0.0240
8	P	L	0.2658
9	A	L	0.5645
10	I	L	1.1920
11	M	L	0.1679
12	S	L	-0.9223
13	A	L	0.0000
14	S	L	-1.8642
15	P	L	-1.8270
16	G	L	-2.2107
17	E	L	-2.9124
18	K	L	-2.9463
19	V	L	0.0000
20	T	L	-0.6268
21	I	L	0.0000
22	T	L	-0.2472
23	C	L	0.0000
24	S	L	-0.1938
25	A	L	0.0000
26	S	L	0.0073
27	S	L	-0.2954
28	S	L	-0.0245
29	V	L	0.0000
37	I	L	1.8434
38	Y	L	0.9639
39	T	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	F	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.1476
45	K	L	-1.4287
46	P	L	-0.8349
47	G	L	-0.7921
48	T	L	-0.8352
49	S	L	-0.7324
50	P	L	0.0000
51	K	L	-1.9124
52	V	L	0.0000
53	W	L	0.0000
54	I	L	0.0000
55	Y	L	-0.5002
56	R	L	-0.7188
57	T	L	-0.4193
65	S	L	-0.9010
66	N	L	-1.2114
67	L	L	-0.2637
68	A	L	-0.5133
69	S	L	-0.4929
70	G	L	-0.4152
71	V	L	-0.3411
72	P	L	-0.1040
74	A	L	-0.0722
75	R	L	-1.0891
76	F	L	0.0000
77	S	L	-0.4454
78	G	L	-0.6052
79	S	L	-0.7062
80	G	L	-0.3612
83	S	L	-0.0727
84	G	L	0.0562
85	T	L	-0.2201
86	S	L	-0.6100
87	Y	L	0.0000
88	S	L	-0.3494
89	L	L	0.0000
90	T	L	-0.8052
91	I	L	0.0000
92	S	L	-2.1612
93	R	L	-3.3140
94	M	L	0.0000
95	E	L	-2.4406
96	A	L	-1.7105
97	E	L	-2.2918
98	D	L	0.0000
99	A	L	-1.4728
100	A	L	0.0000
101	T	L	-0.7847
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	R	L	-0.3060
108	S	L	0.1861
109	S	L	-0.7496
114	H	L	-1.6695
115	P	L	-1.6618
116	P	L	0.0000
117	T	L	0.0000
118	F	L	0.0000
119	G	L	0.0000
120	A	L	-0.3940
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.1025
124	L	L	0.0000
125	E	L	-1.6235
126	L	L	-1.4115
127	K	L	-1.9405