Project name: 2e1e73c1a9b61b

Chain sequence(s)	A: EVQLVESGGGLVKPGGSLRLSCAASGFTFSGYGMHWVRQAPGKGLEWVAFISNGSGTIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARRGVDYWGQGTLVTVSSGGGSGGGSDVVMTQSPLSLPVTLGQPASISCKSSQSLLYSDGKTYLNWLLQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQSTHFPFTFGQGTKLEIK
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:00)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:01)

• Minimal score value: -2.8771
• Maximal score value: 1.773
• Average score: -0.5837
• Total score value: -136.5805

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	A	-2.1887
2	V	A	-1.3647
3	Q	A	-1.3978
4	L	A	0.0000
5	V	A	0.8353
6	E	A	0.0000
7	S	A	-0.2322
8	G	A	-0.7875
9	G	A	0.1516
10	G	A	0.6693
11	L	A	1.3506
12	V	A	-0.2417
13	K	A	-1.8394
14	P	A	-1.8485
15	G	A	-1.4906
16	G	A	-1.0941
17	S	A	-1.3689
18	L	A	-1.1205
19	R	A	-2.2478
20	L	A	0.0000
21	S	A	-0.4794
22	C	A	0.0000
23	A	A	-0.1790
24	A	A	0.0000
25	S	A	-1.1218
26	G	A	-1.3150
27	F	A	-0.5515
28	T	A	-0.2745
29	F	A	0.0000
30	S	A	-1.0140
31	G	A	-0.7588
32	Y	A	-0.5236
33	G	A	0.0000
34	M	A	0.0000
35	H	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.6047
40	A	A	-0.8763
41	P	A	-1.0734
42	G	A	-1.4534
43	K	A	-2.3646
44	G	A	-1.5238
45	L	A	0.0000
46	E	A	-1.0187
47	W	A	0.0000
48	V	A	0.0000
49	A	A	0.0000
50	F	A	0.0000
51	I	A	0.0000
52	S	A	-0.6359
53	N	A	-1.3851
54	G	A	-1.1024
55	S	A	-0.8011
56	G	A	-0.6230
57	T	A	0.0964
58	I	A	1.0854
59	Y	A	1.0096
60	Y	A	-0.1264
61	A	A	0.0000
62	D	A	-2.6521
63	S	A	-1.8460
64	V	A	0.0000
65	K	A	-2.2935
66	G	A	-1.6178
67	R	A	-1.4197
68	F	A	0.0000
69	T	A	-0.6920
70	I	A	0.0000
71	S	A	-0.3079
72	R	A	-1.0886
73	D	A	-1.5888
74	N	A	-1.8603
75	A	A	-1.3691
76	K	A	-2.2914
77	N	A	-1.7080
78	S	A	-1.0089
79	L	A	0.0000
80	Y	A	-0.6250
81	L	A	0.0000
82	Q	A	-1.5178
83	M	A	0.0000
84	N	A	-1.4395
85	S	A	-1.2815
86	L	A	0.0000
87	R	A	-2.2731
88	A	A	-1.7458
89	E	A	-1.6369
90	D	A	0.0000
91	T	A	-0.0664
92	A	A	0.0000
93	V	A	0.8769
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.9074
99	R	A	-1.9790
100	G	A	-0.9555
101	V	A	0.0000
102	D	A	-0.8509
103	Y	A	-0.4362
104	W	A	-0.4435
105	G	A	0.0000
106	Q	A	-1.1261
107	G	A	0.0000
108	T	A	0.6376
109	L	A	1.7730
110	V	A	0.0000
111	T	A	0.4120
112	V	A	0.0000
113	S	A	-0.9035
114	S	A	-1.2782
115	G	A	-1.4937
116	G	A	-1.4402
117	G	A	-1.3007
118	S	A	-0.9889
119	G	A	-1.2275
120	G	A	-1.3949
121	G	A	-1.5020
122	S	A	-0.7632
123	D	A	-1.0276
124	V	A	0.1709
125	V	A	0.9165
126	M	A	0.0000
127	T	A	-0.4360
128	Q	A	0.0000
129	S	A	-0.2998
130	P	A	0.1378
131	L	A	0.8065
132	S	A	-0.1047
133	L	A	-0.3235
134	P	A	-0.8764
135	V	A	0.0000
136	T	A	-0.8495
137	L	A	-0.4178
138	G	A	0.0000
139	Q	A	-1.8310
140	P	A	-1.8467
141	A	A	0.0000
142	S	A	-0.7470
143	I	A	0.0000
144	S	A	-0.8783
145	C	A	0.0000
146	K	A	-2.2412
147	S	A	0.0000
148	S	A	-0.8347
149	Q	A	-1.3852
150	S	A	-0.6237
151	L	A	0.0000
152	L	A	1.0175
153	Y	A	0.6756
154	S	A	-0.5342
155	D	A	-1.7808
156	G	A	-1.0279
157	K	A	-0.6755
158	T	A	0.2489
159	Y	A	0.6020
160	L	A	0.0000
161	N	A	0.0000
162	W	A	0.0000
163	L	A	0.0000
164	L	A	0.0000
165	Q	A	-0.9718
166	R	A	-1.5860
167	P	A	-0.9402
168	G	A	-1.2597
169	Q	A	-1.6355
170	S	A	-1.1589
171	P	A	0.0000
172	R	A	-1.1374
173	R	A	0.0000
174	L	A	0.0000
175	I	A	0.0000
176	Y	A	0.1201
177	L	A	0.0828
178	V	A	0.0000
179	S	A	-0.5662
180	K	A	-0.8507
181	L	A	-0.4818
182	D	A	-0.7500
183	S	A	-0.6017
184	G	A	-0.7813
185	V	A	0.0000
186	P	A	-1.1122
187	D	A	-2.1561
188	R	A	-2.0090
189	F	A	0.0000
190	S	A	-1.1383
191	G	A	-0.6272
192	S	A	-0.8440
193	G	A	-1.1400
194	S	A	-0.7656
195	G	A	-0.7611
196	T	A	-1.5566
197	D	A	-2.3091
198	F	A	0.0000
199	T	A	-1.0640
200	L	A	0.0000
201	K	A	-1.5575
202	I	A	0.0000
203	S	A	-2.1890
204	R	A	-2.8771
205	V	A	0.0000
206	E	A	-1.7111
207	A	A	-0.9224
208	E	A	-2.0106
209	D	A	0.0000
210	V	A	-0.7927
211	G	A	0.0000
212	V	A	-0.4017
213	Y	A	0.0000
214	Y	A	0.0000
215	C	A	0.0000
216	W	A	0.0000
217	Q	A	0.0000
218	S	A	0.3922
219	T	A	0.0000
220	H	A	0.2252
221	F	A	0.7895
222	P	A	0.1322
223	F	A	0.5537
224	T	A	0.2636
225	F	A	0.1336
226	G	A	0.0000
227	Q	A	-0.9935
228	G	A	0.0000
229	T	A	0.0000
230	K	A	-0.9889
231	L	A	0.0000
232	E	A	-1.2022
233	I	A	-0.3435
234	K	A	-1.4604