| Chain sequence(s) |
A: GPLPLNPEPELRSTDEYVTPTDLLYYAESDLLTRTGNPTKDIIVDGKVVIPRVSATQFRVFRLTLPDPNQLPLPSEDAVDFATEILIWRLLAYYIGIGGPLGVGSYGHENFNAFGDVSNPTEPQHETEDDTQNLSWRPKRLQEYVIGDRPPLGVYTAKAEPAPGLPPGARPPLKKVTSIIEDGDMADIGFGAKDFAALEPEKDNVPDIILDTTTKVIDYEGMKAEPWGDRMFDYDRFESSKDVKKYVRDGPDLFPLPDTPGPSKLYVRPSPESPYYVRPSTDYFTLPDRGEITEDDLLFNKPIWLEKTAGLNNGVLWHNRLFITVVDNTREEIETIEVRISTPEEDVYNPEDYVSFKRYTEEYQLSLIVQLCRVPLTPETLAEIERRDPSILVNARLPDVPPVVRPDPYAGLKFNDIDLTDKLSSDLSKSPLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2081 | |
| 2 | P | A | 0.4239 | |
| 3 | L | A | 1.3912 | |
| 4 | P | A | 0.7094 | |
| 5 | L | A | 0.8558 | |
| 6 | N | A | -1.0177 | |
| 7 | P | A | -1.7439 | |
| 8 | E | A | -2.5488 | |
| 9 | P | A | -2.1555 | |
| 10 | E | A | -2.2620 | |
| 11 | L | A | -0.8652 | |
| 12 | R | A | -1.2752 | |
| 13 | S | A | -1.3134 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.8752 | |
| 16 | E | A | -2.7397 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -1.0111 | |
| 20 | P | A | -0.9526 | |
| 21 | T | A | -1.0033 | |
| 22 | D | A | -1.6840 | |
| 23 | L | A | -0.5740 | |
| 24 | L | A | -0.1692 | |
| 25 | Y | A | -0.0199 | |
| 26 | Y | A | -0.2910 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8455 | |
| 29 | S | A | 0.0000 | |
| 30 | D | A | -1.4311 | |
| 31 | L | A | 0.4126 | |
| 32 | L | A | -0.0979 | |
| 33 | T | A | -0.5503 | |
| 34 | R | A | -1.1174 | |
| 35 | T | A | -0.7159 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.2534 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5080 | |
| 40 | K | A | -1.8485 | |
| 41 | D | A | -0.4081 | |
| 42 | I | A | 1.5629 | |
| 43 | I | A | 2.5237 | |
| 44 | V | A | 1.7561 | |
| 45 | D | A | -0.9101 | |
| 46 | G | A | -0.5027 | |
| 47 | K | A | -0.1508 | |
| 48 | V | A | 1.9787 | |
| 49 | V | A | 2.5325 | |
| 50 | I | A | 1.4418 | |
| 51 | P | A | 0.1101 | |
| 52 | R | A | -0.9711 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | -1.6509 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.4473 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.0095 | |
| 67 | D | A | -1.0083 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | 0.0000 | |
| 70 | Q | A | -1.4348 | |
| 71 | L | A | -0.4177 | |
| 72 | P | A | -0.3502 | |
| 73 | L | A | -0.3636 | |
| 74 | P | A | -0.8034 | |
| 75 | S | A | -1.1829 | |
| 76 | E | A | -2.0298 | |
| 77 | D | A | -1.5513 | |
| 78 | A | A | -0.9630 | |
| 79 | V | A | -0.9445 | |
| 80 | D | A | -1.5806 | |
| 81 | F | A | -0.5298 | |
| 82 | A | A | -0.3149 | |
| 83 | T | A | -0.5169 | |
| 84 | E | A | -0.5819 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3295 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.3035 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | -0.1671 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | I | A | 0.0000 | |
| 98 | G | A | -0.5239 | |
| 99 | G | A | -0.8573 | |
| 100 | P | A | -0.3406 | |
| 101 | L | A | 0.1182 | |
| 102 | G | A | 0.3292 | |
| 103 | V | A | 0.6596 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.2657 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.4297 | |
| 108 | H | A | -2.4001 | |
| 109 | E | A | -3.2863 | |
| 110 | N | A | -3.2638 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.6331 | |
| 117 | V | A | -1.0940 | |
| 118 | S | A | -1.3012 | |
| 119 | N | A | -2.0243 | |
| 120 | P | A | -1.6261 | |
| 121 | T | A | -1.5084 | |
| 122 | E | A | -2.4035 | |
| 123 | P | A | -1.2508 | |
| 124 | Q | A | -1.5766 | |
| 125 | H | A | -2.0150 | |
| 126 | E | A | -3.1100 | |
| 127 | T | A | -2.8037 | |
| 128 | E | A | -3.1605 | |
| 129 | D | A | -3.3891 | |
| 130 | D | A | -2.4890 | |
| 131 | T | A | -2.2520 | |
| 132 | Q | A | -2.3158 | |
| 133 | N | A | -2.7118 | |
| 134 | L | A | -1.4567 | |
| 135 | S | A | -1.0677 | |
| 136 | W | A | 0.0000 | |
| 137 | R | A | -0.5548 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.2229 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.4664 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | 0.0538 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.0694 | |
| 155 | Y | A | -0.6300 | |
| 156 | T | A | -1.1752 | |
| 157 | A | A | 0.0000 | |
| 158 | K | A | -2.0949 | |
| 159 | A | A | -1.7294 | |
| 160 | E | A | -2.2471 | |
| 161 | P | A | -1.3429 | |
| 162 | A | A | -0.5617 | |
| 163 | P | A | -0.5522 | |
| 164 | G | A | -0.3007 | |
| 165 | L | A | -0.0377 | |
| 166 | P | A | -0.4711 | |
| 167 | P | A | -0.7130 | |
| 168 | G | A | -0.7890 | |
| 169 | A | A | -0.9607 | |
| 170 | R | A | -1.7460 | |
| 171 | P | A | -1.4626 | |
| 172 | P | A | -1.0086 | |
| 173 | L | A | -0.6581 | |
| 174 | K | A | -2.1004 | |
| 175 | K | A | -2.1093 | |
| 176 | V | A | -0.9092 | |
| 177 | T | A | -0.2114 | |
| 178 | S | A | 0.2363 | |
| 179 | I | A | 0.1133 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -0.9203 | |
| 182 | D | A | -1.2483 | |
| 183 | G | A | -0.8109 | |
| 184 | D | A | -0.7229 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2099 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5433 | |
| 190 | F | A | -0.1090 | |
| 191 | G | A | -0.2674 | |
| 192 | A | A | -0.4388 | |
| 193 | K | A | -1.0975 | |
| 194 | D | A | -1.1647 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.6581 | |
| 197 | A | A | -0.8817 | |
| 198 | L | A | -1.0449 | |
| 199 | E | A | -1.9395 | |
| 200 | P | A | -2.0661 | |
| 201 | E | A | -2.9520 | |
| 202 | K | A | -3.4917 | |
| 203 | D | A | -2.6157 | |
| 204 | N | A | -1.5139 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -2.2108 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.9891 | |
| 211 | D | A | -2.2254 | |
| 212 | T | A | -1.1404 | |
| 213 | T | A | -0.7675 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.5241 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | -0.7157 | |
| 219 | Y | A | 0.0000 | |
| 220 | E | A | -2.4762 | |
| 221 | G | A | -1.5913 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.2768 | |
| 224 | A | A | -1.3912 | |
| 225 | E | A | -1.1598 | |
| 226 | P | A | -0.4299 | |
| 227 | W | A | -0.1434 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6231 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.5368 | |
| 234 | Y | A | -0.6193 | |
| 235 | D | A | -1.4773 | |
| 236 | R | A | -2.0671 | |
| 237 | F | A | -1.0042 | |
| 238 | E | A | -1.2925 | |
| 239 | S | A | -1.1793 | |
| 240 | S | A | -1.6882 | |
| 241 | K | A | -2.6623 | |
| 242 | D | A | -2.2827 | |
| 243 | V | A | -0.3409 | |
| 244 | K | A | -1.5482 | |
| 245 | K | A | -1.5226 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | D | A | -1.5568 | |
| 250 | G | A | -0.9631 | |
| 251 | P | A | -0.2262 | |
| 252 | D | A | 0.2250 | |
| 253 | L | A | 1.6142 | |
| 254 | F | A | 2.4094 | |
| 255 | P | A | 0.6750 | |
| 256 | L | A | 0.4223 | |
| 257 | P | A | -0.6623 | |
| 258 | D | A | -2.2173 | |
| 259 | T | A | -1.4256 | |
| 260 | P | A | -1.2446 | |
| 261 | G | A | -1.1579 | |
| 262 | P | A | -0.5282 | |
| 263 | S | A | -0.6390 | |
| 264 | K | A | -0.7285 | |
| 265 | L | A | 0.9866 | |
| 266 | Y | A | 0.9008 | |
| 267 | V | A | 0.9413 | |
| 268 | R | A | -0.6744 | |
| 269 | P | A | -0.2111 | |
| 270 | S | A | -0.6805 | |
| 271 | P | A | -0.9094 | |
| 272 | E | A | -1.6145 | |
| 273 | S | A | -0.4999 | |
| 274 | P | A | -0.0956 | |
| 275 | Y | A | 1.1200 | |
| 276 | Y | A | 0.8842 | |
| 277 | V | A | 1.3261 | |
| 278 | R | A | 0.4289 | |
| 279 | P | A | -0.5877 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.5832 | |
| 282 | D | A | -1.2213 | |
| 283 | Y | A | 0.2148 | |
| 284 | F | A | -0.2338 | |
| 285 | T | A | -0.7332 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -1.7837 | |
| 292 | I | A | -1.1072 | |
| 293 | T | A | -1.8961 | |
| 294 | E | A | -2.7189 | |
| 295 | D | A | -2.9222 | |
| 296 | D | A | -2.0884 | |
| 297 | L | A | -1.2220 | |
| 298 | L | A | -1.0656 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0084 | |
| 301 | K | A | -1.1227 | |
| 302 | P | A | -0.5151 | |
| 303 | I | A | 0.0896 | |
| 304 | W | A | -0.4340 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5138 | |
| 307 | K | A | -2.7675 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.5977 | |
| 310 | G | A | -0.6054 | |
| 311 | L | A | -0.4155 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.2660 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.3740 | |
| 319 | N | A | -0.5031 | |
| 320 | R | A | -0.6880 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | E | A | 0.0000 | |
| 332 | E | A | -1.2013 | |
| 333 | I | A | -1.1131 | |
| 334 | E | A | -2.0775 | |
| 335 | T | A | -0.9803 | |
| 336 | I | A | 0.2267 | |
| 337 | E | A | -0.5173 | |
| 338 | V | A | 1.0241 | |
| 339 | R | A | 0.0188 | |
| 340 | I | A | 1.4975 | |
| 341 | S | A | 0.2061 | |
| 342 | T | A | -0.8703 | |
| 343 | P | A | -1.5380 | |
| 344 | E | A | -2.8751 | |
| 345 | E | A | -2.8839 | |
| 346 | D | A | -2.0173 | |
| 347 | V | A | 0.4977 | |
| 348 | Y | A | 0.8915 | |
| 349 | N | A | -0.7605 | |
| 350 | P | A | -1.0986 | |
| 351 | E | A | -1.6504 | |
| 352 | D | A | -0.5645 | |
| 353 | Y | A | 0.3270 | |
| 354 | V | A | 0.8406 | |
| 355 | S | A | 0.1675 | |
| 356 | F | A | 0.3087 | |
| 357 | K | A | -1.4574 | |
| 358 | R | A | -1.2500 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -1.0595 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.6563 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.5560 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3463 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.5810 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -0.5125 | |
| 376 | L | A | -0.0419 | |
| 377 | T | A | -0.5621 | |
| 378 | P | A | -0.9177 | |
| 379 | E | A | -1.9306 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.6954 | |
| 382 | A | A | -1.3266 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | E | A | -2.4216 | |
| 386 | R | A | -1.7935 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -1.1085 | |
| 389 | P | A | -1.1002 | |
| 390 | S | A | -0.4009 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0839 | |
| 393 | V | A | 0.9156 | |
| 394 | N | A | -0.2297 | |
| 395 | A | A | -0.6965 | |
| 396 | R | A | -1.5614 | |
| 397 | L | A | -0.6203 | |
| 398 | P | A | -0.9434 | |
| 399 | D | A | -1.2689 | |
| 400 | V | A | 0.7385 | |
| 401 | P | A | 0.4387 | |
| 402 | P | A | 0.7362 | |
| 403 | V | A | 2.2470 | |
| 404 | V | A | 1.9785 | |
| 405 | R | A | 0.1519 | |
| 406 | P | A | -0.4398 | |
| 407 | D | A | -0.9108 | |
| 408 | P | A | -0.7740 | |
| 409 | Y | A | 0.0000 | |
| 410 | A | A | -0.6556 | |
| 411 | G | A | -0.7015 | |
| 412 | L | A | -0.6715 | |
| 413 | K | A | -2.0407 | |
| 414 | F | A | -1.5988 | |
| 415 | N | A | -1.9544 | |
| 416 | D | A | -2.7707 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.9543 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6003 | |
| 421 | D | A | -2.3177 | |
| 422 | K | A | -1.8591 | |
| 423 | L | A | -0.6775 | |
| 424 | S | A | -0.8350 | |
| 425 | S | A | -0.5662 | |
| 426 | D | A | -1.4901 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.9525 | |
| 429 | K | A | -2.4490 | |
| 430 | S | A | 0.0000 | |
| 431 | P | A | -1.5585 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.9139 | |
| 435 | E | A | -2.3561 | |
| 436 | Y | A | -1.0802 | |
| 437 | L | A | -0.5439 | |
| 438 | N | A | -2.2183 | |
| 439 | R | A | -2.3786 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine