Project name: 2f84aef5a813b34

Chain sequence(s)	H: EVQLQQSGAELVRSGASVKLSCTASGFDIQDYYMQWVNQRPEQGLEWIGWIDPESGETEYAPKFQGKATMTADTSSNTAYLQLNSLTSEDTAVYYCNAFNWDEGGYSGMDYWGQGTSVTVSS; L: DIVMTQSPSSLSVSAGEKVTMSCKSSQSLLKSGNQKNYLAWYQQKPGQPPKLLIYGASIRESGVPDRFTGSGSGTDFTLTVSSVQAEDLAVYYCQNAHSFPFTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:12)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:13)

• Minimal score value: -3.2626
• Maximal score value: 0.9899
• Average score: -0.7294
• Total score value: -171.4041

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9834
2	V	H	-1.2648
3	Q	H	-1.6687
4	L	H	0.0000
5	Q	H	-1.7737
6	Q	H	0.0000
7	S	H	-0.9118
8	G	H	-0.9462
9	A	H	-0.2222
11	E	H	-0.4529
12	L	H	0.7179
13	V	H	0.0000
14	R	H	-1.9623
15	S	H	-1.3691
16	G	H	-1.2410
17	A	H	-1.0682
18	S	H	-1.1322
19	V	H	0.0000
20	K	H	-1.3157
21	L	H	0.0000
22	S	H	-0.4677
23	C	H	0.0000
24	T	H	-0.8989
25	A	H	0.0000
26	S	H	-1.3665
27	G	H	-1.3792
28	F	H	-1.5977
29	D	H	-2.5282
30	I	H	0.0000
35	Q	H	-3.1863
36	D	H	-2.9810
37	Y	H	-1.5502
38	Y	H	-0.5655
39	M	H	0.0000
40	Q	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	N	H	0.0000
44	Q	H	-0.9440
45	R	H	-1.5633
46	P	H	-1.5271
47	E	H	-2.5032
48	Q	H	-2.1598
49	G	H	-1.2835
50	L	H	0.0000
51	E	H	-1.0645
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	W	H	0.0000
56	I	H	0.0000
57	D	H	0.0000
58	P	H	0.0000
59	E	H	-3.2626
62	S	H	-2.0509
63	G	H	-2.1663
64	E	H	-2.5058
65	T	H	-1.2526
66	E	H	-0.9506
67	Y	H	-0.7462
68	A	H	0.0000
69	P	H	-1.7245
70	K	H	-2.3127
71	F	H	0.0000
72	Q	H	-2.0999
74	G	H	-1.4920
75	K	H	-1.3728
76	A	H	0.0000
77	T	H	-0.6615
78	M	H	0.0000
79	T	H	-0.5316
80	A	H	-0.9498
81	D	H	-1.0907
82	T	H	-1.4144
83	S	H	-0.7029
84	S	H	-0.6833
85	N	H	-1.0501
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.1250
89	L	H	0.0000
90	Q	H	-0.8764
91	L	H	0.0000
92	N	H	-0.9610
93	S	H	-0.9771
94	L	H	0.0000
95	T	H	-1.3129
96	S	H	-1.3413
97	E	H	-1.9685
98	D	H	0.0000
99	T	H	-0.6252
100	A	H	0.0000
101	V	H	0.1035
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	N	H	0.0000
106	A	H	0.0000
107	F	H	0.0000
108	N	H	-1.1013
109	W	H	-0.8808
110	D	H	-2.6415
111	E	H	-2.7264
111A	G	H	-2.0020
112A	G	H	-1.6061
112	Y	H	0.0000
113	S	H	-0.5855
114	G	H	0.0000
115	M	H	0.0000
116	D	H	0.0000
117	Y	H	0.0528
118	W	H	-0.5665
119	G	H	0.0000
120	Q	H	-1.8353
121	G	H	-0.9801
122	T	H	0.0000
123	S	H	-0.1663
124	V	H	0.0000
125	T	H	-0.1326
126	V	H	-0.7113
127	S	H	-0.6008
128	S	H	-0.7799
1	D	L	-1.3442
2	I	L	-0.2244
3	V	L	0.9899
4	M	L	0.0000
5	T	L	-0.2576
6	Q	L	0.0000
7	S	L	-0.6203
8	P	L	-0.5551
9	S	L	-0.6885
10	S	L	-0.7254
11	L	L	-0.4836
12	S	L	-0.7038
13	V	L	-0.9454
14	S	L	-1.5573
15	A	L	-1.5363
16	G	L	-1.7997
17	E	L	-2.8635
18	K	L	-2.1813
19	V	L	0.0000
20	T	L	-0.5441
21	M	L	0.0000
22	S	L	-0.6995
23	C	L	0.0000
24	K	L	-1.4686
25	S	L	0.0000
26	S	L	-0.7820
27	Q	L	-1.5174
28	S	L	-1.1190
29	L	L	0.0000
30	L	L	-0.7465
31	K	L	-1.3032
32	S	L	-1.2354
33	G	L	-1.5187
34	N	L	-2.0702
35	Q	L	-2.1357
36	K	L	-1.3973
37	N	L	-0.8561
38	Y	L	0.0000
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.3869
46	P	L	-1.1044
47	G	L	-1.4562
48	Q	L	-2.0987
49	P	L	-1.3567
50	P	L	0.0000
51	K	L	-1.3281
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1474
56	G	L	-0.1826
57	A	L	0.0000
65	S	L	-0.1007
66	I	L	0.3889
67	R	L	-0.8960
68	E	L	-0.7634
69	S	L	-0.6279
70	G	L	-0.9280
71	V	L	-0.9264
72	P	L	-1.2786
74	D	L	-2.1505
75	R	L	-1.4679
76	F	L	0.0000
77	T	L	-0.6267
78	G	L	0.0000
79	S	L	-0.5728
80	G	L	-1.1697
83	S	L	-1.1233
84	G	L	-1.0335
85	T	L	-1.5476
86	D	L	-2.2333
87	F	L	0.0000
88	T	L	-0.6951
89	L	L	0.0000
90	T	L	-0.4127
91	V	L	0.0000
92	S	L	-1.5675
93	S	L	-1.7337
94	V	L	0.0000
95	Q	L	-1.6783
96	A	L	-1.1373
97	E	L	-1.6943
98	D	L	0.0000
99	L	L	-0.0566
100	A	L	0.0000
101	V	L	-0.2161
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	N	L	0.0000
107	A	L	0.0000
108	H	L	-0.3120
109	S	L	-0.0770
114	F	L	0.2506
115	P	L	-0.3948
116	F	L	0.0000
117	T	L	0.1031
118	F	L	0.1870
119	G	L	0.0000
120	G	L	-0.6289
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.0447
124	L	L	0.0000
125	E	L	-0.5199
126	I	L	-0.8574
127	K	L	-1.6751